JPWO2020132269A5 - - Google Patents
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- JPWO2020132269A5 JPWO2020132269A5 JP2021531985A JP2021531985A JPWO2020132269A5 JP WO2020132269 A5 JPWO2020132269 A5 JP WO2020132269A5 JP 2021531985 A JP2021531985 A JP 2021531985A JP 2021531985 A JP2021531985 A JP 2021531985A JP WO2020132269 A5 JPWO2020132269 A5 JP WO2020132269A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- trifluoromethyl
- pyrazolo
- pyrimidine
- benzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024102890A JP2024150464A (ja) | 2018-12-20 | 2024-06-26 | 置換されたピラゾロピリミジン及び置換されたプリンならびにユビキチン特異的プロセシングプロテアーゼ１（ｕｓｐ１）阻害剤としてのそれらの使用 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862783014P | 2018-12-20 | 2018-12-20 | |
| US62/783,014 | 2018-12-20 | ||
| US201962799423P | 2019-01-31 | 2019-01-31 | |
| US62/799,423 | 2019-01-31 | ||
| US201962857986P | 2019-06-06 | 2019-06-06 | |
| US62/857,986 | 2019-06-06 | ||
| US201962868616P | 2019-06-28 | 2019-06-28 | |
| US62/868,616 | 2019-06-28 | ||
| US201962946263P | 2019-12-10 | 2019-12-10 | |
| US62/946,263 | 2019-12-10 | ||
| PCT/US2019/067521 WO2020132269A1 (en) | 2018-12-20 | 2019-12-19 | Substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (usp1) inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024102890A Division JP2024150464A (ja) | 2018-12-20 | 2024-06-26 | 置換されたピラゾロピリミジン及び置換されたプリンならびにユビキチン特異的プロセシングプロテアーゼ１（ｕｓｐ１）阻害剤としてのそれらの使用 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022511515A JP2022511515A (ja) | 2022-01-31 |
| JP2022511515A5 JP2022511515A5 (https=) | 2022-12-26 |
| JPWO2020132269A5 true JPWO2020132269A5 (https=) | 2022-12-26 |
| JP7662519B2 JP7662519B2 (ja) | 2025-04-15 |
Family
ID=71100912
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021531985A Active JP7662519B2 (ja) | 2018-12-20 | 2019-12-19 | 置換されたピラゾロピリミジン及び置換されたプリンならびにユビキチン特異的プロセシングプロテアーゼ１（ｕｓｐ１）阻害剤としてのそれらの使用 |
| JP2024102890A Pending JP2024150464A (ja) | 2018-12-20 | 2024-06-26 | 置換されたピラゾロピリミジン及び置換されたプリンならびにユビキチン特異的プロセシングプロテアーゼ１（ｕｓｐ１）阻害剤としてのそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024102890A Pending JP2024150464A (ja) | 2018-12-20 | 2024-06-26 | 置換されたピラゾロピリミジン及び置換されたプリンならびにユビキチン特異的プロセシングプロテアーゼ１（ｕｓｐ１）阻害剤としてのそれらの使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11485736B2 (https=) |
| EP (1) | EP3897652A4 (https=) |
| JP (2) | JP7662519B2 (https=) |
| KR (1) | KR102912147B1 (https=) |
| CN (1) | CN113164485A (https=) |
| AU (1) | AU2019405925B2 (https=) |
| BR (1) | BR112021010715A2 (https=) |
| CA (1) | CA3122108A1 (https=) |
| CL (1) | CL2021001575A1 (https=) |
| CO (1) | CO2021009078A2 (https=) |
| IL (1) | IL284050B2 (https=) |
| MX (1) | MX2021007179A (https=) |
| PH (1) | PH12021551402A1 (https=) |
| SG (1) | SG11202106232TA (https=) |
| TW (2) | TWI895986B (https=) |
| WO (1) | WO2020132269A1 (https=) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10189841B2 (en) | 2015-11-20 | 2019-01-29 | Forma Therapeutics, Inc. | Purinones as ubiquitin-specific protease 1 inhibitors |
