JPWO2020014618A5 - - Google Patents

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Publication number
JPWO2020014618A5
JPWO2020014618A5 JP2021500804A JP2021500804A JPWO2020014618A5 JP WO2020014618 A5 JPWO2020014618 A5 JP WO2020014618A5 JP 2021500804 A JP2021500804 A JP 2021500804A JP 2021500804 A JP2021500804 A JP 2021500804A JP WO2020014618 A5 JPWO2020014618 A5 JP WO2020014618A5
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JP
Japan
Prior art keywords
endogenous protein
heterologous polypeptide
cell
lamb1
endogenous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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JP2021500804A
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English (en)
Japanese (ja)
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JP2021530225A (ja
JP2021530225A5 (https=
JP7543246B2 (ja
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Priority claimed from PCT/US2019/041615 external-priority patent/WO2020014618A1/en
Publication of JP2021530225A publication Critical patent/JP2021530225A/ja
Publication of JPWO2020014618A5 publication Critical patent/JPWO2020014618A5/ja
Publication of JP2021530225A5 publication Critical patent/JP2021530225A5/ja
Priority to JP2024139532A priority Critical patent/JP2024161560A/ja
Application granted granted Critical
Publication of JP7543246B2 publication Critical patent/JP7543246B2/ja
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JP2021500804A 2018-07-13 2019-07-12 内因性タンパク質のレベルを低下させることによって生物学的産物の産生を改善する方法 Active JP7543246B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024139532A JP2024161560A (ja) 2018-07-13 2024-08-21 内因性タンパク質のレベルを低下させることによって生物学的産物の産生を改善する方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862697480P 2018-07-13 2018-07-13
US62/697,480 2018-07-13
PCT/US2019/041615 WO2020014618A1 (en) 2018-07-13 2019-07-12 Methods for improving production of biological products by reducing the level of endogenous protein

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024139532A Division JP2024161560A (ja) 2018-07-13 2024-08-21 内因性タンパク質のレベルを低下させることによって生物学的産物の産生を改善する方法

Publications (4)

Publication Number Publication Date
JP2021530225A JP2021530225A (ja) 2021-11-11
JPWO2020014618A5 true JPWO2020014618A5 (https=) 2022-07-13
JP2021530225A5 JP2021530225A5 (https=) 2022-07-13
JP7543246B2 JP7543246B2 (ja) 2024-09-02

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ID=67660787

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021500804A Active JP7543246B2 (ja) 2018-07-13 2019-07-12 内因性タンパク質のレベルを低下させることによって生物学的産物の産生を改善する方法
JP2024139532A Pending JP2024161560A (ja) 2018-07-13 2024-08-21 内因性タンパク質のレベルを低下させることによって生物学的産物の産生を改善する方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024139532A Pending JP2024161560A (ja) 2018-07-13 2024-08-21 内因性タンパク質のレベルを低下させることによって生物学的産物の産生を改善する方法

Country Status (8)

Country Link
US (2) US12497624B2 (https=)
EP (1) EP3807399A1 (https=)
JP (2) JP7543246B2 (https=)
KR (1) KR20210030949A (https=)
CN (2) CN120174006A (https=)
IL (1) IL280086B2 (https=)
SG (1) SG11202013191TA (https=)
WO (1) WO2020014618A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI912369B (zh) * 2020-09-21 2026-01-21 法商賽諾菲公司 用於生產治療蛋白之高生產重組中國倉鼠卵巢細胞株之世代
WO2024178239A1 (en) * 2023-02-22 2024-08-29 Shattuck Labs, Inc. Engineered cell lines and uses thereof
EP4438622A1 (en) * 2023-03-30 2024-10-02 Sartorius Stedim Cellca GmbH Cho cells with optimized ecm profile

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9022545D0 (en) 1990-10-17 1990-11-28 Wellcome Found Culture medium
IT1258959B (it) 1992-06-09 1996-03-11 Impianto a moduli mobili per lo sviluppo e la produzione di prodotti biotecnologici su scala pilota
EP1958962A3 (en) 1997-06-12 2013-05-01 Novartis International Pharmaceutical Ltd. Artificial antibody polypeptides
DE10256083A1 (de) 2002-11-29 2004-08-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Expressionsvektor, Verfahren zur Herstellung von heterologen Genprodukten und Selektionsverfahren für hochproduzierende rekombinante Zellen
EP1719025B1 (en) 2004-02-03 2019-10-23 GE Healthcare Bio-Sciences Corp. System and method for manufacturing
MXPA06014099A (es) 2004-06-04 2007-05-09 Xcellerex Inc Sistemas biorreactores desechables y metodos.
US7531327B2 (en) * 2004-07-23 2009-05-12 Immunomedics, Inc. Methods and compositions for increasing longevity and protein yield from a cell culture
CA2632520A1 (en) 2005-12-05 2007-06-14 Ernest G. Hope Prevalidated, modular good manufacturing practice-compliant facility
EP2528002B1 (en) 2007-04-16 2015-11-04 Momenta Pharmaceuticals, Inc. Defined glycoprotein products and related methods
EP2216395A1 (en) 2009-02-09 2010-08-11 Lonza Biologics plc. Bioreactor for the cultivation of mammalian cells
US8771635B2 (en) 2010-04-26 2014-07-08 Toyota Motor Engineering & Manufacturing North America, Inc. Hydrogen release from complex metal hydrides by solvation in ionic liquids
US10371394B2 (en) 2010-09-20 2019-08-06 Biologics Modular Llc Mobile, modular cleanroom facility
WO2012082509A2 (en) * 2010-12-15 2012-06-21 Sigma-Aldrich Co. Llc Biomarkers for enhanced protein production
US9388373B2 (en) 2011-03-08 2016-07-12 University Of Maryland Baltimore County Microscale bioprocessing system and method for protein manufacturing
KR102530118B1 (ko) * 2012-07-25 2023-05-08 더 브로드 인스티튜트, 인코퍼레이티드 유도 ｄｎａ 결합 단백질 및 게놈 교란 도구 및 이의 적용
SI2970875T2 (sl) 2013-03-15 2026-03-31 F. Hoffmann-La Roche Ag Sestavki celičnih kultur z antioksidanti in postopki za proizvodnjo polipeptidov
WO2015103438A2 (en) * 2014-01-02 2015-07-09 Genelux Corporation Oncolytic virus adjunct therapy with agents that increase virus infectivity
EP3556858A3 (en) 2014-04-09 2020-01-22 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating cystic fibrosis
WO2017186671A1 (en) * 2016-04-25 2017-11-02 Danmarks Tekniske Universitet Engineered mammalian cells for production of recombinant proteins
CN107354157B (zh) * 2017-07-20 2020-05-19 浙江大学 特异性抑制LAMB1基因表达的siRNA及其重组载体和应用

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