JPWO2020243502A5 - - Google Patents
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- Publication number
- JPWO2020243502A5 JPWO2020243502A5 JP2021567966A JP2021567966A JPWO2020243502A5 JP WO2020243502 A5 JPWO2020243502 A5 JP WO2020243502A5 JP 2021567966 A JP2021567966 A JP 2021567966A JP 2021567966 A JP2021567966 A JP 2021567966A JP WO2020243502 A5 JPWO2020243502 A5 JP WO2020243502A5
- Authority
- JP
- Japan
- Prior art keywords
- column
- acetonitrile
- methanol
- lipid analytes
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 12
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- 150000002632 lipids Chemical class 0.000 description 8
- 239000002904 solvent Substances 0.000 description 5
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 4
- 230000000717 retained effect Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 2
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 2
- 239000005695 Ammonium acetate Substances 0.000 description 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 2
- 235000019257 ammonium acetate Nutrition 0.000 description 2
- 229940043376 ammonium acetate Drugs 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 235000019253 formic acid Nutrition 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 239000012156 elution solvent Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 150000003408 sphingolipids Chemical class 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024172920A JP7804023B2 (ja) | 2019-05-31 | 2024-10-02 | 二次元ｌｃ－ｍｓ／ｍｓシステム |
| JP2026001177A JP2026062952A (ja) | 2019-05-31 | 2026-01-07 | 二次元ｌｃ－ｍｓ／ｍｓシステム |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962855636P | 2019-05-31 | 2019-05-31 | |
| US62/855,636 | 2019-05-31 | ||
| PCT/US2020/035231 WO2020243502A1 (en) | 2019-05-31 | 2020-05-29 | Two-dimensional lc-ms/ms systems |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024172920A Division JP7804023B2 (ja) | 2019-05-31 | 2024-10-02 | 二次元ｌｃ－ｍｓ／ｍｓシステム |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022534363A JP2022534363A (ja) | 2022-07-29 |
| JP2022534363A5 JP2022534363A5 (https=) | 2023-06-01 |
| JPWO2020243502A5 true JPWO2020243502A5 (https=) | 2023-06-01 |
| JP7568648B2 JP7568648B2 (ja) | 2024-10-16 |
Family
ID=72193559
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021567966A Active JP7568648B2 (ja) | 2019-05-31 | 2020-05-29 | 二次元ｌｃ－ｍｓ／ｍｓシステム |
| JP2024172920A Active JP7804023B2 (ja) | 2019-05-31 | 2024-10-02 | 二次元ｌｃ－ｍｓ／ｍｓシステム |
| JP2026001177A Pending JP2026062952A (ja) | 2019-05-31 | 2026-01-07 | 二次元ｌｃ－ｍｓ／ｍｓシステム |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024172920A Active JP7804023B2 (ja) | 2019-05-31 | 2024-10-02 | 二次元ｌｃ－ｍｓ／ｍｓシステム |
| JP2026001177A Pending JP2026062952A (ja) | 2019-05-31 | 2026-01-07 | 二次元ｌｃ－ｍｓ／ｍｓシステム |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US12292424B2 (https=) |
| EP (2) | EP3976218B1 (https=) |
| JP (3) | JP7568648B2 (https=) |
| KR (2) | KR20260040656A (https=) |
| CN (2) | CN119861166A (https=) |
| AU (1) | AU2020282831B2 (https=) |
| CA (1) | CA3140183A1 (https=) |
| DK (1) | DK3976218T3 (https=) |
| ES (1) | ES3026686T3 (https=) |
| HU (1) | HUE071194T2 (https=) |
| IL (2) | IL288497B1 (https=) |
| PL (1) | PL3976218T3 (https=) |
| TW (1) | TWI862597B (https=) |
| WO (1) | WO2020243502A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN120254137B (zh) * | 2025-06-05 | 2026-04-14 | 科诺美(北京)科技有限公司 | 辅酶q10的检测方法及其应用 |
| CN120820662B (zh) * | 2025-09-17 | 2025-11-18 | 岛津企业管理（中国）有限公司 | 一种同步分析检测水产品中代谢物和脂质的方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0998229A4 (en) * | 1997-06-17 | 2001-04-04 | Cool Laser Optics Inc | METHOD AND APPARATUS FOR REGULATING BIOLOGICAL TISSUE TEMPERATURE BY SIMULTANEOUS IRRADIATION |
| WO2000045929A1 (en) * | 1999-02-08 | 2000-08-10 | Admetric Biochem Inc. | Chromatographic system with pre-detector eluent switching |
| JP2003028849A (ja) | 2001-07-10 | 2003-01-29 | Hiromasa Tojo | 自動化脂質組成一斉分析装置 |
| JP2004184215A (ja) | 2002-12-03 | 2004-07-02 | Shimadzu Corp | アクリルアミドの分析方法及び装置 |