| BR112021010715A2 (pt) | 2018-12-20 | 2021-11-16 | Ksq Therapeutics Inc | Pirazolopirimidinas substituídas e purinas substituídas e seu uso como inibidores de protease de processamento ubiquitina-específica 1 (usp1) |
| JP7253640B2 (ja) | 2019-01-31 | 2023-04-06 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| ES3025474T3 (en) * | 2020-01-15 | 2025-06-09 | Ksq Therapeutics Inc | Compositions of substituted pyrazolopyrimidines and uses thereof |
| CA3168009A1 (en) * | 2020-02-14 | 2021-08-19 | KSQ Therapeutics, Inc. | Therapeutic combinations comprising ubiquitin-specific-processing protease 1 (usp1) inhibitors and poly (adp-ribose) polymerase (parp) inhibitors |
| EP4161494A4 (en) * | 2020-06-02 | 2024-07-17 | KSQ Therapeutics, Inc. | NITROGEN-CONTAINING FUSED BICYCLIC COMPOUNDS AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS |
| WO2022053998A1 (en) * | 2020-09-10 | 2022-03-17 | Universidade Do Porto | New pharmaceutical compounds, methods and uses thereof |
| KR20230098186A (ko) * | 2020-10-30 | 2023-07-03 | 케이에스큐 세러퓨틱스 인코포레이티드 | 치환된 피라졸로피리미딘의 고체 상태 형태 및 이의 용도 |
| US20240182481A1 (en) * | 2021-02-15 | 2024-06-06 | Tango Therapeutics, Inc. | Pyrrolo[3,2-d]pyrimidine compounds and methods of use in the treatment of cancer |
| AU2022238886A1 (en) * | 2021-03-17 | 2023-09-14 | Medivir Ab | Purine derivatives as anticancer agents |
| MX2023011709A (es) * | 2021-04-07 | 2023-10-12 | Forma Therapeutics Inc | Inhibidor de la proteasa 1 especifica de ubiquitina (usp1). |
| CN117337290B (zh) * | 2021-05-03 | 2026-01-02 | 轩竹生物科技股份有限公司 | 三并环类泛素特异性蛋白酶1抑制剂及其用途 |
| WO2022253188A1 (en) * | 2021-05-31 | 2022-12-08 | Impact Therapeutics (Shanghai) , Inc | Nitrogen-containing fused heteroaromatic bicyclic compounds as usp1 inhibitors and the use thereof |
| GB202114863D0 (en) | 2021-10-18 | 2021-12-01 | Syngenta Crop Protection Ag | Improvements in or relating to organic compounds |
| JP2024540921A (ja) * | 2021-10-19 | 2024-11-06 | 上海瑛派▲薬▼▲業▼有限公司 | Ｕｓｐ１阻害剤としての置換トリアゾロヘテロアリール化合物及びその応用 |
| CN114031556B (zh) * | 2021-11-08 | 2023-03-31 | 温州大学 | 一种绿色的一锅法制备5-氨基-n-芳基-3-芳基吡唑类化合物的合成方法 |
| GEAP202416531A (en) * | 2021-11-12 | 2024-10-28 | Insilico Medicine Ip Ltd | Small molecule inhibitors of ubiquitin specific protease 1 (usp1) and uses thereof |
| CR20240191A (es) * | 2021-11-12 | 2024-09-13 | Insilico Medicine Ip Ltd | Inhibidores de molécula pequeña de proteasa 1 específica de ubiquitina (usp1) y usos de los mismos |
| EP4430041A4 (en) * | 2021-11-12 | 2025-09-24 | Insilico Medicine Ip Ltd | SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 1 (USP1) AND THEIR USES |
| CN114181237B (zh) * | 2021-12-01 | 2024-02-23 | 上海凌凯医药科技有限公司 | 一种1-异丙基吡唑-5-硼酸频那醇酯的合成方法 |
| IL312982A (en) * | 2021-12-09 | 2024-07-01 | Ksq Therapeutics Inc | Methods for the preparation of converted pyrazolopyrimidines |
