JPWO2019209787A5 - - Google Patents
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- Publication number
- JPWO2019209787A5 JPWO2019209787A5 JP2020556946A JP2020556946A JPWO2019209787A5 JP WO2019209787 A5 JPWO2019209787 A5 JP WO2019209787A5 JP 2020556946 A JP2020556946 A JP 2020556946A JP 2020556946 A JP2020556946 A JP 2020556946A JP WO2019209787 A5 JPWO2019209787 A5 JP WO2019209787A5
- Authority
- JP
- Japan
- Prior art keywords
- sustained release
- liposome
- mol
- release composition
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 23
- 239000002502 liposome Substances 0.000 claims 20
- 238000013268 sustained release Methods 0.000 claims 17
- 239000012730 sustained-release form Substances 0.000 claims 17
- 150000003904 phospholipids Chemical class 0.000 claims 13
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims 9
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 9
- 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 claims 9
- 229940079593 drug Drugs 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 239000002245 particle Substances 0.000 claims 6
- 229920001223 polyethylene glycol Polymers 0.000 claims 6
- 150000002632 lipids Chemical class 0.000 claims 5
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 229930182558 Sterol Natural products 0.000 claims 4
- 150000003432 sterols Chemical class 0.000 claims 4
- 235000003702 sterols Nutrition 0.000 claims 4
- 208000019693 Lung disease Diseases 0.000 claims 3
- 239000000232 Lipid Bilayer Substances 0.000 claims 2
- -1 phosphatidylethanolamine lipids Chemical class 0.000 claims 2
- 239000002516 radical scavenger Substances 0.000 claims 2
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 1
- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 claims 1
- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 claims 1
- BYJWPEVWNDKYJY-WJFHKOEASA-N CCCCCCCCCCCCCCCC(OC[C@H](COP([O-])(OCC[N+](C)(C)C)=O)OC(CCCCCCCCCCCCCCC)=O)=O.CCCCCCCCCCCCCCCC(OC[C@H](COP([O-])(OCC[N+](C)(C)C)=O)OC(CCCCCCCCCCCCCCC)=O)=O Chemical compound CCCCCCCCCCCCCCCC(OC[C@H](COP([O-])(OCC[N+](C)(C)C)=O)OC(CCCCCCCCCCCCCCC)=O)=O.CCCCCCCCCCCCCCCC(OC[C@H](COP([O-])(OCC[N+](C)(C)C)=O)OC(CCCCCCCCCCCCCCC)=O)=O BYJWPEVWNDKYJY-WJFHKOEASA-N 0.000 claims 1
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 1
- 239000002147 L01XE04 - Sunitinib Substances 0.000 claims 1
- 239000005511 L01XE05 - Sorafenib Substances 0.000 claims 1
- 239000003798 L01XE11 - Pazopanib Substances 0.000 claims 1
- 239000002118 L01XE12 - Vandetanib Substances 0.000 claims 1
- 239000002138 L01XE21 - Regorafenib Substances 0.000 claims 1
- 239000002176 L01XE26 - Cabozantinib Substances 0.000 claims 1
- 201000009594 Systemic Scleroderma Diseases 0.000 claims 1
- 206010042953 Systemic sclerosis Diseases 0.000 claims 1
- JLPULHDHAOZNQI-JLOPVYAASA-N [(2r)-3-hexadecanoyloxy-2-[(9e,12e)-octadeca-9,12-dienoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC JLPULHDHAOZNQI-JLOPVYAASA-N 0.000 claims 1
- 238000012387 aerosolization Methods 0.000 claims 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical group N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims 1
- 235000011130 ammonium sulphate Nutrition 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 229960003005 axitinib Drugs 0.000 claims 1
