JPWO2021183675A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2021183675A5
JPWO2021183675A5 JP2022554178A JP2022554178A JPWO2021183675A5 JP WO2021183675 A5 JPWO2021183675 A5 JP WO2021183675A5 JP 2022554178 A JP2022554178 A JP 2022554178A JP 2022554178 A JP2022554178 A JP 2022554178A JP WO2021183675 A5 JPWO2021183675 A5 JP WO2021183675A5
Authority
JP
Japan
Prior art keywords
cells
cell
population
engineered
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022554178A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023517063A (ja
JP2023517063A5 (https=
Publication date
Priority claimed from US17/144,834 external-priority patent/US11896619B2/en
Application filed filed Critical
Priority claimed from PCT/US2021/021758 external-priority patent/WO2021183675A2/en
Publication of JP2023517063A publication Critical patent/JP2023517063A/ja
Priority to JP2024088657A priority Critical patent/JP2024119881A/ja
Publication of JP2023517063A5 publication Critical patent/JP2023517063A5/ja
Publication of JPWO2021183675A5 publication Critical patent/JPWO2021183675A5/ja
Pending legal-status Critical Current

Links

JP2022554178A 2020-03-10 2021-03-10 操作されたメモリー様nk細胞を作製するための方法およびその組成物 Pending JP2023517063A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024088657A JP2024119881A (ja) 2020-03-10 2024-05-31 操作されたメモリー様nk細胞を作製するための方法およびその組成物

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US202062987612P 2020-03-10 2020-03-10
US62/987,612 2020-03-10
US202063119959P 2020-12-01 2020-12-01
US63/119,959 2020-12-01
US202063121127P 2020-12-03 2020-12-03
US63/121,127 2020-12-03
US17/144,834 US11896619B2 (en) 2020-03-10 2021-01-08 Compositions and methods for immunotherapy of NPM1c-positive cancer
US17/144,834 2021-01-08
PCT/US2021/021758 WO2021183675A2 (en) 2020-03-10 2021-03-10 Methods for generating engineered memory-like nk cells and compositions thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024088657A Division JP2024119881A (ja) 2020-03-10 2024-05-31 操作されたメモリー様nk細胞を作製するための方法およびその組成物

Publications (3)

Publication Number Publication Date
JP2023517063A JP2023517063A (ja) 2023-04-21
JP2023517063A5 JP2023517063A5 (https=) 2024-06-11
JPWO2021183675A5 true JPWO2021183675A5 (https=) 2024-06-11

Family

ID=77672439

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022554178A Pending JP2023517063A (ja) 2020-03-10 2021-03-10 操作されたメモリー様nk細胞を作製するための方法およびその組成物
JP2024088657A Pending JP2024119881A (ja) 2020-03-10 2024-05-31 操作されたメモリー様nk細胞を作製するための方法およびその組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024088657A Pending JP2024119881A (ja) 2020-03-10 2024-05-31 操作されたメモリー様nk細胞を作製するための方法およびその組成物

Country Status (11)

Country Link
US (1) US20230149460A1 (https=)
EP (1) EP4117716A2 (https=)
JP (2) JP2023517063A (https=)
KR (2) KR20240096884A (https=)
CN (1) CN115768464A (https=)
AU (1) AU2021236145A1 (https=)
BR (1) BR112022018105A2 (https=)
CA (1) CA3173527A1 (https=)
IL (1) IL296242A (https=)
MX (1) MX2022011080A (https=)
WO (1) WO2021183675A2 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113599395B (zh) * 2021-09-22 2022-08-12 郑州源创吉因实业有限公司 含有nk细胞的治疗癌症的药物组合物
MX2024003250A (es) * 2021-09-22 2024-05-28 Sonoma Biotherapeutics Inc Marcadores de superficie celular il5ra.
CN119256084A (zh) * 2022-05-13 2025-01-03 莱顿大学医学中心附属莱顿教学医院 血液系统恶性肿瘤的治疗
CN116478931A (zh) * 2023-05-16 2023-07-25 新乡医学院 一种高亲和型抗肿瘤nk细胞及其制备方法和应用
WO2025166096A1 (en) * 2024-02-01 2025-08-07 Inndura Therapeutics Inc. Method of induction of immune cells into a memory-like state
EP4600264A1 (en) * 2024-02-08 2025-08-13 Ecole Polytechnique Fédérale de Lausanne (EPFL) Engineered type 2 cytokine signalling to improve car-t cell effector functions
CN119776278B (zh) * 2025-03-12 2025-06-27 四川大学华西医院 一种增强型nk细胞及其制备方法和应用

