JPWO2019175776A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2019175776A5 JPWO2019175776A5 JP2020548916A JP2020548916A JPWO2019175776A5 JP WO2019175776 A5 JPWO2019175776 A5 JP WO2019175776A5 JP 2020548916 A JP2020548916 A JP 2020548916A JP 2020548916 A JP2020548916 A JP 2020548916A JP WO2019175776 A5 JPWO2019175776 A5 JP WO2019175776A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- compound
- salt
- pharmaceutical
- mammal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 3
- 210000003169 central nervous system Anatomy 0.000 claims 3
- 239000008177 pharmaceutical agent Substances 0.000 claims 3
- 208000006593 Urologic Neoplasms Diseases 0.000 claims 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 2
- 230000004663 cell proliferation Effects 0.000 claims 2
- 206010046766 uterine cancer Diseases 0.000 claims 2
- 206010000830 Acute leukaemia Diseases 0.000 claims 1
- 206010061424 Anal cancer Diseases 0.000 claims 1
- 208000007860 Anus Neoplasms Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 206010006143 Brain stem glioma Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001976 Endocrine Gland Neoplasms Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 102000003996 Interferon-beta Human genes 0.000 claims 1
- 108090000467 Interferon-beta Proteins 0.000 claims 1
- 208000005016 Intestinal Neoplasms Diseases 0.000 claims 1
- 206010061252 Intraocular melanoma Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 206010052178 Lymphocytic lymphoma Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000000821 Parathyroid Neoplasms Diseases 0.000 claims 1
- 208000002471 Penile Neoplasms Diseases 0.000 claims 1
- 206010034299 Penile cancer Diseases 0.000 claims 1
- 208000007913 Pituitary Neoplasms Diseases 0.000 claims 1
- 201000005746 Pituitary adenoma Diseases 0.000 claims 1
- 206010061538 Pituitary tumour benign Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000021712 Soft tissue sarcoma Diseases 0.000 claims 1
- 101710196623 Stimulator of interferon genes protein Proteins 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 201000005969 Uveal melanoma Diseases 0.000 claims 1
- 201000005188 adrenal gland cancer Diseases 0.000 claims 1
- 208000024447 adrenal gland neoplasm Diseases 0.000 claims 1
- 201000011165 anus cancer Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000024207 chronic leukemia Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 208000030381 cutaneous melanoma Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 210000004392 genitalia Anatomy 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 229960001388 interferon-beta Drugs 0.000 claims 1
- 201000002313 intestinal cancer Diseases 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000029559 malignant endocrine neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000026045 malignant tumor of parathyroid gland Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000002575 ocular melanoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 208000021310 pituitary gland adenoma Diseases 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000003708 skin melanoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046885 vaginal cancer Diseases 0.000 claims 1
- 208000013139 vaginal neoplasm Diseases 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862643467P | 2018-03-15 | 2018-03-15 | |
| US62/643,467 | 2018-03-15 | ||
