|
JPH0739379B2
(ja)
|
1988-12-28 |
1995-05-01 |
クリンゲ・ファルマ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング |
トランス‐１，１，２‐トリフェニル―ブト‐１‐エン誘導体の製造方法
|
|
BRPI0408284B8
(pt)
|
2003-03-12 |
2021-05-25 |
Kudos Pharm Ltd |
compostos derivados de ftalazinona, seu uso e composição farmacêutica compreendendo os mesmos
|
|
CN1867331B
(zh)
|
2003-09-17 |
2010-05-26 |
美国政府健康及人类服务部 |
作为TNF-α调节剂的沙利度胺类似物
|
|
DK1794163T3
(da)
|
2004-09-22 |
2010-04-12 |
Pfizer |
Fremgangsmåde til fremstilling af poly(ADP-ribose)polymeraseinhibitorer
|
|
AR064777A1
(es)
|
2007-01-10 |
2009-04-22 |
Inst Di Reserche D Biolog Mole |
Indazoles sustituidos con amida como inhibidores de poli (adp- ribosa) polimerasa (parp)
|
|
KR101791757B1
(ko)
|
2007-03-20 |
2017-10-30 |
셀진 코포레이션 |
4'-ｏ-치환된 아이소인돌린 유도체 및 이를 포함하는 조성물 및 이의 사용 방법
|
|
TWI389893B
(zh)
|
2007-07-06 |
2013-03-21 |
Astellas Pharma Inc |
二（芳胺基）芳基化合物
|
|
US7981903B2
(en)
|
2007-08-08 |
2011-07-19 |
Glaxosmithkline Llc |
2-[2-{phenylamino}-1H-pyrrolo[2,3-D]pyrimidin-4-yl)amino] benzamide derivatives as IGF-1R inhibitors for the treatment of cancer
|
|
PT2300013T
(pt)
|
2008-05-21 |
2017-10-31 |
Ariad Pharma Inc |
Derivados de fósforo como inibidores de cinases
|
|
EP3613729A1
(en)
|
2009-06-10 |
2020-02-26 |
Chugai Seiyaku Kabushiki Kaisha |
Tetracyclic compounds
|
|
EP2536706B1
(en)
|
2010-02-11 |
2017-06-14 |
Celgene Corporation |
Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
|
|
UY33539A
(es)
|
2010-08-02 |
2012-02-29 |
Astrazeneca Ab |
Compuestos químicos alk
|
|
EA024809B1
(ru)
|
2010-10-08 |
2016-10-31 |
Икскавери Холдинг Кампани, Ллс |
Замещенные соединения пиридазинкарбоксамида
|
|
US8927725B2
(en)
|
2011-12-02 |
2015-01-06 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Thio compounds
|
|
GB201311891D0
(en)
|
2013-07-03 |
2013-08-14 |
Glaxosmithkline Ip Dev Ltd |
Novel compound
|
|
CN103396397A
(zh)
|
2013-08-14 |
2013-11-20 |
中国人民解放军军事医学科学院毒物药物研究所 |
来那度胺衍生物及其作为药物的用途
|
|
CN103787802B
(zh)
*
|
2014-02-11 |
2015-08-19 |
华东师范大学 |
一类芳基烷基硫醚化合物及其合成方法
|
|
AU2015247817C1
(en)
|
2014-04-14 |
2022-02-10 |
Arvinas Operations, Inc. |
Imide-based modulators of proteolysis and associated methods of use
|
|
US20160022642A1
(en)
|
2014-07-25 |
2016-01-28 |
Yale University |
Compounds Useful for Promoting Protein Degradation and Methods Using Same
|
|
KR20170042598A
(ko)
*
|
2014-08-22 |
2017-04-19 |
셀진 코포레이션 |
항체와 조합된 면역조절 화합물을 이용하여 다발성 골수종을 치료하는 방법
|
|
CN111205268B
(zh)
|
2014-10-30 |
2021-01-26 |
