JPWO2020081562A5 - - Google Patents
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- JPWO2020081562A5 JPWO2020081562A5 JP2021545286A JP2021545286A JPWO2020081562A5 JP WO2020081562 A5 JPWO2020081562 A5 JP WO2020081562A5 JP 2021545286 A JP2021545286 A JP 2021545286A JP 2021545286 A JP2021545286 A JP 2021545286A JP WO2020081562 A5 JPWO2020081562 A5 JP WO2020081562A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- glaucoma
- therapeutic agent
- eye
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 32
- 239000003814 drug Substances 0.000 claims 11
- 229940124597 therapeutic agent Drugs 0.000 claims 10
- 208000010412 Glaucoma Diseases 0.000 claims 7
- 229960001160 latanoprost Drugs 0.000 claims 5
- GGXICVAJURFBLW-CEYXHVGTSA-N latanoprost Chemical group CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1 GGXICVAJURFBLW-CEYXHVGTSA-N 0.000 claims 5
- 206010030043 Ocular hypertension Diseases 0.000 claims 4
- 239000000674 adrenergic antagonist Substances 0.000 claims 4
- 229960001999 phentolamine Drugs 0.000 claims 4
- MRBDMNSDAVCSSF-UHFFFAOYSA-N phentolamine Chemical compound C1=CC(C)=CC=C1N(C=1C=C(O)C=CC=1)CC1=NCCN1 MRBDMNSDAVCSSF-UHFFFAOYSA-N 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 208000010038 Ischemic Optic Neuropathy Diseases 0.000 claims 3
- 206010030924 Optic ischaemic neuropathy Diseases 0.000 claims 3
- 230000004410 intraocular pressure Effects 0.000 claims 3
- 201000002761 non-arteritic anterior ischemic optic neuropathy Diseases 0.000 claims 3
- 102100029503 E3 ubiquitin-protein ligase TRIM32 Human genes 0.000 claims 2
- 101000634982 Homo sapiens E3 ubiquitin-protein ligase TRIM32 Proteins 0.000 claims 2
- 229940127523 NMDA Receptor Antagonists Drugs 0.000 claims 2
- 239000000695 adrenergic alpha-agonist Substances 0.000 claims 2
- 229940006133 antiglaucoma drug and miotics carbonic anhydrase inhibitors Drugs 0.000 claims 2
- 239000002876 beta blocker Substances 0.000 claims 2
- 229940097320 beta blocking agent Drugs 0.000 claims 2
- 239000003489 carbonate dehydratase inhibitor Substances 0.000 claims 2
- 239000000064 cholinergic agonist Substances 0.000 claims 2
- 239000003379 purinergic P1 receptor agonist Substances 0.000 claims 2
- 239000000018 receptor agonist Substances 0.000 claims 2
- 229940044601 receptor agonist Drugs 0.000 claims 2
- 230000002459 sustained effect Effects 0.000 claims 2
- QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 claims 1
- TWBNMYSKRDRHAT-RCWTXCDDSA-N (S)-timolol hemihydrate Chemical compound O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 TWBNMYSKRDRHAT-RCWTXCDDSA-N 0.000 claims 1
- PPWLAQVKIFDULF-UHFFFAOYSA-N 2-phenyl-1h-pyrrolo[2,3-b]pyridine Chemical group N1C2=NC=CC=C2C=C1C1=CC=CC=C1 PPWLAQVKIFDULF-UHFFFAOYSA-N 0.000 claims 1
- XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical compound C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 claims 1
- 201000002862 Angle-Closure Glaucoma Diseases 0.000 claims 1
- 244000287680 Garcinia dulcis Species 0.000 claims 1
- LOVMMUBRQUFEAH-UIEAZXIASA-N Latanoprostene bunod Chemical compound C([C@@H](O)CCC=1C=CC=CC=1)C[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(=O)OCCCCO[N+]([O-])=O LOVMMUBRQUFEAH-UIEAZXIASA-N 0.000 claims 1
- 206010067013 Normal tension glaucoma Diseases 0.000 claims 1
- 206010030348 Open-Angle Glaucoma Diseases 0.000 claims 1
- RSDOPYMFZBJHRL-UHFFFAOYSA-N Oxotremorine Chemical compound O=C1CCCN1CC#CCN1CCCC1 RSDOPYMFZBJHRL-UHFFFAOYSA-N 0.000 claims 1
- QCHFTSOMWOSFHM-UHFFFAOYSA-N SJ000285536 Natural products C1OC(=O)C(CC)C1CC1=CN=CN1C QCHFTSOMWOSFHM-UHFFFAOYSA-N 0.000 claims 1
- OURRXQUGYQRVML-AREMUKBSSA-N [4-[(2s)-3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl]phenyl]methyl 2,4-dimethylbenzoate Chemical compound CC1=CC(C)=CC=C1C(=O)OCC1=CC=C([C@@H](CN)C(=O)NC=2C=C3C=CN=CC3=CC=2)C=C1 OURRXQUGYQRVML-AREMUKBSSA-N 0.000 claims 1
