JPWO2020069445A5 - - Google Patents
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- JPWO2020069445A5 JPWO2020069445A5 JP2021517802A JP2021517802A JPWO2020069445A5 JP WO2020069445 A5 JPWO2020069445 A5 JP WO2020069445A5 JP 2021517802 A JP2021517802 A JP 2021517802A JP 2021517802 A JP2021517802 A JP 2021517802A JP WO2020069445 A5 JPWO2020069445 A5 JP WO2020069445A5
- Authority
- JP
- Japan
- Prior art keywords
- glycero
- composition
- phosphocholine
- composition according
- phosphoethanolamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862738717P | 2018-09-28 | 2018-09-28 | |
| US62/738,717 | 2018-09-28 | ||
| US201962885036P | 2019-08-09 | 2019-08-09 | |
| US62/885,036 | 2019-08-09 | ||
| PCT/US2019/053661 WO2020069445A1 (en) | 2018-09-28 | 2019-09-27 | Lipid nanoparticle formulations comprising lipidated cationic peptide compounds for nucleic acid delivery |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022502451A JP2022502451A (ja) | 2022-01-11 |
| JP2022502451A5 JP2022502451A5 (https=) | 2022-10-05 |
| JPWO2020069445A5 true JPWO2020069445A5 (https=) | 2022-10-05 |
| JP7430713B2 JP7430713B2 (ja) | 2024-02-13 |
Family
ID=69952323
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021517802A Active JP7430713B2 (ja) | 2018-09-28 | 2019-09-27 | 核酸送達のための脂質化カチオン性ペプチド化合物を含む脂質ナノ粒子製剤 |
| JP2021517865A Active JP7418419B2 (ja) | 2018-09-28 | 2019-09-27 | 核酸送達のための第三級アミノ脂質化カチオン性ペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021517865A Active JP7418419B2 (ja) | 2018-09-28 | 2019-09-27 | 核酸送達のための第三級アミノ脂質化カチオン性ペプチド |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US20210322575A1 (https=) |
| EP (2) | EP3856757A4 (https=) |
| JP (2) | JP7430713B2 (https=) |
| KR (2) | KR20210068092A (https=) |
| CN (2) | CN112789031B (https=) |
| AU (2) | AU2019347774A1 (https=) |
| BR (2) | BR112021005815A2 (https=) |
| CA (2) | CA3110914A1 (https=) |
| IL (2) | IL281135B2 (https=) |
| MX (2) | MX2021003420A (https=) |
| MY (1) | MY204458A (https=) |
| SG (2) | SG11202102164PA (https=) |
| WO (2) | WO2020069442A1 (https=) |
| ZA (2) | ZA202101376B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112789031B (zh) * | 2018-09-28 | 2023-03-24 | 胡桃钳医疗公司 | 用于核酸递送的包含脂化的阳离子肽化合物的脂质纳米颗粒制剂 |
| MX2022001660A (es) * | 2019-08-09 | 2022-04-18 | Nutcracker Therapeutics Inc | Composiciones peg de péptidos catiónicos lipidados para la administración de ácidos nucleicos. |
| IL297161A (en) * | 2020-04-22 | 2022-12-01 | Nutcracker Therapeutics Inc | Therapeutic mrna nanoparticles |
| NL2026825B1 (en) | 2020-08-07 | 2022-04-05 | Nutcracker Therapeutics Inc | Multicomponent delivery system for polyanionic cargo compound delivery |
| US20230293706A1 (en) | 2020-08-07 | 2023-09-21 | Nutcracker Therapeutics, Inc. | Multicomponent Delivery Systems for Polyanionic Cargo Compound Delivery |
| US20240024466A1 (en) * | 2020-12-07 | 2024-01-25 | Trustees Of Tufts College | Lipidoid compositions and methods of use thereof |
| EP4333898A4 (en) * | 2021-05-05 | 2026-03-25 | Arcturus Therapeutics Inc | PEPTIDE-LIPID CONJUGATES |
