JPWO2020264426A5 - - Google Patents
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- JPWO2020264426A5 JPWO2020264426A5 JP2021577528A JP2021577528A JPWO2020264426A5 JP WO2020264426 A5 JPWO2020264426 A5 JP WO2020264426A5 JP 2021577528 A JP2021577528 A JP 2021577528A JP 2021577528 A JP2021577528 A JP 2021577528A JP WO2020264426 A5 JPWO2020264426 A5 JP WO2020264426A5
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- classifier
- tnf therapy
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- 238000002560 therapeutic procedure Methods 0.000 claims 47
- 238000000034 method Methods 0.000 claims 46
- 239000008194 pharmaceutical composition Substances 0.000 claims 38
- 238000011282 treatment Methods 0.000 claims 31
- 108090000623 proteins and genes Proteins 0.000 claims 21
- 208000023275 Autoimmune disease Diseases 0.000 claims 20
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 20
- 230000000875 corresponding effect Effects 0.000 claims 15
- 201000010099 disease Diseases 0.000 claims 14
- 230000001225 therapeutic effect Effects 0.000 claims 13
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 11
- 108010074051 C-Reactive Protein Proteins 0.000 claims 10
- 102100032752 C-reactive protein Human genes 0.000 claims 10
- 230000004044 response Effects 0.000 claims 10
- 230000004043 responsiveness Effects 0.000 claims 10
- 239000002773 nucleotide Substances 0.000 claims 9
- 125000003729 nucleotide group Chemical group 0.000 claims 9
- 102000054765 polymorphisms of proteins Human genes 0.000 claims 9
- 206010009900 Colitis ulcerative Diseases 0.000 claims 8
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 8
- 208000035475 disorder Diseases 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 102100037278 Actin-related protein 2/3 complex subunit 1A Human genes 0.000 claims 5
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 5
- 102100037828 Charged multivesicular body protein 7 Human genes 0.000 claims 5
- 101710153987 Charged multivesicular body protein 7 Proteins 0.000 claims 5
- 102100041021 Coronin-2B Human genes 0.000 claims 5
- 208000011231 Crohn disease Diseases 0.000 claims 5
- 101150016994 Cysltr2 gene Proteins 0.000 claims 5
- 102100033539 Cysteinyl leukotriene receptor 2 Human genes 0.000 claims 5
- 108010008165 Etanercept Proteins 0.000 claims 5
- 102100032563 Golgin subfamily A member 1 Human genes 0.000 claims 5
- 101000806644 Homo sapiens Actin-related protein 2/3 complex subunit 1A Proteins 0.000 claims 5
- 101000748863 Homo sapiens Coronin-2B Proteins 0.000 claims 5
- 101001014628 Homo sapiens Golgin subfamily A member 1 Proteins 0.000 claims 5
- 101001076642 Homo sapiens Inosine-5'-monophosphate dehydrogenase 2 Proteins 0.000 claims 5
- 101000945442 Homo sapiens Kelch domain-containing protein 3 Proteins 0.000 claims 5
- 101000663639 Homo sapiens Kunitz-type protease inhibitor 2 Proteins 0.000 claims 5
- 101000879758 Homo sapiens Sjoegren syndrome nuclear autoantigen 1 Proteins 0.000 claims 5
- 101000831927 Homo sapiens Stomatin-like protein 2, mitochondrial Proteins 0.000 claims 5
- 101000643865 Homo sapiens Sulfite oxidase, mitochondrial Proteins 0.000 claims 5
- 102100025891 Inosine-5'-monophosphate dehydrogenase 2 Human genes 0.000 claims 5
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 5
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 5
- 102100033602 Kelch domain-containing protein 3 Human genes 0.000 claims 5
- 102100039020 Kunitz-type protease inhibitor 2 Human genes 0.000 claims 5