| EP1635174A1 (en) | 2003-02-28 | 2006-03-15 | Japan Science and Technology Agency | Method of separating sugar from compound having glycoside bond, sugar separation system, sugar separation agent kit, standardized sample for sugar separation and assessment system |
| KR100614099B1 (ko) | 2005-11-25 | 2006-08-22 | 한국과학기술연구원 | 뇨 또는 플라즈마 시료 중의 디에이치이에이 설페이트의검출방법 |
| JP4790435B2 (ja) * | 2006-02-03 | 2011-10-12 | 株式会社日立ハイテクノロジーズ | ３次元液体クロマトグラフィ |
| US20080183401A1 (en) * | 2007-01-29 | 2008-07-31 | Teledyne Isco, Inc. | Apparatuses and methods for wireless monitoring and control of enviromental sampling and chromatographic apparatuses |
| JP5054439B2 (ja) | 2007-06-15 | 2012-10-24 | 株式会社日立ハイテクノロジーズ | イオン交換および順相カラムによる２次元液体クロマトグラフ |
| DE102008013500A1 (de) * | 2008-03-10 | 2009-09-17 | Evonik Degussa Gmbh | Neue chirale Selektoren und stationäre Phasen zur Trennung von Enantiomerengemischen |
| WO2012129076A1 (en) * | 2011-03-23 | 2012-09-27 | Idex Health & Science Llc | Valve and splitting system for multi-dimensional liquid analysis |
| ES2731920T3 (es) | 2013-05-14 | 2019-11-19 | Centogene Ag | Método para el diagnóstico de la enfermedad de Niemann-Pick |
| LT3004896T (lt) * | 2013-06-07 | 2020-01-10 | Genzyme Corporation | Rūgštinės sfingomielinazės sutrikimų žymuo ir jo panaudojimas |
| JP6385103B2 (ja) * | 2014-03-31 | 2018-09-05 | 株式会社島津製作所 | 順相・逆相カラムを備えた超臨界流体クロマトグラフとそれを用いた分析方法 |
| KR101574272B1 (ko) * | 2014-08-20 | 2015-12-07 | 한국표준과학연구원 | 하트 컷 방법을 위한 이차원 액체 크로마토그래피 시스템 |
| US20160195502A1 (en) * | 2014-12-31 | 2016-07-07 | Castle Medical, LLC | Method for chiral separation of methamphetamine and amphatamine enantiomers |
| WO2016160544A1 (en) * | 2015-03-27 | 2016-10-06 | The Scripps Research Institute | Lipid probes and uses thereof |
| GB201601667D0 (en) | 2016-01-29 | 2016-03-16 | Ge Healthcare Bio Sciences Ab | Improvements in and relating to liquid fraction collectors |
| JP6716087B2 (ja) | 2016-03-25 | 2020-07-01 | 公立大学法人大阪 | 分析方法及び分析装置 |
| TWI613445B (zh) | 2016-04-01 | 2018-02-01 | 行政院農業委員會農業藥物毒物試驗所 | 搭配質譜影像分析檢驗農藥殘留之方法及其系統 |
| US20180306797A1 (en) | 2017-04-24 | 2018-10-25 | Washington University | Methods of detecting ceramide |
| HUE057483T2 (hu) | 2017-06-02 | 2022-05-28 | Genzyme Corp | Eljárások kis gyakoriságú polipeptidek abszolút kvantifikálására tömeg-spektrometria alkalmazásával |
| KR20250025051A (ko) * | 2017-08-24 | 2025-02-20 | 사노피 | 산성 스핑고미엘린분해효소 결핍증 환자에서의 비정상적 골병태의 치료 |
| CN109187822A (zh) | 2018-11-22 | 2019-01-11 | 上海烟草集团有限责任公司 | 一种中心切割二维色谱质谱联用分析烟草中农残的方法 |
-
2020
- 2020-05-29 EP EP20760972.8A patent/EP3976218B1/en active Active
- 2020-05-29 PL PL20760972.8T patent/PL3976218T3/pl unknown
- 2020-05-29 CN CN202411857382.XA patent/CN119861166A/zh active Pending
- 2020-05-29 JP JP2021567966A patent/JP7568648B2/ja active Active
- 2020-05-29 CA CA3140183A patent/CA3140183A1/en active Pending
- 2020-05-29 US US17/615,291 patent/US12292424B2/en active Active
- 2020-05-29 HU HUE20760972A patent/HUE071194T2/hu unknown
- 2020-05-29 WO PCT/US2020/035231 patent/WO2020243502A1/en not_active Ceased
- 2020-05-29 IL IL288497A patent/IL288497B1/en unknown
- 2020-05-29 IL IL326850A patent/IL326850A/en unknown
- 2020-05-29 ES ES20760972T patent/ES3026686T3/es active Active
- 2020-05-29 DK DK20760972.8T patent/DK3976218T3/da active
- 2020-05-29 EP EP25156668.3A patent/EP4560320A3/en active Pending
- 2020-05-29 AU AU2020282831A patent/AU2020282831B2/en active Active
- 2020-05-29 KR KR1020267006791A patent/KR20260040656A/ko active Pending
- 2020-05-29 CN CN202080040211.1A patent/CN114364980B/zh active Active
- 2020-05-29 KR KR1020217040904A patent/KR102936574B1/ko active Active
- 2020-05-29 TW TW109118223A patent/TWI862597B/zh active
-
2024
- 2024-10-02 JP JP2024172920A patent/JP7804023B2/ja active Active
-
2025
- 2025-04-02 US US19/098,541 patent/US20250327780A1/en active Pending
-
2026
- 2026-01-07 JP JP2026001177A patent/JP2026062952A/ja active Pending
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