| US20240307526A1 (en) | 2021-08-06 | 2024-09-19 | Nutcracker Therapeutics, Inc. | Compositions comprising hydroxyethyl-capped cationic peptoids |
| NL2029057B1 (en) | 2021-08-06 | 2023-02-21 | Nutcracker Therapeutics Inc | Compositions comprising hydroxyethyl-capped cationic peptoids |
| CN114778712B (zh) * | 2022-03-21 | 2023-06-02 | 天津键凯科技有限公司 | 一种聚乙二醇脂质及含有该脂质的脂质纳米粒含量的检测方法 |
| KR20250065342A (ko) | 2022-09-09 | 2025-05-12 | 넛크래커 테라퓨틱스 인코포레이티드 | 핵산 전달용 2-아미노프로판-1,3-다이올 캡핑된 양이온성 펩토이드 |
| WO2025006851A1 (en) | 2023-06-29 | 2025-01-02 | Nutcracker Therapeutics, Inc. | Ethyl modified rna caps and methods of use |
| WO2025053636A1 (ko) * | 2023-09-05 | 2025-03-13 | 한국생명공학연구원 | 지질 나노 입자를 이용한 핵산 전달 시스템 |
| WO2025137277A1 (en) | 2023-12-19 | 2025-06-26 | Nutcracker Therapeutics, Inc. | Degradable peptoids |
| WO2025189064A1 (en) | 2024-03-08 | 2025-09-12 | Genzyme Corporation | Lipid nanoparticles |
| WO2026003582A2 (en) | 2024-06-27 | 2026-01-02 | Axelyf ehf. | Lipids and lipid nanoparticles |
| WO2026030375A2 (en) | 2024-07-30 | 2026-02-05 | Genzyme Corporation | Lipid nanoparticles and methods of manufacture and use thereof |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7422902B1 (en) | 1995-06-07 | 2008-09-09 | The University Of British Columbia | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
| US5981501A (en) | 1995-06-07 | 1999-11-09 | Inex Pharmaceuticals Corp. | Methods for encapsulating plasmids in lipid bilayers |
| CA2289702C (en) | 1997-05-14 | 2008-02-19 | Inex Pharmaceuticals Corp. | High efficiency encapsulation of charged therapeutic agents in lipid vesicles |
| US6191115B1 (en) * | 1998-08-12 | 2001-02-20 | Abbott Laboratories | C-terminus modified heptapeptide LHRH analogs |
| WO2001016306A2 (en) | 1999-08-27 | 2001-03-08 | Chiron Corporation | Chimeric antisense oligonucleotides and cell transfecting formulations thereof |
| JP2004535388A (ja) * | 2001-04-30 | 2004-11-25 | ターゲティッド ジェネティクス コーポレイション | 脂質含有薬物送達複合体およびそれらの生成方法 |
| US7901708B2 (en) | 2002-06-28 | 2011-03-08 | Protiva Biotherapeutics, Inc. | Liposomal apparatus and manufacturing methods |
| ES2559828T3 (es) * | 2003-07-16 | 2016-02-16 | Protiva Biotherapeutics Inc. | ARN de interferencia encapsulado en lípidos |
| CA2549720C (en) * | 2003-12-19 | 2013-10-15 | Chiron Corporation | Cell transfecting formulations of small interfering rna, related compositions and methods of making and use |
| ITMI20061607A1 (it) * | 2006-08-09 | 2008-02-10 | Maria Vincenza Carriero | Peptidi con attivita farmacologica |
| CA2689145A1 (en) | 2007-06-04 | 2008-12-11 | Pressure Biosciences Inc. | Pressure-enhanced extraction and partitioning of molecules |
| AU2009238175C1 (en) | 2008-04-15 | 2023-11-30 | Arbutus Biopharma Corporation | Novel lipid formulations for nucleic acid delivery |
| WO2009132131A1 (en) * | 2008-04-22 | 2009-10-29 | Alnylam Pharmaceuticals, Inc. | Amino lipid based improved lipid formulation |
| HUE037082T2 (hu) | 2008-11-10 | 2018-08-28 | Arbutus Biopharma Corp | Új lipidek és készítmények terápiás hatóanyagok szállítására |
| TW201019969A (en) * | 2008-11-17 | 2010-06-01 | Enzon Pharmaceuticals Inc | Branched cationic lipids for nucleic acids delivery system |
