JPWO2021050915A5 - - Google Patents

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JPWO2021050915A5
JPWO2021050915A5 JP2022516295A JP2022516295A JPWO2021050915A5 JP WO2021050915 A5 JPWO2021050915 A5 JP WO2021050915A5 JP 2022516295 A JP2022516295 A JP 2022516295A JP 2022516295 A JP2022516295 A JP 2022516295A JP WO2021050915 A5 JPWO2021050915 A5 JP WO2021050915A5
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alkyl
cancer
compound
cyano
carcinoma
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JP2022516295A
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Japanese (ja)
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JP7789662B2 (ja
JP2022548255A (ja
JP2022548255A5 (https=
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Priority claimed from PCT/US2020/050457 external-priority patent/WO2021050915A1/en
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JP2022516295A 2019-09-12 2020-09-11 Mta協働prmt5阻害剤 Active JP7789662B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201962899575P 2019-09-12 2019-09-12
US62/899,575 2019-09-12
US201962942833P 2019-12-03 2019-12-03
US62/942,833 2019-12-03
US202062961371P 2020-01-15 2020-01-15
US62/961,371 2020-01-15
US202062994927P 2020-03-26 2020-03-26
US62/994,927 2020-03-26
US202063060261P 2020-08-03 2020-08-03
US63/060,261 2020-08-03
PCT/US2020/050457 WO2021050915A1 (en) 2019-09-12 2020-09-11 Mta-cooperative prmt5 inhibitors

Publications (4)

Publication Number Publication Date
JP2022548255A JP2022548255A (ja) 2022-11-17
JPWO2021050915A5 true JPWO2021050915A5 (https=) 2023-09-13
JP2022548255A5 JP2022548255A5 (https=) 2023-09-13
JP7789662B2 JP7789662B2 (ja) 2025-12-22

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JP2022516295A Active JP7789662B2 (ja) 2019-09-12 2020-09-11 Mta協働prmt5阻害剤

Country Status (17)

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US (3) US11492351B2 (https=)
EP (1) EP4028388A1 (https=)
JP (1) JP7789662B2 (https=)
KR (1) KR20220083691A (https=)
CN (2) CN114728912A (https=)
AU (1) AU2020345899B2 (https=)
BR (1) BR112022004248A2 (https=)
CA (1) CA3150515A1 (https=)
CL (1) CL2022000603A1 (https=)
CO (1) CO2022004513A2 (https=)
IL (2) IL290341B2 (https=)
MX (1) MX2022002938A (https=)
NO (1) NO20220309A1 (https=)
PH (1) PH12022550399A1 (https=)
SA (1) SA522431915B1 (https=)
TW (1) TW202122387A (https=)
WO (1) WO2021050915A1 (https=)

