JPWO2021102234A5 - - Google Patents
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- Publication number
- JPWO2021102234A5 JPWO2021102234A5 JP2022529681A JP2022529681A JPWO2021102234A5 JP WO2021102234 A5 JPWO2021102234 A5 JP WO2021102234A5 JP 2022529681 A JP2022529681 A JP 2022529681A JP 2022529681 A JP2022529681 A JP 2022529681A JP WO2021102234 A5 JPWO2021102234 A5 JP WO2021102234A5
- Authority
- JP
- Japan
- Prior art keywords
- capsid protein
- modified
- seq
- targeting peptide
- aav capsid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025044678A JP2025102825A (ja) | 2019-11-22 | 2025-03-19 | アデノ随伴ウイルスベクター変種 |
| JP2025116303A JP2025148448A (ja) | 2019-11-22 | 2025-07-10 | アデノ随伴ウイルスベクター変種 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962939315P | 2019-11-22 | 2019-11-22 | |
| US62/939,315 | 2019-11-22 | ||
| US202063084709P | 2020-09-29 | 2020-09-29 | |
| US63/084,709 | 2020-09-29 | ||
| PCT/US2020/061464 WO2021102234A1 (en) | 2019-11-22 | 2020-11-20 | Adeno-associated viral vector variants |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025044678A Division JP2025102825A (ja) | 2019-11-22 | 2025-03-19 | アデノ随伴ウイルスベクター変種 |
| JP2025116303A Division JP2025148448A (ja) | 2019-11-22 | 2025-07-10 | アデノ随伴ウイルスベクター変種 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2023503455A JP2023503455A (ja) | 2023-01-30 |
| JPWO2021102234A5 true JPWO2021102234A5 (https=) | 2024-01-30 |
| JP2023503455A5 JP2023503455A5 (https=) | 2024-01-30 |
| JP7712271B2 JP7712271B2 (ja) | 2025-07-23 |
Family
ID=75980202
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022529681A Active JP7712271B2 (ja) | 2019-11-22 | 2020-11-20 | アデノ随伴ウイルスベクター変種 |
| JP2025044678A Pending JP2025102825A (ja) | 2019-11-22 | 2025-03-19 | アデノ随伴ウイルスベクター変種 |
| JP2025116303A Pending JP2025148448A (ja) | 2019-11-22 | 2025-07-10 | アデノ随伴ウイルスベクター変種 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025044678A Pending JP2025102825A (ja) | 2019-11-22 | 2025-03-19 | アデノ随伴ウイルスベクター変種 |
| JP2025116303A Pending JP2025148448A (ja) | 2019-11-22 | 2025-07-10 | アデノ随伴ウイルスベクター変種 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20230346981A1 (https=) |
| EP (1) | EP4061427A4 (https=) |
| JP (3) | JP7712271B2 (https=) |
| KR (1) | KR20220116459A (https=) |
| CN (2) | CN115023242B (https=) |
| AU (1) | AU2020388404A1 (https=) |
| BR (1) | BR112022009864A2 (https=) |
| CA (1) | CA3159113A1 (https=) |
| CO (1) | CO2022008507A2 (https=) |
| IL (1) | IL293140A (https=) |
| MX (1) | MX2022006188A (https=) |
| PH (1) | PH12022551247A1 (https=) |
| WO (1) | WO2021102234A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2022013030A (es) * | 2020-04-17 | 2023-03-09 | Regeneron Pharma | Ensayos de deteccion para anticuerpos neutralizantes de coronavirus. |
| MX2024004217A (es) | 2021-10-08 | 2024-06-26 | Dyno Therapeutics Inc | Variantes de cápside y métodos de uso de estas. |
| WO2023205397A1 (en) * | 2022-04-22 | 2023-10-26 | The Children's Hospital Of Philadelphia | Human ependyma-specific promoter and uses thereof |
| AU2023269646A1 (en) * | 2022-05-11 | 2024-12-05 | The Children's Hospital Of Philadelphia | Adeno-associated viral vectors for targeting deep brain structures |
| CN119562959A (zh) * | 2022-05-13 | 2025-03-04 | 费城儿童医院 | 用于靶向脑微脉管系统的腺相关病毒载体 |
| AU2023273809A1 (en) | 2022-05-16 | 2025-01-02 | Genzyme Corporation | Methods of treating metachromatic leukodystrophy |
| CN119894920A (zh) | 2022-07-22 | 2025-04-25 | 上海天泽云泰生物医药有限公司 | 用于靶向神经系统的新型aav衣壳及其用途 |
| KR102870168B1 (ko) * | 2022-08-26 | 2025-10-13 | 김선아 | 활막 표적화 화합물 및 이의 용도 |
| JP2025532627A (ja) * | 2022-09-19 | 2025-10-01 | ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア | ＳＰＬｉＴ－ｓｅｑを用いたシングルセル解像でのＡＡＶ進化 |
| IL322459A (en) * | 2023-01-31 | 2025-09-01 | Childrens Hospital Philadelphia | Innovative gene therapy construct for cln2 disease |
| TW202502803A (zh) | 2023-03-10 | 2025-01-16 | 美商戴諾治療公司 | 衣殼多肽及其使用方法 |
| CN118005749B (zh) * | 2023-07-21 | 2024-07-16 | 广州派真生物技术有限公司 | 腺相关病毒突变体及其应用 |
| TW202525832A (zh) | 2023-08-31 | 2025-07-01 | 美商戴諾治療公司 | 衣殼多肽及其使用方法(二) |
| WO2025090631A1 (en) * | 2023-10-23 | 2025-05-01 | The Children's Hospital Of Philadelphia | Aav vectors for delivery of apoe2 |