- RITAVMQDGBJQJZ-FMIVXFBMSA-N axitinib Chemical compound CNC(=O)C1=CC=CC=C1SC1=CC=C(C(\C=C\C=2N=CC=CC=2)=NN2)C2=C1 RITAVMQDGBJQJZ-FMIVXFBMSA-N 0.000 claims 1
- 229960001292 cabozantinib Drugs 0.000 claims 1
- ONIQOQHATWINJY-UHFFFAOYSA-N cabozantinib Chemical compound C=12C=C(OC)C(OC)=CC2=NC=CC=1OC(C=C1)=CC=C1NC(=O)C1(C(=O)NC=2C=CC(F)=CC=2)CC1 ONIQOQHATWINJY-UHFFFAOYSA-N 0.000 claims 1
- 238000011068 loading method Methods 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 229960004378 nintedanib Drugs 0.000 claims 1
- XZXHXSATPCNXJR-ZIADKAODSA-N nintedanib Chemical group O=C1NC2=CC(C(=O)OC)=CC=C2\C1=C(C=1C=CC=CC=1)\NC(C=C1)=CC=C1N(C)C(=O)CN1CCN(C)CC1 XZXHXSATPCNXJR-ZIADKAODSA-N 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 229960000639 pazopanib Drugs 0.000 claims 1
- CUIHSIWYWATEQL-UHFFFAOYSA-N pazopanib Chemical compound C1=CC2=C(C)N(C)N=C2C=C1N(C)C(N=1)=CC=NC=1NC1=CC=C(C)C(S(N)(=O)=O)=C1 CUIHSIWYWATEQL-UHFFFAOYSA-N 0.000 claims 1
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
- 229960004836 regorafenib Drugs 0.000 claims 1
- FNHKPVJBJVTLMP-UHFFFAOYSA-N regorafenib Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 FNHKPVJBJVTLMP-UHFFFAOYSA-N 0.000 claims 1
- 229960003787 sorafenib Drugs 0.000 claims 1
- 229960001796 sunitinib Drugs 0.000 claims 1
- WINHZLLDWRZWRT-ATVHPVEESA-N sunitinib Chemical compound CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C WINHZLLDWRZWRT-ATVHPVEESA-N 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 229960000241 vandetanib Drugs 0.000 claims 1
- UHTHHESEBZOYNR-UHFFFAOYSA-N vandetanib Chemical compound COC1=CC(C(/N=CN2)=N/C=3C(=CC(Br)=CC=3)F)=C2C=C1OCC1CCN(C)CC1 UHTHHESEBZOYNR-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862661217P | 2018-04-23 | 2018-04-23 | |
| US62/661,217 | 2018-04-23 | ||
| PCT/US2019/028647 WO2019209787A1 (en) | 2018-04-23 | 2019-04-23 | Inhalable liposomal sustained release composition for use in treating pulmonary diseases |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021522163A JP2021522163A (ja) | 2021-08-30 |
| JPWO2019209787A5 true JPWO2019209787A5 (https=) | 2022-04-19 |
| JP2021522163A5 JP2021522163A5 (https=) | 2022-04-19 |
| JP7391039B2 JP7391039B2 (ja) | 2023-12-04 |
Family
ID=66821301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020556946A Active JP7391039B2 (ja) | 2018-04-23 | 2019-04-23 | 肺疾患の処置に使用するための吸入可能なリポソーム徐放性組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11534399B2 (https=) |
| EP (1) | EP3784213B1 (https=) |
| JP (1) | JP7391039B2 (https=) |
| KR (1) | KR20210003197A (https=) |
| CN (1) | CN112004527B (https=) |
| AU (1) | AU2019261329B2 (https=) |
| BR (1) | BR112020021412A8 (https=) |
| CA (1) | CA3101102A1 (https=) |
| ES (1) | ES2964413T3 (https=) |
| IL (1) | IL278079B2 (https=) |
| TW (1) | TWI866908B (https=) |
| WO (1) | WO2019209787A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112004527B (zh) | 2018-04-23 | 2024-09-24 | 盈擘生技股份有限公司 | 用于治疗肺部疾病的可吸入脂质体缓释组合物 |
| WO2020055713A1 (en) * | 2018-09-10 | 2020-03-19 | Taiwan Liposome Co., Ltd. | Sustained-release ophthalmic pharmaceutical compositions and uses thereof |
