JPWO2021067458A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2021067458A5 JPWO2021067458A5 JP2022518653A JP2022518653A JPWO2021067458A5 JP WO2021067458 A5 JPWO2021067458 A5 JP WO2021067458A5 JP 2022518653 A JP2022518653 A JP 2022518653A JP 2022518653 A JP2022518653 A JP 2022518653A JP WO2021067458 A5 JPWO2021067458 A5 JP WO2021067458A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- poly
- formula
- integer
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962908435P | 2019-09-30 | 2019-09-30 | |
| US62/908,435 | 2019-09-30 | ||
| PCT/US2020/053572 WO2021067458A1 (en) | 2019-09-30 | 2020-09-30 | Protein-macromolecule conjugates and methods of use thereof |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022549295A JP2022549295A (ja) | 2022-11-24 |
| JPWO2021067458A5 true JPWO2021067458A5 (https=) | 2023-11-13 |
| JP2022549295A5 JP2022549295A5 (https=) | 2023-11-13 |
| JP7784993B2 JP7784993B2 (ja) | 2025-12-12 |
Family
ID=75337536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022518653A Active JP7784993B2 (ja) | 2019-09-30 | 2020-09-30 | タンパク質－巨大分子コンジュゲート及びその使用方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20220401561A1 (https=) |
| EP (1) | EP4037715A4 (https=) |
| JP (1) | JP7784993B2 (https=) |
| KR (1) | KR20220074897A (https=) |
| CN (1) | CN114630818A (https=) |
| AU (1) | AU2020360397A1 (https=) |
| BR (1) | BR112022005465A2 (https=) |
| CA (1) | CA3153644A1 (https=) |
| IL (1) | IL291730B2 (https=) |
| MX (1) | MX2022003065A (https=) |
| TW (1) | TW202126332A (https=) |
| WO (1) | WO2021067458A1 (https=) |
| ZA (1) | ZA202204162B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220109436A (ko) | 2019-12-03 | 2022-08-04 | 에보텍 인터내셔널 게엠베하 | 인터페론-결합된 항원 결합 단백질 및 이의 용도 |
| WO2022103983A2 (en) * | 2020-11-11 | 2022-05-19 | Sutro Biopharma, Inc. | Fluorenylmethyloxycarbonyl and fluorenylmethylaminocarbonyl compounds, protein conjugates thereof, and methods for their use |
| AU2022249281B2 (en) * | 2021-03-29 | 2025-08-14 | Aj Sciences (Yixing) Co., Ltd | Protein-macromolecule conjugates and methods of use thereof |
| CN113929731B (zh) * | 2021-12-16 | 2022-05-10 | 北京春雷杰创生物科技有限公司 | 一种促进低分子量蛋白体外复性和提高免疫原性的方法 |
| EP4539887A1 (en) * | 2022-06-16 | 2025-04-23 | Merck Sharp & Dohme LLC | Interleukin-2 prodrugs |
| CN115947745B (zh) * | 2022-12-26 | 2024-02-27 | 中山大学 | 一种基于白蛋白的光热转换纳米材料及其制备方法和应用 |
| CN120737012B (zh) * | 2025-08-29 | 2025-11-18 | 苏州金顶生物有限公司 | 一种新型保护氨基酸、制备方法及其应用 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5116943A (en) | 1985-01-18 | 1992-05-26 | Cetus Corporation | Oxidation-resistant muteins of Il-2 and other protein |
| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| US5089261A (en) | 1989-01-23 | 1992-02-18 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| US4902502A (en) | 1989-01-23 | 1990-02-20 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| US5153310A (en) | 1989-02-28 | 1992-10-06 | Du Pont Merck Pharmaceutical Company | Il-2 analogs containing n-linked glycosylation sites |
| US5635597A (en) | 1994-05-27 | 1997-06-03 | Affymax Technologies, N.V. | Peptides that bind IL-2 receptors |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| IL119029A0 (en) | 1996-08-07 | 1996-11-14 | Yeda Res & Dev | Long-acting drugs and pharamaceutical compositions comprising them |
| DK1411075T3 (da) | 1998-03-12 | 2008-10-27 | Nektar Therapeutics Al Corp | Fremgangsmåde til fremstilling af polymerkonjugater |
| US6168785B1 (en) | 1998-07-16 | 2001-01-02 | Institut Pasteur | Biological applications of new peptides of IL-2 and derivatives and use as therapeutic agents |
| FR2826365B1 (fr) | 2001-06-20 | 2003-09-26 | Oreal | Compositions cosmetiques photoprotectrices contenant des derives amides, sulfonamides ou carbamates aromatiques d'acrylonitrile et nouveaux derives amides, sulfonamides ou carbamates d'acrylonitrile |
| US20070027073A1 (en) | 2003-04-08 | 2007-02-01 | Menachem Rubinstein | Long-acting derivatives of pyy agonists |
| WO2005007121A2 (en) | 2003-07-18 | 2005-01-27 | Massachusetts Institute Of Technology | Mutant interleukin-2(il-2) polypeptides |