| ES2613498T3 (es) | 2009-07-01 | 2017-05-24 | Protiva Biotherapeutics Inc. | Nuevas formulaciones de lípidos para el suministro de agentes terapéuticos a tumores sólidos |
| US20110053829A1 (en) * | 2009-09-03 | 2011-03-03 | Curevac Gmbh | Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids |
| CA2816925C (en) | 2009-11-04 | 2023-01-10 | The University Of British Columbia | Nucleic acid-containing lipid particles and related methods |
| HUE042177T2 (hu) | 2009-12-01 | 2019-06-28 | Translate Bio Inc | Szteroidszármazék mRNS szállítására humán genetikai betegségekben |
| US8748667B2 (en) | 2010-06-04 | 2014-06-10 | Sirna Therapeutics, Inc. | Low molecular weight cationic lipids for oligonucleotide delivery |
| WO2012000104A1 (en) | 2010-06-30 | 2012-01-05 | Protiva Biotherapeutics, Inc. | Non-liposomal systems for nucleic acid delivery |
| DK2631291T3 (da) | 2010-10-22 | 2019-06-11 | Olix Pharmaceuticals Inc | Nukleinsyremolekyler, der inducerer rna-interferens, og anvendelser deraf |
| EP2686342A2 (en) * | 2011-04-12 | 2014-01-22 | The Government of The United States of America, as represented by The Secretary, Department of Health and Human Services | Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use |
| PL3586861T3 (pl) | 2011-06-08 | 2022-05-23 | Translate Bio, Inc. | Kompozycje nanocząstek lipidowych i sposoby dostarczania mrna |
| US9579338B2 (en) | 2011-11-04 | 2017-02-28 | Nitto Denko Corporation | Method of producing lipid nanoparticles for drug delivery |
| US9035039B2 (en) | 2011-12-22 | 2015-05-19 | Protiva Biotherapeutics, Inc. | Compositions and methods for silencing SMAD4 |
| WO2013148541A1 (en) | 2012-03-27 | 2013-10-03 | Merck Sharp & Dohme Corp. | DIETHER BASED BIODEGRADABLE CATIONIC LIPIDS FOR siRNA DELIVERY |
| KR101480055B1 (ko) | 2012-04-04 | 2015-01-09 | 주식회사 삼양바이오팜 | 음이온성 약물 전달체의 제조 방법 |
| US10245229B2 (en) | 2012-06-08 | 2019-04-02 | Translate Bio, Inc. | Pulmonary delivery of mRNA to non-lung target cells |
| US20150182461A1 (en) | 2012-06-19 | 2015-07-02 | Massachussets Institute Of Technology | Mass Production and Size Control of Nanoparticles Through Controlled Microvortices |
| TW201726600A (zh) | 2012-07-06 | 2017-08-01 | 協和醱酵麒麟有限公司 | 陽離子性脂質 |
| US9687448B2 (en) | 2012-12-07 | 2017-06-27 | Alnylam Pharmaceuticals, Inc. | Nucleic acid lipid particle formulations |
| SG11201507474QA (en) | 2013-03-14 | 2015-10-29 | Shire Human Genetic Therapies | RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS |
| SG11201510747RA (en) | 2013-08-21 | 2016-03-30 | Curevac Ag | Method for increasing expression of rna-encoded proteins |
| SG10201912038TA (en) | 2014-04-23 | 2020-02-27 | Modernatx Inc | Nucleic acid vaccines |
| WO2015191693A2 (en) | 2014-06-10 | 2015-12-17 | Massachusetts Institute Of Technology | Method for gene editing |
| ES2555160B1 (es) | 2014-06-24 | 2016-10-25 | Aptus Biotech, S.L. | Aptámeros específicos de TLR-4 y usos de los mismos |
| JP7105065B2 (ja) | 2014-12-15 | 2022-07-22 | ダイセルナ ファーマシューティカルズ， インコーポレイテッド | リガンド修飾二本鎖核酸 |
| SMT202100196T1 (it) | 2015-07-22 | 2021-05-07 | Nitto Denko Corp | Composizioni e metodi per forme liofile di nanoparticelle |
