JPWO2020208379A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2020208379A5
JPWO2020208379A5 JP2021560095A JP2021560095A JPWO2020208379A5 JP WO2020208379 A5 JPWO2020208379 A5 JP WO2020208379A5 JP 2021560095 A JP2021560095 A JP 2021560095A JP 2021560095 A JP2021560095 A JP 2021560095A JP WO2020208379 A5 JPWO2020208379 A5 JP WO2020208379A5
Authority
JP
Japan
Prior art keywords
plasmid
helper
gene
functional
vector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2021560095A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022530192A (ja
JP7562558B2 (ja
JP2022530192A5 (https=
Publication date
Priority claimed from GBGB1905263.8A external-priority patent/GB201905263D0/en
Priority claimed from EP19169121.1A external-priority patent/EP3722434B1/en
Application filed filed Critical
Priority claimed from PCT/GB2020/050947 external-priority patent/WO2020208379A1/en
Publication of JP2022530192A publication Critical patent/JP2022530192A/ja
Publication of JPWO2020208379A5 publication Critical patent/JPWO2020208379A5/ja
Publication of JP2022530192A5 publication Critical patent/JP2022530192A5/ja
Application granted granted Critical
Publication of JP7562558B2 publication Critical patent/JP7562558B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2021560095A 2019-04-12 2020-04-14 プラスミドシステム Active JP7562558B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1905263.8 2019-04-12
EP19169121.1 2019-04-12
GBGB1905263.8A GB201905263D0 (en) 2019-04-12 2019-04-12 Plasmid system
EP19169121.1A EP3722434B1 (en) 2019-04-12 2019-04-12 Plasmid system
PCT/GB2020/050947 WO2020208379A1 (en) 2019-04-12 2020-04-14 Plasmid system

Publications (4)

Publication Number Publication Date
JP2022530192A JP2022530192A (ja) 2022-06-28
JPWO2020208379A5 true JPWO2020208379A5 (https=) 2023-04-17
JP2022530192A5 JP2022530192A5 (https=) 2023-04-17
JP7562558B2 JP7562558B2 (ja) 2024-10-07

Family

ID=70295566

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021560095A Active JP7562558B2 (ja) 2019-04-12 2020-04-14 プラスミドシステム

Country Status (11)

