JPWO2019246450A5 - - Google Patents
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- Publication number
- JPWO2019246450A5 JPWO2019246450A5 JP2020570909A JP2020570909A JPWO2019246450A5 JP WO2019246450 A5 JPWO2019246450 A5 JP WO2019246450A5 JP 2020570909 A JP2020570909 A JP 2020570909A JP 2020570909 A JP2020570909 A JP 2020570909A JP WO2019246450 A5 JPWO2019246450 A5 JP WO2019246450A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- cancer
- rna molecule
- rig
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862687606P | 2018-06-20 | 2018-06-20 | |
| US62/687,606 | 2018-06-20 | ||
| US201862743369P | 2018-10-09 | 2018-10-09 | |
| US62/743,369 | 2018-10-09 | ||
| US201962815870P | 2019-03-08 | 2019-03-08 | |
| US62/815,870 | 2019-03-08 | ||
| PCT/US2019/038323 WO2019246450A1 (en) | 2018-06-20 | 2019-06-20 | Rig-i agonists and treatments using same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021529173A JP2021529173A (ja) | 2021-10-28 |
| JPWO2019246450A5 true JPWO2019246450A5 (https=) | 2022-06-10 |
| JP2021529173A5 JP2021529173A5 (https=) | 2022-06-10 |
Family
ID=68982664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020570909A Pending JP2021529173A (ja) | 2018-06-20 | 2019-06-20 | Ｒｉｇ−ｉアゴニストおよびそれを使用した処置 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US12472198B2 (https=) |
| EP (1) | EP3810151B1 (https=) |
| JP (1) | JP2021529173A (https=) |
| CN (1) | CN112672748A (https=) |
| CA (1) | CA3110102A1 (https=) |
| WO (1) | WO2019246450A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180133327A1 (en) | 2015-03-16 | 2018-05-17 | Amal Therapeutics Sa | Cell Penetrating Peptides and Complexes Comprising the Same |
| DK3429618T5 (da) | 2016-03-16 | 2024-09-16 | Amal Therapeutics Sa | Kombination af en immuncheckpoint-modulator og et kompleks som omfatter et cellepenetrerende peptid, en last og en tlr-peptidagonist til anvendelse i medicin |
| DK3515476T3 (da) | 2016-09-21 | 2024-09-02 | Amal Therapeutics Sa | Fusion der omfatter et cellepenetrerende peptid, en multiepitop og en trl-peptidagnost til behandlingen af cancer |
| WO2019204743A1 (en) * | 2018-04-19 | 2019-10-24 | Checkmate Pharmaceuticals, Inc. | Synthetic rig-i-like receptor agonists |
| JP2022512651A (ja) * | 2018-10-09 | 2022-02-07 | イエール ユニバーシティ | Ｒｉｇ－ｉアゴニストおよびそれを使用する方法 |
| US20220395487A1 (en) * | 2019-11-04 | 2022-12-15 | Yale University | Rig-i innate immune receptor antagonists and methods of using same |
| EP4228681A1 (en) * | 2020-10-14 | 2023-08-23 | Boehringer Ingelheim International GmbH | Combination of a sting agonist and a complex comprising a cell penetrating peptide, a cargo and a tlr peptide agonist |
| US11786545B2 (en) * | 2020-12-09 | 2023-10-17 | Yale University | Compositions and methods for treating SARS-CoV-2 infection |
| JP2024527322A (ja) | 2021-07-02 | 2024-07-24 | イエール ユニバーシティ | がんを治療するための組成物および方法 |
| WO2023034864A1 (en) | 2021-08-31 | 2023-03-09 | Yale University | Compositions and methods for treating cancers |
| WO2023168352A1 (en) | 2022-03-03 | 2023-09-07 | Yale University | Humanized 3e10 antibodies, variants, and antigen binding fragments thereof |
