JPWO2019173380A5 - - Google Patents
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- Publication number
- JPWO2019173380A5 JPWO2019173380A5 JP2020570407A JP2020570407A JPWO2019173380A5 JP WO2019173380 A5 JPWO2019173380 A5 JP WO2019173380A5 JP 2020570407 A JP2020570407 A JP 2020570407A JP 2020570407 A JP2020570407 A JP 2020570407A JP WO2019173380 A5 JPWO2019173380 A5 JP WO2019173380A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- pharmaceutically acceptable
- acceptable salt
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024014959A JP2024032976A (ja) | 2018-03-05 | 2024-02-02 | アデノシン受容体アンタゴニストおよびその使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862638737P | 2018-03-05 | 2018-03-05 | |
| US62/638,737 | 2018-03-05 | ||
| US201862688088P | 2018-06-21 | 2018-06-21 | |
| US62/688,088 | 2018-06-21 | ||
| PCT/US2019/020810 WO2019173380A1 (en) | 2018-03-05 | 2019-03-05 | Adenosine receptor antagonists and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024014959A Division JP2024032976A (ja) | 2018-03-05 | 2024-02-02 | アデノシン受容体アンタゴニストおよびその使用 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021517164A JP2021517164A (ja) | 2021-07-15 |
| JP2021517164A5 JP2021517164A5 (https=) | 2022-04-01 |
| JPWO2019173380A5 true JPWO2019173380A5 (https=) | 2022-04-01 |
| JP7849948B2 JP7849948B2 (ja) | 2026-04-22 |
Family
ID=67847428
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020570407A Active JP7849948B2 (ja) | 2018-03-05 | 2019-03-05 | アデノシン受容体アンタゴニストおよびその使用 |
| JP2024014959A Withdrawn JP2024032976A (ja) | 2018-03-05 | 2024-02-02 | アデノシン受容体アンタゴニストおよびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024014959A Withdrawn JP2024032976A (ja) | 2018-03-05 | 2024-02-02 | アデノシン受容体アンタゴニストおよびその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20210040097A1 (https=) |
| EP (2) | EP3762386B1 (https=) |
| JP (2) | JP7849948B2 (https=) |
| KR (1) | KR102754522B1 (https=) |
| CN (1) | CN112218867B (https=) |
| AU (2) | AU2019232736B2 (https=) |
| BR (1) | BR112020018158A2 (https=) |
| ES (1) | ES2975753T3 (https=) |
| IL (1) | IL277144B2 (https=) |
| MX (1) | MX2020009286A (https=) |
| SG (1) | SG11202008611UA (https=) |
| WO (1) | WO2019173380A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2975753T3 (es) | 2018-03-05 | 2024-07-12 | Teon Therapeutics Inc | Antagonistas del receptor de adenosina y usos de los mismos |
| WO2022032091A1 (en) * | 2020-08-07 | 2022-02-10 | Teon Therapeutics, Inc. | Combination therapy with adenosine receptor antagonists |
| CN116322698A (zh) * | 2020-09-04 | 2023-06-23 | 泰昂治疗公司 | 腺苷a2b受体拮抗剂的共晶 |
| WO2022256550A1 (en) | 2021-06-04 | 2022-12-08 | Teon Therapeutics, Inc. | Crystalline forms of an adenosine a2b receptor antagonist |
| TW202327612A (zh) * | 2021-09-10 | 2023-07-16 | 美商天恩治療有限公司 | 使用腺苷受體拮抗劑之改良療法 |
| EP4554943A1 (en) * | 2022-07-14 | 2025-05-21 | Teon Therapeutics, Inc. | Adenosine receptor antagonists and uses thereof |
| WO2026035860A1 (en) | 2024-08-07 | 2026-02-12 | Teon Therapeutics, Inc. | Formulations of adenosine receptor antagonist |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5466811A (en) * | 1994-07-18 | 1995-11-14 | Merck & Co., Inc. | Dioxolenylmethyl carbamates pro moieties for amine drugs |
| CA2323047C (en) * | 1998-04-15 | 2005-03-15 | Warner-Lambert Company | Prodrugs of benzofuranylmethyl carbamate nk, antagonists |
| US20080318983A1 (en) | 2001-11-09 | 2008-12-25 | Rao Kalla | A2b adenosine receptor antagonists |
| US6977300B2 (en) | 2001-11-09 | 2005-12-20 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| US7317017B2 (en) | 2002-11-08 | 2008-01-08 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| US7125993B2 (en) | 2001-11-09 | 2006-10-24 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| US7304070B2 (en) | 2001-11-09 | 2007-12-04 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| DK1444233T3 (da) * | 2001-11-09 | 2011-10-17 | Gilead Palo Alto Inc | A2B-adenosinreceptorantagonister |
