JPWO2020039093A5 - - Google Patents
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- Publication number
- JPWO2020039093A5 JPWO2020039093A5 JP2021534826A JP2021534826A JPWO2020039093A5 JP WO2020039093 A5 JPWO2020039093 A5 JP WO2020039093A5 JP 2021534826 A JP2021534826 A JP 2021534826A JP 2021534826 A JP2021534826 A JP 2021534826A JP WO2020039093 A5 JPWO2020039093 A5 JP WO2020039093A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutically acceptable
- acceptable salt
- compound
- qnr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 26
- 150000001875 compounds Chemical class 0.000 claims 20
- 229910052799 carbon Inorganic materials 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 14
- 229910052739 hydrogen Inorganic materials 0.000 claims 13
- 239000003814 drug Substances 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 150000002367 halogens Chemical class 0.000 claims 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 10
- 229940124597 therapeutic agent Drugs 0.000 claims 10
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 8
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 125000004497 pyrazol-5-yl group Chemical group N1N=CC=C1* 0.000 claims 1
- OYRRZWATULMEPF-UHFFFAOYSA-N pyrimidin-4-amine Chemical compound NC1=CC=NC=N1 OYRRZWATULMEPF-UHFFFAOYSA-N 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SG10201807244X | 2018-08-24 | ||
| SG10201807244X | 2018-08-24 | ||
| PCT/EP2019/072641 WO2020039093A1 (en) | 2018-08-24 | 2019-08-23 | Tetrahydropyridopyrimidine derivatives as ahr modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021535213A JP2021535213A (ja) | 2021-12-16 |
| JP2021535213A5 JP2021535213A5 (https=) | 2022-08-30 |
| JPWO2020039093A5 true JPWO2020039093A5 (https=) | 2022-08-30 |
Family
ID=67982013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021534826A Pending JP2021535213A (ja) | 2018-08-24 | 2019-08-23 | ＡｈＲモジュレーターとしてのテトラヒドロピリドピリミジン誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US12221439B2 (https=) |
| EP (1) | EP3841102B1 (https=) |
| JP (1) | JP2021535213A (https=) |
| KR (1) | KR20210049135A (https=) |
| CN (1) | CN112739698A (https=) |
| AU (1) | AU2019323714A1 (https=) |
| BR (1) | BR112021003529A2 (https=) |
| CA (1) | CA3110402A1 (https=) |
| IL (1) | IL281023A (https=) |
| MX (1) | MX2021002215A (https=) |
| PH (1) | PH12021550382A1 (https=) |
| SG (1) | SG11202101441SA (https=) |
| WO (1) | WO2020039093A1 (https=) |
| ZA (1) | ZA202100931B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3715471A1 (en) | 2019-03-29 | 2020-09-30 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Ahr signature marker set |
| EP3721894A1 (en) | 2019-04-10 | 2020-10-14 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Interleukin-4-induced gene 1 (il4i1) as a biomarker and uses thereof |
| EP3835432A1 (en) | 2019-12-10 | 2021-06-16 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Interleukin-4-induced gene 1 (il4i1) and respective metabolites as biomarkers for cancer |
| US20230279000A1 (en) | 2020-02-26 | 2023-09-07 | Jaguahr Therapeutics Pte Ltd | Pyridopyrimidine derivatives useful in modulation of ahr signalling |
| WO2021210970A1 (en) * | 2020-04-17 | 2021-10-21 | Dong-A St Co., Ltd. | Pyridopyrimidinone derivatives and their use as aryl hydrocarbon receptor modulators |
| WO2022078356A1 (zh) * | 2020-10-15 | 2022-04-21 | 山东轩竹医药科技有限公司 | 杂芳环类AhR抑制剂 |
| WO2023033742A1 (en) * | 2021-09-02 | 2023-03-09 | Jaguahr Therapeutics Pte Ltd | Compounds useful in modulation of ahr signalling |
| WO2023033741A1 (en) * | 2021-09-02 | 2023-03-09 | Jaguahr Therapeutics Pte Ltd | Compounds useful in modulation of ahr signalling |
| WO2024076300A1 (en) | 2022-10-03 | 2024-04-11 | Jaguahr Therapeutics Pte Ltd | Compounds useful in modulation of ahr signalling |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
| EP1317450B1 (en) | 2000-09-15 | 2006-11-22 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| ZA200601859B (en) | 2003-08-05 | 2008-03-26 | Vertex Pharma | Condensed pyrimidine compounds as inhibitors of voltagegated ion channels |
| WO2006044762A2 (en) * | 2004-10-15 | 2006-04-27 | Bayer Pharmaceuticals Corporation | Tetrahydro-5h-pyrimido[4,5-d]azepine derivatives useful for the treatment of diseases associated with the 5-ht2c receptor |
| MY159230A (en) | 2008-10-02 | 2016-12-30 | Respivert Ltd | P38 map kinase inhibitors |
| PE20100362A1 (es) | 2008-10-30 | 2010-05-27 | Irm Llc | Derivados de purina que expanden las celulas madre hematopoyeticas |
| US8691827B2 (en) | 2009-08-17 | 2014-04-08 | Merck Sharp & Dohme Corp. | Amino tetrahydro-pyridopyrimidine PDE10 inhibitors |
| BR112013002079B1 (pt) | 2010-07-27 | 2021-09-14 | Trustees Of Boston University | Modificadores do receptor de aril hidrocarboneto (ahr) como novos terapêuticos contra o câncer |
| WO2016154110A1 (en) * | 2015-03-20 | 2016-09-29 | Cleave Biosciences, Inc. | Companion diagnostic for p97 inhibitor therapy and methods of use thereof |
| CA3025227A1 (en) | 2016-05-25 | 2017-11-30 | Bayer Pharma Aktiengesellschaft | 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamides |
| US20230279000A1 (en) | 2020-02-26 | 2023-09-07 | Jaguahr Therapeutics Pte Ltd | Pyridopyrimidine derivatives useful in modulation of ahr signalling |
-
2019
- 2019-08-23 CN CN201980060477.XA patent/CN112739698A/zh active Pending
- 2019-08-23 CA CA3110402A patent/CA3110402A1/en active Pending
- 2019-08-23 EP EP19769387.2A patent/EP3841102B1/en active Active
- 2019-08-23 WO PCT/EP2019/072641 patent/WO2020039093A1/en not_active Ceased
- 2019-08-23 JP JP2021534826A patent/JP2021535213A/ja active Pending
- 2019-08-23 AU AU2019323714A patent/AU2019323714A1/en not_active Abandoned
- 2019-08-23 MX MX2021002215A patent/MX2021002215A/es unknown
- 2019-08-23 SG SG11202101441SA patent/SG11202101441SA/en unknown
- 2019-08-23 US US17/270,626 patent/US12221439B2/en active Active
- 2019-08-23 BR BR112021003529-0A patent/BR112021003529A2/pt not_active Application Discontinuation
- 2019-08-23 KR KR1020217008532A patent/KR20210049135A/ko not_active Ceased
-
2021
- 2021-02-10 ZA ZA2021/00931A patent/ZA202100931B/en unknown
- 2021-02-22 IL IL281023A patent/IL281023A/en unknown
- 2021-02-24 PH PH12021550382A patent/PH12021550382A1/en unknown
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