| CN114814231B (zh) * | 2022-03-08 | 2024-08-27 | 上海交通大学医学院附属瑞金医院 | 维甲酸诱导基因i在癌症治疗中的应用 |
| WO2025040743A1 (en) | 2023-08-22 | 2025-02-27 | Univerza V Ljubljani | Conjugated tlr7 and rig-i agonists |
| WO2026039779A1 (en) | 2024-08-15 | 2026-02-19 | Yale University | Humanized 3e10 antibodies and antigen binding fragments optimized for rad51 binding |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3687808A (en) | 1969-08-14 | 1972-08-29 | Univ Leland Stanford Junior | Synthetic polynucleotides |
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| US5350674A (en) | 1992-09-04 | 1994-09-27 | Becton, Dickinson And Company | Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof |
| US6156501A (en) | 1993-10-26 | 2000-12-05 | Affymetrix, Inc. | Arrays of modified nucleic acid probes and methods of use |
| FR2722506B1 (fr) | 1994-07-13 | 1996-08-14 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucleiques, preparation et utilisations |
| ES2192672T3 (es) | 1996-11-18 | 2003-10-16 | Takeshi Imanishi | Nuevos analogos de nucleotidos. |
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| US6143877A (en) | 1997-04-30 | 2000-11-07 | Epoch Pharmaceuticals, Inc. | Oligonucleotides including pyrazolo[3,4-D]pyrimidine bases, bound in double stranded nucleic acids |
| AU9063398A (en) | 1997-09-12 | 1999-04-05 | Exiqon A/S | Oligonucleotide analogues |
| US6127121A (en) | 1998-04-03 | 2000-10-03 | Epoch Pharmaceuticals, Inc. | Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination |
| JP4768132B2 (ja) | 1999-03-24 | 2011-09-07 | エクシコン エ／エス | ［２．２．１］ビシクロヌクレオシドの改良された製法 |
| EP1178999B1 (en) | 1999-05-04 | 2007-03-14 | Santaris Pharma A/S | L-ribo-lna analogues |
| US6287778B1 (en) | 1999-10-19 | 2001-09-11 | Affymetrix, Inc. | Allele detection using primer extension with sequence-coded identity tags |
| US6660845B1 (en) | 1999-11-23 | 2003-12-09 | Epoch Biosciences, Inc. | Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof |
| US20090247613A1 (en) | 2002-02-20 | 2009-10-01 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF B-CELL CLL/LYMPHOMA-2 (BCL2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| US8017737B2 (en) | 2002-11-19 | 2011-09-13 | Hasan Kulaksiz | Diagnostic methods for diseases by screening for hepcidin in human or animal tissues, blood or body fluids; monoclonal antibodies specific to human hepcidin and associated uses therefor |
| US20070270360A1 (en) | 2003-04-15 | 2007-11-22 | Sirna Therapeutics, Inc. | Rna Interference Mediated Inhibition of Severe Acute Respiratory Syndrome (Sars) Gene Expression Using Short Interfering Nucleic Acid |
| CA2538169A1 (en) | 2003-09-09 | 2005-03-17 | Albert Einstein College Of Medicine Of Yeshiva University | Transition state analog inhibitors of ricin a-chain |
| US20080293053A1 (en) | 2006-12-28 | 2008-11-27 | The Regents Of The University Of Michigan | shRNA Materials and Methods of Using Same for Inhibition of DKK-1 |
| US20090123501A1 (en) | 2007-05-17 | 2009-05-14 | Baylor College Of Medicine | Inhibition of the sh2-domain containing protein tyr-phosphatase, shp-1, to enhance vaccines |
| JP2011518116A (ja) | 2008-02-21 | 2011-06-23 | ユニバーシティ オブ ケンタッキー リサーチ ファウンデーション | トール様受容体３拮抗薬としての超小型ｒｎａ |