- 229960003216 aceclidine Drugs 0.000 claims 1
- 229960000571 acetazolamide Drugs 0.000 claims 1
- BZKPWHYZMXOIDC-UHFFFAOYSA-N acetazolamide Chemical compound CC(=O)NC1=NN=C(S(N)(=O)=O)S1 BZKPWHYZMXOIDC-UHFFFAOYSA-N 0.000 claims 1
- WRJPSSPFHGNBMG-UHFFFAOYSA-N acetic acid 1-azabicyclo[2.2.2]octan-3-yl ester Chemical compound C1CC2C(OC(=O)C)CN1CC2 WRJPSSPFHGNBMG-UHFFFAOYSA-N 0.000 claims 1
- 229940006138 antiglaucoma drug and miotics prostaglandin analogues Drugs 0.000 claims 1
- 229960002470 bimatoprost Drugs 0.000 claims 1
- AQOKCDNYWBIDND-FTOWTWDKSA-N bimatoprost Chemical compound CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCC1=CC=CC=C1 AQOKCDNYWBIDND-FTOWTWDKSA-N 0.000 claims 1
- 229960003679 brimonidine Drugs 0.000 claims 1
- 229960000722 brinzolamide Drugs 0.000 claims 1
- HCRKCZRJWPKOAR-JTQLQIEISA-N brinzolamide Chemical compound CCN[C@H]1CN(CCCOC)S(=O)(=O)C2=C1C=C(S(N)(=O)=O)S2 HCRKCZRJWPKOAR-JTQLQIEISA-N 0.000 claims 1
- AIXAANGOTKPUOY-UHFFFAOYSA-N carbachol Chemical compound [Cl-].C[N+](C)(C)CCOC(N)=O AIXAANGOTKPUOY-UHFFFAOYSA-N 0.000 claims 1
- 229960004484 carbachol Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229960003933 dorzolamide Drugs 0.000 claims 1
- IAVUPMFITXYVAF-XPUUQOCRSA-N dorzolamide Chemical compound CCN[C@H]1C[C@H](C)S(=O)(=O)C2=C1C=C(S(N)(=O)=O)S2 IAVUPMFITXYVAF-XPUUQOCRSA-N 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 201000002978 low tension glaucoma Diseases 0.000 claims 1
- 229960004083 methazolamide Drugs 0.000 claims 1
- FLOSMHQXBMRNHR-DAXSKMNVSA-N methazolamide Chemical compound CC(=O)\N=C1/SC(S(N)(=O)=O)=NN1C FLOSMHQXBMRNHR-DAXSKMNVSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000011294 monotherapeutic Methods 0.000 claims 1
- 229950009210 netarsudil Drugs 0.000 claims 1
- 201000005111 ocular hyperemia Diseases 0.000 claims 1
- 229960003056 phentolamine mesylate Drugs 0.000 claims 1
- 229960001416 pilocarpine Drugs 0.000 claims 1
- BKVUSNOUTQMSBE-XCMGCKIWSA-N propan-2-yl 4-[(3s,5ar,6r,7r,8as)-6-[(e,3r)-4-(2,5-difluorophenoxy)-3-hydroxybut-1-enyl]-7-hydroxy-3,4,5,5a,6,7,8,8a-octahydro-2h-cyclopenta[b]oxepin-3-yl]butanoate Chemical compound C([C@H](O)/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1CC[C@@H](CO2)CCCC(=O)OC(C)C)OC1=CC(F)=CC=C1F BKVUSNOUTQMSBE-XCMGCKIWSA-N 0.000 claims 1
- 125000003259 prostaglandin group Chemical class 0.000 claims 1
- 239000003590 rho kinase inhibitor Substances 0.000 claims 1
- 102000000568 rho-Associated Kinases Human genes 0.000 claims 1
- 108010041788 rho-Associated Kinases Proteins 0.000 claims 1
- QSKQVZWVLOIIEV-NSHDSACASA-N ripasudil Chemical compound C[C@H]1CNCCCN1S(=O)(=O)C1=CC=CC2=CN=CC(F)=C12 QSKQVZWVLOIIEV-NSHDSACASA-N 0.000 claims 1
- 229950007455 ripasudil Drugs 0.000 claims 1
- 229960004458 tafluprost Drugs 0.000 claims 1
- WSNODXPBBALQOF-VEJSHDCNSA-N tafluprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\C(F)(F)COC1=CC=CC=C1 WSNODXPBBALQOF-VEJSHDCNSA-N 0.000 claims 1
- 229960004605 timolol Drugs 0.000 claims 1
- 229960002368 travoprost Drugs 0.000 claims 1
- MKPLKVHSHYCHOC-AHTXBMBWSA-N travoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)COC1=CC=CC(C(F)(F)F)=C1 MKPLKVHSHYCHOC-AHTXBMBWSA-N 0.000 claims 1
- 238000011269 treatment regimen Methods 0.000 claims 1
- 230000002618 waking effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862745806P | 2018-10-15 | 2018-10-15 | |
| US62/745,806 | 2018-10-15 | ||
| US201862752088P | 2018-10-29 | 2018-10-29 | |
| US62/752,088 | 2018-10-29 | ||
| PCT/US2019/056324 WO2020081562A1 (en) | 2018-10-15 | 2019-10-15 | Methods and compositions for treatment of glaucoma and related conditions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022508715A JP2022508715A (ja) | 2022-01-19 |
| JP2022508715A5 JP2022508715A5 (https=) | 2022-10-21 |
