JPWO2019241503A5 - - Google Patents
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- JPWO2019241503A5 JPWO2019241503A5 JP2020569002A JP2020569002A JPWO2019241503A5 JP WO2019241503 A5 JPWO2019241503 A5 JP WO2019241503A5 JP 2020569002 A JP2020569002 A JP 2020569002A JP 2020569002 A JP2020569002 A JP 2020569002A JP WO2019241503 A5 JPWO2019241503 A5 JP WO2019241503A5
- Authority
- JP
- Japan
- Prior art keywords
- dose
- aminosterol
- pharmaceutical composition
- subject
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000008194 pharmaceutical composition Substances 0.000 claims 41
- WUJVPODXELZABP-FWJXURDUSA-N trodusquemine Chemical compound C([C@@H]1C[C@H]2O)[C@@H](NCCCNCCCCNCCCN)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CC[C@H](C(C)C)OS(O)(=O)=O)[C@@]2(C)CC1 WUJVPODXELZABP-FWJXURDUSA-N 0.000 claims 40
- 150000003839 salts Chemical class 0.000 claims 28
- 238000000034 method Methods 0.000 claims 22
- 230000004770 neurodegeneration Effects 0.000 claims 21
- 208000019116 sleep disease Diseases 0.000 claims 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 15
- 208000015122 neurodegenerative disease Diseases 0.000 claims 15
- 238000012360 testing method Methods 0.000 claims 14
- 230000003111 delayed effect Effects 0.000 claims 12
- 208000024891 symptom Diseases 0.000 claims 12
- 208000035475 disorder Diseases 0.000 claims 11
- 230000007958 sleep Effects 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 9
- 206010012289 Dementia Diseases 0.000 claims 8
- 230000006872 improvement Effects 0.000 claims 8
- 230000013872 defecation Effects 0.000 claims 7
- 238000009472 formulation Methods 0.000 claims 7
- 208000010877 cognitive disease Diseases 0.000 claims 6
- 230000012010 growth Effects 0.000 claims 5
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- 208000024827 Alzheimer disease Diseases 0.000 claims 4
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 4
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 230000003930 cognitive ability Effects 0.000 claims 2
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- 238000007920 subcutaneous administration Methods 0.000 claims 2
- ZCXUVYAZINUVJD-AHXZWLDOSA-N 2-deoxy-2-((18)F)fluoro-alpha-D-glucose Chemical compound OC[C@H]1O[C@H](O)[C@H]([18F])[C@@H](O)[C@@H]1O ZCXUVYAZINUVJD-AHXZWLDOSA-N 0.000 claims 1
- AOYNUTHNTBLRMT-SLPGGIOYSA-N 2-deoxy-2-fluoro-aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](F)C=O AOYNUTHNTBLRMT-SLPGGIOYSA-N 0.000 claims 1
- 206010000125 Abnormal dreams Diseases 0.000 claims 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 1
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- 206010008111 Cerebral haemorrhage Diseases 0.000 claims 1
- 206010067466 Cerebral microangiopathy Diseases 0.000 claims 1
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- 238000013019 agitation Methods 0.000 claims 1
- 102000003802 alpha-Synuclein Human genes 0.000 claims 1
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- 239000003795 chemical substances by application Substances 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
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- 102000004169 proteins and genes Human genes 0.000 claims 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862684496P | 2018-06-13 | 2018-06-13 | |
| US62/684,496 | 2018-06-13 | ||