| TW201729835A (zh) | 2015-10-22 | 2017-09-01 | 現代公司 | 呼吸道病毒疫苗 |
| WO2017100154A1 (en) * | 2015-12-07 | 2017-06-15 | Purdue Research Foundation | Inhibitors for proliferating cell nuclear antigen and uses |
| JP6457704B2 (ja) | 2015-12-13 | 2019-01-23 | 日東電工株式会社 | 高活性及びオフターゲット削減のためのｓｉＲＮＡ構造 |
| WO2018064755A1 (en) * | 2016-10-03 | 2018-04-12 | Precision Nanosystems Inc. | Compositions for transfecting resistant cell types |
| MX2019005470A (es) | 2016-11-10 | 2019-11-21 | Translate Bio Inc | Formulación de nanopartículas lipídicas basadas en ice mejorada para el suministro de arnm. |
| WO2018107061A1 (en) | 2016-12-09 | 2018-06-14 | Board Of Regents, The University Of Texas System | Hybrid exosomal-polymeric (hexpo) nano-platform for delivery of rnai therapeutics |
| JP7406793B2 (ja) | 2017-06-23 | 2023-12-28 | ユニバーシティー オブ マサチューセッツ | ２テイル自己デリバリー型ｓｉＲＮＡおよび関連方法 |
| CN112789031B (zh) * | 2018-09-28 | 2023-03-24 | 胡桃钳医疗公司 | 用于核酸递送的包含脂化的阳离子肽化合物的脂质纳米颗粒制剂 |
-
2019
- 2019-09-27 CN CN201980062278.2A patent/CN112789031B/zh not_active Expired - Fee Related
- 2019-09-27 AU AU2019347774A patent/AU2019347774A1/en not_active Abandoned
- 2019-09-27 MY MYPI2021001653A patent/MY204458A/en unknown
- 2019-09-27 JP JP2021517802A patent/JP7430713B2/ja active Active
- 2019-09-27 IL IL281135A patent/IL281135B2/en unknown
- 2019-09-27 CN CN201980062070.0A patent/CN112805294A/zh active Pending
- 2019-09-27 KR KR1020217012768A patent/KR20210068092A/ko not_active Ceased
- 2019-09-27 US US17/279,460 patent/US20210322575A1/en not_active Abandoned
- 2019-09-27 MX MX2021003420A patent/MX2021003420A/es unknown
- 2019-09-27 CA CA3110914A patent/CA3110914A1/en active Pending
- 2019-09-27 EP EP19866196.9A patent/EP3856757A4/en active Pending
- 2019-09-27 US US17/279,508 patent/US20210324002A1/en not_active Abandoned
- 2019-09-27 SG SG11202102164PA patent/SG11202102164PA/en unknown
- 2019-09-27 KR KR1020217012769A patent/KR20210068093A/ko not_active Ceased
- 2019-09-27 JP JP2021517865A patent/JP7418419B2/ja active Active
- 2019-09-27 AU AU2019351268A patent/AU2019351268A1/en not_active Abandoned
- 2019-09-27 BR BR112021005815-0A patent/BR112021005815A2/pt not_active IP Right Cessation
- 2019-09-27 BR BR112021004929-0A patent/BR112021004929A2/pt not_active IP Right Cessation
- 2019-09-27 CA CA3111476A patent/CA3111476A1/en active Pending
- 2019-09-27 WO PCT/US2019/053655 patent/WO2020069442A1/en not_active Ceased
- 2019-09-27 EP EP19864088.0A patent/EP3856146A4/en not_active Withdrawn
- 2019-09-27 SG SG11202102163SA patent/SG11202102163SA/en unknown
- 2019-09-27 MX MX2021003421A patent/MX2021003421A/es unknown
- 2019-09-27 WO PCT/US2019/053661 patent/WO2020069445A1/en not_active Ceased
-
2021
- 2021-02-26 ZA ZA2021/01376A patent/ZA202101376B/en unknown
- 2021-03-03 ZA ZA2021/01465A patent/ZA202101465B/en unknown
- 2021-03-19 IL IL281653A patent/IL281653A/en unknown
- 2021-06-14 US US17/347,539 patent/US11446394B2/en active Active
- 2021-06-14 US US17/347,498 patent/US11701434B2/en active Active
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