| CN118525022A (zh) * | 2022-01-27 | 2024-08-20 | 西藏海思科制药有限公司 | 一种氮杂并环衍生物及其在医药上的应用 |
| US20250163049A1 (en) * | 2022-02-03 | 2025-05-22 | Exelixis, Inc. | Fused bicyclic heterocyclyl compounds as usp1 inhibitors |
| US20250382289A1 (en) * | 2022-02-18 | 2025-12-18 | Xizang Haisco Pharmaceutical Co., Ltd. | Pyrazolopyridine derivative and application thereof in medicine |
| IL315748A (en) * | 2022-04-08 | 2024-11-01 | Ksq Therapeutics Inc | Therapeutic combinations containing ubiquitin-specific processing protease 1 (USP1) inhibitors and chemotherapy agents |
| CN116925098B (zh) * | 2022-04-09 | 2026-02-17 | 深圳湾实验室 | 靶向泛素特异性蛋白酶1(usp1)的小分子抑制剂及其应用 |
| AU2023261809A1 (en) * | 2022-04-29 | 2024-12-05 | Asieris Pharmaceuticals (Shanghai) Co., Ltd. | Pyrimidine compound, method for preparing same, and pharmaceutical use thereof |
| EP4543890A1 (en) * | 2022-06-23 | 2025-04-30 | Forma Therapeutics, Inc. | Usp1 inhibitors and uses thereof |
| WO2024006879A1 (en) * | 2022-06-29 | 2024-01-04 | Zentaur Therapeutics Usa Inc. | Usp1 inhibitors and uses thereof |
| WO2024022266A1 (en) * | 2022-07-25 | 2024-02-01 | Guangdong Newopp Biopharmaceuticals Co., Ltd. | Heteroaryl compounds as inhibitors of usp1 |
| WO2024022519A1 (zh) * | 2022-07-28 | 2024-02-01 | 先声再明医药有限公司 | 杂环并嘧啶类化合物及其应用 |
| CN119522224A (zh) * | 2022-08-09 | 2025-02-25 | 上海济煜医药科技有限公司 | 含氮杂环化合物作为泛素-特异性蛋白酶1抑制剂的制备方法、应用及其用途 |
| CN117263944B (zh) * | 2022-08-24 | 2025-10-17 | 轩竹生物科技股份有限公司 | 泛素特异性蛋白酶1抑制剂及其用途 |
| CN119790043A (zh) * | 2022-08-26 | 2025-04-08 | 海南先声再明医药股份有限公司 | 三环类化合物及其应用 |
| US20250368667A1 (en) * | 2022-09-02 | 2025-12-04 | Shanghai Qilu Pharmaceutical Research And Development Centre Ltd. | Usp1 inhibitor |
| TW202411231A (zh) * | 2022-09-09 | 2024-03-16 | 大陸商正大天晴藥業集團股份有限公司 | 用作泛素-特異性蛋白酶抑制劑的取代嘌呤酮衍生物 |
| IL319492A (en) * | 2022-09-20 | 2025-05-01 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | A carbonyl-fused heterocyclic derivative that acts as a ubiquitin-specific protease |
| CN117384187B (zh) * | 2022-09-30 | 2026-01-30 | 轩竹生物科技股份有限公司 | 泛素特异性蛋白酶1抑制剂 |
| WO2024078436A1 (zh) * | 2022-10-09 | 2024-04-18 | 海南先声再明医药股份有限公司 | 杂环并嘧啶类化合物、药物组合物及其应用 |
| WO2024086790A1 (en) | 2022-10-21 | 2024-04-25 | Exelixis, Inc. | 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-c]PYRIDINE COMPOUNDS AND DERIVATIVES AS USP1 INHIBITORS |
| WO2024094170A1 (zh) * | 2022-11-04 | 2024-05-10 | 深圳晶泰科技有限公司 | 泛素特异性蛋白酶1的抑制剂及其应用 |
| CN120513237A (zh) | 2023-01-12 | 2025-08-19 | 先正达农作物保护股份公司 | 除草咪唑化合物 |
| CN120603835A (zh) * | 2023-01-20 | 2025-09-05 | 杭州英创医药科技有限公司 | 作为usp1抑制剂的化合物 |
| WO2024222880A1 (zh) * | 2023-04-27 | 2024-10-31 | 西藏海思科制药有限公司 | 一种吡啶并吡唑衍生物的药物组合物及其在医药上的应用 |
| WO2024233605A1 (en) | 2023-05-08 | 2024-11-14 | Tango Therapeutics, Inc. | Compounds and their use against cancer |
| WO2024233665A1 (en) | 2023-05-08 | 2024-11-14 | Tango Therapeutics, Inc. | Compounds and their use against cancer |
