JPWO2020181283A5 - - Google Patents
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- JPWO2020181283A5 JPWO2020181283A5 JP2021553031A JP2021553031A JPWO2020181283A5 JP WO2020181283 A5 JPWO2020181283 A5 JP WO2020181283A5 JP 2021553031 A JP2021553031 A JP 2021553031A JP 2021553031 A JP2021553031 A JP 2021553031A JP WO2020181283 A5 JPWO2020181283 A5 JP WO2020181283A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- pyrimidine
- carboxamide
- dichlorophenyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19161323 | 2019-03-07 | ||
| EP19161323.1 | 2019-03-07 | ||
| US201962879597P | 2019-07-29 | 2019-07-29 | |
| US62/879,597 | 2019-07-29 | ||
| PCT/US2020/021726 WO2020181283A1 (en) | 2019-03-07 | 2020-03-09 | Carboxamide-pyrimidine derivatives as shp2 antagonists |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022524759A JP2022524759A (ja) | 2022-05-10 |
| JPWO2020181283A5 true JPWO2020181283A5 (https=) | 2023-03-15 |
| JP2022524759A5 JP2022524759A5 (https=) | 2023-03-15 |
| JP7734586B2 JP7734586B2 (ja) | 2025-09-05 |
Family
ID=70057354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021553031A Active JP7734586B2 (ja) | 2019-03-07 | 2020-03-09 | Ｓｈｐ２アンタゴニストとしてのカルボキサミド－ピリミジン誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11033547B2 (https=) |
| EP (1) | EP3935049A1 (https=) |
| JP (1) | JP7734586B2 (https=) |
| CN (1) | CN113795483B (https=) |
| AU (1) | AU2020232026B2 (https=) |
| CA (1) | CA3127361A1 (https=) |
| IL (1) | IL286077A (https=) |
| WO (1) | WO2020181283A1 (https=) |
Families Citing this family (37)
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| MX2023002248A (es) | 2020-09-03 | 2023-05-16 | Revolution Medicines Inc | Uso de inhibidores de sos1 para tratar neoplasias malignas con mutaciones de shp2. |
| MX2023003060A (es) | 2020-09-15 | 2023-04-05 | Revolution Medicines Inc | Derivados indolicos como inhibidores de ras en el tratamiento del cancer. |
| CA3217393A1 (en) | 2021-05-05 | 2022-11-10 | Elena S. Koltun | Ras inhibitors |
| AU2022268962A1 (en) | 2021-05-05 | 2023-12-14 | Revolution Medicines, Inc. | Ras inhibitors for the treatment of cancer |
| MX2023012929A (es) * | 2021-05-05 | 2023-11-13 | Huyabio Int Llc | Terapias de combinacion que comprenden inhibidores de shp2 e inhibidores de tirosina cinasa egfr. |
| WO2022235866A1 (en) | 2021-05-05 | 2022-11-10 | Revolution Medicines, Inc. | Covalent ras inhibitors and uses thereof |
| WO2022259157A1 (en) | 2021-06-09 | 2022-12-15 | Novartis Ag | A triple pharmaceutical combination comprising dabrafenib, trametinib and a shp2 inhibitor |
| TW202317100A (zh) | 2021-06-23 | 2023-05-01 | 瑞士商諾華公司 | 包含ｋｒａｓ ｇ１２ｃ抑制劑的藥物組合及其用於治療癌症之用途 |
| CA3224341A1 (en) | 2021-09-01 | 2023-03-09 | Novartis Ag | Pharmaceutical combinations comprising a tead inhibitor and uses thereof for the treatment of cancers |
| AR127308A1 (es) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | Inhibidores ras |
| CN114181159B (zh) * | 2021-12-28 | 2024-02-20 | 南通大学 | 含2,4,5-三取代嘧啶酰肼衍生物及其制备方法与应用 |
| CN119136806A (zh) | 2022-03-08 | 2024-12-13 | 锐新医药公司 | 用于治疗免疫难治性肺癌的方法 |
| WO2023240263A1 (en) | 2022-06-10 | 2023-12-14 | Revolution Medicines, Inc. | Macrocyclic ras inhibitors |
| CN116332908B (zh) * | 2023-03-21 | 2024-07-02 | 杭州医学院 | 一种shp2变构抑制剂及其制备方法和应用 |
| EP4687905A1 (en) | 2023-03-30 | 2026-02-11 | Revolution Medicines, Inc. | Compositions for inducing ras gtp hydrolysis and uses thereof |
| CN121263418A (zh) | 2023-04-07 | 2026-01-02 | 锐新医药公司 | 大环ras抑制剂 |
| KR20260005904A (ko) | 2023-04-07 | 2026-01-12 | 레볼루션 메디슨즈, 인크. | 매크로사이클릭 ras 억제제 |
| AU2024252105A1 (en) | 2023-04-14 | 2025-10-16 | Revolution Medicines, Inc. | Crystalline forms of ras inhibitors, compositions containing the same, and methods of use thereof |
| KR20250172857A (ko) | 2023-04-14 | 2025-12-09 | 레볼루션 메디슨즈, 인크. | Ras 억제제의 결정형 |
| AU2024265078A1 (en) | 2023-05-04 | 2025-12-11 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
| TW202502334A (zh) * | 2023-05-25 | 2025-01-16 | 大陸商正大天晴藥業集團股份有限公司 | 含有醯胺取代的芳香環的化合物、其藥物組成物及用途 |
| IL326136A (en) | 2023-08-07 | 2026-03-01 | Revolution Medicines Inc | RMC-6291 for use in the treatment of a disease or disorder associated with the RAS protein |
| US20250154171A1 (en) | 2023-10-12 | 2025-05-15 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| US20250375445A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026072904A2 (en) | 2024-09-26 | 2026-04-02 | Revolution Medicines, Inc. | Compositions and methods for treating lung cancer |
| CN120842203B (zh) * | 2025-09-24 | 2025-12-05 | 山东大学 | 特异性检测shp2的近红外荧光探针的制备方法和应用 |
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| TW202028183A (zh) * | 2018-10-10 | 2020-08-01 | 大陸商江蘇豪森藥業集團有限公司 | 含氮雜芳類衍生物調節劑、其製備方法和應用 |
| WO2021143823A1 (zh) * | 2020-01-16 | 2021-07-22 | 浙江海正药业股份有限公司 | 吡啶或嘧啶类衍生物及其制备方法和用途 |
| CN115916765B (zh) * | 2020-07-10 | 2025-04-18 | 浙江海正药业股份有限公司 | 吡啶或嘧啶类衍生物及其制备方法和用途 |
-
2020
- 2020-03-09 CA CA3127361A patent/CA3127361A1/en active Pending
- 2020-03-09 CN CN202080033849.2A patent/CN113795483B/zh active Active
- 2020-03-09 JP JP2021553031A patent/JP7734586B2/ja active Active
- 2020-03-09 AU AU2020232026A patent/AU2020232026B2/en active Active
- 2020-03-09 WO PCT/US2020/021726 patent/WO2020181283A1/en not_active Ceased
- 2020-03-09 EP EP20715647.2A patent/EP3935049A1/en active Pending
- 2020-03-09 US US16/813,192 patent/US11033547B2/en active Active
-
2021
- 2021-04-30 US US17/245,423 patent/US11696916B2/en active Active
- 2021-09-02 IL IL286077A patent/IL286077A/en unknown
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