JPWO2021021959A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2021021959A5 JPWO2021021959A5 JP2022502227A JP2022502227A JPWO2021021959A5 JP WO2021021959 A5 JPWO2021021959 A5 JP WO2021021959A5 JP 2022502227 A JP2022502227 A JP 2022502227A JP 2022502227 A JP2022502227 A JP 2022502227A JP WO2021021959 A5 JPWO2021021959 A5 JP WO2021021959A5
- Authority
- JP
- Japan
- Prior art keywords
- multimeric oligonucleotide
- oligonucleotide
- multimeric
- linker
- subunits
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962880591P | 2019-07-30 | 2019-07-30 | |
| US62/880,591 | 2019-07-30 | ||
| PCT/US2020/044110 WO2021021959A2 (en) | 2019-07-30 | 2020-07-29 | Subcutaneous delivery of multimeric oligonucleotides with enhanced bioactivity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022543191A JP2022543191A (ja) | 2022-10-11 |
| JP2022543191A5 JP2022543191A5 (https=) | 2023-08-07 |
| JPWO2021021959A5 true JPWO2021021959A5 (https=) | 2023-08-07 |
Family
ID=74228530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022502227A Withdrawn JP2022543191A (ja) | 2019-07-30 | 2020-07-29 | 増強された生理活性を有する多量体オリゴヌクレオチドの皮下送達 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230114023A1 (https=) |
| EP (1) | EP4004205A4 (https=) |
| JP (1) | JP2022543191A (https=) |
| CN (1) | CN114466929A (https=) |
| AU (1) | AU2020319911A1 (https=) |
| CA (1) | CA3144467A1 (https=) |
| IL (1) | IL289801A (https=) |
| WO (1) | WO2021021959A2 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101141544B1 (ko) | 2009-03-13 | 2012-05-03 | 한국과학기술원 | 에스아이알엔에이 다중 접합체 및 이의 제조방법 |
| IL316159A (en) | 2015-06-15 | 2024-12-01 | Mpeg La Llc | Defined Oligonucleotide Multimers and Methods for Manufacture Thereof |
| EP3576752A4 (en) | 2017-02-06 | 2020-12-16 | Mpeg La, LLC | MULTIMERIC OLIGONUCLEOTIDES WITH REDUCED RENAL CLEARANCE |
| US20230372508A1 (en) * | 2022-05-19 | 2023-11-23 | Olix Us, Inc. | Linkers coupling functional ligands to macromolecules |
| WO2025100427A1 (ja) * | 2023-11-06 | 2025-05-15 | 国立研究開発法人国立循環器病研究センター | 肺高血圧症の予防および／または治療用医薬 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060035815A1 (en) * | 2004-05-04 | 2006-02-16 | Nastech Pharmaceutical Company Inc. | Pharmaceutical compositions for delivery of ribonucleic acid to a cell |
| DK2539451T3 (da) * | 2010-02-24 | 2016-04-04 | Arrowhead Res Corp | Sammensætninger til målrettet tilførsel af siRNA |
| EP2895200B1 (en) * | 2012-09-14 | 2019-11-06 | Translate Bio MA, Inc. | Multimeric oligonucleotide compounds |
| US10077443B2 (en) * | 2012-11-15 | 2018-09-18 | Roche Innovation Center Copenhagen A/S | Oligonucleotide conjugates |
| CN104955952A (zh) * | 2013-01-30 | 2015-09-30 | 弗·哈夫曼-拉罗切有限公司 | Lna寡核苷酸碳水化合物缀合物 |
| IL316159A (en) * | 2015-06-15 | 2024-12-01 | Mpeg La Llc | Defined Oligonucleotide Multimers and Methods for Manufacture Thereof |
| EP3576752A4 (en) * | 2017-02-06 | 2020-12-16 | Mpeg La, LLC | MULTIMERIC OLIGONUCLEOTIDES WITH REDUCED RENAL CLEARANCE |
-
2020
- 2020-07-29 AU AU2020319911A patent/AU2020319911A1/en not_active Abandoned
- 2020-07-29 US US17/631,087 patent/US20230114023A1/en not_active Abandoned
- 2020-07-29 CA CA3144467A patent/CA3144467A1/en active Pending
- 2020-07-29 JP JP2022502227A patent/JP2022543191A/ja not_active Withdrawn
- 2020-07-29 CN CN202080068000.9A patent/CN114466929A/zh active Pending
- 2020-07-29 WO PCT/US2020/044110 patent/WO2021021959A2/en not_active Ceased
- 2020-07-29 EP EP20848521.9A patent/EP4004205A4/en not_active Withdrawn
-
2022
- 2022-01-12 IL IL289801A patent/IL289801A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10941400B2 (en) | Compounds and methods for enhanced cellular uptake | |
| TWI823866B (zh) | 用於抑制類血管生成素蛋白-3(ANGPTL3)表現的RNAi藥劑及組合物及使用方法 | |
| EP2611927B1 (en) | Novel single chemical entities and methods for delivery of oligonucleotides | |
| JP2021533804A5 (https=) | ||
| CN102869774A (zh) | 用于靶向递送siRNA的组合物 | |
| US20240117351A1 (en) | Compositions and methods for inhibiting gene expression in the central nervous system | |
| JP6773677B2 (ja) | 改善されたジスルフィド含有アルキン連結剤 | |
| US10933081B2 (en) | Myostatin iRNA compositions and methods of use thereof | |
| US9862950B2 (en) | Targeting microRNAs for metabolic disorders | |
| JPWO2018003739A1 (ja) | 機能的リガンドを含む核酸複合体 | |
| BR112020008546A2 (pt) | construtos de oligonucleotídeo e usos dos mesmos | |
| JP6847852B2 (ja) | 癌治療のためのヒト抗原Ｒ発現のｓｉＲＮＡ阻害 | |
| JPWO2017068790A1 (ja) | 核酸複合体 | |
| JPWO2020150636A5 (https=) | ||
| JPWO2020041769A5 (https=) | ||
| JPWO2021021959A5 (https=) | ||
| TW202237189A (zh) | 具有增強之肝靶向的ｓ抗原運輸抑制寡核苷酸聚合物之接合物 | |
| JPWO2021222065A5 (https=) | ||
| JPWO2020180897A5 (https=) | ||
| JPWO2023278607A5 (https=) | ||
| JP2024518564A (ja) | 中枢神経系のニューロンを標的とするための脂質コンジュゲーション | |
| CN121057819A (zh) | 双重沉默 | |
| JPWO2021239825A5 (https=) | ||
| TW202609059A (zh) | 用於抑制類血管生成素蛋白-3 (ANGPTL3)表現的RNAi藥劑及組合物及使用方法 | |
| HK1221257B (en) | Compounds and methods for enhanced cellular uptake |