| US201862666204P | 2018-05-03 | 2018-05-03 | |
| US62/666,204 | 2018-05-03 | ||
| US201862742532P | 2018-10-08 | 2018-10-08 | |
| US62/742,532 | 2018-10-08 | ||
| US201962809990P | 2019-02-25 | 2019-02-25 | |
| US62/809,990 | 2019-02-25 | ||
| PCT/IB2019/052009 WO2019175776A1 (en) | 2018-03-15 | 2019-03-12 | Cyclopentane-based modulators of sting (stimulator of interferon genes) |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021518335A JP2021518335A (ja) | 2021-08-02 |
| JP2021518335A5 JP2021518335A5 (https=) | 2022-03-16 |
| JPWO2019175776A5 true JPWO2019175776A5 (https=) | 2022-03-16 |
| JP7266942B2 JP7266942B2 (ja) | 2023-05-01 |
Family
ID=66103038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020548916A Active JP7266942B2 (ja) | 2018-03-15 | 2019-03-12 | Ｓｔｉｎｇ（インターフェロン遺伝子刺激因子）のシクロペンタン－ベースのモジュレーター |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US10538542B2 (https=) |
| EP (1) | EP3765474B1 (https=) |
| JP (1) | JP7266942B2 (https=) |
| KR (1) | KR20200131878A (https=) |
| CN (1) | CN111918871A (https=) |
| AU (1) | AU2019234043A1 (https=) |
| BR (1) | BR112020018593A2 (https=) |
| CA (1) | CA3093631C (https=) |
| CL (1) | CL2020002352A1 (https=) |
| CR (1) | CR20200382A (https=) |
| DO (1) | DOP2020000160A (https=) |
| EC (1) | ECSP20057847A (https=) |
| ES (1) | ES2923298T3 (https=) |
| IL (1) | IL277278A (https=) |
| MA (1) | MA52012A (https=) |
| MX (1) | MX2020009587A (https=) |
| NI (1) | NI202000058A (https=) |
| PE (1) | PE20210412A1 (https=) |
| PH (1) | PH12020551486A1 (https=) |
| PY (1) | PY1919127A (https=) |
| RU (1) | RU2020130048A (https=) |
| SG (1) | SG11202008102VA (https=) |
| TW (1) | TWI741268B (https=) |
| UY (1) | UY38145A (https=) |
| WO (1) | WO2019175776A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10966999B2 (en) | 2017-12-20 | 2021-04-06 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| CN111511754B (zh) | 2017-12-20 | 2023-09-12 | 捷克共和国有机化学与生物化学研究所 | 活化sting转接蛋白的具有膦酸酯键的2’3’环状二核苷酸 |
| US10538542B2 (en) * | 2018-03-15 | 2020-01-21 | Pfizer Inc. | Cyclopentane-based modulators of STING (stimulator of interferon genes) |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TW202028179A (zh) | 2018-10-08 | 2020-08-01 | 美商普萊恩醫療公司 | 胺基酸化合物及使用方法 |
| JP2022550297A (ja) * | 2019-09-25 | 2022-12-01 | ファイザー・インク | Ｓｔｉｎｇ（インターフェロン遺伝子刺激因子）のヘテロ多環式モジュレーター |
| WO2021206158A1 (ja) | 2020-04-10 | 2021-10-14 | 小野薬品工業株式会社 | がん治療方法 |
| JP2023553069A (ja) * | 2020-12-08 | 2023-12-20 | エフ． ホフマン－ラ ロシュ アーゲー | ホスホロジチオエートオリゴヌクレオチドの新規合成 |
| US11964978B2 (en) * | 2021-03-18 | 2024-04-23 | Pfizer Inc. | Modulators of STING (stimulator of interferon genes) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| PE20170198A1 (es) * | 2014-06-04 | 2017-04-08 | Glaxosmithkline Ip Dev Ltd | Dinucleotidos ciclicos como moduladores de sting |
| GB201501462D0 (en) * | 2015-01-29 | 2015-03-18 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| US10538542B2 (en) * | 2018-03-15 | 2020-01-21 | Pfizer Inc. | Cyclopentane-based modulators of STING (stimulator of interferon genes) |
-
2019
- 2019-03-11 US US16/297,910 patent/US10538542B2/en active Active
- 2019-03-11 TW TW108108048A patent/TWI741268B/zh not_active IP Right Cessation
- 2019-03-12 MX MX2020009587A patent/MX2020009587A/es unknown
- 2019-03-12 SG SG11202008102VA patent/SG11202008102VA/en unknown
- 2019-03-12 CR CR20200382A patent/CR20200382A/es unknown
