JPWO2021046265A5 - - Google Patents
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- JPWO2021046265A5 JPWO2021046265A5 JP2022514708A JP2022514708A JPWO2021046265A5 JP WO2021046265 A5 JPWO2021046265 A5 JP WO2021046265A5 JP 2022514708 A JP2022514708 A JP 2022514708A JP 2022514708 A JP2022514708 A JP 2022514708A JP WO2021046265 A5 JPWO2021046265 A5 JP WO2021046265A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- item
- itr
- disease
- lipid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962896980P | 2019-09-06 | 2019-09-06 | |
| US62/896,980 | 2019-09-06 | ||
| US201962910720P | 2019-10-04 | 2019-10-04 | |
| US62/910,720 | 2019-10-04 | ||
| US201962940104P | 2019-11-25 | 2019-11-25 | |
| US62/940,104 | 2019-11-25 | ||
| PCT/US2020/049266 WO2021046265A1 (en) | 2019-09-06 | 2020-09-03 | Lipid nanoparticle compositions comprising closed-ended dna and cleavable lipids and methods of use thereof |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022546597A JP2022546597A (ja) | 2022-11-04 |
| JP2022546597A5 JP2022546597A5 (https=) | 2023-09-11 |
| JPWO2021046265A5 true JPWO2021046265A5 (https=) | 2023-09-11 |
| JP7700101B2 JP7700101B2 (ja) | 2025-06-30 |
Family
ID=74853052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022514708A Active JP7700101B2 (ja) | 2019-09-06 | 2020-09-03 | 閉端ｄｎａおよび切断可能脂質を含む脂質ナノ粒子組成物ならびにそれらの使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20220280427A1 (https=) |
| EP (1) | EP4025196A4 (https=) |
| JP (1) | JP7700101B2 (https=) |
| CN (1) | CN114929205B (https=) |
| AU (1) | AU2020342668B2 (https=) |
| CA (1) | CA3150452A1 (https=) |
| IL (1) | IL291038A (https=) |
| WO (1) | WO2021046265A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021060440A1 (ja) * | 2019-09-26 | 2021-04-01 | 日油株式会社 | 脂質ナノ粒子の凍結乾燥組成物 |
| IL296763B2 (en) | 2020-03-27 | 2026-04-01 | Generation Bio Co | New lipids and their nanoparticle compositions |
| US20230181764A1 (en) * | 2020-05-18 | 2023-06-15 | Generation Bio Co. | Novel lipids and nanoparticle compositions thereof |
| MX2023000806A (es) * | 2020-07-17 | 2023-04-11 | Generation Bio Co | Métodos para encapsular polinucleótidos en tamaños reducidos de nanopartículas lipídicas y formulación novedosa de estos. |
| CN116234917A (zh) | 2020-07-27 | 2023-06-06 | 安杰瑞姆生物科学公司 | Dna分子组合物及其制备方法和使用方法 |
| CZ310613B6 (cs) | 2020-09-23 | 2026-01-28 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Lipidoidy pro transfekci nukleových kyselin a jejich použití |
| IL303195A (en) | 2020-11-25 | 2023-07-01 | Akagera Medicines Inc | Lipid nanoparticles for delivery of nucleic acids and related methods of use |
| CA3221454A1 (en) * | 2021-06-07 | 2022-12-15 | Michelle LEBLANC | Apoe and apob modified lipid nanoparticle compositions and uses thereof |
| WO2022266032A1 (en) * | 2021-06-14 | 2022-12-22 | Generation Bio Co. | Cationic lipids and compositions thereof |
| KR20240038705A (ko) * | 2021-06-22 | 2024-03-25 | 인텔리아 테라퓨틱스, 인크. | 간 유전자의 생체 내 편집 방법 |
| CZ310443B6 (cs) | 2021-07-19 | 2025-06-25 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Cyklohexanové lipidoidy pro transfekci nukleových kyselin a jejich použití |
| US12251471B2 (en) * | 2021-07-26 | 2025-03-18 | Oregon State University | Inhalable therapeutics |
| WO2023054242A1 (ja) * | 2021-09-30 | 2023-04-06 | 日油株式会社 | 核酸をリンパ管内皮細胞に送達するために用いられる脂質ナノ粒子 |
| CN114432502B (zh) * | 2021-12-31 | 2023-02-03 | 中山大学附属第八医院（深圳福田） | 一种负载op3-4多肽、抗cxcl9抗体的水凝胶及其制备方法与应用 |
| CN118973614A (zh) * | 2022-03-28 | 2024-11-15 | 日油株式会社 | 用于向脾脏组织递送核酸的脂质纳米粒子以及使用其向脾脏组织递送核酸的方法 |
