JPWO2019090169A5 - - Google Patents
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- JPWO2019090169A5 JPWO2019090169A5 JP2020524637A JP2020524637A JPWO2019090169A5 JP WO2019090169 A5 JPWO2019090169 A5 JP WO2019090169A5 JP 2020524637 A JP2020524637 A JP 2020524637A JP 2020524637 A JP2020524637 A JP 2020524637A JP WO2019090169 A5 JPWO2019090169 A5 JP WO2019090169A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762580887P | 2017-11-02 | 2017-11-02 | |
| US62/580,887 | 2017-11-02 | ||
| US201862687015P | 2018-06-19 | 2018-06-19 | |
| US62/687,015 | 2018-06-19 | ||
| PCT/US2018/059085 WO2019090169A1 (en) | 2017-11-02 | 2018-11-02 | Methods of rescuing stop codons via genetic reassignment with ace-trna |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021502078A JP2021502078A (en) | 2021-01-28 |
| JPWO2019090169A5 true JPWO2019090169A5 (en) | 2022-01-31 |
Family
ID=66332719
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020524637A Pending JP2021502078A (en) | 2017-11-02 | 2018-11-02 | How to rescue a stop codon through gene reassignment by ACE-tRNA |
| JP2020524562A Active JP7474511B2 (en) | 2017-11-02 | 2018-11-02 | Method for Rescuing Stop Codons via Genetic Reassignment Using ACE-tRNA |
| JP2023085389A Active JP7474532B2 (en) | 2017-11-02 | 2023-05-24 | Method for Rescuing Stop Codons via Genetic Reassignment Using ACE-tRNA |
| JP2024022138A Pending JP2024054361A (en) | 2017-11-02 | 2024-02-16 | Methods for rescuing stop codons via genetic reassignment with ace-trna |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020524562A Active JP7474511B2 (en) | 2017-11-02 | 2018-11-02 | Method for Rescuing Stop Codons via Genetic Reassignment Using ACE-tRNA |
| JP2023085389A Active JP7474532B2 (en) | 2017-11-02 | 2023-05-24 | Method for Rescuing Stop Codons via Genetic Reassignment Using ACE-tRNA |
| JP2024022138A Pending JP2024054361A (en) | 2017-11-02 | 2024-02-16 | Methods for rescuing stop codons via genetic reassignment with ace-trna |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US11661600B2 (en) |
| EP (2) | EP3703701A4 (en) |
| JP (4) | JP2021502078A (en) |
| KR (2) | KR20200090171A (en) |
| CN (2) | CN111818945A (en) |
| AU (2) | AU2018360065A1 (en) |
| BR (2) | BR112020008733A2 (en) |
| CA (2) | CA3081692A1 (en) |
| IL (2) | IL274356A (en) |
| MX (2) | MX2020004587A (en) |
| RU (2) | RU2020117928A (en) |
| WO (2) | WO2019090154A1 (en) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112020008733A2 (en) | 2017-11-02 | 2020-11-03 | University Of Iowa Research Foundation | method of rescuing stop codons through genetic reassignment with ace-trna |
| AU2019350869A1 (en) * | 2018-09-26 | 2021-05-20 | Case Western Reserve University | Methods and compositions for treating a premature stop codon-mediated disorder |
| EP4041317A4 (en) * | 2019-10-11 | 2024-05-22 | University of Massachusetts | Raav-mediated in vivo delivery of suppressor trnas |
| WO2021087401A1 (en) * | 2019-11-01 | 2021-05-06 | Tevard Bio, Inc. | Methods and compositions for treating a premature termination codon-mediated disorder |
| AU2020396868A1 (en) * | 2019-12-02 | 2022-07-14 | Shape Therapeutics Inc. | Targeted transfer RNAS for treatment of diseases |
| AU2021255583A1 (en) * | 2020-04-14 | 2022-11-10 | Flagship Pioneering Innovations Vi, Llc | Trem compositions and uses thereof |
| CN116133668A (en) | 2020-06-12 | 2023-05-16 | 罗切斯特大学 | Coding and expression of ACE-tRNA |
| JP2024502044A (en) * | 2020-12-31 | 2024-01-17 | ユニバーシティー オブ アイオワ リサーチ ファンデーション | Sense suppressor transfer RNA compositions and related uses and functions |
| CA3209374A1 (en) * | 2021-02-25 | 2022-09-01 | Kambiz MOUSAVI | Engineered expression constructs to increase protein expression from synthetic ribonucleic acid (rna) |
| AU2022269633A1 (en) * | 2021-05-05 | 2023-11-02 | Tevard Biosciences, Inc. | Methods and compositions for treating a premature termination codon-mediated disorder |