康朴生物医药技术（上海）有限公司 |
异吲哚啉衍生物、其中间体、制备方法、药物组合物及应用
|
|
HUE054149T2
(hu)
|
2015-06-04 |
2021-08-30 |
Arvinas Operations Inc |
Proteolízis imid-alapú modulátorai és ezekkel kapcsolatos felhasználási eljárások
|
|
AU2016349781A1
(en)
|
2015-11-02 |
2018-05-10 |
Yale University |
Proteolysis targeting chimera compounds and methods of preparing and using same
|
|
US20190016703A1
(en)
|
2015-12-30 |
2019-01-17 |
Dana-Farber Cancer Institute, Inc. |
Bifunctional compounds for her3 degradation and methods of use
|
|
AU2017246452C1
(en)
|
2016-04-06 |
2021-06-03 |
The Regents Of The University Of Michigan |
MDM2 protein degraders
|
|
WO2017176958A1
(en)
|
2016-04-06 |
2017-10-12 |
The Regents Of The University Of Michigan |
Monofunctional intermediates for ligand-dependent target protein degradation
|
|
EP3445357B1
(en)
|
2016-04-22 |
2021-05-26 |
Dana-Farber Cancer Institute, Inc. |
Bifunctional molecules for degradation of egfr and methods of use
|
|
WO2017185031A1
(en)
|
2016-04-22 |
2017-10-26 |
Dana-Farber Cancer Institute, Inc. |
Degradation of cyclin-dependent kinase 4/6 (cdk4/6) by conjugation of cdk4/6 inhibitors with e3 ligase ligand and methods of use
|
|
CN109790143A
(zh)
|
2016-05-10 |
2019-05-21 |
C4医药公司 |
用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体
|
|
WO2017197056A1
(en)
|
2016-05-10 |
2017-11-16 |
C4 Therapeutics, Inc. |
Bromodomain targeting degronimers for target protein degradation
|
|
CN106432104A
(zh)
|
2016-05-16 |
2017-02-22 |
大连医科大学 |
金刚烷基喹唑啉化合物、组合物及其用途
|
|
CA3036841A1
(en)
|
2016-09-13 |
2018-03-22 |
The Regents Of The University Of Michigan |
Fused 1,4-diazepines as bet protein degraders
|
|
EP3512855B1
(en)
|
2016-09-13 |
2022-07-27 |
The Regents of the University of Michigan |
Fused 1,4-oxazepines as bet protein degraders
|
|
WO2018071606A1
(en)
*
|
2016-10-11 |
2018-04-19 |
Arvinas, Inc. |
Compounds and methods for the targeted degradation of androgen receptor
|
|
IL290809B2
(en)
|
2016-11-01 |
2024-01-01 |
Arvinas Operations Inc |
Tau-protein targeting protacs and associated methods of use
|
|
KR20190080956A
(ko)
|
2016-11-22 |
2019-07-08 |
다나-파버 캔서 인스티튜트 인크. |
Ｅ3 리가아제 리간드와 브루톤 티로신 키나아제(ｂｔｋ) 억제제의 컨쥬게이션에 의한 ｂｔｋ의 분해 및 사용 방법
|
|
KR102674902B1
(ko)
|
2016-12-01 |
2024-06-14 |
아비나스 오퍼레이션스, 인코포레이티드 |
에스트로겐 수용체 분해제로서의 테트라히드로나프탈렌 및 테트라히드로이소퀴놀린 유도체
|
|
MX2019007646A
(es)
|
2016-12-23 |
2019-09-06 |
Arvinas Operations Inc |
Moleculas quimericas dirigidas a la proteolisis del egfr y metodos asociados de uso.
