JPWO2020210508A5 - - Google Patents
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- JPWO2020210508A5 JPWO2020210508A5 JP2021559950A JP2021559950A JPWO2020210508A5 JP WO2020210508 A5 JPWO2020210508 A5 JP WO2020210508A5 JP 2021559950 A JP2021559950 A JP 2021559950A JP 2021559950 A JP2021559950 A JP 2021559950A JP WO2020210508 A5 JPWO2020210508 A5 JP WO2020210508A5
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- JP
- Japan
- Prior art keywords
- alkyl
- cells
- cbl
- inhibitor
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000001257 hydrogen Substances 0.000 claims 30
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- 150000001875 compounds Chemical class 0.000 claims 24
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 17
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- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 claims 16
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- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 9
- 125000000623 heterocyclic group Chemical group 0.000 claims 9
- 229910052757 nitrogen Inorganic materials 0.000 claims 9
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 8
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