| US12599557B2 (en) | 2019-04-25 | 2026-04-14 | Tlc Biopharmaceuticals, Inc. | Liposomal sustained-release compositions containing a therapeutic drug and use thereof |
| CN114040750B (zh) * | 2019-05-14 | 2025-11-11 | 盈擘生技股份有限公司 | 用于治疗肺部疾病的可吸入支气管扩张剂缓释组合物 |
| TW202143949A (zh) * | 2020-03-22 | 2021-12-01 | 盈擘醫藥股份有限公司 | 用於預防或暴露後治療感染或呼吸疾病的抗病毒組成物 |
| CN112472791A (zh) * | 2020-11-16 | 2021-03-12 | 复旦大学 | CsA脂质体在制备抗SARS-CoV-2药物中的应用 |
| CN116635009A (zh) * | 2020-12-14 | 2023-08-22 | 纳米科技制药公司 | 用于递送抗癌剂的具有改进的治疗指数的组合物和方法 |
| CN114642656B8 (zh) * | 2020-12-18 | 2025-12-12 | 盈科瑞（天津）创新医药研究有限公司 | 一种吸入用尼达尼布溶液及其制备方法 |
| WO2023022520A1 (ko) * | 2021-08-18 | 2023-02-23 | 주식회사 삼양홀딩스 | 룩소리티닙의 경구용 정제 조성물 및 이의 제조 방법 |
| KR102348901B1 (ko) * | 2021-08-26 | 2022-01-07 | 충북대학교 산학협력단 | 레고라페닙을 유효성분으로 포함하는 만성폐쇄성 폐질환의 예방 또는 치료용 조성물 |
| CN116064394A (zh) * | 2021-11-01 | 2023-05-05 | 中国医学科学院医药生物技术研究所 | 肿瘤细胞外泌体与脂质体的杂化外泌体、其制备方法及其抗肿瘤用途 |
| JP2025069482A (ja) * | 2022-03-25 | 2025-05-01 | 国立研究開発法人医薬基盤・健康・栄養研究所 | 特発性肺線維症の治療または予防剤 |
| TW202415382A (zh) * | 2022-09-30 | 2024-04-16 | 大陸商上海濟煜醫藥科技有限公司 | 脂質體藥物組合物及其製備方法和用途 |
| BE1031669B1 (fr) * | 2023-06-02 | 2025-01-14 | Inhatarget Therapeutics | Composition pharmaceutique pour inhalation |
| EP4637764A1 (en) * | 2023-12-22 | 2025-10-29 | Zedira GmbH | Oxo-pyridine derivatives as inhibitors of transglutaminases for use in the treatment of pulmonary fibrosis |
| WO2025138298A1 (zh) * | 2023-12-30 | 2025-07-03 | 北京睿创康泰医药研究院有限公司 | 一种尼达尼布超分子复合体的药物组合物 |
| CN117899020A (zh) * | 2024-01-16 | 2024-04-19 | 中山大学 | 一种载抗生素黏液渗透型脂质体粉雾剂的制备方法及其应用 |
| CN118948812A (zh) * | 2024-08-06 | 2024-11-15 | 北京悦康科创医药科技股份有限公司 | 一种多肽脂质体吸入剂及其制备方法和应用 |
| KR102859152B1 (ko) * | 2024-10-24 | 2025-09-12 | 주식회사 한국리포좀 | 합성 지질 리포좀 기반의 일본 뇌염 바이러스 백신 및 그의 제조방법 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3686025T2 (de) | 1985-05-22 | 1993-01-07 | Liposome Technology Inc | Verfahren und system zum einatmen von liposomen. |
| IE63869B1 (en) | 1986-11-06 | 1995-06-14 | Res Dev Foundation | Aerosols containing liposomes and method for their preparation |
| US5958378A (en) | 1996-07-03 | 1999-09-28 | Research Development Foundation | High dose liposomal aerosol formulations containing cyclosporin A or budesonide |
| GB9912639D0 (en) | 1999-05-28 | 1999-07-28 | Britannia Pharmaceuticals Ltd | Improvements in and relating to treatment of respiratory conditions |
| DE10214983A1 (de) | 2002-04-04 | 2004-04-08 | TransMIT Gesellschaft für Technologietransfer mbH | Vernebelbare Liposomen und ihre Verwendung zur pulmonalen Applikation von Wirkstoffen |
| DE10237423A1 (de) | 2002-08-16 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen |
| EP1581236B1 (en) | 2002-10-29 | 2013-10-16 | Insmed Incorporated | Sustained release of antiinfectives |
| US7718189B2 (en) | 2002-10-29 | 2010-05-18 | Transave, Inc. | Sustained release of antiinfectives |
| KR20060015265A (ko) * | 2003-05-30 | 2006-02-16 | 알자 코포레이션 | 제제의 폐 투여 방법 |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| HUE029994T2 (en) | 2005-12-08 | 2017-04-28 | Insmed Inc | Lipid-based compositions of antiinfectives for treating pulmonary infections |
| US8071127B2 (en) | 2006-10-24 | 2011-12-06 | Aradigm Corporation | Dual action, inhaled formulations providing both an immediate and sustained release profile |
