JPWO2020176432A5 - - Google Patents
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- JPWO2020176432A5 JPWO2020176432A5 JP2021548664A JP2021548664A JPWO2020176432A5 JP WO2020176432 A5 JPWO2020176432 A5 JP WO2020176432A5 JP 2021548664 A JP2021548664 A JP 2021548664A JP 2021548664 A JP2021548664 A JP 2021548664A JP WO2020176432 A5 JPWO2020176432 A5 JP WO2020176432A5
- Authority
- JP
- Japan
- Prior art keywords
- patient
- pharmaceutical composition
- composition
- administering
- glyceryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 238000000034 method Methods 0.000 claims 20
- 239000000203 mixture Substances 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- ITRIWXSLDIKBHK-UHFFFAOYSA-N (3-benzoyloxy-2-hydroxypropyl) benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC(O)COC(=O)C1=CC=CC=C1 ITRIWXSLDIKBHK-UHFFFAOYSA-N 0.000 claims 3
- HIZCTWCPHWUPFU-UHFFFAOYSA-N Glycerol tribenzoate Chemical compound C=1C=CC=CC=1C(=O)OCC(OC(=O)C=1C=CC=CC=1)COC(=O)C1=CC=CC=C1 HIZCTWCPHWUPFU-UHFFFAOYSA-N 0.000 claims 3
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims 2
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 229930016911 cinnamic acid Natural products 0.000 claims 2
- 235000013985 cinnamic acid Nutrition 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000004471 Glycine Substances 0.000 claims 1
- 208000035544 Nonketotic hyperglycinaemia Diseases 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 201000011205 glycine encephalopathy Diseases 0.000 claims 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims 1
- 235000010234 sodium benzoate Nutrition 0.000 claims 1
- 239000004299 sodium benzoate Substances 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962810055P | 2019-02-25 | 2019-02-25 | |
| US62/810,055 | 2019-02-25 | ||
| PCT/US2020/019568 WO2020176432A1 (en) | 2019-02-25 | 2020-02-25 | Compositions including cinnamic acid and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022521233A JP2022521233A (ja) | 2022-04-06 |
| JPWO2020176432A5 true JPWO2020176432A5 (https=) | 2023-03-07 |
| JP2022521233A5 JP2022521233A5 (https=) | 2023-03-07 |
Family
ID=72238701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021548664A Withdrawn JP2022521233A (ja) | 2019-02-25 | 2020-02-25 | 桂皮酸を含む組成物及びその使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US12478598B2 (https=) |
| EP (1) | EP3930704A4 (https=) |
| JP (1) | JP2022521233A (https=) |
| KR (1) | KR20210130772A (https=) |
| CN (1) | CN113473981A (https=) |
| AU (1) | AU2020229316A1 (https=) |
| CA (1) | CA3130761A1 (https=) |
| EA (1) | EA202192199A1 (https=) |
| WO (1) | WO2020176432A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB202002639D0 (en) * | 2020-02-25 | 2020-04-08 | Ucl Business Ltd | Therapy |
| CN116390761A (zh) * | 2020-10-28 | 2023-07-04 | 拉什大学医学中心 | 肉桂酸苄酯组合物在治疗甘氨酸脑病和尿素循环障碍中的应用 |
| KR20240112921A (ko) * | 2021-12-01 | 2024-07-19 | 사바 헬스케어 리미티드 | 약제학적 제제 및 그 제조 방법 |
| JP2025503457A (ja) * | 2021-12-16 | 2025-02-04 | ザ ユナイテッド ステイツ ガバメント アズ リプレゼンティド バイ ザ デパートメント オブ ヴェテランズ アフェアーズ | 神経系損傷及び障害の治療のための安息香酸塩 |
| WO2024201533A1 (en) * | 2023-03-31 | 2024-10-03 | Sava Healthcare Limited | A parenteral composition of cinnamic acid |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100479405B1 (ko) * | 2002-05-24 | 2005-03-30 | 주식회사 싸이제닉 | 신남산 이합체, 그 제조방법 및 퇴행성 뇌질환 치료를위한 그의 용도 |
| WO2015109215A1 (en) * | 2014-01-17 | 2015-07-23 | Pahan Kalipada | The use of a benzoate containing composition in urea cycle disorders and neurodegenerativre disordrs |
| JP6698643B2 (ja) * | 2014-09-29 | 2020-05-27 | セリックス バイオ プライヴェート リミテッドＣｅｌｌｉｘ Ｂｉｏ Ｐｒｉｖａｔｅ Ｌｉｍｉｔｅｄ | 多発性硬化症の治療のための組成物及び方法 |
| WO2016081365A1 (en) * | 2014-11-19 | 2016-05-26 | Rush University Medical Center | Compositions and methods for treating lysosomal disorders |
| ES2936094T3 (es) | 2016-06-13 | 2023-03-14 | Syneurx Int Taiwan Corp | Cocristales de benzoato de sodio y usos de los mismos |
| EA202090666A1 (ru) * | 2017-10-06 | 2020-08-05 | Раш Юниверсити Медикал Сентер | Применение содержащей бензоат композиции для лечения глициновой энцефалопатии |
| GB202002639D0 (en) | 2020-02-25 | 2020-04-08 | Ucl Business Ltd | Therapy |
| CN116390761A (zh) * | 2020-10-28 | 2023-07-04 | 拉什大学医学中心 | 肉桂酸苄酯组合物在治疗甘氨酸脑病和尿素循环障碍中的应用 |
| CN116723870A (zh) * | 2021-01-20 | 2023-09-08 | 拉什大学医学中心 | 球形细胞脑白质营养不良症或克拉伯病的改良治疗 |
-
2020
- 2020-02-25 US US17/433,730 patent/US12478598B2/en active Active
- 2020-02-25 AU AU2020229316A patent/AU2020229316A1/en not_active Abandoned
- 2020-02-25 EA EA202192199A patent/EA202192199A1/ru unknown
- 2020-02-25 WO PCT/US2020/019568 patent/WO2020176432A1/en not_active Ceased
- 2020-02-25 EP EP20763119.3A patent/EP3930704A4/en active Pending
- 2020-02-25 CN CN202080016447.1A patent/CN113473981A/zh active Pending
- 2020-02-25 JP JP2021548664A patent/JP2022521233A/ja not_active Withdrawn
- 2020-02-25 CA CA3130761A patent/CA3130761A1/en active Pending
- 2020-02-25 KR KR1020217030331A patent/KR20210130772A/ko not_active Withdrawn
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