JPWO2019173569A5 - - Google Patents
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- Publication number
- JPWO2019173569A5 JPWO2019173569A5 JP2020546964A JP2020546964A JPWO2019173569A5 JP WO2019173569 A5 JPWO2019173569 A5 JP WO2019173569A5 JP 2020546964 A JP2020546964 A JP 2020546964A JP 2020546964 A JP2020546964 A JP 2020546964A JP WO2019173569 A5 JPWO2019173569 A5 JP WO2019173569A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- tagged
- tbrf
- labeled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 52
- 208000007865 relapsing fever Diseases 0.000 claims description 32
- 201000006427 tick-borne relapsing fever Diseases 0.000 claims description 32
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 26
- 239000000523 sample Substances 0.000 claims description 20
- 239000012472 biological sample Substances 0.000 claims description 19
- 241000589968 Borrelia Species 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 9
- 208000016604 Lyme disease Diseases 0.000 claims description 8
- 238000009739 binding Methods 0.000 claims description 7
- 238000001514 detection method Methods 0.000 claims description 7
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 6
- 241000894007 species Species 0.000 claims description 5
- 241000589975 Borrelia coriaceae Species 0.000 claims description 4
- 241000589978 Borrelia hermsii Species 0.000 claims description 4
- 241000216520 Borrelia miyamotoi Species 0.000 claims description 4
- 241000589977 Borrelia turicatae Species 0.000 claims description 4
- 239000002033 PVDF binder Substances 0.000 claims description 4
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims description 4
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims description 3
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims description 3
- 102000004190 Enzymes Human genes 0.000 claims description 3
- 108090000790 Enzymes Proteins 0.000 claims description 3
- 229960002685 biotin Drugs 0.000 claims description 3
- 235000020958 biotin Nutrition 0.000 claims description 3
- 239000011616 biotin Substances 0.000 claims description 3
- 230000002285 radioactive effect Effects 0.000 claims description 3
- 229920000936 Agarose Polymers 0.000 claims description 2
- 239000000020 Nitrocellulose Substances 0.000 claims description 2
- 239000004677 Nylon Substances 0.000 claims description 2
- 239000011324 bead Substances 0.000 claims description 2
- 229920001220 nitrocellulos Polymers 0.000 claims description 2
- 229920001778 nylon Polymers 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 description 4
- 108090000695 Cytokines Proteins 0.000 description 4
- 241000334732 Borrelia turcica Species 0.000 description 3
- 210000001744 T-lymphocyte Anatomy 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 2
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 229960003130 interferon gamma Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 150000007523 nucleic acids Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/916,717 | 2018-03-09 | ||
| US15/916,717 US10718767B2 (en) | 2018-03-09 | 2018-03-09 | Species specific antigen sequences for tick-borne relapsing fever (TBRF) and methods of use |
| PCT/US2019/021113 WO2019173569A1 (en) | 2018-03-09 | 2019-03-07 | Species specific antigen sequences for tick-borne relapsing fever (tbrf) and methods of use |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021516340A JP2021516340A (ja) | 2021-07-01 |
| JP2021516340A5 JP2021516340A5 (https=) | 2022-03-15 |
| JPWO2019173569A5 true JPWO2019173569A5 (https=) | 2022-03-15 |
| JP7366041B2 JP7366041B2 (ja) | 2023-10-20 |
Family
ID=67843846
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020546964A Active JP7366041B2 (ja) | 2018-03-09 | 2019-03-07 | ダニ媒介性回帰熱（ｔｂｒｆ）に対する種特異的抗原配列および使用方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10718767B2 (https=) |
| EP (1) | EP3762725B1 (https=) |
| JP (1) | JP7366041B2 (https=) |
| CA (1) | CA3092156A1 (https=) |
| WO (1) | WO2019173569A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220229055A1 (en) * | 2021-01-15 | 2022-07-21 | Id-Fish Technology, Inc. | Species-specific antigen sequences for tick-borne relapsing fever (tbrf) and methods of use |
| BR112023021860A2 (pt) * | 2021-04-23 | 2023-12-19 | Id Fish Tech Inc | Composição, método para detectar infecção por uma ou mais espécies de babesia, método para detectar infecção espécie-específica por b. microti ou b. duncani e vetor |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE142888T1 (de) * | 1990-03-05 | 1996-10-15 | Us Health | Antigen-wirkende proteine von borrelia burgdorferi |
| WO1996022392A2 (en) * | 1995-01-19 | 1996-07-25 | Gen-Probe Incorporated | Nucleic acid amplification oligonucleotides and probes to lyme disease associated borrelia |
| US8247181B2 (en) * | 2007-09-07 | 2012-08-21 | The Regents Of The University Of California | Borrelia diagnostics and screening methods |
| WO2011163258A2 (en) * | 2010-06-21 | 2011-12-29 | Pharmason Labs, Inc. | Compositions and methods for diagnosing and monitoring disease and treatment via antigen-specific molecules |
| HK1244534A1 (zh) | 2014-10-07 | 2018-08-10 | The Research Foundation For The State University Of New York | 重组疏螺旋体蛋白及其使用方法 |
| US20190093149A1 (en) * | 2017-09-27 | 2019-03-28 | The United States Of America, As Represented By The Secretary Of Agriculture | Assays for detecting multiple tick-borne pathogens |
-
2018
- 2018-03-09 US US15/916,717 patent/US10718767B2/en active Active
-
2019
- 2019-03-07 CA CA3092156A patent/CA3092156A1/en active Pending
- 2019-03-07 EP EP19763607.9A patent/EP3762725B1/en active Active
- 2019-03-07 WO PCT/US2019/021113 patent/WO2019173569A1/en not_active Ceased
- 2019-03-07 JP JP2020546964A patent/JP7366041B2/ja active Active
-
2020
- 2020-06-30 US US16/916,273 patent/US11353457B2/en active Active
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