JPWO2021168317A5 - - Google Patents
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- JPWO2021168317A5 JPWO2021168317A5 JP2022549793A JP2022549793A JPWO2021168317A5 JP WO2021168317 A5 JPWO2021168317 A5 JP WO2021168317A5 JP 2022549793 A JP2022549793 A JP 2022549793A JP 2022549793 A JP2022549793 A JP 2022549793A JP WO2021168317 A5 JPWO2021168317 A5 JP WO2021168317A5
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- JP
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- transmembrane domain
- intracellular signaling
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- 230000004068 intracellular signaling Effects 0.000 claims 27
- 108091008042 inhibitory receptors Proteins 0.000 claims 23
- 102000004169 proteins and genes Human genes 0.000 claims 17
- 108090000623 proteins and genes Proteins 0.000 claims 17
- 210000004027 cell Anatomy 0.000 claims 16
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 8
- 108050001049 Extracellular proteins Proteins 0.000 claims 8
- 101000984190 Homo sapiens Leukocyte immunoglobulin-like receptor subfamily B member 1 Proteins 0.000 claims 8
- 102100025584 Leukocyte immunoglobulin-like receptor subfamily B member 1 Human genes 0.000 claims 8
- 108700010039 chimeric receptor Proteins 0.000 claims 8
- 239000000427 antigen Substances 0.000 claims 7
- 102000036639 antigens Human genes 0.000 claims 7
- 108091007433 antigens Proteins 0.000 claims 7
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims 6
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 6
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims 6
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 6
- 101000945351 Homo sapiens Killer cell immunoglobulin-like receptor 3DL1 Proteins 0.000 claims 6
- 102100033627 Killer cell immunoglobulin-like receptor 3DL1 Human genes 0.000 claims 6
- 108091008874 T cell receptors Proteins 0.000 claims 6
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 230000004957 immunoregulator effect Effects 0.000 claims 5
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 4
- 101150069255 KLRC1 gene Proteins 0.000 claims 4
- 101100404845 Macaca mulatta NKG2A gene Proteins 0.000 claims 4
- 102100022682 NKG2-A/NKG2-B type II integral membrane protein Human genes 0.000 claims 4
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 230000004913 activation Effects 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 125000006850 spacer group Chemical group 0.000 claims 4
- 102100023990 60S ribosomal protein L17 Human genes 0.000 claims 3
- -1 CD3zeta Proteins 0.000 claims 3
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 3
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims 3
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 3
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims 3
- 102000017578 LAG3 Human genes 0.000 claims 3
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 3
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims 3
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 230000002519 immonomodulatory effect Effects 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 2
- 230000021633 leukocyte mediated immunity Effects 0.000 claims 2
- 210000004882 non-tumor cell Anatomy 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 230000001850 reproductive effect Effects 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 claims 2
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 1
- 101001047640 Homo sapiens Linker for activation of T-cells family member 1 Proteins 0.000 claims 1
- 101001047659 Homo sapiens Lymphocyte transmembrane adapter 1 Proteins 0.000 claims 1
- 101000692455 Homo sapiens Platelet-derived growth factor receptor beta Proteins 0.000 claims 1
- 101000702132 Homo sapiens Protein spinster homolog 1 Proteins 0.000 claims 1
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims 1
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 1
- 102100024032 Linker for activation of T-cells family member 1 Human genes 0.000 claims 1
- 102100029193 Low affinity immunoglobulin gamma Fc region receptor III-A Human genes 0.000 claims 1
- 101710099301 Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 102100024034 Lymphocyte transmembrane adapter 1 Human genes 0.000 claims 1
- 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 claims 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 1
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 101001038499 Yarrowia lipolytica (strain CLIB 122 / E 150) Lysine acetyltransferase Proteins 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 210000003651 basophil Anatomy 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002124 endocrine Effects 0.000 claims 1
- 210000003038 endothelium Anatomy 0.000 claims 1
- 210000003979 eosinophil Anatomy 0.000 claims 1
- 210000002304 esc Anatomy 0.000 claims 1
- 210000000232 gallbladder Anatomy 0.000 claims 1