- 101001033610 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Inosine-5'-monophosphate dehydrogenase Proteins 0.000 claims 5
- 201000004681 Psoriasis Diseases 0.000 claims 5
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 5
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 5
- 102100037330 Sjoegren syndrome nuclear autoantigen 1 Human genes 0.000 claims 5
- 102100024172 Stomatin-like protein 2, mitochondrial Human genes 0.000 claims 5
- 102100020951 Sulfite oxidase, mitochondrial Human genes 0.000 claims 5
- ZUPXXZAVUHFCNV-UHFFFAOYSA-N [[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [5-(3-carbamoyl-4h-pyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate;potassium Chemical compound [K].C1=CCC(C(=O)N)=CN1C1C(O)C(O)C(COP(O)(=O)OP(O)(=O)OCC2C(C(O)C(O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ZUPXXZAVUHFCNV-UHFFFAOYSA-N 0.000 claims 5
- 229960002964 adalimumab Drugs 0.000 claims 5
- 229960000106 biosimilars Drugs 0.000 claims 5
- 229960003115 certolizumab pegol Drugs 0.000 claims 5
- 230000001684 chronic effect Effects 0.000 claims 5
- 229960000403 etanercept Drugs 0.000 claims 5
- 208000002557 hidradenitis Diseases 0.000 claims 5
- 201000007162 hidradenitis suppurativa Diseases 0.000 claims 5
- 229960000598 infliximab Drugs 0.000 claims 5
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 5
- 238000010801 machine learning Methods 0.000 claims 4
- 229960003697 abatacept Drugs 0.000 claims 3
- 229960004641 rituximab Drugs 0.000 claims 3
- 229950006348 sarilumab Drugs 0.000 claims 3
- 229960003989 tocilizumab Drugs 0.000 claims 3
- 229960004247 tofacitinib citrate Drugs 0.000 claims 3
- SYIKUFDOYJFGBQ-YLAFAASESA-N tofacitinib citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)C1=NC=NC2=C1C=CN2 SYIKUFDOYJFGBQ-YLAFAASESA-N 0.000 claims 3
- 229960004914 vedolizumab Drugs 0.000 claims 3
- 230000002596 correlated effect Effects 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 238000007637 random forest analysis Methods 0.000 claims 2
- 230000009257 reactivity Effects 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 238000003559 RNA-seq method Methods 0.000 claims 1
- 238000010208 microarray analysis Methods 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962867853P | 2019-06-27 | 2019-06-27 | |
| US62/867,853 | 2019-06-27 | ||
| US201962882402P | 2019-08-02 | 2019-08-02 | |
| US62/882,402 | 2019-08-02 | ||
| US202062965486P | 2020-01-24 | 2020-01-24 | |
| US62/965,486 | 2020-01-24 | ||
| PCT/US2020/039991 WO2020264426A1 (en) | 2019-06-27 | 2020-06-26 | Developing classifiers for stratifying patients |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022541125A JP2022541125A (ja) | 2022-09-22 |
| JPWO2020264426A5 true JPWO2020264426A5 (https=) | 2023-05-30 |
| JP2022541125A5 JP2022541125A5 (https=) | 2023-05-30 |
Family
ID=74061318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021577528A Pending JP2022541125A (ja) | 2019-06-27 | 2020-06-26 | 患者を層別化するための分類子の開発 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US11195595B2 (https=) |
| EP (1) | EP3990656B1 (https=) |
| JP (1) | JP2022541125A (https=) |
| KR (1) | KR20220044720A (https=) |
| CN (1) | CN114402084A (https=) |
| AU (1) | AU2020308906A1 (https=) |
| CA (1) | CA3145237A1 (https=) |
| GB (1) | GB2603294A (https=) |
| IL (1) | IL289304A (https=) |
| MX (1) | MX2022000128A (https=) |
| WO (1) | WO2020264426A1 (https=) |
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| WO2019178546A1 (en) | 2018-03-16 | 2019-09-19 | Scipher Medicine Corporation | Methods and systems for predicting response to anti-tnf therapies |