| EP4501361A4 (en) * | 2022-03-28 | 2026-01-28 | Nof Corp | Lipid nanoparticles for delivering nucleic acid to peripheral blood mononuclear cells, and a method for delivering nucleic acid to peripheral blood mononuclear cells using them |
| EP4531819A2 (en) | 2022-05-25 | 2025-04-09 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids and methods of use thereof |
| WO2024112943A1 (en) * | 2022-11-22 | 2024-05-30 | University Of Maryland, Baltimore | Activated nanotherapy for sickle cell disease |
| EP4628496A1 (en) | 2022-12-29 | 2025-10-08 | Jenkem Technology Co., Ltd. (Liaoning) | Steroid-cationic lipid compound and use thereof |
| US12311033B2 (en) | 2023-05-31 | 2025-05-27 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| WO2025188836A1 (en) * | 2024-03-05 | 2025-09-12 | Saliogen Therapeutics, Inc. | Compositions and methods of using gene coding for treating ocular disease |
| WO2025213139A1 (en) * | 2024-04-04 | 2025-10-09 | The General Hospital Corporation | Enpp1 gene therapy for the treatment of vascular disease |
| WO2026003582A2 (en) | 2024-06-27 | 2026-01-02 | Axelyf ehf. | Lipids and lipid nanoparticles |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5885613A (en) | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
| US5928906A (en) | 1996-05-09 | 1999-07-27 | Sequenom, Inc. | Process for direct sequencing during template amplification |
| CA2289702C (en) | 1997-05-14 | 2008-02-19 | Inex Pharmaceuticals Corp. | High efficiency encapsulation of charged therapeutic agents in lipid vesicles |
| US6320017B1 (en) | 1997-12-23 | 2001-11-20 | Inex Pharmaceuticals Corp. | Polyamide oligomers |
| US7201898B2 (en) | 2000-06-01 | 2007-04-10 | The University Of North Carolina At Chapel Hill | Methods and compounds for controlled release of recombinant parvovirus vectors |
| US20030077829A1 (en) | 2001-04-30 | 2003-04-24 | Protiva Biotherapeutics Inc.. | Lipid-based formulations |
| US7901708B2 (en) | 2002-06-28 | 2011-03-08 | Protiva Biotherapeutics, Inc. | Liposomal apparatus and manufacturing methods |
| US20050164212A1 (en) | 2003-03-06 | 2005-07-28 | Todd Hauser | Modulation of gene expression using DNA-RNA hybrids |
| US20050148531A1 (en) | 2003-05-15 | 2005-07-07 | Todd Hauser | Modulation of gene expression using DNA-DNA hybrids |
| NZ592917A (en) | 2003-09-15 | 2012-12-21 | Protiva Biotherapeutics Inc | Stable polyethyleneglycol (PEG) dialkyloxypropyl (DAA) lipid conjugates |
| US7404969B2 (en) | 2005-02-14 | 2008-07-29 | Sirna Therapeutics, Inc. | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules |
| US9005654B2 (en) | 2005-07-27 | 2015-04-14 | Protiva Biotherapeutics, Inc. | Systems and methods for manufacturing liposomes |
| EP3192788A1 (en) * | 2006-10-03 | 2017-07-19 | Arbutus Biopharma Corporation | Lipid containing formulations |
| US20100015218A1 (en) | 2007-02-16 | 2010-01-21 | Vasant Jadhav | Compositions and methods for potentiated activity of biologically active molecules |
| WO2009086558A1 (en) | 2008-01-02 | 2009-07-09 | Tekmira Pharmaceuticals Corporation | Improved compositions and methods for the delivery of nucleic acids |
| AU2009238175C1 (en) | 2008-04-15 | 2023-11-30 | Arbutus Biopharma Corporation | Novel lipid formulations for nucleic acid delivery |
| JP5642673B2 (ja) | 2008-07-10 | 2014-12-17 | セリナ・セラピユーテイツクス・インコーポレーテツド | 不活性末端基を有するポリオキサゾリン類、保護された開始基から調製されるポリオキサゾリン類及び関連化合物 |
| MX342785B (es) | 2009-06-10 | 2016-10-12 | Alnylam Pharmaceuticals Inc | Formulacion mejorada de lipido. |
| EP2558074B1 (en) | 2010-04-08 | 2018-06-06 | The Trustees of Princeton University | Preparation of lipid nanoparticles |
| WO2011139911A2 (en) | 2010-04-29 | 2011-11-10 | Isis Pharmaceuticals, Inc. | Lipid formulated single stranded rna |
