JPWO2021222188A5 - - Google Patents

Info

Publication number

JPWO2021222188A5

JPWO2021222188A5 JP2023509466A JP2023509466A JPWO2021222188A5 JP WO2021222188 A5 JPWO2021222188 A5 JP WO2021222188A5 JP 2023509466 A JP2023509466 A JP 2023509466A JP 2023509466 A JP2023509466 A JP 2023509466A JP WO2021222188 A5 JPWO2021222188 A5 JP WO2021222188A5

Authority

JP

Japan

Prior art keywords

administered

antibody

day

chemotherapeutic agent

weeks

Prior art date

2024-05-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 claims description 137
• 238000002512 chemotherapy Methods 0.000 claims description 96
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 30
• SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical group C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims description 28
• 239000000203 mixture Substances 0.000 claims description 26
• 229930182474 N-glycoside Natural products 0.000 claims description 19
• 206010028980 Neoplasm Diseases 0.000 claims description 19
• 201000011510 cancer Diseases 0.000 claims description 19
• 150000001413 amino acids Chemical class 0.000 claims description 16
• 150000001720 carbohydrates Chemical group 0.000 claims description 16
• 229960001592 paclitaxel Drugs 0.000 claims description 15
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 15
• 229930012538 Paclitaxel Natural products 0.000 claims description 11
• 102100023990 60S ribosomal protein L17 Human genes 0.000 claims description 10
• 101710089372 Programmed cell death protein 1 Proteins 0.000 claims description 10
• 201000008129 pancreatic ductal adenocarcinoma Diseases 0.000 claims description 10
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• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 9
• 201000002528 pancreatic cancer Diseases 0.000 claims description 9
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• 229960002621 pembrolizumab Drugs 0.000 claims description 9
• 230000037396 body weight Effects 0.000 claims description 6
• SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims description 6
• 229960005277 gemcitabine Drugs 0.000 claims description 6
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• 108010012934 Albumin-Bound Paclitaxel Proteins 0.000 claims description 2
• 206010006187 Breast cancer Diseases 0.000 claims description 2
• 206010055113 Breast cancer metastatic Diseases 0.000 claims description 2
• 208000026310 Breast neoplasm Diseases 0.000 claims description 2
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
• 201000005202 lung cancer Diseases 0.000 claims description 2
• 208000020816 lung neoplasm Diseases 0.000 claims description 2
• 201000001441 melanoma Diseases 0.000 claims description 2
• 230000001394 metastastic effect Effects 0.000 claims description 2
• 206010061289 metastatic neoplasm Diseases 0.000 claims description 2
• 239000002246 antineoplastic agent Substances 0.000 claims 78
• 229940127089 cytotoxic agent Drugs 0.000 claims 78
• 239000008194 pharmaceutical composition Substances 0.000 claims 28
• 239000003814 drug Substances 0.000 claims 8
• 239000008177 pharmaceutical agent Substances 0.000 claims 8
• 239000012829 chemotherapy agent Substances 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
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