| HRP20040853A2 (en) * | 2002-03-20 | 2004-12-31 | Bristol Myers Squibb Co | Phosphate prodrugs of fluorooxindoles |
| DE60322748D1 (de) * | 2003-05-06 | 2008-09-18 | Cv Therapeutics Inc | Xanthinderivate als a2b-adenosinrezeptorantagonisten |
| MX2007002437A (es) * | 2004-09-01 | 2007-08-14 | Cv Therapeutics Inc | Metodo para el sanado de heridas utilizando antagonistas del receptor de adenosina a2b. |
| EP1799221A1 (en) | 2004-10-15 | 2007-06-27 | Cv Therapeutics, Inc. | Method of preventing and treating airway remodeling and pulmonary inflammation using a2b adenosine receptor antagonists |
| EP1891070A1 (en) | 2005-06-16 | 2008-02-27 | Cv Therapeutics, Inc. | Prodrugs of a2b adenosine receptor antagonists |
| AU2007227021B2 (en) | 2006-03-17 | 2012-12-20 | Gilead Sciences, Inc. | Method of preventing and treating hepatic disease using A2B adenosine receptor antagonists |
| WO2008066627A2 (en) | 2006-10-24 | 2008-06-05 | Board Of Regents, The University Of Texas System | Adenosine signaling in diagnosis, treatment and prevention of priapism and erectile dysfunction |
| WO2009088518A1 (en) | 2008-01-11 | 2009-07-16 | Cv Therapeutics, Inc. | A2b adenosine receptor antagonists for the treatment of cancer |
| EP2268641B1 (en) * | 2008-03-26 | 2014-09-03 | Advinus Therapeutics Pvt. Ltd. | Heterocyclic compounds as adenosine receptor antagonist |
| WO2009157938A1 (en) | 2008-06-26 | 2009-12-30 | Cv Therapeutics, Inc. | A2b adenosine receptor antagonists for treating cancer |
| AU2011270701B2 (en) * | 2010-06-24 | 2015-05-14 | Alkermes Pharma Ireland Limited | Prodrugs of NH-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives |
| BR112012032766A2 (pt) | 2010-06-30 | 2019-09-24 | Gilead Sciences Inc | uso de antagonistas do receptor de adenosina a2b para o tratamento da hipertensão pulmonar |
| CN103261200B (zh) * | 2010-09-13 | 2016-03-30 | 阿迪维纳斯疗法有限公司 | 作为a2b腺苷受体拮抗剂的前药的嘌呤化合物、它们的制备方法及医药用途 |
| AR085942A1 (es) * | 2011-04-07 | 2013-11-06 | Gilead Sciences Inc | Uso de receptor de aadenosina para tratar la insuficiencia cardiaca y la arritmia en pacientes posinfarto de miocardio |
| WO2012170209A2 (en) * | 2011-05-23 | 2012-12-13 | Nectid, Inc. | Benzofuran-2 carboxamide compounds |
| US10117868B2 (en) | 2011-10-25 | 2018-11-06 | Case Western Reserve University | Systems pharmacology for treating ocular disorders |
| CN111093669A (zh) | 2017-08-14 | 2020-05-01 | 法斯瑞斯公司 | 用于治疗癌症的腺苷受体拮抗剂的微颗粒制剂 |
| CN111741752A (zh) | 2017-12-19 | 2020-10-02 | Gpcr治疗公司 | Gpcr异聚体抑制剂及其用途 |
| ES2975753T3 (es) | 2018-03-05 | 2024-07-12 | Teon Therapeutics Inc | Antagonistas del receptor de adenosina y usos de los mismos |
-
2019
- 2019-03-05 ES ES19764343T patent/ES2975753T3/es active Active
- 2019-03-05 IL IL277144A patent/IL277144B2/en unknown
- 2019-03-05 JP JP2020570407A patent/JP7849948B2/ja active Active
- 2019-03-05 AU AU2019232736A patent/AU2019232736B2/en active Active
- 2019-03-05 CN CN201980030563.6A patent/CN112218867B/zh active Active
- 2019-03-05 KR KR1020207028522A patent/KR102754522B1/ko active Active
- 2019-03-05 US US16/978,040 patent/US20210040097A1/en not_active Abandoned
- 2019-03-05 MX MX2020009286A patent/MX2020009286A/es unknown
- 2019-03-05 SG SG11202008611UA patent/SG11202008611UA/en unknown
- 2019-03-05 EP EP19764343.0A patent/EP3762386B1/en active Active
- 2019-03-05 WO PCT/US2019/020810 patent/WO2019173380A1/en not_active Ceased
- 2019-03-05 BR BR112020018158-7A patent/BR112020018158A2/pt unknown
- 2019-03-05 EP EP24152200.2A patent/EP4364727A3/en active Pending
-
2021
- 2021-02-02 US US17/165,736 patent/US11124515B2/en active Active
- 2021-08-02 US US17/391,245 patent/US20220056033A1/en not_active Abandoned
-
2024
- 2024-02-02 JP JP2024014959A patent/JP2024032976A/ja not_active Withdrawn
- 2024-06-28 AU AU2024204483A patent/AU2024204483B2/en active Active
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