Country Link
US (1) US20220162642A1 (https=)
EP (1) EP3953482A1 (https=)
JP (1) JP7562558B2 (https=)
KR (1) KR20220019669A (https=)
CN (1) CN113891942A (https=)
AU (1) AU2020272557A1 (https=)
BR (1) BR112021020401A2 (https=)
CA (1) CA3136545A1 (https=)
IL (2) IL296544A (https=)
SG (1) SG11202111149VA (https=)
WO (1) WO2020208379A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202545984A (zh) 2017-08-09 2025-12-01 美商生物化學醫療公司 核酸分子及其用途
WO2020033863A1 (en) 2018-08-09 2020-02-13 Bioverativ Therapeutics Inc. Nucleic acid molecules and uses thereof for non-viral gene therapy
EP3722434B1 (en) 2019-04-12 2022-07-27 Freeline Therapeutics Limited Plasmid system
EP4051704A2 (en) 2019-11-01 2022-09-07 Freeline Therapeutics Limited Factor viii construct
JP2024504365A (ja) * 2021-01-22 2024-01-31 バイオジェン・エムエイ・インコーポレイテッド 組換えウイルスベクター力価を増加させる微小管不安定化剤添加剤
AU2022227005B2 (en) * 2021-02-26 2025-09-11 Logicbio Therapeutics, Inc. Manufacturing and use of recombinant aav vectors
EP4410971A4 (en) * 2021-09-30 2025-06-04 FUJIFILM Corporation METHOD FOR PRODUCING AN ADENO-ASSOCIATED VIRUS, CELLS AND EXPRESSION VECTOR
GB202214328D0 (en) 2022-09-29 2022-11-16 Freeline Therapeutics Ltd Method
WO2024160232A1 (zh) * 2023-02-01 2024-08-08 纽福斯(苏州)生物科技有限公司 质粒包装系统及其应用
CN118633572A (zh) * 2023-03-06 2024-09-13 北京锦篮基因科技有限公司 神经元核内包涵体病小鼠模型构建方法及应用
WO2024223931A1 (en) * 2023-04-28 2024-10-31 AstraZeneca Ireland Limited Manufacturing and use of recombinant self-complementary aav vectors
TW202525832A (zh) 2023-08-31 2025-07-01 美商戴諾治療公司 衣殼多肽及其使用方法(二)
WO2025083617A1 (en) * 2023-10-18 2025-04-24 Nanocell Therapeutics Holdings B.V. Methods and compositions for nucleic construct delivery
TW202545971A (zh) 2024-02-08 2025-12-01 美商戴諾治療公司 殼體多肽及其使用方法
TW202548023A (zh) 2024-03-14 2025-12-16 美商雅菲納治療公司 用於生產重組腺相關病毒的質體系統
EP4628576A1 (en) 2024-04-07 2025-10-08 Ascend Advanced Therapies GmbH Microrna molecules for use in methods for improving recombinant aav production
WO2025238067A1 (en) 2024-05-15 2025-11-20 Ascend Advanced Therapies Gmbh Novel vector system for aav production
WO2026064444A1 (en) 2024-09-18 2026-03-26 Dyno Therapeutics, Inc. Capsid polypeptides and methods of use thereof
WO2026064428A2 (en) 2024-09-18 2026-03-26 Dyno Therapeutics, Inc. Capsid polypeptides and methods of use thereof
WO2026064442A2 (en) 2024-09-18 2026-03-26 Dyno Therapeutics, Inc. Capsid polypeptides and methods of use thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10044384A1 (de) 2000-09-08 2002-04-18 Medigene Ag Wirtszellen zur Verpackung von rekombinantem Adeno-assoziiertem Virus (rAAV), Verfahren zu ihrer Herstellung und deren Verwendung
EP1419245A4 (en) * 2001-07-13 2006-04-05 Univ Iowa Res Found ADENO-ASSOCIATED PSEUDOTYPE VIRUSES AND USES THEREOF
US20050080027A1 (en) 2001-11-30 2005-04-14 Markus Horer Optimized production of viral vectors derived from paroviruses in packaging and production cells by hsv infection or treatment with dna methylation inhibitors
ES2330826B1 (es) * 2008-06-04 2010-07-26 Proyecto De Biomedicina Cima, S.L. Sistema para empaquetamiento de adenovirus de alta capacidad.
PL2403867T3 (pl) * 2009-03-04 2019-12-31 Deutsches Krebsforschungszentrum Białko aktywujące składanie (aap) i jego zastosowanie do wytwarzania cząstek parwowirusa zasadniczo składających się z vp3
ES2857773T5 (es) 2011-08-24 2024-06-04 Univ Leland Stanford Junior Nuevas proteínas de la cápside de AAV para la transferencia de ácidos nucleicos
JP6348064B2 (ja) 2011-11-22 2018-06-27 ザ チルドレンズ ホスピタル オブ フィラデルフィア 効率の高いトランスジーン送達のためのウイルスベクター
GB201420139D0 (en) 2014-11-12 2014-12-24 Ucl Business Plc Factor IX gene therapy
GB201508026D0 (en) 2015-05-11 2015-06-24 Ucl Business Plc Capsid
US10385320B2 (en) 2015-12-02 2019-08-20 The Board Of Trustees Of The Leland Stanford Junior University Recombinant adeno-associated virus capsids with enhanced human skeletal muscle tropism
CN108048483B (zh) * 2018-01-30 2021-02-02 中国疾病预防控制中心病毒病预防控制所 复制型重组腺病毒HAdV-5载体系统及其应用

Similar Documents

Publication Publication Date Title
JPWO2020208379A5 (https=)
JP6174318B2 (ja) アデノ随伴ウイルス構築物を含んでなるコンダクティング気道細胞を標的とするための組成物
JP7796702B2 (ja) スペーサーを含む核酸分子およびその使用の方法
US8409842B2 (en) Recombinant adeno-associated virus production
US7220577B2 (en) Modified AAV
US20060094116A1 (en) High-efficiency wild-type-free AAV helper functions
GB2592751A (en) Process for making adenoassociated viral vectors
JP2001500015A (ja) Ｔ７ポリメラーゼを利用する組換えアデノ随伴ウイルスの誘導可能な製造方法
CA2366861A1 (en) Compositions and methods for helper-free production of recombinant adeno-associated viruses
CA2349838A1 (en) Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same
US20250236888A1 (en) Recombinant parvoviral vectors and method of making and use thereof
CN115151647B (zh) Dna扩增方法
JPWO2020223231A5 (https=)
CA3218360A1 (en) System for high-level raav production
US7148341B2 (en) AAV DNA comprising helper virus sequences
CN119842817A (zh) 一种用于生产重组腺相关病毒的新型辅助质粒及其构建方法和应用
CN119569834A (zh) 靶向心肌细胞的aav衣壳蛋白变体及其用途
US6294370B1 (en) System for the production of AAV vectors
US6541012B2 (en) System for the production of AAV vectors
WO2025262205A1 (en) Nucleic acid sequences
JPWO2022223954A5 (https=)
HK40061787A (en) Dna amplification method
JP2000512501A (ja) Ａａｖベクターの生産系
WO2025262203A1 (en) Nucleic acid sequences
JPWO2023220502A5 (https=)