| WO2009126933A2 (en) | 2008-04-11 | 2009-10-15 | Alnylam Pharmaceuticals, Inc. | Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components |
| EP2297323A1 (en) | 2008-05-21 | 2011-03-23 | Hartmann, Gunther | 5' triphosphate oligonucleotide with blunt end and uses thereof |
| EP2318528A1 (en) | 2008-07-24 | 2011-05-11 | Rxi Pharmaceuticals Corporation | Rnai constructs and uses therof |
| US8283460B2 (en) | 2008-10-15 | 2012-10-09 | Somagenics, Inc. | Short hairpin RNAs for inhibition of gene expression |
| WO2010111891A1 (zh) | 2009-04-03 | 2010-10-07 | 北京大学 | 修饰的寡聚核酸分子及其制备方法和应用 |
| EP2508530A1 (en) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
| JP2015502365A (ja) | 2011-12-12 | 2015-01-22 | オンコイミューニン，インコーポレイティド | オリゴヌクレオチドのイン−ビボ送達 |
| US10947543B2 (en) * | 2013-03-13 | 2021-03-16 | Yale University | Interferon production using short RNA duplexes |
| RS59500B1 (sr) * | 2013-05-18 | 2019-12-31 | Aduro Biotech Inc | Sastavi i metode za aktiviranje signaliziranja koje je zavisno od „stimulatora gena za interferon“ |
| US10392444B2 (en) | 2014-08-08 | 2019-08-27 | Oncoquest, Inc. | Tumor antigen specific antibodies and TLR3 stimulation to enhance the performance of checkpoint interference therapy of cancer |
| CA3089875A1 (en) * | 2016-02-15 | 2017-08-24 | Trizell Ltd. | Improved interferon therapy |
| WO2017173427A1 (en) | 2016-04-01 | 2017-10-05 | Vycellix Inc | Novel rna construct and methods of use thereof for enhancing the therapeutic effects of cytotoxic cells and stem cells |
| MX2019001920A (es) * | 2016-08-19 | 2019-07-01 | Curevac Ag | Arn la terapia contra el cancer. |
| US11382966B2 (en) * | 2017-03-24 | 2022-07-12 | Rigontec Gmbh | Method for designing RIG-I ligands |
| US10710272B2 (en) | 2017-12-14 | 2020-07-14 | United Technologies Corporation | Hybrid material airflow impression molds |
| US10736957B2 (en) | 2017-12-19 | 2020-08-11 | President And Fellows Of Harvard College | Enhanced immunogenicity of mRNA with co-encoded adjuvant sequences |
| EP3727146A4 (en) | 2017-12-19 | 2021-10-06 | Blaze Bioscience, Inc. | TUMOR HOMING AND CELL-PENETANT PEPTIDE IMMUNO-ONCOLOGY AGENT COMPLEX AND METHOD OF USE |
| TW201930591A (zh) * | 2018-01-08 | 2019-08-01 | 瑞士商諾華公司 | 用於與嵌合抗原受體療法併用之免疫增強rna |
| US11499157B2 (en) * | 2018-01-17 | 2022-11-15 | Nanyang Technological University | Immunomodulatory small hairpin RNA molecules |
| WO2019204743A1 (en) | 2018-04-19 | 2019-10-24 | Checkmate Pharmaceuticals, Inc. | Synthetic rig-i-like receptor agonists |
-
2019
- 2019-06-20 CA CA3110102A patent/CA3110102A1/en active Pending
- 2019-06-20 EP EP19822447.9A patent/EP3810151B1/en active Active
- 2019-06-20 US US17/251,921 patent/US12472198B2/en active Active
- 2019-06-20 CN CN201980055031.8A patent/CN112672748A/zh not_active Withdrawn
- 2019-06-20 WO PCT/US2019/038323 patent/WO2019246450A1/en not_active Ceased
- 2019-06-20 JP JP2020570909A patent/JP2021529173A/ja active Pending
- 2019-09-03 US US16/558,564 patent/US20200061097A1/en not_active Abandoned
-
2022
- 2022-07-13 US US17/864,199 patent/US20230201242A1/en not_active Abandoned
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