Family Cites Families (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714350A (en) 1992-03-09 1998-02-03 Protein Design Labs, Inc. Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
US6005079A (en) 1992-08-21 1999-12-21 Vrije Universiteit Brussels Immunoglobulins devoid of light chains
AU701578B2 (en) 1992-08-21 1999-02-04 Vrije Universiteit Brussel Immunoglobulins devoid of light chains
WO1994025591A1 (en) 1993-04-29 1994-11-10 Unilever N.V. PRODUCTION OF ANTIBODIES OR (FUNCTIONALIZED) FRAGMENTS THEREOF DERIVED FROM HEAVY CHAIN IMMUNOGLOBULINS OF $i(CAMELIDAE)
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
US6001329A (en) 1996-05-06 1999-12-14 Uab Research Foundation Radiolabeled fusion toxins for cancer therapy
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
US6995259B1 (en) 1998-10-23 2006-02-07 Sirna Therapeutics, Inc. Method for the chemical synthesis of oligonucleotides
US7723111B2 (en) 2001-03-09 2010-05-25 The United States Of America As Represented By The Department Of Health And Human Services Activated dual specificity lymphocytes and their methods of use
US7070995B2 (en) 2001-04-11 2006-07-04 City Of Hope CE7-specific redirected immune cells
US20090257994A1 (en) 2001-04-30 2009-10-15 City Of Hope Chimeric immunoreceptor useful in treating human cancers
MXPA05000511A (es) 2001-07-12 2005-09-30 Jefferson Foote Anticuepros super humanizados.
US7446190B2 (en) 2002-05-28 2008-11-04 Sloan-Kettering Institute For Cancer Research Nucleic acids encoding chimeric T cell receptors
AU2003265948B8 (en) 2002-09-06 2009-09-03 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy
TW200423951A (en) 2002-11-13 2004-11-16 Ming-Chung Wong Method of preparing anti-angiogenic drug from cartilage and chondrocytes and methods of use
US20130266551A1 (en) 2003-11-05 2013-10-10 St. Jude Children's Research Hospital, Inc. Chimeric receptors with 4-1bb stimulatory signaling domain
US20070036773A1 (en) 2005-08-09 2007-02-15 City Of Hope Generation and application of universal T cells for B-ALL
CA2651174A1 (en) 2006-05-03 2007-11-15 Government Of The United States Of America, Represented By The Secretary , Department Of Health And Human Services Chimeric t cell receptors and related materials and methods of use
DE102006031054B4 (de) 2006-07-05 2010-08-05 Hänel & Co. Hochregal mit Lagergutanwahl
US9334330B2 (en) 2006-10-10 2016-05-10 Universite De Nantes Use of monoclonal antibodies specific to the O-acetylated form of GD2 ganglioside for the treatment of certain cancers
AU2008206442B2 (en) 2007-01-12 2012-10-18 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services gp100-specific T cell receptors and related materials and methods of use
CA2682527C (en) 2007-03-30 2017-07-11 Memorial Sloan-Kettering Cancer Center Constitutive expression of costimulatory ligands on adoptively transferred t lymphocytes
WO2008131445A1 (en) 2007-04-23 2008-10-30 The Board Of Regents, The University Of Texas System Device and method for transfecting cells for therapeutic use
US20110213288A1 (en) 2007-04-23 2011-09-01 The Board Of Regents, The University Of Texas System Device And Method For Transfecting Cells For Therapeutic Uses
US20100297093A1 (en) 2007-09-25 2010-11-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Modified t cell receptors and related materials and methods
CN101335956B (zh) 2008-08-05 2011-10-05 国民技术股份有限公司 借助误码率统计数据判断通信距离的系统和方法
EP2169837B1 (en) 2008-09-29 2013-01-30 Telefonaktiebolaget LM Ericsson (publ) Technique for suppressing noise in a transmitter device
US20100322909A1 (en) 2009-06-17 2010-12-23 The University Of Pittsburgh - Of The Commonwealth System Of Higher Education Th1-associated micrornas and their use for tumor immunotherapy