| WO2025090598A1 (en) * | 2023-10-23 | 2025-05-01 | The Children's Hospital Of Philadelphia | Aav vectors for treatment of cln2 disease |
| WO2025106874A1 (en) * | 2023-11-15 | 2025-05-22 | Genzyme Corporation | Methods of treating neurodegenerative disorders |
| US20250152747A1 (en) | 2023-11-15 | 2025-05-15 | Genzyme Corporation | Methods of treating gaucher disease and gba-parkinson’s disease |
| TW202545971A (zh) | 2024-02-08 | 2025-12-01 | 美商戴諾治療公司 | 殼體多肽及其使用方法 |
| WO2025213097A1 (en) * | 2024-04-05 | 2025-10-09 | The Children's Hospital Of Philadelphia | Novel gene therapy constructs for stxbp1 haploinsufficiency |
| WO2025231406A1 (en) * | 2024-05-02 | 2025-11-06 | The Children's Hospital Of Philadelphia | Methods to increase transduction of ependyma cells in brain |
| WO2026064442A2 (en) | 2024-09-18 | 2026-03-26 | Dyno Therapeutics, Inc. | Capsid polypeptides and methods of use thereof |
| CN120242044B (zh) * | 2025-06-06 | 2025-09-23 | 昆明理工大学 | 一种靶向性的药物递送载体及其制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040031072A1 (en) * | 1999-05-06 | 2004-02-12 | La Rosa Thomas J. | Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement |
| DK2359869T3 (en) * | 2001-12-17 | 2019-04-15 | Univ Pennsylvania | Sequences of adeno-associated virus (AAV) serotype 8, vectors containing these, and uses thereof |
| US9585971B2 (en) * | 2013-09-13 | 2017-03-07 | California Institute Of Technology | Recombinant AAV capsid protein |
| DE102014207498A1 (de) * | 2014-04-17 | 2015-10-22 | Universitätsklinikum Hamburg-Eppendorf | Viraler Vektor für den zielgerichteten Gentransfer in Gehirn und Rückenmark |
| KR102423442B1 (ko) * | 2015-12-11 | 2022-07-20 | 캘리포니아 인스티튜트 오브 테크놀로지 | 아데노-관련 바이러스를 지시하기 위한 타겟팅 펩타이드 |
| BR112019016769A2 (pt) * | 2017-02-15 | 2020-05-26 | The University Of North Carolina At Chapel Hill | Métodos e composições para transferência genética através da vasculatura |
| MX2019013528A (es) * | 2017-05-12 | 2020-07-14 | The Children´S Hospital Of Philadelphia | Variantes de sulfamidasa (sgsh) y vectores, composiciones, metodos y usos para tratar la mucopolisacaridosis tipo iiia (mps iiia). |
| SG11202002276VA (en) * | 2017-09-20 | 2020-04-29 | 4D Molecular Therapeutics Inc | Adeno-associated virus variant capsids and methods of use thereof |
| US20200263199A1 (en) * | 2017-09-29 | 2020-08-20 | Voyager Therapeutics, Inc. | Rescue of central and peripheral neurological phenotype of friedreich's ataxia by intravenous delivery |
| WO2019113538A2 (en) * | 2017-12-07 | 2019-06-13 | California Institute Of Technology | Methods and systems for noninvasive control of brain cells and related vectors and compositions |
| TW202015742A (zh) * | 2018-05-15 | 2020-05-01 | 美商航海家醫療公司 | 投遞腺相關病毒（ａａｖ）之組成物和方法 |
| CN112703198B (zh) * | 2018-07-11 | 2025-05-30 | 布里格姆妇女医院 | 用于跨血脑屏障递送试剂的方法和组合物 |
-
2020
- 2020-11-20 PH PH1/2022/551247A patent/PH12022551247A1/en unknown
- 2020-11-20 JP JP2022529681A patent/JP7712271B2/ja active Active
- 2020-11-20 IL IL293140A patent/IL293140A/en unknown
- 2020-11-20 CN CN202080094086.2A patent/CN115023242B/zh active Active
- 2020-11-20 US US17/778,783 patent/US20230346981A1/en active Pending
- 2020-11-20 KR KR1020227021143A patent/KR20220116459A/ko active Pending
- 2020-11-20 CN CN202510215753.2A patent/CN119978146A/zh active Pending
- 2020-11-20 AU AU2020388404A patent/AU2020388404A1/en active Pending
- 2020-11-20 WO PCT/US2020/061464 patent/WO2021102234A1/en not_active Ceased
- 2020-11-20 BR BR112022009864A patent/BR112022009864A2/pt unknown
- 2020-11-20 CA CA3159113A patent/CA3159113A1/en active Pending
- 2020-11-20 MX MX2022006188A patent/MX2022006188A/es unknown
- 2020-11-20 EP EP20890214.8A patent/EP4061427A4/en active Pending
-
2022
- 2022-06-16 CO CONC2022/0008507A patent/CO2022008507A2/es unknown
-
2023
- 2023-10-20 US US18/491,365 patent/US20240100194A1/en active Pending
-
2025
- 2025-03-19 JP JP2025044678A patent/JP2025102825A/ja active Pending
- 2025-07-10 JP JP2025116303A patent/JP2025148448A/ja active Pending
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