| JPWO2020081562A5 true JPWO2020081562A5 (https=) | 2022-10-21 |
Family
ID=70283123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021545286A Pending JP2022508715A (ja) | 2018-10-15 | 2019-10-15 | 緑内障および関連状態の処置のための方法および組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12161629B2 (https=) |
| EP (1) | EP3866790A4 (https=) |
| JP (1) | JP2022508715A (https=) |
| CN (1) | CN113164451A (https=) |
| AU (1) | AU2019360953A1 (https=) |
| WO (1) | WO2020081562A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3116589A1 (en) | 2018-10-26 | 2020-04-30 | Ocuphire Pharma, Inc. | Methods and compositions for treatment of presbyopia, mydriasis, and other ocular disorders |
| WO2022034909A1 (ja) * | 2020-08-13 | 2022-02-17 | 参天製薬株式会社 | セペタプロストを含有する医薬製剤 |
| CN117529316A (zh) * | 2021-04-23 | 2024-02-06 | 奥库菲尔制药股份有限公司 | 用于治疗瞳孔散大、青光眼和其他眼部病症的方法和组合物 |
| EP4408535A1 (en) * | 2021-09-30 | 2024-08-07 | Regeneron Pharmaceuticals, Inc. | Treatment of glaucoma with rho guanine nucleotide exchange factor 12 (arhgef12) inhibitors |
| CN114796219B (zh) * | 2022-05-18 | 2024-08-20 | 沈阳药科大学 | 一种用于治疗青光眼的复方药物组合物及其用途 |
| IT202300017430A1 (it) * | 2023-08-22 | 2025-02-22 | Service Biotech srl | Soluzione oftalmica in forma di collirio contenente una isoforma umana ricombinante di manganese superossido dismutasi (rmnsod) per la cura di patologie dell’occhio |
| WO2025090106A1 (en) * | 2023-10-23 | 2025-05-01 | Ophthalmic Therapeutic Innovation Llc | Compositions and methods for treating neural degeneration in glaucoma and related conditions |
| EP4559900A1 (en) * | 2023-11-21 | 2025-05-28 | Opus Genetics, Inc. | Phentolamine mesylate and therapeutic uses thereof |
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| US20130029919A1 (en) | 2011-07-26 | 2013-01-31 | Allergan, Inc. | Two part formulation system for opthalmic delivery |
| CA2863760A1 (en) | 2012-02-02 | 2013-08-08 | Alpha Synergy Development, Inc. | Compositions and methods for treatment of glaucoma |
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| US10507245B2 (en) | 2012-07-19 | 2019-12-17 | Luis Felipe Vejarano Restrepo | Ophthalmic formulation and method for ameliorating presbyopia |
| AU2014212275B2 (en) | 2013-02-01 | 2018-09-06 | Ocuphire Pharma, Inc. | Methods and compositions for daily ophthalmic administration of phentolamine to improve visual performance |
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| US8597629B1 (en) | 2013-06-21 | 2013-12-03 | Premium Ocular Solutions LLC. | Artificial tear compositions comprising a combination of nonionic surfactants |
| US10064818B2 (en) | 2013-08-28 | 2018-09-04 | Presbyopia Therapies, LLC | Compositions and methods for the treatment of presbyopia |
| US9968594B2 (en) | 2013-08-28 | 2018-05-15 | Presbyopia Therapies Llc | Compositions and methods for the treatment of presbyopia |
| WO2017152129A2 (en) * | 2016-03-03 | 2017-09-08 | Ocular Technologies Sarl | Treatment of glaucoma and/or retinal diseases and formulations useful therefore |
| AU2017311636B2 (en) | 2016-08-19 | 2023-08-10 | Orasis Pharmaceuticals Ltd. | Ophthalmic pharmaceutical compositions and uses relating thereto |
| HUE058931T2 (hu) | 2018-04-24 | 2022-09-28 | Allergan Inc | Pilokarpin hidroklorid alkalmazása presbyopia kezelésére |
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-
2019
- 2019-10-15 EP EP19872569.9A patent/EP3866790A4/en not_active Withdrawn
- 2019-10-15 US US17/283,038 patent/US12161629B2/en active Active
- 2019-10-15 CN CN201980076399.2A patent/CN113164451A/zh active Pending
- 2019-10-15 AU AU2019360953A patent/AU2019360953A1/en not_active Abandoned
- 2019-10-15 JP JP2021545286A patent/JP2022508715A/ja active Pending
- 2019-10-15 WO PCT/US2019/056324 patent/WO2020081562A1/en not_active Ceased
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