JPWO2021237118A5 - - Google Patents
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- JPWO2021237118A5 JPWO2021237118A5 JP2022571786A JP2022571786A JPWO2021237118A5 JP WO2021237118 A5 JPWO2021237118 A5 JP WO2021237118A5 JP 2022571786 A JP2022571786 A JP 2022571786A JP 2022571786 A JP2022571786 A JP 2022571786A JP WO2021237118 A5 JPWO2021237118 A5 JP WO2021237118A5
- Authority
- JP
- Japan
- Prior art keywords
- active
- variant
- kinase
- sample
- kras4a
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063028729P | 2020-05-22 | 2020-05-22 | |
| US63/028,729 | 2020-05-22 | ||
| US202063109103P | 2020-11-03 | 2020-11-03 | |
| US63/109,103 | 2020-11-03 | ||
| PCT/US2021/033703 WO2021237118A2 (en) | 2020-05-22 | 2021-05-21 | Enhancement of kinase target engagement |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2023526677A JP2023526677A (ja) | 2023-06-22 |
| JPWO2021237118A5 true JPWO2021237118A5 (https=) | 2024-05-28 |
| JP2023526677A5 JP2023526677A5 (https=) | 2024-05-28 |
| JP7677997B2 JP7677997B2 (ja) | 2025-05-15 |
Family
ID=76959042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022571786A Active JP7677997B2 (ja) | 2020-05-22 | 2021-05-21 | キナーゼターゲットエンゲージメントの増強 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20210363565A1 (https=) |
| EP (1) | EP4153770A2 (https=) |
| JP (1) | JP7677997B2 (https=) |
| WO (1) | WO2021237118A2 (https=) |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US103A (en) | 1836-12-10 | Process | ||
| US8669A (en) | 1852-01-20 | John waters | ||
| US4812409A (en) | 1986-01-31 | 1989-03-14 | Eastman Kodak Company | Hydrolyzable fluorescent substrates and analytical determinations using same |
| US4810636A (en) | 1986-12-09 | 1989-03-07 | Miles Inc. | Chromogenic acridinone enzyme substrates |
| US5368484A (en) | 1992-05-22 | 1994-11-29 | Atari Games Corp. | Vehicle simulator with realistic operating feedback |
| US6162931A (en) | 1996-04-12 | 2000-12-19 | Molecular Probes, Inc. | Fluorinated xanthene derivatives |
| US7393656B2 (en) | 2001-07-10 | 2008-07-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for risk stratification |
| US7268229B2 (en) | 2001-11-02 | 2007-09-11 | Promega Corporation | Compounds to co-localize luminophores with luminescent proteins |
| US7429472B2 (en) | 2003-01-31 | 2008-09-30 | Promega Corporation | Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule |
| EP1594962B1 (en) | 2003-01-31 | 2014-08-27 | Promega Corporation | Covalent tethering of functional groups to proteins |
| US7425436B2 (en) | 2004-07-30 | 2008-09-16 | Promega Corporation | Covalent tethering of functional groups to proteins and substrates therefor |
| WO2007016975A1 (en) * | 2005-07-29 | 2007-02-15 | F. Hoffmann-La Roche Ag | Kinase and phosphatase assays based on fret |
| AR065015A1 (es) * | 2007-01-26 | 2009-05-13 | Smithkline Beecham Corp | Derivados de antranilamida, composiciones farmaceuticas que los contienen, y usos para el tratamiento del cancer |
| ES2795287T3 (es) | 2009-05-01 | 2020-11-23 | Promega Corp | Luciferasas de Oplophorus sintéticas con mayor emisión de luz |
| SG10202103336SA (en) | 2010-11-02 | 2021-04-29 | Promega Corp | Novel coelenterazine substrates and methods of use |
| US20140099654A1 (en) | 2012-09-26 | 2014-04-10 | Promega Corporation | Real-time monitoring |
| ES2926463T3 (es) | 2013-03-15 | 2022-10-26 | Promega Corp | Activación de la bioluminiscencia mediante complementación estructural |
| WO2014176700A1 (en) * | 2013-05-01 | 2014-11-06 | Université de Montréal | Biosensors for ras-dependent signaling pathways and use thereof |
| JP7092677B2 (ja) | 2016-02-15 | 2022-06-28 | プロメガ コーポレイション | セレンテラジン類似体 |
| JP7212612B2 (ja) | 2016-07-28 | 2023-01-25 | プロメガ コーポレイション | セレンテラジン類縁体 |
| US9943505B2 (en) | 2016-09-09 | 2018-04-17 | Corcept Therapeutics, Inc. | Glucocorticoid receptor modulators to treat pancreatic cancer |
| US11442063B2 (en) * | 2018-05-30 | 2022-09-13 | Promega Corporation | Broad spectrum kinase binding agents |
-
2021
- 2021-05-21 US US17/327,319 patent/US20210363565A1/en not_active Abandoned
- 2021-05-21 WO PCT/US2021/033703 patent/WO2021237118A2/en not_active Ceased
- 2021-05-21 JP JP2022571786A patent/JP7677997B2/ja active Active
- 2021-05-21 EP EP21742931.5A patent/EP4153770A2/en active Pending
-
2024
- 2024-08-22 US US18/812,371 patent/US20250188510A1/en active Pending
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