US8465743B2 (en) 2009-10-01 2013-06-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer
AU2010312594B2 (en) 2009-10-27 2013-06-20 Delta-Fly Pharma, Inc. Novel 5-fluorouracil derivative
WO2011059836A2 (en) 2009-10-29 2011-05-19 Trustees Of Dartmouth College T cell receptor-deficient t cell compositions
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
US20110104128A1 (en) 2009-10-30 2011-05-05 The Board Of Regents, The University Of Texas System Device and Method for Transfecting Cells for Therapeutic Use
DK2496698T3 (en) 2009-11-03 2019-04-15 Hope City TRUNCATED EPIDERIMAL GROWTH FACTOR RECEPTOR (EGFRt) FOR TRUNCATED T-CELL SELECTION
US8956828B2 (en) 2009-11-10 2015-02-17 Sangamo Biosciences, Inc. Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
WO2011150420A1 (en) 2010-05-28 2011-12-01 Baylor College Of Medicine Modified gold nanoparticles for therapy
DK3323830T3 (da) 2010-06-19 2023-09-25 Memorial Sloan Kettering Cancer Center Anti-gd2 antibodies
CA2993567C (en) 2010-07-21 2022-06-28 Sangamo Biosciences, Inc. Methods and compositions for modification of a t-cell receptor gene
US9163258B2 (en) 2010-07-23 2015-10-20 Fred Hutchinson Cancer Research Center Method for the treatment of obesity
CA2805097A1 (en) 2010-07-28 2012-02-02 DePuy Synthes Products, Inc. System or bone fixation using biodegradable screw having radial cutouts
US9487800B2 (en) 2010-09-08 2016-11-08 Chemotherapeutisches Forschunginstitut Georg-Speyer-Haus Interleukin 15 as selectable marker for gene transfer in lymphocytes
CN103124740B (zh) 2010-09-21 2015-09-02 美国卫生和人力服务部 抗-ssx-2t细胞受体和相关材料及使用方法
WO2012044999A2 (en) * 2010-10-01 2012-04-05 Ludwig Institute For Cancer Research Ltd. Reversible protein multimers, methods for their production and use
CN108424462A (zh) 2010-10-27 2018-08-21 贝勒医学院 使t细胞重定向针对cd70阳性恶性肿瘤的嵌合cd27受体
WO2012071420A1 (en) 2010-11-23 2012-05-31 The Trustees Of Columbia University In The City Of New York Enzyme combinations to reduce brain tissue swelling
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
ES2791716T3 (es) 2010-12-14 2020-11-05 Univ Maryland Células T que expresan al receptor de antígeno quimérico antietiqueta universal y métodos para el tratamiento del cáncer
KR101796322B1 (ko) 2011-01-07 2017-12-01 삼성전자주식회사 항법 알고리즘을 이용한 위치 정보 검출 장치 및 방법
US9402865B2 (en) 2011-01-18 2016-08-02 The Trustees Of The University Of Pennsylvania Compositions and methods for treating cancer
SG193023A1 (en) 2011-02-11 2013-10-30 Sloan Kettering Inst Cancer Hla-restricted, peptide-specific antigen binding proteins
WO2012148552A2 (en) 2011-02-24 2012-11-01 The Research Foundation Of State University Of New York Rectifying electromagnetic nanosensors
CN110200997A (zh) 2011-03-23 2019-09-06 弗雷德哈钦森癌症研究中心 用于细胞免疫治疗的方法和组合物
US20130071414A1 (en) 2011-04-27 2013-03-21 Gianpietro Dotti Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies
GB201108236D0 (en) 2011-05-17 2011-06-29 Ucl Business Plc Method
EP3549611B1 (en) 2011-07-29 2021-06-30 The Trustees of the University of Pennsylvania Switch costimulatory receptors
US9833476B2 (en) 2011-08-31 2017-12-05 The Trustees Of Dartmouth College NKP30 receptor targeted therapeutics
ES2834070T3 (es) 2011-09-15 2021-06-16 Us Health Receptores de células T que reconocen MAGE restringido por HLA-A1 o HLA-Cw7
EP3692794A1 (en) 2011-09-16 2020-08-12 Baylor College of Medicine Targeting the tumor microenvironment using manipulated nkt cells
WO2013051718A1 (ja) 2011-10-07 2013-04-11 国立大学法人三重大学 キメラ抗原受容体
WO2013059593A1 (en) 2011-10-20 2013-04-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-cd22 chimeric antigen receptors
JP6074435B2 (ja) 2011-10-26 2017-02-01 ナショナル キャンサー センター 変異ctla4遺伝子移入t細胞及びこれを含む抗がん免疫治療用組成物
