JPWO2020252240A5 - - Google Patents
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- JPWO2020252240A5 JPWO2020252240A5 JP2021573832A JP2021573832A JPWO2020252240A5 JP WO2020252240 A5 JPWO2020252240 A5 JP WO2020252240A5 JP 2021573832 A JP2021573832 A JP 2021573832A JP 2021573832 A JP2021573832 A JP 2021573832A JP WO2020252240 A5 JPWO2020252240 A5 JP WO2020252240A5
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- JP
- Japan
- Prior art keywords
- independently selected
- optionally substituted
- alkyl
- group
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 112
- 229910052757 nitrogen Inorganic materials 0.000 claims description 73
- 125000005842 heteroatom Chemical group 0.000 claims description 64
- 125000006413 ring segment Chemical group 0.000 claims description 64
- 150000001875 compounds Chemical class 0.000 claims description 51
- 125000003545 alkoxy group Chemical group 0.000 claims description 39
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 36
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims description 31
- 125000001072 heteroaryl group Chemical group 0.000 claims description 30
- 229910052760 oxygen Inorganic materials 0.000 claims description 29
- 125000001424 substituent group Chemical group 0.000 claims description 28
- 125000005843 halogen group Chemical group 0.000 claims description 26
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 24
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims description 22
- 125000000623 heterocyclic group Chemical group 0.000 claims description 16
- 125000002947 alkylene group Chemical group 0.000 claims description 14
- 125000003118 aryl group Chemical group 0.000 claims description 14
- 125000004429 atom Chemical group 0.000 claims description 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 14
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 12
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 12
- 101710196623 Stimulator of interferon genes protein Proteins 0.000 claims description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 9
- 229910052717 sulfur Inorganic materials 0.000 claims description 9
- 229910052799 carbon Inorganic materials 0.000 claims description 8
- 125000005549 heteroarylene group Chemical group 0.000 claims description 8
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- -1 1,1,3,3-tetramethylbutyl Chemical group 0.000 claims description 6
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 5
- 125000005309 thioalkoxy group Chemical group 0.000 claims description 5
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims description 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 4
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 claims description 4
- 125000002619 bicyclic group Chemical group 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 208000035475 disorder Diseases 0.000 claims description 4
- 125000001188 haloalkyl group Chemical group 0.000 claims description 4
- 125000001041 indolyl group Chemical group 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 125000001624 naphthyl group Chemical group 0.000 claims description 4
- 230000011664 signaling Effects 0.000 claims description 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims description 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 2
- 125000006651 (C3-C20) cycloalkyl group Chemical group 0.000 claims description 2
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 150000001540 azides Chemical class 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 125000002993 cycloalkylene group Chemical group 0.000 claims description 2
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims description 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 125000002541 furyl group Chemical group 0.000 claims description 2
- 230000028993 immune response Effects 0.000 claims description 2
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 239000012948 isocyanate Chemical group 0.000 claims description 2
- 150000002513 isocyanates Chemical group 0.000 claims description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims description 2
- 125000006574 non-aromatic ring group Chemical group 0.000 claims description 2
- 125000002971 oxazolyl group Chemical group 0.000 claims description 2