| CN113308463A (en) * | 2021-05-12 | 2021-08-27 | 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） | Application of tRNA edited by anticodon as molecular switch in precise control of protein expression and virus replication |
| WO2023122785A1 (en) * | 2021-12-23 | 2023-06-29 | Shape Therapeutics Inc. | Compositions and methods of trna silencing |
| AU2023210521A1 (en) | 2022-01-21 | 2024-08-29 | David H. Altreuter | Modified transfer rna with improved activity |
| AU2023212951A1 (en) * | 2022-01-25 | 2024-08-29 | Hc Bioscience, Inc. | Universal suppressor trnas and uses thereof |
| WO2023150753A1 (en) | 2022-02-07 | 2023-08-10 | University Of Rochester | Optimized sequences for enhanced trna expression or/and nonsense mutation suppression |
| CN114717204B (en) * | 2022-03-08 | 2023-12-26 | 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） | Replication-defective pseudorabies virus, construction method and application thereof |
| TW202405173A (en) | 2022-04-18 | 2024-02-01 | 美商維泰克斯製藥公司 | Compositions and methods for enhancing aav therapy and decreasing tropism of aav to the liver |
| WO2023220083A1 (en) * | 2022-05-09 | 2023-11-16 | Flagship Pioneering Innovations Vi, Llc | Trem compositions and methods of use for treating proliferative disorders |
| WO2023220342A2 (en) * | 2022-05-13 | 2023-11-16 | Shape Therapeutics Inc. | Engineered tranfer rnas |
| WO2024155745A1 (en) * | 2023-01-18 | 2024-07-25 | The Broad Institute, Inc. | Base editing-mediated readthrough of premature termination codons (bert) |
| WO2024155741A1 (en) * | 2023-01-18 | 2024-07-25 | The Broad Institute, Inc. | Prime editing-mediated readthrough of premature termination codons (pert) |
| CN118147231B (en) * | 2024-05-11 | 2024-07-12 | 北京大学 | Nucleic acid constructs comprising engineered transport ribonucleic acid molecules and uses thereof |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4687737A (en) | 1982-11-12 | 1987-08-18 | Massachusetts Institute Of Technology | Mammalian suppressor genes |
| US5840702A (en) * | 1996-03-22 | 1998-11-24 | Uab Research Foundation | Cystic fibrosis treatment |
| JP2002508959A (en) | 1998-01-14 | 2002-03-26 | ヒューマン ジーン セラピー リサーチ インスティテュート | Human suppressor tRNA oligonucleotide and method using the same |
| JPWO2002102361A1 (en) * | 2001-06-13 | 2004-09-30 | 正行 荒川 | Therapeutic agent for diseases caused by nonsense mutation |
| US6964859B2 (en) | 2001-10-16 | 2005-11-15 | Massachusetts Institute Of Technology | Suppressor tRNA system |
| EP1968635B1 (en) | 2005-12-14 | 2014-09-17 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
| GB0600948D0 (en) | 2006-01-18 | 2006-02-22 | Univ Dundee | Prevention/Treatment Of Ichthyosis Vulgaris, Atopy And Other Disorders |
| FR2902439A1 (en) * | 2006-06-14 | 2007-12-21 | Univ Rene Descartes Paris V Et | CHIMERIC TRANSFER RNA AND USE THEREOF FOR THE PRODUCTION OF RNA BY A CELL |
| WO2009086497A2 (en) | 2007-12-28 | 2009-07-09 | Ardell David H | Genetic encryption |
| US20120077186A1 (en) * | 2010-05-07 | 2012-03-29 | Oregon Health & Science University | Use of cysteine-derived suppressor trnas for non-native amino acid incorporation |
| US10513699B2 (en) | 2014-09-03 | 2019-12-24 | Bioatla, Llc | Discovering and producing conditionally active biologic proteins in the same eukaryotic cell production hosts |
| HUE032749T2 (en) | 2014-12-22 | 2017-11-28 | Sandoz Ag | Sequence variants |
| JP2018509172A (en) | 2015-03-27 | 2018-04-05 | ザ ユニバーシティ オブ クィーンズランド | Platform for unnatural amino acid incorporation into proteins |
| WO2017049409A1 (en) | 2015-09-25 | 2017-03-30 | The Centre For Drug Research And Development | Compositions for promoting readthrough of premature termination codons, and methods of using the same |
| CN107177592B (en) * | 2016-03-10 | 2021-03-30 | 北京大学 | Truncated proteins in diseases where suppressor tRNA reads through early stop codons |
