JPWO2020049549A5 - - Google Patents

Info

Publication number

JPWO2020049549A5

JPWO2020049549A5 JP2021513276A JP2021513276A JPWO2020049549A5 JP WO2020049549 A5 JPWO2020049549 A5 JP WO2020049549A5 JP 2021513276 A JP2021513276 A JP 2021513276A JP 2021513276 A JP2021513276 A JP 2021513276A JP WO2020049549 A5 JPWO2020049549 A5 JP WO2020049549A5

Authority

JP

Japan

Prior art keywords

use according

preparation

per dose

formulation

optionally

Prior art date

2022-06-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 238000009472 formulation Methods 0.000 claims 9
• 239000000203 mixture Substances 0.000 claims 9
• 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 7
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 6
• PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims 5
• 239000003963 antioxidant agent Substances 0.000 claims 5
• 230000003078 antioxidant effect Effects 0.000 claims 5
• 235000006708 antioxidants Nutrition 0.000 claims 5
• 208000019423 liver disease Diseases 0.000 claims 5
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 4
• RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims 4
• CXQWRCVTCMQVQX-LSDHHAIUSA-N (+)-taxifolin Chemical group C1([C@@H]2[C@H](C(C3=C(O)C=C(O)C=C3O2)=O)O)=CC=C(O)C(O)=C1 CXQWRCVTCMQVQX-LSDHHAIUSA-N 0.000 claims 3
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 3
• XCGZWJIXHMSSQC-UHFFFAOYSA-N dihydroquercetin Natural products OC1=CC2OC(=C(O)C(=O)C2C(O)=C1)c1ccc(O)c(O)c1 XCGZWJIXHMSSQC-UHFFFAOYSA-N 0.000 claims 3
• 239000003205 fragrance Substances 0.000 claims 3
• 239000011777 magnesium Substances 0.000 claims 3
• 229910052749 magnesium Inorganic materials 0.000 claims 3
• 229960005336 magnesium citrate Drugs 0.000 claims 3
• 239000004337 magnesium citrate Substances 0.000 claims 3
• 235000002538 magnesium citrate Nutrition 0.000 claims 3
• 229940091250 magnesium supplement Drugs 0.000 claims 3
• 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 3
• PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 claims 3
• YEDFEBOUHSBQBT-UHFFFAOYSA-N 2,3-dihydroflavon-3-ol Chemical group O1C2=CC=CC=C2C(=O)C(O)C1C1=CC=CC=C1 YEDFEBOUHSBQBT-UHFFFAOYSA-N 0.000 claims 2
• RZALONVQKUWRRY-FYZOBXCZSA-N 2,3-dihydroxybutanedioic acid;(3r)-3-hydroxy-4-(trimethylazaniumyl)butanoate Chemical compound OC(=O)C(O)C(O)C(O)=O.C[N+](C)(C)C[C@H](O)CC([O-])=O RZALONVQKUWRRY-FYZOBXCZSA-N 0.000 claims 2
• CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims 2
• PVXPPJIGRGXGCY-DJHAAKORSA-N 6-O-alpha-D-glucopyranosyl-alpha-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@](O)(CO)O1 PVXPPJIGRGXGCY-DJHAAKORSA-N 0.000 claims 2
• 208000022309 Alcoholic Liver disease Diseases 0.000 claims 2
• 206010016654 Fibrosis Diseases 0.000 claims 2
• LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims 2
• 235000010323 ascorbic acid Nutrition 0.000 claims 2
• 229960005070 ascorbic acid Drugs 0.000 claims 2
• 239000011668 ascorbic acid Substances 0.000 claims 2
• 229960001948 caffeine Drugs 0.000 claims 2
• VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims 2
• 229960004203 carnitine Drugs 0.000 claims 2
• 229930003939 flavanonol Natural products 0.000 claims 2
• 229910052500 inorganic mineral Inorganic materials 0.000 claims 2
• OVGXLJDWSLQDRT-UHFFFAOYSA-L magnesium lactate Chemical compound [Mg+2].CC(O)C([O-])=O.CC(O)C([O-])=O OVGXLJDWSLQDRT-UHFFFAOYSA-L 0.000 claims 2
• 229960004658 magnesium lactate Drugs 0.000 claims 2
• 239000000626 magnesium lactate Substances 0.000 claims 2
• 235000015229 magnesium lactate Nutrition 0.000 claims 2
• 239000011707 mineral Substances 0.000 claims 2
• 235000010755 mineral Nutrition 0.000 claims 2
• 235000010241 potassium sorbate Nutrition 0.000 claims 2
• 229940069338 potassium sorbate Drugs 0.000 claims 2
• 239000004302 potassium sorbate Substances 0.000 claims 2
• 235000013343 vitamin Nutrition 0.000 claims 2
• 229940088594 vitamin Drugs 0.000 claims 2
• 229930003231 vitamin Natural products 0.000 claims 2
• 239000011782 vitamin Substances 0.000 claims 2
• 150000003722 vitamin derivatives Chemical class 0.000 claims 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
• 208000004930 Fatty Liver Diseases 0.000 claims 1
• 235000012545 Vaccinium macrocarpon Nutrition 0.000 claims 1
• 240000001717 Vaccinium macrocarpon Species 0.000 claims 1
• 235000002118 Vaccinium oxycoccus Nutrition 0.000 claims 1
• 239000007864 aqueous solution Substances 0.000 claims 1
• 239000002775 capsule Substances 0.000 claims 1
• 230000007882 cirrhosis Effects 0.000 claims 1
• 208000019425 cirrhosis of liver Diseases 0.000 claims 1
• 229960004106 citric acid Drugs 0.000 claims 1
• 235000004634 cranberry Nutrition 0.000 claims 1
• 235000015872 dietary supplement Nutrition 0.000 claims 1
• 208000010706 fatty liver disease Diseases 0.000 claims 1
• 230000004761 fibrosis Effects 0.000 claims 1
• 208000006454 hepatitis Diseases 0.000 claims 1
• 231100000283 hepatitis Toxicity 0.000 claims 1
• -1 sclarose Substances 0.000 claims 1