- 230000007170 pathology Effects 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims description 2
- 125000004076 pyridyl group Chemical group 0.000 claims description 2
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims description 2
- 208000024891 symptom Diseases 0.000 claims description 2
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims description 2
- 125000003944 tolyl group Chemical group 0.000 claims description 2
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000732 arylene group Chemical group 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024208554A JP2025037981A (ja) | 2019-06-14 | 2024-11-29 | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962861714P | 2019-06-14 | 2019-06-14 | |
| US62/861,714 | 2019-06-14 | ||
| US201962955924P | 2019-12-31 | 2019-12-31 | |
| US62/955,924 | 2019-12-31 | ||
| PCT/US2020/037403 WO2020252240A1 (en) | 2019-06-14 | 2020-06-12 | Compounds and compositions for treating conditions associated with sting activity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024208554A Division JP2025037981A (ja) | 2019-06-14 | 2024-11-29 | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022536755A JP2022536755A (ja) | 2022-08-18 |
| JP2022536755A5 JP2022536755A5 (https=) | 2023-06-19 |
| JPWO2020252240A5 true JPWO2020252240A5 (https=) | 2023-06-19 |
Family
ID=71465411
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021573832A Pending JP2022536755A (ja) | 2019-06-14 | 2020-06-12 | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
| JP2024208554A Pending JP2025037981A (ja) | 2019-06-14 | 2024-11-29 | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024208554A Pending JP2025037981A (ja) | 2019-06-14 | 2024-11-29 | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230092163A1 (https=) |
| EP (1) | EP3983383A1 (https=) |
| JP (2) | JP2022536755A (https=) |
| MA (1) | MA56193A (https=) |
| PY (1) | PY2026348A (https=) |
| TW (1) | TWI873145B (https=) |
| UY (1) | UY38751A (https=) |
| WO (1) | WO2020252240A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112823036B (zh) | 2018-07-03 | 2024-11-08 | 艾福姆德尤股份有限公司 | 用于治疗与sting活性有关的疾病的化合物和组合物 |
| MA54753A (fr) * | 2019-01-17 | 2021-11-24 | Ifm Due Inc | Composés et compositions pour traiter des états pathologiques associés à une activité de sting |
| WO2021206158A1 (ja) | 2020-04-10 | 2021-10-14 | 小野薬品工業株式会社 | がん治療方法 |
| WO2022133098A2 (en) * | 2020-12-16 | 2022-06-23 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| CN117222634A (zh) * | 2020-12-16 | 2023-12-12 | 艾福姆德尤股份有限公司 | 用于治疗与sting活性有关的疾病的化合物和组合物 |
| WO2022140397A1 (en) | 2020-12-22 | 2022-06-30 | Ifm Due, Inc. | Methods of treating cancer |
| US20240060982A1 (en) | 2020-12-22 | 2024-02-22 | Ifm Due, Inc. | Methods of treating cancer |
| EP4267128A1 (en) | 2020-12-22 | 2023-11-01 | IFM Due, Inc. | Methods of treating cancer |
| EP4267129A1 (en) | 2020-12-22 | 2023-11-01 | IFM Due, Inc. | Methods of treating cancer |
| TW202235073A (zh) | 2021-01-08 | 2022-09-16 | 美商Ｉｆｍ Ｄｕｅ有限公司 | 用於治療與sting活性相關的病狀之化合物及組合物 |
| CN112920170B (zh) * | 2021-01-29 | 2023-06-20 | 中国医科大学 | N-（吲哚-5-基）芳香杂环酰胺类化合物及其制备方法和用途 |
| CN116981668A (zh) * | 2021-04-09 | 2023-10-31 | 百济神州(北京)生物科技有限公司 | 制备bcl-2抑制剂的中间体的方法 |
| UY39892A (es) | 2021-08-10 | 2023-03-31 | Novartis Pharma Ag | Compuestos y composiciones para tratar afecciones asociadas con la actividad de STING |
| CN115710255B (zh) * | 2021-08-23 | 2025-05-06 | 上海交通大学 | 一类含有苯并杂环取代的脲类衍生物及其制备和用途 |
| WO2024064358A1 (en) | 2022-09-23 | 2024-03-28 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| WO2024096753A1 (en) | 2022-11-02 | 2024-05-10 | Captor Therapeutics S.A. | Nek7 degraders and methods of use thereof |
| IT202200024963A1 (it) * | 2022-12-05 | 2024-06-05 | Angelini Pharma S P A | Composti attivatori dei canali potassio Kv7.2/Kv7.3 |
| CN117756698A (zh) * | 2022-12-16 | 2024-03-26 | 中国药科大学 | 脲类化合物及其作为sting抑制剂的医药用途 |
| WO2024151919A1 (en) * | 2023-01-13 | 2024-07-18 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| EP4709708A1 (en) * | 2023-05-09 | 2026-03-18 | Angelini Pharma S.P.A. | Novel carboxamide derivatives |
| WO2024263860A1 (en) * | 2023-06-22 | 2024-12-26 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| IL326865A (en) * | 2023-08-30 | 2026-04-01 | Jiangsu Chia Tai Fenghai Pharmaceutical Co Ltd | Compound for regulating microRNA activity A-124 |
