JPWO2020033867A5 - - Google Patents
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- JPWO2020033867A5 JPWO2020033867A5 JP2021506690A JP2021506690A JPWO2020033867A5 JP WO2020033867 A5 JPWO2020033867 A5 JP WO2020033867A5 JP 2021506690 A JP2021506690 A JP 2021506690A JP 2021506690 A JP2021506690 A JP 2021506690A JP WO2020033867 A5 JPWO2020033867 A5 JP WO2020033867A5
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- JP
- Japan
- Prior art keywords
- salp
- bone
- composition
- administration
- months
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000000988 Bone and Bones Anatomy 0.000 claims description 66
- 230000003442 weekly Effects 0.000 claims description 32
- 206010017076 Fracture Diseases 0.000 claims description 25
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 25
- 239000003937 drug carrier Substances 0.000 claims description 19
- 229940112871 Bisphosphonate drugs affecting bone structure and mineralization Drugs 0.000 claims description 15
- 210000003127 Knee Anatomy 0.000 claims description 15
- 150000004663 bisphosphonates Chemical class 0.000 claims description 15
- 239000011780 sodium chloride Substances 0.000 claims description 15
- 238000001356 surgical procedure Methods 0.000 claims description 15
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 14
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- 206010039722 Scoliosis Diseases 0.000 claims description 12
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims description 11
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims description 11
- 208000003019 Neurofibromatosis 1 Diseases 0.000 claims description 10
- 238000003780 insertion Methods 0.000 claims description 10
- 201000004931 neurofibromatosis Diseases 0.000 claims description 10
- 239000001488 sodium phosphate Substances 0.000 claims description 10
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 10
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 10
- 238000007920 subcutaneous administration Methods 0.000 claims description 9
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims description 8
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims description 8
- 230000004927 fusion Effects 0.000 claims description 8
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 8
- 229910052751 metal Inorganic materials 0.000 claims description 8
- 239000002184 metal Substances 0.000 claims description 8
- 239000011707 mineral Substances 0.000 claims description 8
- 208000001097 Ankle Fracture Diseases 0.000 claims description 6
- 210000001624 Hip Anatomy 0.000 claims description 6
- 210000002435 Tendons Anatomy 0.000 claims description 6
- 238000001804 debridement Methods 0.000 claims description 6
- 238000007918 intramuscular administration Methods 0.000 claims description 5
- 238000007913 intrathecal administration Methods 0.000 claims description 5
- 238000001990 intravenous administration Methods 0.000 claims description 5
- 238000002324 minimally invasive surgery Methods 0.000 claims description 5
- SUHOOTKUPISOBE-UHFFFAOYSA-N O-phosphoethanolamine Chemical compound NCCOP(O)(O)=O SUHOOTKUPISOBE-UHFFFAOYSA-N 0.000 claims description 4
- 230000003247 decreasing Effects 0.000 claims description 4
- 230000003628 erosive Effects 0.000 claims description 4
- 239000007943 implant Substances 0.000 claims description 4
- 210000003423 Ankle Anatomy 0.000 claims description 3
- 210000001264 Anterior Cruciate Ligament Anatomy 0.000 claims description 3
- 210000003109 Clavicle Anatomy 0.000 claims description 3
- 210000001513 Elbow Anatomy 0.000 claims description 3
- 208000003527 Femoral Neck Fractures Diseases 0.000 claims description 3
- 210000002082 Fibula Anatomy 0.000 claims description 3
- 210000003205 Muscles Anatomy 0.000 claims description 3
- 210000000282 Nails Anatomy 0.000 claims description 3
- 210000000513 Rotator Cuff Anatomy 0.000 claims description 3
- 210000002832 Shoulder Anatomy 0.000 claims description 3
- 210000003491 Skin Anatomy 0.000 claims description 3
- 210000000623 Ulna Anatomy 0.000 claims description 3
- 210000000707 Wrist Anatomy 0.000 claims description 3
- 230000022159 cartilage development Effects 0.000 claims description 3
- 230000011164 ossification Effects 0.000 claims description 3
- 238000002271 resection Methods 0.000 claims description 3
- 241000272525 Anas platyrhynchos Species 0.000 claims description 2
- 210000004369 Blood Anatomy 0.000 claims description 2
- 206010006002 Bone pain Diseases 0.000 claims description 2
- 208000001590 Congenital Abnormality Diseases 0.000 claims description 2
- 206010020590 Hypercalciuria Diseases 0.000 claims description 2
- 206010023509 Kyphosis Diseases 0.000 claims description 2
- 208000001132 Osteoporosis Diseases 0.000 claims description 2
- 206010058907 Spinal deformity Diseases 0.000 claims description 2
- 208000007103 Spondylolisthesis Diseases 0.000 claims description 2
- 210000002700 Urine Anatomy 0.000 claims description 2
- 230000033558 biomineral tissue development Effects 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 230000018678 bone mineralization Effects 0.000 claims description 2
- OLSDWRNWUGHKSY-UHFFFAOYSA-J dicalcium;phosphonato phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O OLSDWRNWUGHKSY-UHFFFAOYSA-J 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 230000005499 meniscus Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 23