WO2013063419A2 (en) 2011-10-28 2013-05-02 The Trustees Of The University Of Pennsylvania A fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting
WO2013067492A1 (en) 2011-11-03 2013-05-10 The Trustees Of The University Of Pennsylvania Isolated b7-h4 specific compositions and methods of use thereof
WO2013070468A1 (en) 2011-11-08 2013-05-16 The Trustees Of The University Of Pennsylvania Glypican-3-specific antibody and uses thereof
KR102134932B1 (ko) 2011-11-11 2020-07-17 프레드 헛친슨 켄서 리서치 센터 암을 위한 사이클린 a1―표적화된 t―세포 면역요법
WO2013074916A1 (en) 2011-11-18 2013-05-23 Board Of Regents, The University Of Texas System Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla
US8772058B2 (en) 2012-02-02 2014-07-08 Harris Corporation Method for making a redistributed wafer using transferrable redistribution layers
WO2013121960A1 (ja) 2012-02-13 2013-08-22 電気化学工業株式会社 クロロプレンゴム組成物、該クロロプレンゴム組成物を用いた接着剤組成物
MX2014010185A (es) 2012-02-22 2014-11-14 Univ Pennsylvania Uso de dominio de señalizacion cd2 en receptores de antigeno quimericos de segunda generacion.
WO2013126712A1 (en) 2012-02-22 2013-08-29 The Trustees Of The University Of Pennsylvania Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer
CA3205751A1 (en) 2012-02-22 2013-08-29 The Trustees Of The University Of Pennsylvania Use of icos-based cars to enhance antitumor activity and car persistence
EA033110B1 (ru) 2012-04-11 2019-08-30 Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез Химерный рецептор антигена, направленный на антиген созревания b-клеток, кодирующая его нуклеиновая кислота, соответствующие экспрессионный вектор, клетка-хозяин, применения и способы
GB201206559D0 (en) 2012-04-13 2012-05-30 Ucl Business Plc Polypeptide
US20130280220A1 (en) 2012-04-20 2013-10-24 Nabil Ahmed Chimeric antigen receptor for bispecific activation and targeting of t lymphocytes
ES2719495T5 (en) 2012-05-07 2025-09-10 Dartmouth College Anti-b7-h6 antibody, fusion proteins, and methods of using the same
KR102437522B1 (ko) 2012-05-25 2022-08-26 셀렉티스 면역요법을 위한 동종이형 및 면역억제제 저항성인 t 세포의 조작 방법
US20150017136A1 (en) 2013-07-15 2015-01-15 Cellectis Methods for engineering allogeneic and highly active t cell for immunotherapy
AU2013289979A1 (en) 2012-07-13 2015-01-22 The Trustees Of The University Of Pennsylvania Methods of assessing the suitability of transduced T cells for administration
KR20150029714A (ko) 2012-07-13 2015-03-18 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 이중특이적 항체의 공-도입에 의한 car 세포의 활성 증강
JP5822798B2 (ja) 2012-08-08 2015-11-24 三菱電機株式会社 断熱箱体及びこの断熱箱体を備えた冷蔵庫
US20140065629A1 (en) 2012-08-29 2014-03-06 Israel Barken Methods of treating diseases
WO2014039513A2 (en) 2012-09-04 2014-03-13 The Trustees Of The University Of Pennsylvania Inhibition of diacylglycerol kinase to augment adoptive t cell transfer
EP2893003B1 (en) 2012-09-04 2021-03-31 Inven2 AS Selective and controlled expansion of educated nk cells
EP2893566B1 (fr) 2012-09-05 2016-05-18 Institut National des Sciences Appliquées de Lyon Procede de fabrication d'un transistor a effet de champ a jonction jfet
WO2014055442A2 (en) 2012-10-01 2014-04-10 The Trustees Of The University Of Pennsylvania Compositions and methods for targeting stromal cells for the treatment of cancer
US9598489B2 (en) 2012-10-05 2017-03-21 The Trustees Of The Univeristy Of Pennsylvania Human alpha-folate receptor chimeric antigen receptor
EP2906684B8 (en) 2012-10-10 2020-09-02 Sangamo Therapeutics, Inc. T cell modifying compounds and uses thereof
US20140120136A1 (en) 2012-10-12 2014-05-01 The Babraham Institute Mir-155 enhancement of cd8+ t cell immunity
JO3529B1 (ar) 2013-02-08 2020-07-05 Amgen Res Munich Gmbh مضاد التصاق خلايا الدم البيض من أجل التخفيف من الاثار السلبية الممكنة الناتجة عن مجالات ارتباط cd3- المحدد