| WO2025079045A1 (en) * | 2023-10-12 | 2025-04-17 | Novartis Pharma Ag | Compounds and compositions for treating conditions associated with sting activity |
| WO2025153990A1 (en) * | 2024-01-19 | 2025-07-24 | Novartis Pharma Ag | Compounds and compositions for treating conditions associated with sting activity |
| WO2025188646A1 (en) * | 2024-03-04 | 2025-09-12 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods and materials for treating cancer |
| CN120794982A (zh) * | 2024-05-14 | 2025-10-17 | 中国药科大学 | 吡唑类sting抑制剂及其医药用途 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR930702334A (ko) * | 1990-09-13 | 1993-09-08 | 데이비드 로버트 | 5 하이드록시트립타민 수용체 길항제로서의 인돌우레아 |
| US5439906A (en) * | 1993-11-22 | 1995-08-08 | Merck & Co., Inc. | Antiarrhythmic benzodiazepines |
| US6093742A (en) * | 1997-06-27 | 2000-07-25 | Vertex Pharmaceuticals, Inc. | Inhibitors of p38 |
| GB9823873D0 (en) * | 1998-10-30 | 1998-12-30 | Pharmacia & Upjohn Spa | 2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents |
| AU2804400A (en) * | 1999-02-12 | 2000-08-29 | Smithkline Beecham Plc | Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists |
| US6387900B1 (en) * | 1999-08-12 | 2002-05-14 | Pharmacia & Upjohn S.P.A. | 3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents |
| EP1256578B1 (en) * | 2001-05-11 | 2006-01-11 | Pfizer Products Inc. | Thiazole derivatives and their use as cdk inhibitors |
| JP2003192587A (ja) * | 2001-12-26 | 2003-07-09 | Bayer Ag | 尿素誘導体 |
| US7927613B2 (en) | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
| US7557129B2 (en) * | 2003-02-28 | 2009-07-07 | Bayer Healthcare Llc | Cyanopyridine derivatives useful in the treatment of cancer and other disorders |
| RU2402544C2 (ru) * | 2005-01-14 | 2010-10-27 | Си Джи Ай ФАРМАСЬЮТИКАЛЗ, ИНК. | 1,3-диарилзамещенные мочевины как модуляторы киназной активности |
| BRPI0615307A2 (pt) * | 2005-08-25 | 2009-08-04 | Schering Corp | agonistas de adrenorreceptor alfa2c |
| CA2674865A1 (en) * | 2007-01-15 | 2008-07-24 | Santen Pharmaceutical Co., Ltd. | Indole derivative having i.kappa.b kinase .beta. inhibitory activity |
| WO2009084695A1 (ja) * | 2007-12-28 | 2009-07-09 | Carna Biosciences Inc. | ２－アミノキナゾリン誘導体 |
| WO2012075380A1 (en) | 2010-12-03 | 2012-06-07 | The Trustees Of The University Of Pennsylvania | Tip60 inhibitors |
| CN109394752A (zh) | 2013-10-21 | 2019-03-01 | 德雷克塞尔大学 | 治疗慢性乙型肝炎病毒感染的sting激动剂的用途 |
| CA2993809C (en) * | 2015-07-30 | 2023-09-05 | Taipei Medical University | Compounds and pharmaceutical composition associated with ubiquitination-proteasome system |
| US20170146519A1 (en) * | 2015-11-20 | 2017-05-25 | Oregon Health & Science University | Sting agonists and methods of selecting sting agonists |
| JP2020524718A (ja) * | 2017-06-22 | 2020-08-20 | キュラデブ・ファーマ・リミテッドＣｕｒａｄｅｖ Ｐｈａｒｍａ Ｌｉｍｉｔｅｄ | ヒトｓｔｉｎｇの複素環式小分子調節因子 |
| PE20200696A1 (es) * | 2017-06-22 | 2020-06-16 | Curadev Pharma Ltd | Moduladores de moleculas pequenas de sting humana |
| MX2020002183A (es) * | 2017-08-31 | 2020-10-05 | Abbvie Inc | Inhibidores de la ectonucleótido pirofosfatasa-fosfodiesterasa 1 (enpp-1) y usos de los mismos. |
| EP3556362A1 (en) * | 2018-04-16 | 2019-10-23 | Ecole Polytechnique Federale De Lausanne (Epfl) | Sting inhibitors |
| CN112823036B (zh) * | 2018-07-03 | 2024-11-08 | 艾福姆德尤股份有限公司 | 用于治疗与sting活性有关的疾病的化合物和组合物 |
| US20210236466A1 (en) * | 2018-07-03 | 2021-08-05 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| CN109734677A (zh) * | 2019-03-07 | 2019-05-10 | 四川大学 | 抑制组蛋白赖氨酸甲基转移酶nsd2的小分子化合物及其应用 |
-
2020
- 2020-06-12 US US17/618,345 patent/US20230092163A1/en not_active Abandoned
- 2020-06-12 EP EP20736815.0A patent/EP3983383A1/en not_active Withdrawn
- 2020-06-12 JP JP2021573832A patent/JP2022536755A/ja active Pending
- 2020-06-12 MA MA056193A patent/MA56193A/fr unknown
- 2020-06-12 WO PCT/US2020/037403 patent/WO2020252240A1/en not_active Ceased
- 2020-06-15 UY UY0001038751A patent/UY38751A/es not_active Application Discontinuation
- 2020-06-15 PY PY202002026348A patent/PY2026348A/es unknown
- 2020-06-15 TW TW109120089A patent/TWI873145B/zh active
-
2024
- 2024-11-29 JP JP2024208554A patent/JP2025037981A/ja active Pending
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