| GB2603294A (en) | 2019-06-27 | 2022-08-03 | Scipher Medicine Corp | Developing classifiers for stratifying patients |
| CA3178405A1 (en) | 2020-05-14 | 2021-11-18 | Katherine A. OWEN | Methods and systems for machine learning analysis of single nucleotide polymorphisms in lupus |
| IL300978A (en) * | 2020-09-01 | 2023-04-01 | Scipher Medicine Corp | Methods and systems for predicting response to anti-TNF treatments |
| US11430575B2 (en) * | 2020-11-13 | 2022-08-30 | Specialty Diagnostic (SDI) Laboratories, Inc. | Systems and methods for a data driven disease test result prediction |
| US12271832B2 (en) * | 2021-02-12 | 2025-04-08 | Tempus Ai, Inc. | Artificial intelligence engine for directed hypothesis generation and ranking |
| IL305934A (en) * | 2021-03-19 | 2023-11-01 | Scipher Medicine Corp | Methods for classifying and treating patients |
| EP4338163A4 (en) | 2021-05-13 | 2024-11-06 | Scipher Medicine Corporation | ASSESSMENT OF RESPONSE TO THERAPY |
| US20220399092A1 (en) * | 2021-06-10 | 2022-12-15 | Rajant Health Inc. | Ai-enabled health platform |
| MX2023015447A (es) * | 2021-06-22 | 2024-05-09 | Scipher Medicine Corp | Métodos y sistemas para la supervisión de terapias y el diseño de ensayos. |
| WO2023150731A2 (en) * | 2022-02-04 | 2023-08-10 | Scipher Medicine Corporation | Systems and methods for predicting response to anti-tnf therapies |
| CN114861764B (zh) * | 2022-04-11 | 2024-11-22 | 中国科学院计算技术研究所 | 基于auc优化的多类别分类方法及系统 |
| CN115206439B (zh) * | 2022-05-20 | 2025-07-18 | 南开大学 | 跨语言平台的空间转录组数据转换方法及系统 |
| WO2024081737A1 (en) * | 2022-10-12 | 2024-04-18 | Exagen Inc. | Biomarker selection for machine learning enabled prediction of treatment response |
| CN116312796B (zh) * | 2022-12-27 | 2023-11-14 | 江苏先声医学诊断有限公司 | 一种基于期望最大化算法的宏基因组丰度估计方法及系统 |
| WO2024249568A1 (en) | 2023-05-30 | 2024-12-05 | Paragon Therapeutics, Inc. | Alpha4beta7 integrin antibody compositions and methods of use |
| CN121889424A (zh) | 2023-08-14 | 2026-04-17 | 派拉冈医疗公司 | α4β7整联蛋白结合蛋白及使用方法 |
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| GB2603294A (en) | 2019-06-27 | 2022-08-03 | Scipher Medicine Corp | Developing classifiers for stratifying patients |
| IL300978A (en) | 2020-09-01 | 2023-04-01 | Scipher Medicine Corp | Methods and systems for predicting response to anti-TNF treatments |
| IL305934A (en) | 2021-03-19 | 2023-11-01 | Scipher Medicine Corp | Methods for classifying and treating patients |
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-
2020
- 2020-06-26 GB GB2119148.1A patent/GB2603294A/en not_active Withdrawn
- 2020-06-26 JP JP2021577528A patent/JP2022541125A/ja active Pending
- 2020-06-26 MX MX2022000128A patent/MX2022000128A/es unknown
- 2020-06-26 KR KR1020227002006A patent/KR20220044720A/ko active Pending
- 2020-06-26 CA CA3145237A patent/CA3145237A1/en active Pending
- 2020-06-26 EP EP20832235.4A patent/EP3990656B1/en active Active
- 2020-06-26 WO PCT/US2020/039991 patent/WO2020264426A1/en not_active Ceased
- 2020-06-26 CN CN202080060499.9A patent/CN114402084A/zh active Pending
- 2020-06-26 AU AU2020308906A patent/AU2020308906A1/en active Pending
-
2021
- 2021-05-10 US US17/315,580 patent/US11195595B2/en active Active
- 2021-11-02 US US17/517,521 patent/US11456056B2/en active Active
- 2021-12-23 IL IL289304A patent/IL289304A/en unknown
-
2022
- 2022-08-04 US US17/881,441 patent/US11783913B2/en active Active
-
2023
- 2023-08-15 US US18/450,222 patent/US12062415B2/en active Active
-
2024
- 2024-06-25 US US18/753,994 patent/US12525318B2/en active Active
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