JPWO2020081450A5 - - Google Patents
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- JPWO2020081450A5 JPWO2020081450A5 JP2021545273A JP2021545273A JPWO2020081450A5 JP WO2020081450 A5 JPWO2020081450 A5 JP WO2020081450A5 JP 2021545273 A JP2021545273 A JP 2021545273A JP 2021545273 A JP2021545273 A JP 2021545273A JP WO2020081450 A5 JPWO2020081450 A5 JP WO2020081450A5
- Authority
- JP
- Japan
- Prior art keywords
- membered
- heterocycloalkyl
- alkyl
- compound
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 38
- 150000003839 salts Chemical class 0.000 claims 36
- 125000005842 heteroatom Chemical group 0.000 claims 35
- 125000000217 alkyl group Chemical group 0.000 claims 32
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 19
- 125000006578 monocyclic heterocycloalkyl group Chemical group 0.000 claims 19
- 125000006580 bicyclic heterocycloalkyl group Chemical group 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 229920006395 saturated elastomer Polymers 0.000 claims 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 125000002950 monocyclic group Chemical group 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 208000007465 Giant cell arteritis Diseases 0.000 claims 4
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 claims 4
- 230000001363 autoimmune Effects 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 206010043207 temporal arteritis Diseases 0.000 claims 4
- 125000006582 (C5-C6) heterocycloalkyl group Chemical group 0.000 claims 3
- 208000009299 Benign Mucous Membrane Pemphigoid Diseases 0.000 claims 3
- 208000018428 Eosinophilic granulomatosis with polyangiitis Diseases 0.000 claims 3
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- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
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- 206010028980 Neoplasm Diseases 0.000 claims 2
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- 102100036050 Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Human genes 0.000 claims 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims 2
- 208000003670 Pure Red-Cell Aplasia Diseases 0.000 claims 2
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- 201000011510 cancer Diseases 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
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- 125000003003 spiro group Chemical group 0.000 claims 2
- 208000008467 subacute bacterial endocarditis Diseases 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 1
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- 102000001714 Agammaglobulinaemia Tyrosine Kinase Human genes 0.000 claims 1
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- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims 1
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- 208000024869 Goodpasture syndrome Diseases 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 208000015023 Graves' disease Diseases 0.000 claims 1
- 208000035895 Guillain-Barré syndrome Diseases 0.000 claims 1
- 208000001204 Hashimoto Disease Diseases 0.000 claims 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
- 206010019263 Heart block congenital Diseases 0.000 claims 1
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 claims 1
- 206010019939 Herpes gestationis Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 206010020983 Hypogammaglobulinaemia Diseases 0.000 claims 1
- 208000010159 IgA glomerulonephritis Diseases 0.000 claims 1
- 206010021263 IgA nephropathy Diseases 0.000 claims 1
- 208000021330 IgG4-related disease Diseases 0.000 claims 1
- 208000014919 IgG4-related retroperitoneal fibrosis Diseases 0.000 claims 1
- 208000031781 Immunoglobulin G4 related sclerosing disease Diseases 0.000 claims 1
- 208000004187 Immunoglobulin G4-Related Disease Diseases 0.000 claims 1
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- 201000010743 Lambert-Eaton myasthenic syndrome Diseases 0.000 claims 1
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- 206010024434 Lichen sclerosus Diseases 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 1
- 208000027530 Meniere disease Diseases 0.000 claims 1
- 206010049567 Miller Fisher syndrome Diseases 0.000 claims 1
- 208000012192 Mucous membrane pemphigoid Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
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- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
- 208000014767 Myeloproliferative disease Diseases 0.000 claims 1
- 201000002481 Myositis Diseases 0.000 claims 1
- 206010029229 Neuralgic amyotrophy Diseases 0.000 claims 1
- 206010071579 Neuronal neuropathy Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010030136 Oesophageal achalasia Diseases 0.000 claims 1
- 208000003435 Optic Neuritis Diseases 0.000 claims 1
- 206010031252 Osteomyelitis Diseases 0.000 claims 1
- 208000025174 PANDAS Diseases 0.000 claims 1
- 206010053869 POEMS syndrome Diseases 0.000 claims 1
- 208000021155 Paediatric autoimmune neuropsychiatric disorders associated with streptococcal infection Diseases 0.000 claims 1
- 201000011152 Pemphigus Diseases 0.000 claims 1
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- 208000000766 Pityriasis Lichenoides Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