|
|
CN117510491A
(zh)
|
2016-12-23 |
2024-02-06 |
阿尔维纳斯运营股份有限公司 |
用于迅速加速性纤维肉瘤多肽的靶向降解的化合物和方法
|
|
AU2018211975B2
(en)
|
2017-01-26 |
2022-05-26 |
Arvinas Operations, Inc. |
Modulators of estrogen receptor proteolysis and associated methods of use
|
|
TWI793151B
(zh)
|
2017-08-23 |
2023-02-21 |
瑞士商諾華公司 |
3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途
|
|
JP7585034B2
(ja)
|
2017-10-18 |
2024-11-18 |
ノバルティス アーゲー |
選択的タンパク質分解のための組成物及び方法
|
|
CN109912655B
(zh)
|
2017-12-13 |
2021-12-10 |
上海科技大学 |
Alk蛋白降解剂及其抗肿瘤应用
|
|
IL315310A
(en)
|
2017-12-26 |
2024-10-01 |
Kymera Therapeutics Inc |
Irak degraders and uses thereof
|
|
KR20210006356A
(ko)
|
2018-04-04 |
2021-01-18 |
아비나스 오퍼레이션스, 인코포레이티드 |
단백질분해 조절제 및 연관된 사용 방법
|
|
CN110357889B
(zh)
|
2018-04-09 |
2022-03-15 |
上海科技大学 |
蛋白降解靶向化合物、其抗肿瘤应用、其中间体及中间体应用
|
|
KR20250020690A
(ko)
|
2018-06-29 |
2025-02-11 |
다나-파버 캔서 인스티튜트 인크. |
세레블론(crbn)에 대한 리간드
|
|
KR102672549B1
(ko)
|
2018-09-30 |
2024-06-10 |
상하이 인스티튜트 오브 마테리아 메디카 차이니즈 아카데미 오브 싸이언시즈 |
이소인돌린계 화합물, 이의 제조 방법, 약학 조성물 및 용도
|
|
EP3896062A4
(en)
|
2018-12-06 |
2022-06-15 |
Shanghai Institute of Materia Medica, Chinese Academy of Sciences |
ISOINDOLINE COMPOUND, METHOD FOR PREPARATION, PHARMACEUTICAL COMPOSITION AND USE OF ISOINDOLINE COMPOUND
|
|
EP3932922A4
(en)
|
2019-02-25 |
2022-05-11 |
ShanghaiTech University |
SULPHUR-CONTAINING COMPOUND BASED ON A GLUTARIMIDE FRAMEWORK AND ITS USE
|
|
CN109928956B
(zh)
|
2019-02-27 |
2020-10-13 |
杭州偶联医药科技有限公司 |
一种靶向泛素化降解egfr蛋白的化合物及其药物组合物和应用
|
|
CN114269763A
(zh)
|
2019-03-26 |
2022-04-01 |
美国密歇根州立大学试剂中心 |
Stat3的小分子降解剂
|
|
CN110204532B
(zh)
|
2019-05-15 |
2022-03-08 |
浙江工业大学 |
一种靶向egfr蛋白降解的化合物及其制备方法和应用
|
|
WO2021023233A1
(zh)
*
|
2019-08-05 |
2021-02-11 |
上海科技大学 |
Egfr蛋白降解剂及其抗肿瘤应用
|
|
CN110512980B
(zh)
|
2019-09-27 |
2024-08-30 |
苏州光格科技股份有限公司 |
一种防火门自动控制装置
|
|
US11820781B2
(en)
|
2019-12-04 |
2023-11-21 |
Nurix Therapeutics, Inc. |
Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway
|
|
FI3835298T3
(fi)
|
2019-12-12 |
2024-07-29 |
Accutar Biotechnology Inc |
Uusia kromaanijohdannaisia, joilla on estrogeenireseptoria hajottava vaikutus, ja niiden käyttötapoja
|
|
CA3169011A1
(en)
*
|
2020-02-25 |
2021-09-02 |
Xiaobao Yang |
Glutarimide skeleton-based compounds and uses thereof
|
|
EP4144728A4
(en)
*
|
2020-04-30 |
2023-08-23 |
Shanghaitech University |
HETEROCYCLIC COMPOUND BASED ON A GLUTARIMIDE SKELETON AND USES THEREOF
|