- 2019-03-12 AU AU2019234043A patent/AU2019234043A1/en not_active Abandoned
- 2019-03-12 CA CA3093631A patent/CA3093631C/en active Active
- 2019-03-12 ES ES19717149T patent/ES2923298T3/es active Active
- 2019-03-12 KR KR1020207029472A patent/KR20200131878A/ko not_active Withdrawn
- 2019-03-12 EP EP19717149.9A patent/EP3765474B1/en active Active
- 2019-03-12 WO PCT/IB2019/052009 patent/WO2019175776A1/en not_active Ceased
- 2019-03-12 JP JP2020548916A patent/JP7266942B2/ja active Active
- 2019-03-12 CN CN201980019494.9A patent/CN111918871A/zh active Pending
- 2019-03-12 PE PE2020001412A patent/PE20210412A1/es unknown
- 2019-03-12 RU RU2020130048A patent/RU2020130048A/ru unknown
- 2019-03-12 BR BR112020018593-0A patent/BR112020018593A2/pt not_active IP Right Cessation
- 2019-03-12 MA MA052012A patent/MA52012A/fr unknown
- 2019-03-13 PY PY201901919127A patent/PY1919127A/es unknown
- 2019-03-13 UY UY38145A patent/UY38145A/es not_active Application Discontinuation
- 2019-12-04 US US16/702,738 patent/US10968242B2/en active Active
-
2020
- 2020-08-25 DO DO2020000160A patent/DOP2020000160A/es unknown
- 2020-08-28 NI NI202000058A patent/NI202000058A/es unknown
- 2020-09-10 IL IL277278A patent/IL277278A/en unknown
- 2020-09-11 CL CL2020002352A patent/CL2020002352A1/es unknown
- 2020-09-12 PH PH12020551486A patent/PH12020551486A1/en unknown
- 2020-09-15 EC ECSENADI202057847A patent/ECSP20057847A/es unknown
-
2021
- 2021-03-03 US US17/190,924 patent/US20210230196A1/en not_active Abandoned
-
2023
- 2023-07-24 US US18/225,589 patent/US20230382932A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPWO2019150305A5 (https=) | ||
| JP2021518335A5 (https=) | ||
| JP2021512131A5 (https=) | ||
| JP2025024006A5 (https=) | ||
| JPWO2019175776A5 (https=) | ||
| JP2020105190A5 (https=) | ||
| RU2007110480A (ru) | Терапевтические комбинации, содержащие ингибитор поли(адф-рибоза)полимеразы | |
| HRP20191944T1 (hr) | Soli i polimorfi od 8-fluoro-2-{4-[(metilamino)metil]fenil}-1,3,4,5-tetrahidro-6h-azepino[5,4,3-cd]indol-6-ona | |
| RU2014124005A (ru) | Комбинация инотузумаба озогамицина и торизела для лечения рака | |
| RU2005128791A (ru) | Лекарственные формы, содержащие ag013736 | |
| HRP20201334T1 (hr) | Kompozicije koje sadrže kombinaciju ipilimumaba i nivolumaba | |
| RU2008122471A (ru) | Способ лечения аномального роста клеток | |
| Brzozowa-Zasada et al. | Notch signalling pathway as an oncogenic factor involved in cancer development | |
| RU2006134045A (ru) | Применение антител к ctla-4 | |
| JP2020508302A5 (https=) | ||
| JP2018510850A5 (https=) | ||
| RU2010121647A (ru) | Полиморфы ингибитора c-met/hgfr | |
| RU2020113749A (ru) | Аналоги таиланстатина | |
| RU2014141114A (ru) | Комбинированные виды терапии с использованием ингибиторов внеклеточного домена е-кадгерина | |
| Sun et al. | ARHGAP9 inhibits colorectal cancer cell proliferation, invasion and EMT via targeting PI3K/AKT/mTOR signaling pathway | |
| JP2009521685A5 (https=) | ||
| JP2020530844A5 (https=) | ||
| Farhadihosseinabadi et al. | Breast cancer: risk factors, diagnosis and management | |
| Sharma et al. | Cancer: Pathology of the century act as big killers: A disease with uncontrolled division of cells | |
| Li et al. | The effects of nursing intervention on the postoperative quality of life and early compliance of patients with cervical cancer |