JPWO2021032960A5 - - Google Patents

Info

Publication number

JPWO2021032960A5

JPWO2021032960A5 JP2022509648A JP2022509648A JPWO2021032960A5 JP WO2021032960 A5 JPWO2021032960 A5 JP WO2021032960A5 JP 2022509648 A JP2022509648 A JP 2022509648A JP 2022509648 A JP2022509648 A JP 2022509648A JP WO2021032960 A5 JPWO2021032960 A5 JP WO2021032960A5

Authority

JP

Japan

Prior art keywords

seq

antibody

fragment

sequence

amino acid

Prior art date

2023-08-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 239000012634 fragment Substances 0.000 claims description 66
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 28
• 108091008874 T cell receptors Proteins 0.000 claims description 17
• 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 16
• 125000000539 amino acid group Chemical group 0.000 claims description 14
• 239000000427 antigen Substances 0.000 claims description 12
• 108091007433 antigens Proteins 0.000 claims description 12
• 102000036639 antigens Human genes 0.000 claims description 12
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
• 210000004027 cell Anatomy 0.000 claims description 2
• 108700041286 delta Proteins 0.000 claims description 2
• 239000003085 diluting agent Substances 0.000 claims description 2
• 239000000203 mixture Substances 0.000 claims description 2
• 239000008194 pharmaceutical composition Substances 0.000 claims description 2
• 229920001184 polypeptide Polymers 0.000 claims description 2
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
• 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims description 2
• 235000001014 amino acid Nutrition 0.000 claims 4
• 238000004458 analytical method Methods 0.000 claims 4
• 210000001744 T-lymphocyte Anatomy 0.000 claims 2
• 108090000695 Cytokines Proteins 0.000 claims 1
• 102000004127 Cytokines Human genes 0.000 claims 1
• YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical group [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 1
• 238000005481 NMR spectroscopy Methods 0.000 claims 1
• 230000006044 T cell activation Effects 0.000 claims 1
• 230000003213 activating effect Effects 0.000 claims 1
• 238000012867 alanine scanning Methods 0.000 claims 1
• 230000004075 alteration Effects 0.000 claims 1
• 238000003556 assay Methods 0.000 claims 1
• 230000022534 cell killing Effects 0.000 claims 1
• 230000001413 cellular effect Effects 0.000 claims 1
• 238000007385 chemical modification Methods 0.000 claims 1
• 238000012866 crystallographic experiment Methods 0.000 claims 1
• 230000001086 cytosolic effect Effects 0.000 claims 1
• 230000003013 cytotoxicity Effects 0.000 claims 1
• 231100000135 cytotoxicity Toxicity 0.000 claims 1
• 229910052805 deuterium Inorganic materials 0.000 claims 1
• 230000003828 downregulation Effects 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 238000000605 extraction Methods 0.000 claims 1
• 230000014509 gene expression Effects 0.000 claims 1
• 239000003102 growth factor Substances 0.000 claims 1
• 229910052739 hydrogen Inorganic materials 0.000 claims 1
• 239000001257 hydrogen Substances 0.000 claims 1
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
• 230000001965 increasing effect Effects 0.000 claims 1
• 230000004068 intracellular signaling Effects 0.000 claims 1
• 238000002955 isolation Methods 0.000 claims 1
• 238000004949 mass spectrometry Methods 0.000 claims 1
• 230000000869 mutational effect Effects 0.000 claims 1
• 230000007030 peptide scission Effects 0.000 claims 1
• 230000035755 proliferation Effects 0.000 claims 1
• 230000007115 recruitment Effects 0.000 claims 1
• 230000028327 secretion Effects 0.000 claims 1
• 230000004083 survival effect Effects 0.000 claims 1
• 101100112922 Candida albicans CDR3 gene Proteins 0.000 description 8
• 102000040430 polynucleotide Human genes 0.000 description 4
• 108091033319 polynucleotide Proteins 0.000 description 4
• 239000002157 polynucleotide Substances 0.000 description 4
• 238000000034 method Methods 0.000 description 3
• 239000013604 expression vector Substances 0.000 description 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
• 230000002155 anti-virotic effect Effects 0.000 description 1
• 230000020411 cell activation Effects 0.000 description 1
• 238000012986 modification Methods 0.000 description 1
• 230000004048 modification Effects 0.000 description 1
• 230000009258 tissue cross reactivity Effects 0.000 description 1