- 210000004475 gamma-delta t lymphocyte Anatomy 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 210000003630 histaminocyte Anatomy 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 108020001756 ligand binding domains Proteins 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 210000000066 myeloid cell Anatomy 0.000 claims 1
- 210000000581 natural killer T-cell Anatomy 0.000 claims 1
- 210000000944 nerve tissue Anatomy 0.000 claims 1
- 210000000440 neutrophil Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 210000004872 soft tissue Anatomy 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062979309P | 2020-02-20 | 2020-02-20 | |
| US62/979,309 | 2020-02-20 | ||
| US202063044597P | 2020-06-26 | 2020-06-26 | |
| US63/044,597 | 2020-06-26 | ||
| US202163136134P | 2021-01-11 | 2021-01-11 | |
| US63/136,134 | 2021-01-11 | ||
| PCT/US2021/018868 WO2021168317A1 (en) | 2020-02-20 | 2021-02-19 | Inhibitory chimeric receptor architectures |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023515055A JP2023515055A (ja) | 2023-04-12 |
| JPWO2021168317A5 true JPWO2021168317A5 (https=) | 2024-02-29 |
| JP2023515055A5 JP2023515055A5 (https=) | 2024-02-29 |
Family
ID=77391781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022549793A Pending JP2023515055A (ja) | 2020-02-20 | 2021-02-19 | 阻害性キメラ受容体アーキテクチャ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20230235051A1 (https=) |
| EP (1) | EP4107175A4 (https=) |
| JP (1) | JP2023515055A (https=) |
| CN (1) | CN115397845A (https=) |
| TW (1) | TW202144396A (https=) |
| WO (1) | WO2021168317A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022546315A (ja) * | 2019-08-20 | 2022-11-04 | センティ バイオサイエンシズ インコーポレイテッド | キメラ抑制性受容体 |
| CA3261358A1 (en) * | 2022-07-26 | 2024-02-01 | Senti Biosciences, Inc. | CHIMERIC RECEPTOR INHIBITOR ARCHITECTURES |
| WO2024238769A2 (en) * | 2023-05-16 | 2024-11-21 | The Regents Of The University Of California | Inhibitory chimeric antigen receptors that reduce car-t cell "on-target, off-tumor" toxicity |
| WO2025096730A1 (en) * | 2023-11-01 | 2025-05-08 | University Of Virginia Patent Foundation | Novel autoregulated car t cells and uses thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6448035B1 (en) * | 1997-04-24 | 2002-09-10 | Immunex Corporation | Family of immunoregulators designated leukocyte immunoglobulin-like receptor (LIR) |
| US7265208B2 (en) * | 2001-05-01 | 2007-09-04 | The Regents Of The University Of California | Fusion molecules and treatment of IgE-mediated allergic diseases |
| WO2015142314A1 (en) * | 2013-03-15 | 2015-09-24 | Memorial Sloan-Kettering Cancer Center | Compositions and methods for immunotherapy |
| US20160296562A1 (en) * | 2013-11-21 | 2016-10-13 | Ucl Business Plc | Cell |
| US11072644B2 (en) * | 2014-11-12 | 2021-07-27 | Allogene Therapeutics, Inc. | Inhibitory chimeric antigen receptors |
| CA2969384A1 (en) * | 2014-12-17 | 2016-06-23 | Cellectis | Inhibitory chimeric antigen receptor (icar or n-car) expressing non-t cell transduction domain |
| EP3380602A4 (en) * | 2015-11-23 | 2019-09-25 | Trustees of Boston University | METHOD AND COMPOSITIONS RELATED TO CHIMERIC ANTIGEN RECEPTORS |
| CA3007258A1 (en) * | 2015-12-03 | 2017-06-08 | Mark L. Bonyhadi | Compositions and methods for reducing immune responses against cell therapies |
| MX2019003462A (es) * | 2016-09-28 | 2019-08-16 | Gavish Galilee Bio Appl Ltd | Una plataforma universal para el tratamiento con car que se dirige a una novedosa firma antigenica del cancer. |
| CN110582509A (zh) * | 2017-01-31 | 2019-12-17 | 诺华股份有限公司 | 使用具有多特异性的嵌合t细胞受体蛋白治疗癌症 |
| GB201707783D0 (en) * | 2017-05-15 | 2017-06-28 | Autolus Ltd | Cell |
| WO2019016784A1 (en) * | 2017-07-21 | 2019-01-24 | Universidade De Coimbra | ANTI-NUCLEOLIN ANTIBODIES |
| KR20200071740A (ko) * | 2017-09-28 | 2020-06-19 | 임팩트-바이오 리미티드. | 저해성 키메라 항원 수용체 (icar)를 제조하기 위한 보편적 플랫폼 |
| US11866731B2 (en) * | 2017-11-10 | 2024-01-09 | Chineo Medical Technology Co., Ltd | Modified immune cells and uses thereof |
| US20200316120A1 (en) * | 2018-09-28 | 2020-10-08 | Immpact-Bio Ltd. | METHODS FOR IDENTIFYING ACTIVATING ANTIGEN RECEPTOR (aCAR)/INHIBITORY CHIMERIC ANTIGEN RECEPTOR (iCAR) PAIRS FOR USE IN CANCER THERAPIES |
| US20220170097A1 (en) * | 2018-10-29 | 2022-06-02 | The Broad Institute, Inc. | Car t cell transcriptional atlas |
| JP7739261B2 (ja) * | 2019-08-09 | 2025-09-16 | エイ２・バイオセラピューティクス・インコーポレイテッド | ヘテロ接合性の喪失に応答する細胞表面受容体 |
| JP2022546315A (ja) * | 2019-08-20 | 2022-11-04 | センティ バイオサイエンシズ インコーポレイテッド | キメラ抑制性受容体 |
| EP4073103A1 (en) * | 2019-12-11 | 2022-10-19 | A2 Biotherapeutics, Inc. | Lilrb1-based chimeric antigen receptor |
-
2021
- 2021-02-19 CN CN202180028773.9A patent/CN115397845A/zh active Pending
- 2021-02-19 JP JP2022549793A patent/JP2023515055A/ja active Pending
- 2021-02-19 WO PCT/US2021/018868 patent/WO2021168317A1/en not_active Ceased
- 2021-02-19 EP EP21756614.0A patent/EP4107175A4/en active Pending
- 2021-02-19 TW TW110105857A patent/TW202144396A/zh unknown
-
2022
- 2022-08-17 US US17/820,525 patent/US20230235051A1/en active Pending
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