| CA3024135A1 (en) | 2016-05-16 | 2017-11-23 | The Board Of Regents Of The University Of Texas System | Compositions for the delivery of trna as nanoparticles and methods of use therewith |
| WO2018031531A1 (en) | 2016-08-08 | 2018-02-15 | President And Fellows Of Harvard College | Engineered bacteria for non-invasive imaging and therapeutic applications |
| CN118416088A (en) * | 2017-03-03 | 2024-08-02 | 加利福尼亚大学董事会 | RNA targeting of mutations via inhibitory tRNAs and deaminase |
| BR112020008733A2 (en) | 2017-11-02 | 2020-11-03 | University Of Iowa Research Foundation | method of rescuing stop codons through genetic reassignment with ace-trna |
| EP3765609A1 (en) | 2018-03-15 | 2021-01-20 | Universität Hamburg | Synthetic transfer rna with extended anticodon loop |
| AU2019350869A1 (en) | 2018-09-26 | 2021-05-20 | Case Western Reserve University | Methods and compositions for treating a premature stop codon-mediated disorder |
| US10905778B2 (en) | 2018-09-26 | 2021-02-02 | Case Western Reserve University | Methods and compositions for treating a premature stop codon-mediated disorder |
| JP2022528696A (en) | 2019-04-11 | 2022-06-15 | アークタラス テラピュウティクス、インク | Synthetic transfer RNA with extended anticodon loop |
| EP4041317A4 (en) | 2019-10-11 | 2024-05-22 | University of Massachusetts | Raav-mediated in vivo delivery of suppressor trnas |
| WO2021087401A1 (en) | 2019-11-01 | 2021-05-06 | Tevard Bio, Inc. | Methods and compositions for treating a premature termination codon-mediated disorder |
| CN115003810A (en) | 2019-11-04 | 2022-09-02 | 旗舰创业股份有限公司 | TREM compositions for CON-rare codons and related uses |
| AU2020396868A1 (en) | 2019-12-02 | 2022-07-14 | Shape Therapeutics Inc. | Targeted transfer RNAS for treatment of diseases |
-
2018
- 2018-11-02 BR BR112020008733-5A patent/BR112020008733A2/en not_active Application Discontinuation
- 2018-11-02 AU AU2018360065A patent/AU2018360065A1/en active Pending
- 2018-11-02 US US16/761,205 patent/US11661600B2/en active Active
- 2018-11-02 MX MX2020004587A patent/MX2020004587A/en unknown
- 2018-11-02 RU RU2020117928A patent/RU2020117928A/en unknown
- 2018-11-02 EP EP18872570.9A patent/EP3703701A4/en active Pending
- 2018-11-02 WO PCT/US2018/059065 patent/WO2019090154A1/en active Application Filing
- 2018-11-02 JP JP2020524637A patent/JP2021502078A/en active Pending
- 2018-11-02 EP EP18872286.2A patent/EP3703762A4/en active Pending
- 2018-11-02 KR KR1020207015589A patent/KR20200090171A/en not_active Application Discontinuation
- 2018-11-02 CA CA3081692A patent/CA3081692A1/en active Pending
- 2018-11-02 KR KR1020207015631A patent/KR20200083550A/en not_active Application Discontinuation
- 2018-11-02 CA CA3081737A patent/CA3081737A1/en active Pending
- 2018-11-02 BR BR112020008725-4A patent/BR112020008725A2/en unknown
- 2018-11-02 AU AU2018360055A patent/AU2018360055A1/en active Pending
- 2018-11-02 MX MX2020004647A patent/MX2020004647A/en unknown
- 2018-11-02 JP JP2020524562A patent/JP7474511B2/en active Active
- 2018-11-02 CN CN201880079506.2A patent/CN111818945A/en active Pending
- 2018-11-02 RU RU2020117787A patent/RU2020117787A/en unknown
- 2018-11-02 WO PCT/US2018/059085 patent/WO2019090169A1/en unknown
- 2018-11-02 US US16/760,932 patent/US20230203482A1/en not_active Abandoned
- 2018-11-02 CN CN201880085141.4A patent/CN111712248B/en active Active
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2020
- 2020-04-30 IL IL274356A patent/IL274356A/en unknown
- 2020-05-03 IL IL274396A patent/IL274396A/en unknown
-
2023
- 2023-04-21 US US18/137,931 patent/US20240182891A1/en active Pending
- 2023-04-21 US US18/137,942 patent/US20230407300A1/en active Pending
- 2023-05-24 JP JP2023085389A patent/JP7474532B2/en active Active
-
2024
- 2024-02-16 JP JP2024022138A patent/JP2024054361A/en active Pending