JPWO2021146591A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2021146591A5
JPWO2021146591A5 JP2022543381A JP2022543381A JPWO2021146591A5 JP WO2021146591 A5 JPWO2021146591 A5 JP WO2021146591A5 JP 2022543381 A JP2022543381 A JP 2022543381A JP 2022543381 A JP2022543381 A JP 2022543381A JP WO2021146591 A5 JPWO2021146591 A5 JP WO2021146591A5
Authority
JP
Japan
Prior art keywords
cell line
raav
transfected
nucleic acid
ratio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2022543381A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023510590A (ja
JP7846625B2 (ja
JP2023510590A5 (https=
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/013689 external-priority patent/WO2021146591A2/en
Publication of JP2023510590A publication Critical patent/JP2023510590A/ja
Publication of JPWO2021146591A5 publication Critical patent/JPWO2021146591A5/ja
Publication of JP2023510590A5 publication Critical patent/JP2023510590A5/ja
Priority to JP2025195186A priority Critical patent/JP2026032042A/ja
Application granted granted Critical
Publication of JP7846625B2 publication Critical patent/JP7846625B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2022543381A 2020-01-17 2021-01-15 組換えａａｖの産生 Active JP7846625B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025195186A JP2026032042A (ja) 2020-01-17 2025-11-14 組換えａａｖの産生

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062962911P 2020-01-17 2020-01-17
US62/962,911 2020-01-17
PCT/US2021/013689 WO2021146591A2 (en) 2020-01-17 2021-01-15 Recombinant aav production

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025195186A Division JP2026032042A (ja) 2020-01-17 2025-11-14 組換えａａｖの産生

Publications (4)

Publication Number Publication Date
JP2023510590A JP2023510590A (ja) 2023-03-14
JPWO2021146591A5 true JPWO2021146591A5 (https=) 2024-01-23
JP2023510590A5 JP2023510590A5 (https=) 2024-01-23
JP7846625B2 JP7846625B2 (ja) 2026-04-15

Family

ID=76864730

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022543381A Active JP7846625B2 (ja) 2020-01-17 2021-01-15 組換えａａｖの産生
JP2025195186A Pending JP2026032042A (ja) 2020-01-17 2025-11-14 組換えａａｖの産生

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025195186A Pending JP2026032042A (ja) 2020-01-17 2025-11-14 組換えａａｖの産生

Country Status (8)

Country Link
US (1) US20230048994A1 (https=)
EP (1) EP4090750A4 (https=)
JP (2) JP7846625B2 (https=)
CN (1) CN115315518A (https=)
AU (1) AU2021207683A1 (https=)
CA (1) CA3162520A1 (https=)
IL (1) IL294775A (https=)
WO (1) WO2021146591A2 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4189077A1 (en) 2020-07-30 2023-06-07 Shape Therapeutics Inc. Stable cell lines for inducible production of raav virions
AU2022373653A1 (en) 2021-10-18 2024-05-02 Regeneron Pharmaceuticals, Inc. Eukaryotic cells comprising adenovirus-associated virus polynucleotides
WO2024129882A1 (en) * 2022-12-14 2024-06-20 Astellas Gene Therapies, Inc. Compositions and methods for improved production of adeno-associated viral particles
AU2024223271A1 (en) * 2023-02-17 2025-09-18 Synplogen Co., Ltd. Itr-rep gene complex
EP4527938A1 (en) * 2023-09-22 2025-03-26 LenioBio GmbH Method for cell-free polypeptide synthesis

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6995006B2 (en) * 1997-09-05 2006-02-07 Targeted Genetics Corporation Methods for generating high titer helper-free preparations of released recombinant AAV vectors
EP2848253A1 (en) * 2006-06-19 2015-03-18 Asklepios Biopharmaceutical, Inc. Modified factor VIII and factor IX genes and vectors for gene therapy
WO2008105931A2 (en) * 2006-09-15 2008-09-04 Medimmune Vaccines, Inc. Mdck cell lines supporting viral growth to high titers and bioreactor process using the same
GB0901593D0 (en) * 2009-01-30 2009-03-11 Touchlight Genetics Ltd Production of closed linear DNA
US9441206B2 (en) * 2011-10-28 2016-09-13 The University Of North Carolina At Chapel Hill Cell line for production of adeno-associated virus
EP3039129B1 (en) * 2013-08-30 2018-06-27 Amgen Inc. High titer recombinant aav vector production in adherent and suspension cells
AU2016362317B2 (en) * 2015-12-01 2023-03-16 Spark Therapeutics, Inc. Scalable methods for producing recombinant Adeno-Associated Viral (AAV) vector in serum-free suspension cell culture system suitable for clinical use
EP3810782A2 (en) * 2018-06-22 2021-04-28 Asklepios Biopharmaceutical, Inc. Vectors for gene delivery that persist within cells

Similar Documents

Publication Publication Date Title
Samulski Adeno-associated viral vectors
JP7598333B2 (ja) 組換えウイルスベクターの製造方法
US6416992B1 (en) Compositions and methods for producing recombinant adeno-associated virus
JP2004508041A (ja) 組換え型アデノ随伴ウイルス（ｒＡＡＶ）をパッケージングする親細胞、それらの生成方法、およびその使用
JP7846625B2 (ja) 組換えａａｖの産生
JP2023544947A (ja) 昆虫細胞内で重複オープンリーディングフレームを含む遺伝子を発現するための発現カセット及びその使用
JP2024500194A (ja) 重複オープンリーディングフレームを含む遺伝子の発現カセット、及び昆虫細胞におけるこの発現カセット使用
US20220242917A1 (en) Compositions and methods for producing adeno-associated viral vectors
KR20230011935A (ko) 아데노 연관 바이러스 입자 또는 아데노바이러스를 정제하기 위한 방법 및 조성물
US20240279682A1 (en) AAV Manufacturing Methods
JPWO2021146591A5 (https=)
CN116622742A (zh) 一种用于在昆虫细胞中产生rAAV的核酸、VP1衣壳蛋白突变体及应用
WO2024238399A1 (en) Methods of manufacturing adeno-associated viral vectors
CN118127080A (zh) 一种用于在宿主细胞中表达目的基因的双aav载体系统
TW202417619A (zh) 生產重組 ａａｖ 顆粒之方法
JP2023029866A (ja) パルボウイルスベクターの産生
CN1109754C (zh) 用于重组腺伴随病毒生产的全功能辅助病毒的产生及其用途
US12571001B2 (en) Baculovirus vector and use thereof in preparation of recombinant adeno-associated virus (rAAV) in insect cell
CN120905308A (zh) 一种重组杆状病毒载体及昆虫细胞
WO2025205770A1 (ja) スタッファーｄｎａを含む組換えプラスミド
CN120225686A (zh) 用于重组病毒载体生产的修饰的CpG二核苷酸
HK40081423A (en) Recombinant aav production
NZ743041B2 (en) Scalable methods for producing recombinant adeno-associated viral (aav) vector in serum-free suspension cell culture system suitable for clinical use
NZ743041A (en) Scalable methods for producing recombinant adeno-associated viral (aav) vector in serum-free suspension cell culture system suitable for clinical use