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US20240208912A1 (en) * 2021-03-11 2024-06-27 Mirati Therapeutics, Inc. MTA-Cooperative PRMT5 Inhibitors
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IL307392A (en) * 2021-04-08 2023-12-01 Mirati Therapeutics Inc Combination therapies with PRMT5 inhibitors for cancer treatment
EP4347569A4 (en) * 2021-06-02 2025-03-26 Ideaya Biosciences, Inc. Combination therapy comprising a mat2a inhibitor and a type ii prmt inhibitor
EP4412607A1 (en) 2021-10-06 2024-08-14 Mirati Therapeutics, Inc. Combination therapies using prmt5 inhibitors for the treatment of cancer
IL311707A (en) 2021-10-06 2024-05-01 Mirati Therapeutics Inc Methods for the separation of enantiomers
US20260109709A1 (en) 2021-11-05 2026-04-23 Mirati Therapeutics, Inc. 2-amino imidazole derivatives as prmt5 inhibitors
WO2023098439A1 (zh) * 2021-11-30 2023-06-08 上海和誉生物医药科技有限公司 一种吡唑衍生物,其制备方法和在药学上的应用
EP4458812A1 (en) * 2021-12-27 2024-11-06 Medshine Discovery Inc. Pyrazole-1(2h)-phthalazinone compound and application thereof
CN114315735B (zh) * 2021-12-29 2023-08-01 广州中医药大学(广州中医药研究院) 一种鲁米诺酯化衍生物及其制备方法与应用
CN116903611A (zh) * 2022-01-26 2023-10-20 上海优理惠生医药有限公司 一种酞嗪酮类化合物、其制备方法、包含其药物组合物及其应用
EP4493555A4 (en) * 2022-03-15 2026-03-25 Beone Medicines I Gmbh 4-(AMINOMETHYL)-6-(1-METHYL-1H-PYRAZOL-4-YL)ISOQUINOLIN-1(2H)-ONE DERIVATIVES USED AS PRMT5 INHIBITORS COOPERATE WITH MTA
WO2023202626A1 (zh) * 2022-04-22 2023-10-26 北京望实智慧科技有限公司 稠和哒嗪酮化合物作为prmt5抑制剂
CN117843634A (zh) * 2022-05-24 2024-04-09 上海美悦生物科技发展有限公司 Sik抑制剂及其组合物、制备方法和用途
CN116178347B (zh) * 2022-06-29 2025-07-04 苏州浦合医药科技有限公司 Prmt5-mta抑制剂
EP4574816A4 (en) 2022-07-07 2026-01-14 Xizang Haisco Pharmaceutical Co Ltd HETEROCYCLIC COMPOUND CAPABLE OF INHIBITING PRMT5 - MTA AND ITS USE
CN117430596A (zh) * 2022-07-13 2024-01-23 上海海和药物研究开发股份有限公司 二并环类mat2a抑制剂及其用途
CN119301101A (zh) * 2022-07-29 2025-01-10 四川科伦博泰生物医药股份有限公司 甲基吡唑化合物、包含其的药物组合物及其制备方法和用途
CN119585261A (zh) * 2022-08-02 2025-03-07 上海艾力斯医药科技股份有限公司 一种prmt5抑制剂、其制备方法及应用
CN119730853A (zh) 2022-08-15 2025-03-28 阿斯利康(瑞典)有限公司 用于治疗癌症的mta协同prmt5抑制剂
CN119836290A (zh) 2022-09-01 2025-04-15 米拉蒂治疗公司 使用prmt5抑制剂和bcl-2家族抑制剂治疗癌症的组合疗法
WO2024091551A1 (en) * 2022-10-25 2024-05-02 Tango Therapeutics, Inc. Crystalline forms, pharmaceutical compositions and methods of use thereof
EP4628483A1 (en) * 2022-11-29 2025-10-08 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Dihydrophthalazine-containing compound
WO2024173215A1 (en) 2023-02-13 2024-08-22 Mirati Therapeutics, Inc. Crystalline forms of 2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin-6-yl)-1-methyl-1h- pyrazol-5-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile
US20240270719A1 (en) 2023-02-13 2024-08-15 Mirati Therapeutics, Inc. Crystalline forms of 2-(4-(4-(aminomethyl)-1-oxo-1,2-dihydrophthalazin-6-yl)-1-methyl-1h-pyrazol-5-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile
WO2024170488A1 (en) 2023-02-13 2024-08-22 Astrazeneca Ab Prmt5 inhibitor for use in cancer therapy
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KR102818470B1 (ko) * 2023-02-23 2025-06-10 한양대학교 산학협력단 신규한 아미노락톤 유도체 및 이의 신규한 제조방법
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WO2025016323A1 (zh) 2023-07-14 2025-01-23 江苏亚虹医药科技股份有限公司 蛋白质精氨酸酶甲基转移酶-5抑制剂及其医药用途
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AU2024319888A1 (en) * 2023-08-09 2026-02-26 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Heteroaryl compound, preparation method therefor, and use thereof in medicine
WO2025059579A1 (en) 2023-09-15 2025-03-20 Ideaya Biosciences, Inc. Methods of treating mat2a related diseases
WO2025064286A1 (en) * 2023-09-19 2025-03-27 Mirati Therapeutics, Inc. Stable 4-(aminomethyl)-6-(phenylpyrazolyl)phthalazinone compositions and processes for preparation thereof
AU2024344078A1 (en) 2023-09-20 2026-04-02 Ideaya Biosciences, Inc. Combination therapy with a parg inhibitor
WO2025061102A1 (zh) * 2023-09-20 2025-03-27 西藏海思科制药有限公司 一种含氰基的杂环化合物及其用途
WO2025072544A1 (en) 2023-09-27 2025-04-03 Ideaya Biosciences, Inc. Sulfonamino indazole compounds as inhibitors of parg
WO2025068985A1 (en) * 2023-09-28 2025-04-03 Beigene Switzerland Gmbh 1-(1-oxo-1,2-dihydrophthalazin-6-yl)cycloalkyl-1-carboxamide derivatives as mta-cooperative inhibitors of prmt5
TW202532064A (zh) * 2023-11-28 2025-08-16 大陸商正大天晴藥業集團股份有限公司 含有雜環二氫酞嗪的化合物
WO2025180390A1 (zh) * 2024-02-27 2025-09-04 烨辉医药科技(上海)有限公司 具有四环并环结构的mta协同性prmt5抑制剂化合物
WO2025212574A1 (en) 2024-04-02 2025-10-09 Mirati Therapeutics, Inc. Processes for preparation of prmt5 inhibitors and intermediates for making the same
WO2025217008A1 (en) 2024-04-08 2025-10-16 Mirati Therapeutics, Inc. Combination therapies using prmt5 inhibitors and sos1 inhibitors for the treatment of cancer
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TW202122387A (zh) * 2019-09-12 2021-06-16 美商米瑞替療法公司 Mta協同性之prmt5抑制劑

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