- 230000000399 orthopedic Effects 0.000 claims 7
- 230000005021 gait Effects 0.000 claims 1
- 238000002513 implantation Methods 0.000 claims 1
- 238000002684 laminectomy Methods 0.000 claims 1
- 229940112869 Bone morphogenetic proteins Drugs 0.000 description 8
- 238000002591 computed tomography Methods 0.000 description 8
- 238000002601 radiography Methods 0.000 description 4
- 206010010774 Constipation Diseases 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 208000010201 Exanthema Diseases 0.000 description 2
- 102000001554 Hemoglobins Human genes 0.000 description 2
- 108010054147 Hemoglobins Proteins 0.000 description 2
- 206010022061 Injection site erythema Diseases 0.000 description 2
- 206010022998 Irritability Diseases 0.000 description 2
- 206010033078 Otitis media Diseases 0.000 description 2
- 206010035664 Pneumonia Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 206010037844 Rash Diseases 0.000 description 2
- 208000008312 Tooth Loss Diseases 0.000 description 2
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 201000008286 diarrhea Diseases 0.000 description 2
- 201000005884 exanthem Diseases 0.000 description 2
- 201000009240 nasopharyngitis Diseases 0.000 description 2
- 231100000730 tolerability Toxicity 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024034492A JP2024081665A (ja) | 2018-08-10 | 2024-03-07 | アルカリホスファターゼを用いて神経線維腫症１型および関連状態を治療する方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862717371P | 2018-08-10 | 2018-08-10 | |
| US62/717,371 | 2018-08-10 | ||
| PCT/US2019/045963 WO2020033867A2 (fr) | 2018-08-10 | 2019-08-09 | Procédés de traitement de la neurofibromatose de type 1 et d'états apparentés avec une phosphatase alcaline |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024034492A Division JP2024081665A (ja) | 2018-08-10 | 2024-03-07 | アルカリホスファターゼを用いて神経線維腫症１型および関連状態を治療する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021534111A JP2021534111A (ja) | 2021-12-09 |
| JPWO2020033867A5 true JPWO2020033867A5 (fr) | 2022-08-08 |
Family
ID=69415672
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021506690A Pending JP2021534111A (ja) | 2018-08-10 | 2019-08-09 | アルカリホスファターゼを用いて神経線維腫症１型および関連状態を治療する方法 |
| JP2024034492A Pending JP2024081665A (ja) | 2018-08-10 | 2024-03-07 | アルカリホスファターゼを用いて神経線維腫症１型および関連状態を治療する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024034492A Pending JP2024081665A (ja) | 2018-08-10 | 2024-03-07 | アルカリホスファターゼを用いて神経線維腫症１型および関連状態を治療する方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20210162023A1 (fr) |
| EP (1) | EP3833377B1 (fr) |
| JP (2) | JP2021534111A (fr) |
| ES (1) | ES2972119T3 (fr) |
| WO (1) | WO2020033867A2 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3087569A1 (fr) | 2018-01-09 | 2019-07-18 | Synthetic Biologics, Inc. | Agents de phosphatase alcaline pour le traitement de troubles neurodeveloppementaux |
| WO2019183209A1 (fr) | 2018-03-20 | 2019-09-26 | Synthetic Biologics, Inc. | Agents au phosphatase alcaline pour le traitement de troubles dus à une exposition à des radiations |
| CA3094173A1 (fr) | 2018-03-20 | 2019-09-26 | Synthetic Biologics, Inc. | Formulations de phosphatase alcaline intestinale |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5466017B2 (ja) * | 2006-12-22 | 2014-04-09 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Ｂｍｐ結合タンパク質に関する外科的適用 |
| US8685024B2 (en) * | 2010-04-14 | 2014-04-01 | Arrowhead Medical Device Technologies, Llc | Intramedullary fixation device and methods for bone fixation and stabilization |
| US20150140059A1 (en) * | 2012-05-07 | 2015-05-21 | The Regents Of The University Of California | Novel oxysterol analogue, oxy149, induces osteogenesis and hedgehog signaling and inhibits adipogenesis |
| US10052366B2 (en) * | 2012-05-21 | 2018-08-21 | Alexion Pharmaceuticsl, Inc. | Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof |
| JP6235219B2 (ja) * | 2013-03-21 | 2017-11-22 | 旭化成ファーマ株式会社 | 脊椎椎体間固定術後の骨癒合促進剤 |
| US20160097100A1 (en) * | 2013-05-17 | 2016-04-07 | Jeffrey Trent | Genetic test to predict patient response to bone morphogenetic protein in arthrodesis |
| JP2018533571A (ja) * | 2015-10-30 | 2018-11-15 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 患者の頭蓋縫合早期癒合症を治療するための方法 |
| EP3436020A4 (fr) * | 2016-04-01 | 2019-12-25 | Alexion Pharmaceuticals, Inc. | Méthodes de traitement de l'hypophosphatasie chez les adolescents et les adultes |
| WO2017171871A1 (fr) * | 2016-04-01 | 2017-10-05 | Alexion Pharmaceuticals, Inc. | Procédés de traitement de l'hypophosphatasie chez les adolescents et les adultes |
| EP3474886B1 (fr) * | 2016-06-27 | 2021-08-04 | Alexion Pharmaceuticals, Inc. | Méthodes de traitement de l'hypophosphatasie chez l'enfant et l'adolescent |
| CA3173962A1 (fr) * | 2020-09-04 | 2022-03-10 | Anna PETRYK | Methodes de traitement de troubles de la mineralisation osseuse |
-
2019
- 2019-08-09 JP JP2021506690A patent/JP2021534111A/ja active Pending
- 2019-08-09 EP EP19847015.5A patent/EP3833377B1/fr active Active
- 2019-08-09 US US17/265,894 patent/US20210162023A1/en active Pending
- 2019-08-09 WO PCT/US2019/045963 patent/WO2020033867A2/fr unknown
- 2019-08-09 ES ES19847015T patent/ES2972119T3/es active Active
-
2024
- 2024-03-07 JP JP2024034492A patent/JP2024081665A/ja active Pending
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