| US8119156B2 (en) | 2006-10-24 | 2012-02-21 | Aradigm Corporation | Dual action, inhaled formulations providing both an immediate and sustained release profile |
| US8268347B1 (en) | 2006-10-24 | 2012-09-18 | Aradigm Corporation | Dual action, inhaled formulations providing both an immediate and sustained release profile |
| US9333214B2 (en) | 2007-05-07 | 2016-05-10 | Insmed Incorporated | Method for treating pulmonary disorders with liposomal amikacin formulations |
| JP2010540498A (ja) * | 2007-09-28 | 2010-12-24 | ウニヴェルズィテーツシュピタール バーゼル | 癌の治療のための免疫リポソーム |
| WO2012027727A2 (en) * | 2010-08-26 | 2012-03-01 | Kunyuan Cui | Lipomacrocycles and uses thereof |
| WO2012031603A2 (en) | 2010-09-09 | 2012-03-15 | Danish Medical Consults Aps | Airway administration of angiogenesis inhibitors |
| MX2011007675A (es) | 2011-07-19 | 2012-07-11 | Cell Therapy And Technology S A De C V | Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas. |
| EP4309657A3 (en) * | 2013-02-01 | 2024-02-28 | Celator Pharmaceuticals, Inc. | Remote loading of sparingly water-soluble drugs into liposomes |
| JP6799201B2 (ja) * | 2013-07-31 | 2020-12-16 | アヴァリン ファーマ インク． | エアロゾルチロシンキナーゼ阻害剤の化合物、及びその使用 |
| KR20150026613A (ko) * | 2013-09-03 | 2015-03-11 | 삼성전자주식회사 | 소수성 물질 및 조영제를 포함하는 리포좀 및 그의 용도 |
| NZ760541A (en) | 2014-01-10 | 2022-08-26 | Avalyn Pharma Inc | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| WO2016090111A1 (en) | 2014-12-05 | 2016-06-09 | Vindico NanoBio Technology Inc. | Compositions and methods for inducing nanoparticle-mediated microvascular embolization of tumors |
| WO2016178064A1 (en) | 2015-05-06 | 2016-11-10 | Suven Life Sciences Limited | Polymorph of nintedanib ethanesulphonate, processes and intermediates thereof |
| US20180344644A1 (en) * | 2015-09-21 | 2018-12-06 | Mallinckrodt Llc | Improved stability of liposome formulations and uses thereof |
| CN108601746B (zh) * | 2016-01-08 | 2024-09-13 | 加利福尼亚大学董事会 | 用于运载物递送的具有脂质双层包衣的中孔二氧化硅纳米颗粒 |
| CA3013768A1 (en) * | 2016-02-04 | 2017-08-10 | Stem Cell Theranostics, Inc. | Pharmaceutical compositions and methods for countering chemotherapy induced cardiotoxicity |
| CN112004527B (zh) | 2018-04-23 | 2024-09-24 | 盈擘生技股份有限公司 | 用于治疗肺部疾病的可吸入脂质体缓释组合物 |
-
2019
- 2019-04-23 CN CN201980027748.1A patent/CN112004527B/zh active Active
- 2019-04-23 WO PCT/US2019/028647 patent/WO2019209787A1/en not_active Ceased
- 2019-04-23 CA CA3101102A patent/CA3101102A1/en active Pending
- 2019-04-23 TW TW108114188A patent/TWI866908B/zh active
- 2019-04-23 EP EP19729872.2A patent/EP3784213B1/en active Active
- 2019-04-23 US US17/045,940 patent/US11534399B2/en active Active
- 2019-04-23 KR KR1020207033553A patent/KR20210003197A/ko not_active Ceased
- 2019-04-23 JP JP2020556946A patent/JP7391039B2/ja active Active
- 2019-04-23 ES ES19729872T patent/ES2964413T3/es active Active
- 2019-04-23 IL IL278079A patent/IL278079B2/en unknown
- 2019-04-23 BR BR112020021412A patent/BR112020021412A8/pt unknown
- 2019-04-23 AU AU2019261329A patent/AU2019261329B2/en active Active
-
2022
- 2022-11-22 US US17/992,481 patent/US12533313B2/en active Active
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