| CN116768906B (zh) * | 2023-05-29 | 2024-04-09 | 遵义医科大学珠海校区 | 一种三并环化合物及其制备方法和应用 |
| CN121511238A (zh) * | 2023-07-05 | 2026-02-10 | 江苏亚虹医药科技股份有限公司 | 嘧啶类化合物、其制备方法及其医药用途 |
| CN121219283A (zh) * | 2023-07-05 | 2025-12-26 | 江苏亚虹医药科技股份有限公司 | 联嘧啶化合物的晶型及其制备方法和用途 |
| WO2025010245A1 (en) | 2023-07-06 | 2025-01-09 | Exelixis, Inc. | Fused pyrazole derivatives as usp1 inhibitors |
| WO2025015905A1 (en) * | 2023-07-14 | 2025-01-23 | Laekna Therapeutics Shanghai Co., Ltd. | Pyrimidine compounds and their use as usp1 inhibitors |
| TW202530229A (zh) * | 2023-09-26 | 2025-08-01 | 大陸商上海濟煜醫藥科技有限公司 | 氮雜環胺類化合物作為泛素-特異性蛋白酶１抑制劑的製備方法、應用及其用途 |
| WO2025095751A1 (ko) * | 2023-10-30 | 2025-05-08 | 현대약품 주식회사 | 신규한 화합물, 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물 |
| TW202535865A (zh) | 2023-10-31 | 2025-09-16 | 美商必治妥美雅史谷比公司 | 泛素特異性加工蛋白酶1 (usp1) 化合物 |
| WO2025096487A1 (en) | 2023-10-31 | 2025-05-08 | Bristol-Myers Squibb Company | Ubiquitin specific processing protease 1 (usp1) compounds |
| WO2025096488A1 (en) | 2023-10-31 | 2025-05-08 | Bristol-Myers Squibb Company | Ubiquitin specific processing protease 1 (usp1) compounds |
| WO2025102016A1 (en) | 2023-11-10 | 2025-05-15 | Vrise Therapeutics, Inc. | Novel molecules as inhibitors of dna damage repair pathway |
| WO2025151705A1 (en) | 2024-01-10 | 2025-07-17 | Vrise Therapeutics, Inc. | Novel inhibitors of dna damage repair pathway |
| WO2025180502A1 (zh) * | 2024-03-01 | 2025-09-04 | 上海齐鲁制药研究中心有限公司 | 一种联合用药物组合物及其用途 |
| KR20250138136A (ko) * | 2024-03-12 | 2025-09-19 | 현대약품 주식회사 | 신규한 화합물, 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5010175A (en) | 1988-05-02 | 1991-04-23 | The Regents Of The University Of California | General method for producing and selecting peptides with specific properties |
| EP0786469B1 (en) | 1990-06-11 | 2006-03-01 | Gilead Sciences, Inc. | Methods of use of nucleic acid ligands |
| AU672790B2 (en) | 1992-07-15 | 1996-10-17 | Novartis Ag | Variants of parathyroid hormone and its fragments |
| AU3204895A (en) | 1995-02-01 | 1996-08-21 | University Of Massachusetts Medical Center | Methods of selecting a random peptide that binds to a target protein |
| EP0934526B1 (en) | 1996-10-08 | 2003-01-08 | U-BISys B.V. | Methods and means for selecting peptides and proteins having specific affinity for a target |
| US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
| US9512125B2 (en) * | 2004-11-19 | 2016-12-06 | The Regents Of The University Of California | Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents |
| WO2007149484A2 (en) | 2006-06-20 | 2007-12-27 | Dana-Farber Cancer Institute | Inhibitors of usp1 deubiquitinating enzyme complex |
| AU2007325900A1 (en) | 2006-10-20 | 2008-06-05 | Dnar, Inc. | DNA damage repair inhibitors and methods for treating cancer |
| US7964356B2 (en) | 2007-01-16 | 2011-06-21 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| BRPI0817503B8 (pt) * | 2007-10-05 | 2021-05-25 | Sstarbio Pte Ltd | derivados de purina substituídos por pirimidina, composição farmacêutica compreendendo ditos compostos e uso dos mesmos para a prevenção ou tratamento de uma condição proliferativa |
