JPWO2020038435A5 - - Google Patents

Info

Publication number

JPWO2020038435A5

JPWO2020038435A5 JP2021509988A JP2021509988A JPWO2020038435A5 JP WO2020038435 A5 JPWO2020038435 A5 JP WO2020038435A5 JP 2021509988 A JP2021509988 A JP 2021509988A JP 2021509988 A JP2021509988 A JP 2021509988A JP WO2020038435 A5 JPWO2020038435 A5 JP WO2020038435A5

Authority

JP

Japan

Prior art keywords

alkyl

alkoxy

cooh

compound according

propyl

Prior art date

2022-07-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 15
• 150000001875 compounds Chemical class 0.000 claims 15
• -1 frill Chemical group 0.000 claims 15
• 239000002207 metabolite Substances 0.000 claims 9
• 150000001204 N-oxides Chemical class 0.000 claims 6
• 125000003118 aryl group Chemical group 0.000 claims 6
• 125000000623 heterocyclic group Chemical group 0.000 claims 6
• 239000000651 prodrug Substances 0.000 claims 6
• 229940002612 prodrug Drugs 0.000 claims 6
• 150000003839 salts Chemical class 0.000 claims 6
• 239000012453 solvate Substances 0.000 claims 6
• 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 5
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 5
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 5
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 claims 3
• 208000002193 Pain Diseases 0.000 claims 3
• 125000000753 cycloalkyl group Chemical group 0.000 claims 3
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
• 125000002883 imidazolyl group Chemical group 0.000 claims 3
• 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 claims 3
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
• 125000001624 naphthyl group Chemical group 0.000 claims 3
• 125000002971 oxazolyl group Chemical group 0.000 claims 3
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
• 125000003373 pyrazinyl group Chemical group 0.000 claims 3
• 125000003226 pyrazolyl group Chemical group 0.000 claims 3
• 125000004076 pyridyl group Chemical group 0.000 claims 3
• 125000000714 pyrimidinyl group Chemical group 0.000 claims 3
• 125000000168 pyrrolyl group Chemical group 0.000 claims 3
• 125000005493 quinolyl group Chemical group 0.000 claims 3
• 125000001424 substituent group Chemical group 0.000 claims 3
• 125000003831 tetrazolyl group Chemical group 0.000 claims 3
• 125000000335 thiazolyl group Chemical group 0.000 claims 3
• 125000001544 thienyl group Chemical group 0.000 claims 3
• 125000001425 triazolyl group Chemical group 0.000 claims 3
• 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 2
• 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 2
• 208000019901 Anxiety disease Diseases 0.000 claims 2
• 125000002393 azetidinyl group Chemical group 0.000 claims 2
• 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 125000002541 furyl group Chemical group 0.000 claims 2
• 125000002757 morpholinyl group Chemical group 0.000 claims 2
• 125000004193 piperazinyl group Chemical group 0.000 claims 2
• 125000005936 piperidyl group Chemical group 0.000 claims 2
• 125000004368 propenyl group Chemical group C(=CC)* 0.000 claims 2
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
• 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 2
• 208000007848 Alcoholism Diseases 0.000 claims 1
• 201000004384 Alopecia Diseases 0.000 claims 1
• 208000000044 Amnesia Diseases 0.000 claims 1
• 206010002942 Apathy Diseases 0.000 claims 1
• 208000036487 Arthropathies Diseases 0.000 claims 1
• 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
• 206010003805 Autism Diseases 0.000 claims 1
• 208000020706 Autistic disease Diseases 0.000 claims 1
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
• 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 1
• 206010012289 Dementia Diseases 0.000 claims 1
• 208000010228 Erectile Dysfunction Diseases 0.000 claims 1
• 206010020710 Hyperphagia Diseases 0.000 claims 1
• 208000026139 Memory disease Diseases 0.000 claims 1
• 208000019695 Migraine disease Diseases 0.000 claims 1
• 241000208125 Nicotiana Species 0.000 claims 1
• 235000002637 Nicotiana tabacum Nutrition 0.000 claims 1
• 206010029897 Obsessive thoughts Diseases 0.000 claims 1
• 206010034912 Phobia Diseases 0.000 claims 1
• 208000008348 Post-Concussion Syndrome Diseases 0.000 claims 1
• 206010036618 Premenstrual syndrome Diseases 0.000 claims 1
• 206010041250 Social phobia Diseases 0.000 claims 1
• 230000003213 activating effect Effects 0.000 claims 1
• 239000000654 additive Substances 0.000 claims 1
• 230000000996 additive effect Effects 0.000 claims 1
• 201000007930 alcohol dependence Diseases 0.000 claims 1
• 230000036506 anxiety Effects 0.000 claims 1
• 230000036528 appetite Effects 0.000 claims 1
• 235000019789 appetite Nutrition 0.000 claims 1
• 208000030963 borderline personality disease Diseases 0.000 claims 1
• 230000001066 destructive effect Effects 0.000 claims 1
• 208000035475 disorder Diseases 0.000 claims 1
• 208000024963 hair loss Diseases 0.000 claims 1
• 230000003676 hair loss Effects 0.000 claims 1
• 125000001072 heteroaryl group Chemical group 0.000 claims 1
• 150000004677 hydrates Chemical class 0.000 claims 1
• 201000001881 impotence Diseases 0.000 claims 1
• 125000001041 indolyl group Chemical group 0.000 claims 1
• 230000000938 luteal effect Effects 0.000 claims 1
• 230000006984 memory degeneration Effects 0.000 claims 1
• 208000023060 memory loss Diseases 0.000 claims 1
• 206010027599 migraine Diseases 0.000 claims 1
• 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 1
• 230000002981 neuropathic effect Effects 0.000 claims 1
• 208000019899 phobic disease Diseases 0.000 claims 1
• 230000002028 premature Effects 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 208000020016 psychiatric disease Diseases 0.000 claims 1
• 125000002098 pyridazinyl group Chemical group 0.000 claims 1
• 208000019116 sleep disease Diseases 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• GECHUMIMRBOMGK-UHFFFAOYSA-N sulfapyridine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=CC=CC=N1 GECHUMIMRBOMGK-UHFFFAOYSA-N 0.000 claims 1
• 229960002211 sulfapyridine Drugs 0.000 claims 1
• 208000011580 syndromic disease Diseases 0.000 claims 1
• 208000004371 toothache Diseases 0.000 claims 1