TW201446794A (zh) 2013-02-20 2014-12-16 Novartis Ag 利用抗-cd123嵌合抗原受體工程化t細胞之初級人類白血病有效靶向
DK2958943T3 (da) 2013-02-20 2019-12-09 Univ Pennsylvania Behandling af cancer ved anvendelse af humaniseret anti-EGFRvIII kimær antigenreceptor
US9587237B2 (en) 2013-03-14 2017-03-07 Elwha Llc Compositions, methods, and computer systems related to making and administering modified T cells
US9499855B2 (en) 2013-03-14 2016-11-22 Elwha Llc Compositions, methods, and computer systems related to making and administering modified T cells
US20140274801A1 (en) 2013-03-14 2014-09-18 Elwha Llc Compositions, methods, and computer systems related to making and administering modified t cells
EP2970426B1 (en) 2013-03-15 2019-08-28 Michael C. Milone Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
US9446105B2 (en) 2013-03-15 2016-09-20 The Trustees Of The University Of Pennsylvania Chimeric antigen receptor specific for folate receptor β
US9393268B2 (en) 2013-03-15 2016-07-19 Thomas Jefferson University Cell-based anti-cancer compositions with reduced toxicity and methods of making and using the same
US9657105B2 (en) 2013-03-15 2017-05-23 City Of Hope CD123-specific chimeric antigen receptor redirected T cells and methods of their use
UY35468A (es) 2013-03-16 2014-10-31 Novartis Ag Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19
ES3011466T3 (en) 2013-04-18 2025-04-07 Tilt Biotherapeutics Oy Enhanced adoptive cell therapy
WO2014201378A1 (en) 2013-06-13 2014-12-18 Massachusetts Institute Of Technology Synergistic tumor treatment with extended-pk il -2 and adoptive cell therapy
WO2014201319A1 (en) 2013-06-14 2014-12-18 The University Of Houston System Targeting tumor neovasculature with modified chimeric antigen receptors
DE102013212604A1 (de) 2013-06-28 2014-12-31 Robert Bosch Gmbh Bearbeitungswerkzeug
EP3021853A1 (en) 2013-07-18 2016-05-25 Baylor College Of Medicine Method of enhancing potency of immune cells
NO335489B1 (no) 2013-08-27 2014-12-22 Langåker John Magne Multifunksjons varmepumpe
US9351129B2 (en) 2013-08-30 2016-05-24 Hubbell Incorporated WiFi hazardous area VoIP paging telephone and system
WO2015038684A1 (en) 2013-09-10 2015-03-19 Polyera Corporation Attachable article with signaling, split display and messaging features
EP3103153B1 (en) 2014-02-05 2017-08-30 Elcogen OY Assembly method and arrangement for a cell system
KR102229770B1 (ko) 2014-03-17 2021-03-18 나믹스 가부시끼가이샤 수지 조성물
TWI805109B (zh) 2014-08-28 2023-06-11 美商奇諾治療有限公司 對cd19具專一性之抗體及嵌合抗原受體
BR112017008042A2 (pt) 2014-10-20 2017-12-26 Juno Therapeutics Inc métodos e composições para dosagem em terapia de célula adotiva
MA41346A (fr) 2015-01-12 2017-11-21 Juno Therapeutics Inc Eléments régulateurs post-transcriptionnels d'hépatite modifiée
JP6865688B2 (ja) 2015-01-16 2021-04-28 ジュノー セラピューティクス インコーポレイテッド Ror1に特異的な抗体およびキメラ抗原受容体
SG11201708516YA (en) 2015-04-17 2017-11-29 David Maxwell Barrett Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells
AU2016297014B2 (en) 2015-07-21 2021-06-17 Novartis Ag Methods for improving the efficacy and expansion of immune cells
WO2017112877A1 (en) * 2015-12-22 2017-06-29 Icell Gene Therapeutics, Llc Chimeric antigen receptors and enhancement of anti-tumor activity
KR102746901B1 (ko) * 2017-03-03 2024-12-26 옵시디안 테라퓨틱스, 인크. Cd19 조성물 및 면역요법을 위한 방법
US11352389B2 (en) * 2017-06-30 2022-06-07 Academisch Ziekenhuis Leiden (H.O.D.N. Leids Universitair Medisch Centrum) Treatment of haematological malignancies
AU2018318303A1 (en) * 2017-08-18 2020-04-09 Gritstone Bio, Inc. Antigen-binding proteins targeting shared antigens
US11957715B2 (en) * 2017-12-20 2024-04-16 Miltenyi Biotec B.V. & Co. KG Method for NK cell transduction