| CN102014631A (zh) * | 2008-03-03 | 2011-04-13 | 泰格尔医药科技公司 | 酪氨酸激酶抑制剂 |
| JPWO2009157196A1 (ja) * | 2008-06-25 | 2011-12-08 | 武田薬品工業株式会社 | アミド化合物 |
| GB0917934D0 (en) * | 2009-10-13 | 2009-11-25 | Syngenta Ltd | Herbicidal compounds |
| CA2797719C (en) | 2010-04-30 | 2019-11-26 | Dana-Farber Cancer Institute, Inc. | Small molecule inhibitors of usp1 deubiquitinating enzyme activity |
| CA2896731A1 (en) | 2012-12-28 | 2014-07-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inhibitors of the usp1/uaf1 deubiquitinase complex and uses thereof |
| EP3760719A1 (en) | 2013-11-18 | 2021-01-06 | CRISPR Therapeutics AG | Crispr-cas system materials and methods |
| JP2017510628A (ja) * | 2014-03-13 | 2017-04-13 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | 縮合ピリミジン系ヒドロキサメート誘導体 |
| KR101766194B1 (ko) * | 2015-08-07 | 2017-08-10 | 한국과학기술연구원 | RET 키나아제 저해제인 신규 3-(이속사졸-3-일)-피라졸로[3,4-d]피리미딘-4-아민 화합물 |
| US10189841B2 (en) * | 2015-11-20 | 2019-01-29 | Forma Therapeutics, Inc. | Purinones as ubiquitin-specific protease 1 inhibitors |
| BR112021010715A2 (pt) | 2018-12-20 | 2021-11-16 | Ksq Therapeutics Inc | Pirazolopirimidinas substituídas e purinas substituídas e seu uso como inibidores de protease de processamento ubiquitina-específica 1 (usp1) |
| US20240182481A1 (en) | 2021-02-15 | 2024-06-06 | Tango Therapeutics, Inc. | Pyrrolo[3,2-d]pyrimidine compounds and methods of use in the treatment of cancer |
-
2019
- 2019-12-19 BR BR112021010715A patent/BR112021010715A2/pt unknown
- 2019-12-19 TW TW113105437A patent/TWI895986B/zh active
- 2019-12-19 PH PH1/2021/551402A patent/PH12021551402A1/en unknown
- 2019-12-19 JP JP2021531985A patent/JP7662519B2/ja active Active
- 2019-12-19 SG SG11202106232TA patent/SG11202106232TA/en unknown
- 2019-12-19 AU AU2019405925A patent/AU2019405925B2/en active Active
- 2019-12-19 CN CN201980079551.2A patent/CN113164485A/zh active Pending
- 2019-12-19 IL IL284050A patent/IL284050B2/en unknown
- 2019-12-19 US US16/721,079 patent/US11485736B2/en active Active
- 2019-12-19 MX MX2021007179A patent/MX2021007179A/es unknown
- 2019-12-19 EP EP19897934.6A patent/EP3897652A4/en active Pending
- 2019-12-19 KR KR1020217017482A patent/KR102912147B1/ko active Active
- 2019-12-19 WO PCT/US2019/067521 patent/WO2020132269A1/en not_active Ceased
- 2019-12-19 TW TW108146728A patent/TWI834784B/zh active
- 2019-12-19 CA CA3122108A patent/CA3122108A1/en active Pending
-
2021
- 2021-06-16 CL CL2021001575A patent/CL2021001575A1/es unknown
- 2021-07-12 CO CONC2021/0009078A patent/CO2021009078A2/es unknown
-
2022
- 2022-10-11 US US18/045,770 patent/US11787813B2/en active Active
-
2024
- 2024-06-26 JP JP2024102890A patent/JP2024150464A/ja active Pending
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