| BRPI0611872B8 (pt) | 2005-06-16 | 2021-05-25 | Nektar Therapeutics | reagente polimérico, conjugado, método para preparação de um conjugado e composição farmacêutica |
| KR101508621B1 (ko) | 2007-02-28 | 2015-04-07 | 세리나 쎄라퓨틱스, 인코포레이티드 | 활성화된 폴리옥사졸린 및 이를 포함하는 조성물 |
| US7567215B1 (en) | 2007-10-23 | 2009-07-28 | The United States Of America As Represented By The Secretary Of The Navy | Portable and inflatable antenna device |
| CN104529711B (zh) | 2007-11-21 | 2020-02-07 | 乔治亚大学研究基金公司 | 炔烃以及炔烃与1,3-偶极-官能化合物反应的方法 |
| WO2009158668A1 (en) | 2008-06-26 | 2009-12-30 | Prolynx Llc | Prodrugs and drug-macromolecule conjugates having controlled drug release rates |
| US20100240773A1 (en) * | 2009-03-23 | 2010-09-23 | Kenneth Korzekwa | Multifunctional linkers |
| EP2566335B1 (en) * | 2010-05-05 | 2016-06-29 | Prolynx Llc | Controlled release of active compounds from macromolecular conjugates |
| US8703907B2 (en) * | 2010-05-05 | 2014-04-22 | Prolynx Llc | Controlled drug release from dendrimers |
| EP2566334B1 (en) * | 2010-05-05 | 2018-04-18 | Prolynx, LLC | Controlled drug release from solid supports |
| ES2866674T3 (es) | 2010-11-12 | 2021-10-19 | Nektar Therapeutics | Conjugados de una fracción de IL-2 y un polímero |
| WO2013036857A1 (en) * | 2011-09-07 | 2013-03-14 | Prolynx Llc | Sulfone linkers |
| KR102109067B1 (ko) * | 2011-09-07 | 2020-05-13 | 프로린크스 엘엘시 | 생분해성 교차결합을 가지는 하이드로젤 |
| US20140256626A1 (en) * | 2011-10-18 | 2014-09-11 | Prolynx Llc | Peg conjugates of exenatide |
| SG10201803370XA (en) | 2013-10-22 | 2018-06-28 | Prolynx Llc | Conjugates of somatostatin and its analogs |
| WO2016053107A1 (en) * | 2014-10-03 | 2016-04-07 | Synaffix B.V. | Sulfamide linker, conjugates thereof, and methods of preparation |
| WO2019028419A1 (en) | 2017-08-03 | 2019-02-07 | Synthorx, Inc. | CYTOKINE CONJUGATES FOR THE TREATMENT OF PROLIFERATIVE AND INFECTIOUS DISEASES |
| KR20220004134A (ko) | 2019-04-26 | 2022-01-11 | 프로린크스 엘엘시 | 서방형 사이토카인 컨쥬게이트 |
-
2020
- 2020-09-30 CA CA3153644A patent/CA3153644A1/en active Pending
- 2020-09-30 BR BR112022005465A patent/BR112022005465A2/pt unknown
- 2020-09-30 EP EP20871115.0A patent/EP4037715A4/en active Pending
- 2020-09-30 US US17/764,475 patent/US20220401561A1/en active Pending
- 2020-09-30 IL IL291730A patent/IL291730B2/en unknown
- 2020-09-30 JP JP2022518653A patent/JP7784993B2/ja active Active
- 2020-09-30 KR KR1020227012420A patent/KR20220074897A/ko not_active Ceased
- 2020-09-30 AU AU2020360397A patent/AU2020360397A1/en active Pending
- 2020-09-30 WO PCT/US2020/053572 patent/WO2021067458A1/en not_active Ceased
- 2020-09-30 CN CN202080068415.6A patent/CN114630818A/zh active Pending
- 2020-09-30 TW TW109134302A patent/TW202126332A/zh unknown
- 2020-09-30 MX MX2022003065A patent/MX2022003065A/es unknown
-
2022
- 2022-04-12 ZA ZA2022/04162A patent/ZA202204162B/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2005232371B2 (en) | Polymeric prodrug with a self-immolative linker | |
| CN101242859B (zh) | 作为聚合物缀合前药中的连接团的n,n-二（羟乙基）甘氨酰胺 | |
| ES2636741T3 (es) | Composición de insulina de acción prolongada | |
| US7417021B2 (en) | Biologically active conjugate of a biopolymer and therapeutic agent | |
| ES2371865T3 (es) | Conjugados de hidroxialquilalmidón-principio activo. | |
| US9173953B2 (en) | Prodrugs containing an aromatic amine connected by an amido bond to a linker | |
| IL291730B1 (en) | Protein-macromolecule conjugates and methods of using them | |
| JP5448854B2 (ja) | オリゴマー−プロテアーゼ阻害剤複合体 | |
| CN102803297B (zh) | 糖胺聚糖类(gag)与生物活性分子的缀合物的合成方法、聚合缀合物及其相关用途 | |
| SK286654B6 (sk) | Spôsob postupného pripájania polyetylénglykolových častí a použitie PEG-polypeptidových konjugátov vyrobených týmto spôsobom | |
| CA2972318A1 (en) | Prodrugs of c-type natriuretic peptide(cnp) | |
| CN103945870A (zh) | 生物可降解交联的水凝胶 | |
| JP2004517040A (ja) | ポリマー修飾された生物活性な合成ケモカインならびにその製造方法および使用方法 | |
| JPWO2021067458A5 (https=) | ||
| WO2001060412A2 (en) | Modification of biopolymers for improved drug delivery | |
| Wan et al. | Optimizing size and copy number for PEG-fMLF (N-formyl-methionyl-leucyl-phenylalanine) nanocarrier uptake by macrophages | |
| KR20120090961A (ko) | 올리고머-칼슘 모방체 컨쥬게이트 및 관련 화합물 | |
| CN118695874A (zh) | 采用tlr7/8激动剂的癌症疗法 | |
| JPWO2023009759A5 (https=) |