JPWO2020089646A5 - - Google Patents
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- Publication number
- JPWO2020089646A5 JPWO2020089646A5 JP2021524200A JP2021524200A JPWO2020089646A5 JP WO2020089646 A5 JPWO2020089646 A5 JP WO2020089646A5 JP 2021524200 A JP2021524200 A JP 2021524200A JP 2021524200 A JP2021524200 A JP 2021524200A JP WO2020089646 A5 JPWO2020089646 A5 JP WO2020089646A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- seq
- acid sequence
- set forth
- sequence set
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000007523 nucleic acids Chemical class 0.000 claims 128
- 229920001850 Nucleic acid sequence Polymers 0.000 claims 108
- 108020004707 nucleic acids Proteins 0.000 claims 17
- 230000002255 enzymatic Effects 0.000 claims 15
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L MgCl2 Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims 14
- 150000001768 cations Chemical class 0.000 claims 9
- 102000001307 androgen receptors Human genes 0.000 claims 5
- 108010080146 androgen receptors Proteins 0.000 claims 5
- IQFYYKKMVGJFEH-XLPZGREQSA-N DEOXYTHYMIDINE Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 claims 4
- 108020004999 Messenger RNA Proteins 0.000 claims 4
- 230000003197 catalytic Effects 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 229910001629 magnesium chloride Inorganic materials 0.000 claims 4
- 229920002106 messenger RNA Polymers 0.000 claims 4
- 229920000160 (ribonucleotides)n+m Polymers 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 230000000295 complement Effects 0.000 claims 3
- 101000169408 AR Proteins 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 239000000560 biocompatible material Substances 0.000 claims 2
- 210000004027 cells Anatomy 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 102000034729 human AR protein Human genes 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 241000432074 Adeno-associated virus Species 0.000 claims 1
- 229920002395 Aptamer Polymers 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 229920000272 Oligonucleotide Polymers 0.000 claims 1
- -1 cationic lipid Chemical class 0.000 claims 1
- 229920003013 deoxyribonucleic acid Polymers 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 125000001921 locked nucleotide group Chemical group 0.000 claims 1
- 210000004962 mammalian cells Anatomy 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000006011 modification reaction Methods 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- 239000002539 nanocarrier Substances 0.000 claims 1
- 239000002086 nanomaterial Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- 201000010065 polycystic ovary syndrome Diseases 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1817990.3A GB201817990D0 (en) | 2018-11-02 | 2018-11-02 | Enzymatic nucleic acid molecules |
| GB1817990.3 | 2018-11-02 | ||
| PCT/GB2019/053103 WO2020089646A1 (fr) | 2018-11-02 | 2019-10-31 | Molécules d'acide nucléique enzymatique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022512929A JP2022512929A (ja) | 2022-02-07 |
| JPWO2020089646A5 true JPWO2020089646A5 (fr) | 2022-09-21 |
Family
ID=64655396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021524200A Pending JP2022512929A (ja) | 2018-11-02 | 2019-10-31 | 酵素核酸分子 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20210395753A1 (fr) |
| EP (1) | EP3873921A1 (fr) |
| JP (1) | JP2022512929A (fr) |
| CN (1) | CN113302200A (fr) |
| GB (1) | GB201817990D0 (fr) |
| WO (1) | WO2020089646A1 (fr) |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6489163B1 (en) * | 1996-05-08 | 2002-12-03 | Board Of Regents, The University Of Texas System | Ribozyme mediated inactivation of the androgen receptor |
| CN1261920A (zh) * | 1997-04-29 | 2000-08-02 | 斯克里普斯研究学院 | 酶促dna分子 |
| AUPQ201499A0 (en) * | 1999-08-04 | 1999-08-26 | Unisearch Limited | Treatment of inflammatory and malignant diseases |
| AUPQ367699A0 (en) * | 1999-10-26 | 1999-11-18 | Unisearch Limited | Treatment of cancer |
| IL132710A0 (en) * | 1999-11-02 | 2001-03-19 | Intelligene Ltd | Catalytic nucleic acid sequences |
| EP1767632A3 (fr) * | 2001-05-29 | 2009-12-30 | Sirna Therpeutics, Inc. | Méthode d'administration locale d'oligonucléotides synthétiques double-brins dirigés contre un récepteur du VEGF |
| ITMI20011514A1 (it) * | 2001-07-17 | 2003-01-17 | Benelli Armi Spa | Dispositivo di sicurezza per armi da fuoco porttili |
| US20030148971A1 (en) * | 2002-02-04 | 2003-08-07 | Handel Malcolm Lovell | Treatment of inflammatory and malignant diseases |
| EP1539245A2 (fr) * | 2002-06-26 | 2005-06-15 | The Penn State Research Foundation | Procedes et substances pour traiter des infections au virus du papillome humain |
| WO2009068033A2 (fr) * | 2007-11-26 | 2009-06-04 | Santaris Pharma A/S | Antagonistes basés sur les lna ciblant le récepteur de l'androgène |
| CN103627709A (zh) * | 2013-12-06 | 2014-03-12 | 孙仑泉 | 抑制血管内皮生长因子受体基因表达的脱氧核酶 |
-
2018
- 2018-11-02 GB GBGB1817990.3A patent/GB201817990D0/en not_active Ceased
-
2019
- 2019-10-31 US US17/290,119 patent/US20210395753A1/en active Pending
- 2019-10-31 EP EP19798375.2A patent/EP3873921A1/fr active Pending
- 2019-10-31 CN CN201980085501.5A patent/CN113302200A/zh active Pending
- 2019-10-31 WO PCT/GB2019/053103 patent/WO2020089646A1/fr unknown
- 2019-10-31 JP JP2021524200A patent/JP2022512929A/ja active Pending
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