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- 208000031732 Post-Lyme Disease Syndrome Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
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- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims 1
- 108010074605 gamma-Globulins Proteins 0.000 claims 1
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024210877A JP7741282B2 (ja) | 2018-10-15 | 2024-12-04 | ユビキチンプロテオソーム経路を介してｂｔｋを分解するための二官能性化合物 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862745786P | 2018-10-15 | 2018-10-15 | |
| US62/745,786 | 2018-10-15 | ||
| US201862767819P | 2018-11-15 | 2018-11-15 | |
| US62/767,819 | 2018-11-15 | ||
| US201962836398P | 2019-04-19 | 2019-04-19 | |
| US62/836,398 | 2019-04-19 | ||
| US201962887812P | 2019-08-16 | 2019-08-16 | |
| US62/887,812 | 2019-08-16 | ||
| US201962901984P | 2019-09-18 | 2019-09-18 | |
| US62/901,984 | 2019-09-18 | ||
| PCT/US2019/056112 WO2020081450A1 (en) | 2018-10-15 | 2019-10-14 | Bifunctional compounds for degrading btk via ubiquitin proteosome pathway |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024210877A Division JP7741282B2 (ja) | 2018-10-15 | 2024-12-04 | ユビキチンプロテオソーム経路を介してｂｔｋを分解するための二官能性化合物 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022508705A JP2022508705A (ja) | 2022-01-19 |
| JPWO2020081450A5 true JPWO2020081450A5 (https=) | 2022-10-21 |
| JP2022508705A5 JP2022508705A5 (https=) | 2022-10-21 |
| JP7600123B2 JP7600123B2 (ja) | 2024-12-16 |
Family
ID=68425337
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021545273A Active JP7600123B2 (ja) | 2018-10-15 | 2019-10-14 | ユビキチンプロテオソーム経路を介してｂｔｋを分解するための二官能性化合物 |
| JP2024210877A Active JP7741282B2 (ja) | 2018-10-15 | 2024-12-04 | ユビキチンプロテオソーム経路を介してｂｔｋを分解するための二官能性化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024210877A Active JP7741282B2 (ja) | 2018-10-15 | 2024-12-04 | ユビキチンプロテオソーム経路を介してｂｔｋを分解するための二官能性化合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US11479556B1 (https=) |
| EP (1) | EP3867242A1 (https=) |
| JP (2) | JP7600123B2 (https=) |
| KR (1) | KR102816424B1 (https=) |
| CN (2) | CN113412259B (https=) |
| AU (2) | AU2019360928B2 (https=) |
| BR (2) | BR112021007115A2 (https=) |
| CA (1) | CA3115526A1 (https=) |
| IL (1) | IL281904B2 (https=) |
| MX (2) | MX2021004191A (https=) |
| WO (1) | WO2020081450A1 (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3710002A4 (en) | 2017-11-16 | 2021-07-07 | C4 Therapeutics, Inc. | DEGRADER AND DEGRONE FOR TARGETED PROTEIN DEGRADATION |
| EP3728228A1 (en) | 2017-12-22 | 2020-10-28 | Ravenna Pharmaceuticals, Inc. | Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors |
| JP2021519337A (ja) | 2018-03-26 | 2021-08-10 | シー４ セラピューティクス， インコーポレイテッド | Ｉｋａｒｏｓの分解のためのセレブロン結合剤 |
| CN119751456A (zh) | 2018-04-16 | 2025-04-04 | C4医药公司 | 螺环化合物 |
| JP7600123B2 (ja) | 2018-10-15 | 2024-12-16 | ニューリックス セラピューティクス，インコーポレイテッド | ユビキチンプロテオソーム経路を介してｂｔｋを分解するための二官能性化合物 |
| EP3877371A4 (en) | 2018-11-07 | 2022-07-27 | Dana-Farber Cancer Institute, Inc. | IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF |
| WO2020097398A1 (en) | 2018-11-07 | 2020-05-14 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
| WO2020097396A1 (en) | 2018-11-07 | 2020-05-14 | Dana-Farber Cancer Institute, Inc. | Benzimidazole derivatives and aza-benzimidazole derivatives as janus kinase 2 inhibitors and uses thereof |
| WO2020167518A1 (en) | 2019-02-13 | 2020-08-20 | Nurix Therapeutics, Inc. | Bifunctional compounds for degrading btk via ubiquitin proteosome pathway |
| EP3953346A1 (en) | 2019-04-09 | 2022-02-16 | Nurix Therapeutics, Inc. | 3-substituted piperidine compounds for cbl-b inhibition, and use of a cbl-b inhibitor in combination with a cancer vaccine and/or oncolytic virus |
| EP3969447A1 (en) | 2019-05-17 | 2022-03-23 | Nurix Therapeutics, Inc. | Cyano cyclobutyl compounds for cbl-b inhibition and uses thereof |
| KR20220030222A (ko) | 2019-05-31 | 2022-03-10 | 이케나 온콜로지, 인코포레이티드 | Tead 억제제 및 이의 용도 |
| WO2020243423A1 (en) | 2019-05-31 | 2020-12-03 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| TW202112767A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物 |
| MX2021015675A (es) | 2019-06-26 | 2022-02-03 | Nurix Therapeutics Inc | Compuestos de bencil-triazol sustituidos para la inhibicion de cbl-b y otros usos de los mismos. |
| EP4034141A1 (en) | 2019-09-24 | 2022-08-03 | Nurix Therapeutics, Inc. | Cbl inhibitors and compositions for expansion of immune cells |
| US11820781B2 (en) * | 2019-12-04 | 2023-11-21 | Nurix Therapeutics, Inc. | Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway |
| CA3181537A1 (en) | 2020-05-06 | 2021-11-11 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| US11739101B2 (en) * | 2020-05-06 | 2023-08-29 | Nurix Therapeutics, Inc. | Bifunctional degraders of hematopoietic progenitor kinase and therapeutic uses thereof |
| WO2022099117A1 (en) | 2020-11-06 | 2022-05-12 | Prelude Therapeutics Incorporated | Brm targeting compounds and associated methods of use |
| WO2022120355A1 (en) * | 2020-12-02 | 2022-06-09 | Ikena Oncology, Inc. | Tead degraders and uses thereof |
| EP4267574B1 (en) | 2020-12-23 | 2025-04-23 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| US12016860B2 (en) | 2021-04-08 | 2024-06-25 | Nurix Therapeutics, Inc. | Combination therapies with Cbl-b inhibitor compounds |
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