JPWO2019197406A5 - - Google Patents
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- Publication number
- JPWO2019197406A5 JPWO2019197406A5 JP2020555145A JP2020555145A JPWO2019197406A5 JP WO2019197406 A5 JPWO2019197406 A5 JP WO2019197406A5 JP 2020555145 A JP2020555145 A JP 2020555145A JP 2020555145 A JP2020555145 A JP 2020555145A JP WO2019197406 A5 JPWO2019197406 A5 JP WO2019197406A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- use according
- bos
- transplant patients
- lung transplant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 58
- 210000004072 lung Anatomy 0.000 claims 20
- 239000007788 liquid Substances 0.000 claims 9
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 8
- 108010036949 Cyclosporine Proteins 0.000 claims 8
- 229930105110 Cyclosporin A Natural products 0.000 claims 7
- 238000002650 immunosuppressive therapy Methods 0.000 claims 6
- 229960001265 ciclosporin Drugs 0.000 claims 4
- 239000003981 vehicle Substances 0.000 claims 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 3
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 3
- 239000002502 liposome Substances 0.000 claims 3
- RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 claims 3
- 229960004866 mycophenolate mofetil Drugs 0.000 claims 3
- 239000006199 nebulizer Substances 0.000 claims 3
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 3
- 229960004618 prednisone Drugs 0.000 claims 3
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 3
- 229960001967 tacrolimus Drugs 0.000 claims 3
- 206010029888 Obliterative bronchiolitis Diseases 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 201000003848 bronchiolitis obliterans Diseases 0.000 claims 2
- 208000023367 bronchiolitis obliterans with obstructive pulmonary disease Diseases 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000000414 obstructive effect Effects 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 229940122739 Calcineurin inhibitor Drugs 0.000 claims 1
- 102100024123 Calcineurin-binding protein cabin-1 Human genes 0.000 claims 1
- 101710192106 Calcineurin-binding protein cabin-1 Proteins 0.000 claims 1
- 229940123587 Cell cycle inhibitor Drugs 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 238000013276 bronchoscopy Methods 0.000 claims 1
- 229960001334 corticosteroids Drugs 0.000 claims 1
- 229930182912 cyclosporin Natural products 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 1
- 229960002930 sirolimus Drugs 0.000 claims 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024035414A JP2024069355A (ja) | 2018-04-11 | 2024-03-07 | 閉塞性細気管支炎症候群（ｂｏｓ）の治療に使用するためのシクロスポリン製剤 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862656226P | 2018-04-11 | 2018-04-11 | |
| US62/656,226 | 2018-04-11 | ||
| EP18172067 | 2018-05-14 | ||
| EP18172067.3 | 2018-05-14 | ||
| PCT/EP2019/058958 WO2019197406A1 (en) | 2018-04-11 | 2019-04-09 | Cyclosporine formulations for use in the treatment of bronchiolitis obliterans syndrome (bos) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024035414A Division JP2024069355A (ja) | 2018-04-11 | 2024-03-07 | 閉塞性細気管支炎症候群（ｂｏｓ）の治療に使用するためのシクロスポリン製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021520396A JP2021520396A (ja) | 2021-08-19 |
| JPWO2019197406A5 true JPWO2019197406A5 (https=) | 2022-04-18 |
| JP2021520396A5 JP2021520396A5 (https=) | 2022-04-18 |
Family
ID=66049232
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020555145A Pending JP2021520396A (ja) | 2018-04-11 | 2019-04-09 | 閉塞性細気管支炎症候群（ｂｏｓ）の治療に使用するためのシクロスポリン製剤 |
| JP2024035414A Pending JP2024069355A (ja) | 2018-04-11 | 2024-03-07 | 閉塞性細気管支炎症候群（ｂｏｓ）の治療に使用するためのシクロスポリン製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024035414A Pending JP2024069355A (ja) | 2018-04-11 | 2024-03-07 | 閉塞性細気管支炎症候群（ｂｏｓ）の治療に使用するためのシクロスポリン製剤 |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US11484566B2 (https=) |