Similar Documents

Publication Publication Date Title
US11679132B2 (en) Methods for enhancing efficacy of therapeutic immune cells
JP7781243B2 (ja) ガイダンス及びナビゲーションコントロール蛋白質並びにその生産及び使用方法
US20220348631A1 (en) Receptors providing targeted costimulation for adoptive cell therapy
CA3032054A1 (en) Combination therapies of chimeric antigen receptors and pd-1 inhibitors
TW202024330A (zh) 抗間皮素嵌合抗原受體(car)構築體及其用途
JP2021525509A (ja) 細胞療法のための多様な抗原結合ドメイン、新規プラットフォームおよびその他の強化
JP2020513839A5 (https=)
CN110582509A (zh) 使用具有多特异性的嵌合t细胞受体蛋白治疗癌症
KR20220124173A (ko) Lilrb1-기반 키메라 항원 수용체
CA2973529A1 (en) Cll1-specific multi-chain chimeric antigen receptor
CN116829194A (zh) 用于工程化细胞疗法的靶向细胞因子构建体
JP2021536266A (ja) 固形癌のためのキメラ抗原受容体及びキメラ抗原受容体が発現されたt細胞
NZ732570A (en) Chimeric antigen receptors targeting fc receptor-like 5 and uses thereof
US20230277670A1 (en) Chimeric molecules providing targeted costimulation for adoptive cell therapy
JP2017519502A (ja) Cd123特異的多重鎖キメラ抗原受容体
CN112074278A (zh) Bcma-car-t细胞
US20220133792A1 (en) Signaling platforms for chimeric antigen receptor t cells
EP4021485A1 (en) B cell targeted parallel car (pcar) therapeutic agents
US20230331808A1 (en) Chimeric molecules providing targeted costimulation for adoptive cell therapy
KR20230155521A (ko) 면역 세포 기능의 향상
WO2021027785A1 (zh) 共表达趋化因子受体的免疫效应细胞
KR20210111244A (ko) 태반-유래 동종이계 car-t 세포 및 이의 용도
JPWO2021183675A5 (https=)
CN118812723A (zh) 融合蛋白及其应用
JPWO2021183207A5 (https=)