| PCT/US2019/036946 WO2019241503A1 (en) | 2018-06-13 | 2019-06-13 | Methods and compositions for treating and/or preventing the progression and/or onset of age-related neurodegeneration |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021527090A JP2021527090A (ja) | 2021-10-11 |
| JPWO2019241503A5 true JPWO2019241503A5 (https=) | 2022-04-22 |
| JP2021527090A5 JP2021527090A5 (https=) | 2022-04-22 |
Family
ID=68838925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020569002A Pending JP2021527090A (ja) | 2018-06-13 | 2019-06-13 | 老化関連神経変性の進行および／または発症を治療および／または予防するための方法および組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20190381071A1 (https=) |
| EP (1) | EP3806862A4 (https=) |
| JP (1) | JP2021527090A (https=) |
| KR (1) | KR20210009422A (https=) |
| CN (1) | CN112566641A (https=) |
| AU (1) | AU2019285065A1 (https=) |
| BR (1) | BR112020025296A2 (https=) |
| CA (1) | CA3103463A1 (https=) |
| MX (1) | MX2020013614A (https=) |
| SG (1) | SG11202012343TA (https=) |
| WO (1) | WO2019241503A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11464789B2 (en) | 2018-08-03 | 2022-10-11 | Enterin, Inc. | Aminosterol compositions and methods of using the same for treating schizophrenia |
| EP3829587A4 (en) * | 2018-08-03 | 2022-07-20 | Enterin, Inc. | COMPOSITIONS AND METHODS FOR TREATMENT OF BRAIN AND GUESS DISORDERS |
| WO2020028791A1 (en) * | 2018-08-03 | 2020-02-06 | Enterin Laboratories | Low dosage intranasal aminosterol dosage forms and methods of using the same |
| CN110827282B (zh) * | 2020-01-13 | 2020-04-10 | 南京慧脑云计算有限公司 | 一种基于磁共振成像的脑白质纤维束示踪分析方法及系统 |
| CN111110873A (zh) * | 2020-02-24 | 2020-05-08 | 苏州欣影生物医药技术有限公司 | 一种磁共振/核医学双模态分子影像探针的制备方法 |
| CN111528839B (zh) * | 2020-05-29 | 2023-06-23 | 北京京东方健康科技有限公司 | 睡眠检测方法和装置、助眠设备和方法 |
| WO2022244929A1 (ko) * | 2021-05-21 | 2022-11-24 | 애니머스큐어 주식회사 | 이노토디올을 포함하는 근육 질환의 예방 또는 치료용 조성물 |
| WO2025054408A1 (en) * | 2023-09-07 | 2025-03-13 | NeuroTherapia, Inc. | Methods of treating cognitive impairment |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6143738A (en) * | 1995-06-07 | 2000-11-07 | Magainin Pharmaceuticals, Inc. | Therapeutic uses for an aminosterol compound |
| JP2010538072A (ja) * | 2007-09-06 | 2010-12-09 | ジェナエラ コーポレイション | 糖尿病を治療する方法 |
| WO2011066260A2 (en) * | 2009-11-25 | 2011-06-03 | Michael Zasloff | Formulations comprising aminosterols |
| US10040817B2 (en) * | 2013-10-03 | 2018-08-07 | Enterin Laboratories, Inc. | Methods and compositions for stimulation of the intestinal enteroendocrine system for treating diseases or conditions related to the same |
-
2019
- 2019-06-13 AU AU2019285065A patent/AU2019285065A1/en not_active Abandoned
- 2019-06-13 US US16/440,414 patent/US20190381071A1/en not_active Abandoned
- 2019-06-13 EP EP19818961.5A patent/EP3806862A4/en not_active Withdrawn
- 2019-06-13 CN CN201980052151.2A patent/CN112566641A/zh active Pending
- 2019-06-13 US US17/251,322 patent/US20210252023A1/en not_active Abandoned
- 2019-06-13 MX MX2020013614A patent/MX2020013614A/es unknown
- 2019-06-13 CA CA3103463A patent/CA3103463A1/en active Pending
- 2019-06-13 JP JP2020569002A patent/JP2021527090A/ja active Pending
- 2019-06-13 WO PCT/US2019/036946 patent/WO2019241503A1/en not_active Ceased
- 2019-06-13 SG SG11202012343TA patent/SG11202012343TA/en unknown
- 2019-06-13 KR KR1020217000559A patent/KR20210009422A/ko not_active Ceased
- 2019-06-13 BR BR112020025296-4A patent/BR112020025296A2/pt not_active IP Right Cessation
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