| EP (2) | EP4400119A3 (https=) |
| JP (2) | JP2021520396A (https=) |
| CN (1) | CN112105374A (https=) |
| AU (1) | AU2019253137B2 (https=) |
| BR (1) | BR112020020564A2 (https=) |
| CA (1) | CA3094891A1 (https=) |
| CO (1) | CO2020013427A2 (https=) |
| DK (1) | DK3773664T3 (https=) |
| ES (1) | ES2980198T3 (https=) |
| FI (1) | FI3773664T3 (https=) |
| HR (1) | HRP20241022T1 (https=) |
| HU (1) | HUE067518T2 (https=) |
| IL (1) | IL277253B2 (https=) |
| LT (1) | LT3773664T (https=) |
| MX (1) | MX2020010738A (https=) |
| PL (1) | PL3773664T3 (https=) |
| RS (1) | RS65713B1 (https=) |
| SI (1) | SI3773664T1 (https=) |
| SM (1) | SMT202400220T1 (https=) |
| WO (1) | WO2019197406A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3069711A1 (en) * | 2015-03-16 | 2016-09-21 | PARI Pharma GmbH | Cyclosporine formulations for use in the prevention or treatment of pulmonary chronic graft rejection |
| HRP20241022T1 (hr) * | 2018-04-11 | 2024-11-08 | Breath Therapeutics Gmbh | Formulacije ciklosporina za upotrebu u liječenju sindroma bronchiolitis obliterans (bos) |
| US10736847B2 (en) | 2018-07-03 | 2020-08-11 | Becton, Dickinson And Company | Inverting device for liposome preparation by centrifugation |
| CN114642677A (zh) * | 2020-12-21 | 2022-06-21 | 上海凯屹医药科技有限公司 | 一种稳定的含有苦丁皂苷类化合物的液体药物组合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020006901A1 (en) * | 1999-02-05 | 2002-01-17 | Aldo T. Iacono | Use of aerosolized cyclosporine for prevention and treatment of pulmonary disease |
| JP2005508220A (ja) | 2001-10-24 | 2005-03-31 | パーリ・ゲーエムベーハー | 薬用組成物調製用具 |
| DE102006051512A1 (de) | 2005-12-06 | 2007-06-14 | Pari GmbH Spezialisten für effektive Inhalation | Pharmazeutische Medikamentenzusammensetzungen mit Cyclosporin |
| EP3069711A1 (en) | 2015-03-16 | 2016-09-21 | PARI Pharma GmbH | Cyclosporine formulations for use in the prevention or treatment of pulmonary chronic graft rejection |
| HRP20241022T1 (hr) * | 2018-04-11 | 2024-11-08 | Breath Therapeutics Gmbh | Formulacije ciklosporina za upotrebu u liječenju sindroma bronchiolitis obliterans (bos) |
-
2019
- 2019-04-09 HR HRP20241022TT patent/HRP20241022T1/hr unknown
- 2019-04-09 BR BR112020020564-8A patent/BR112020020564A2/pt unknown
- 2019-04-09 CA CA3094891A patent/CA3094891A1/en active Pending
- 2019-04-09 WO PCT/EP2019/058958 patent/WO2019197406A1/en not_active Ceased
- 2019-04-09 EP EP24172897.1A patent/EP4400119A3/en active Pending
- 2019-04-09 RS RS20240768A patent/RS65713B1/sr unknown
- 2019-04-09 IL IL277253A patent/IL277253B2/en unknown
- 2019-04-09 FI FIEP19715929.6T patent/FI3773664T3/fi active
- 2019-04-09 ES ES19715929T patent/ES2980198T3/es active Active
- 2019-04-09 US US17/046,307 patent/US11484566B2/en active Active
- 2019-04-09 MX MX2020010738A patent/MX2020010738A/es unknown
- 2019-04-09 LT LTEPPCT/EP2019/058958T patent/LT3773664T/lt unknown
- 2019-04-09 SI SI201930768T patent/SI3773664T1/sl unknown
- 2019-04-09 CN CN201980025434.8A patent/CN112105374A/zh active Pending
- 2019-04-09 HU HUE19715929A patent/HUE067518T2/hu unknown
- 2019-04-09 EP EP19715929.6A patent/EP3773664B1/en active Active
- 2019-04-09 AU AU2019253137A patent/AU2019253137B2/en active Active
- 2019-04-09 SM SM20240220T patent/SMT202400220T1/it unknown
- 2019-04-09 PL PL19715929.6T patent/PL3773664T3/pl unknown
- 2019-04-09 JP JP2020555145A patent/JP2021520396A/ja active Pending
- 2019-04-09 DK DK19715929.6T patent/DK3773664T3/da active
-
2020
- 2020-10-26 CO CONC2020/0013427A patent/CO2020013427A2/es unknown
-
2022
- 2022-09-26 US US17/935,140 patent/US11701403B2/en active Active
-
2023
- 2023-05-23 US US18/321,788 patent/US12178843B2/en active Active
-
2024
- 2024-03-07 JP JP2024035414A patent/JP2024069355A/ja active Pending
- 2024-11-26 US US18/959,730 patent/US20250090625A1/en active Pending
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