| WO2012000104A1 (en) | 2010-06-30 | 2012-01-05 | Protiva Biotherapeutics, Inc. | Non-liposomal systems for nucleic acid delivery |
| EA201390145A1 (ru) | 2010-08-20 | 2013-11-29 | Серулин Фарма Инк. | Конъюгаты, частицы, композиции и связанные с ними способы |
| ES2888231T3 (es) | 2010-09-20 | 2022-01-03 | Sirna Therapeutics Inc | Lípidos catiónicos de bajo peso molecular para el suministro de oligonucleótidos |
| EP2500434A1 (en) * | 2011-03-12 | 2012-09-19 | Association Institut de Myologie | Capsid-free AAV vectors, compositions, and methods for vector production and gene delivery |
| EP3354644A1 (en) | 2011-06-08 | 2018-08-01 | Translate Bio, Inc. | Cleavable lipids |
| CA2853685C (en) | 2011-11-04 | 2019-09-03 | Nitto Denko Corporation | Single use system for sterilely producing lipid-nucleic acid particles |
| JP6093710B2 (ja) | 2011-11-18 | 2017-03-08 | 日油株式会社 | 細胞内動態を改善したカチオン性脂質 |
| HK1206644A1 (en) | 2012-03-29 | 2016-01-15 | Shire Human Genetic Therapies, Inc. | Lipid-derived neutral nanoparticles |
| US9593077B2 (en) | 2013-11-18 | 2017-03-14 | Arcturus Therapeutics, Inc. | Ionizable cationic lipid for RNA delivery |
| EP4019506A1 (en) | 2013-12-19 | 2022-06-29 | Novartis AG | Lipids and lipid compositions for the delivery of active agents |
| SMT202200502T1 (it) | 2014-06-25 | 2023-01-13 | Acuitas Therapeutics Inc | Nuovi lipidi e formulazioni di nanoparticelle lipidiche per l'erogazione di acidi nucleici |
| WO2016079197A1 (en) * | 2014-11-18 | 2016-05-26 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Delivery enhancers for conjugated sirna and lipid nanoparticles |
| CA2975371C (en) * | 2015-01-30 | 2024-02-13 | Nof Corporation | Cationic lipid for nucleic acid delivery |
| LT3313829T (lt) | 2015-06-29 | 2024-08-12 | Acuitas Therapeutics Inc. | Lipidai ir lipidų nanodalelių sudėtys, skirtos nukleorūgščių tiekimui |
| IL307179A (en) | 2015-10-28 | 2023-11-01 | Acuitas Therapeutics Inc | Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| HRP20220652T1 (hr) | 2015-12-10 | 2022-06-24 | Modernatx, Inc. | Pripravci i postupci unosa terapijskih sredstava |
| EP3397613A1 (en) | 2015-12-30 | 2018-11-07 | Acuitas Therapeutics Inc. | Lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| EP3315125A1 (en) * | 2016-10-31 | 2018-05-02 | Silence Therapeutics (London) Ltd | Lipid nanoparticle formulation |
| WO2018237369A2 (en) * | 2017-06-23 | 2018-12-27 | Vical Incorporated | Lipid nanoparticle (lnp)-mediated delivery of a crispr-expressing plasmid dna for treating chronic hepatitis b virus infection |
| JP2020532981A (ja) * | 2017-09-08 | 2020-11-19 | ジェネレーション バイオ カンパニー | 修飾型閉端ｄｎａ（ｃｅｄｎａ） |
| AU2018330208B2 (en) | 2017-09-08 | 2025-04-17 | Generation Bio Co. | Lipid nanoparticle formulations of non-viral, capsid-free DNA vectors |
| MA51842A (fr) * | 2018-02-14 | 2020-12-23 | Generation Bio Co | Vecteurs d'adn non viraux et utilisations associées pour la production d'anticorps et de protéines de fusion |
| WO2019188867A1 (ja) * | 2018-03-27 | 2019-10-03 | 日油株式会社 | 細胞内動態を改善した新規カチオン性脂質 |
-
2020
- 2020-09-03 JP JP2022514708A patent/JP7700101B2/ja active Active
- 2020-09-03 EP EP20860233.4A patent/EP4025196A4/en active Pending
- 2020-09-03 WO PCT/US2020/049266 patent/WO2021046265A1/en not_active Ceased
- 2020-09-03 CA CA3150452A patent/CA3150452A1/en active Pending
- 2020-09-03 CN CN202080076963.3A patent/CN114929205B/zh active Active
- 2020-09-03 AU AU2020342668A patent/AU2020342668B2/en active Active
- 2020-09-03 US US17/632,262 patent/US20220280427A1/en active Pending
-
2022
- 2022-03-01 IL IL291038A patent/IL291038A/en unknown
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