JPS6327425A - Remedy for acne vulgaris - Google Patents

Abstract

PURPOSE:A remedy for acne vulgaris containing bisabolol, an oily substance, volatile oil and lower alcohol, capable of rapidly dissolving and efficiently removing excessively secreted sebum with sustained effect. CONSTITUTION:A remedy for acne vulgaris obtained by blending (A) bisabolol with (B) an oily substance, (C) a volatile oil having <=10cSt at 5 deg.C, e.g. chain or cyclic silicone, and (D) a lower alcohol. The amounts of the ingredients are as follows. 0.025-10wt% ingredient (A), 2-50wt%, particularly 5-30wt% ingredient (B), 10-70wt%, particularly 20-60wt% ingredient (C) and 10-80wt%, particularly 10-60wt% ingredient (D). The remedy has effects, e.g. capable of readily removing sebum and enhancing chemical concentration on the skin surface and increasing the effect without damaging the skin, etc.

Description

[Detailed Description of the Invention] [Field of Industrial Application] The present invention relates to a drug for treating vulgaris, and more specifically, it quickly penetrates into excessively secreted sebum and dissolves sebum tS, so it can be cleaned with cotton or the like. To provide a therapeutic agent for acne vulgaris that can be efficiently removed by wiping, kills causative bacteria without irritating the affected area or the surrounding skin, and has a lasting effect.

[Conventional technology]

Conventionally, the most basic treatment for acne vulgaris, 4@ (so-called "acne") has been considered to be degreasing and sterilization through washing. Acne generally occurs during adolescence, when sebum production is high, and is caused by acne formation and bacterial infection of the sebaceous glands. The bacteria that cause infection are mainly Staphylococcus, and others include Am bacillus and White coccus.

Beerus and others are also defeated. Therefore, frequent washing with soap etc. will remove excess sebum,
The most common treatment is then to kill the causative bacteria by applying a fungicide or a drug containing sulfa drugs6.

[Problem that the invention seeks to solve]

Acne mainly occurs from mid-teens to late 20s.
He is in his mid-teens. During this period, most of the day is spent at school or work, and facial washing is a must.
The reality is that it is difficult and frustrating to do it frequently. If the drug is applied as is, this will actually clog the sebaceous glands and worsen the infection. Yora K.

At this stage, they are extremely sensitive to their own appearance, so they have no choice but to apply medicine multiple times a day, touch their skin frequently with one hand, and end up making the affected area worse themselves. There are many.

On the other hand, conventional acne treatment drugs generally contain sulfur,
Liquid agents for the purpose of degreasing and sterilization that contain alcohol, sulfa drugs, and disinfectants.

There are ointments and creams that contain anti-inflammatory agents and have antibacterial and anti-inflammatory purposes. However, these treatments are solely aimed at eliminating the cause of acne;
Effects on skin composition are rarely considered. Therefore, if the therapeutic agent is applied many times, the skin surrounding the inflamed papules may be unnecessarily degreased and normal physiological functions may be impaired.

Therefore, it is possible to easily degrease and cleanse the skin anywhere, while maintaining physiological functions without irritating the affected area and the surrounding skin.

There was a need for a hypoallergenic medicine for the treatment of vulgaris that has an effective bactericidal effect.

[Means for solving problems]

Under these circumstances, the present inventor conducted extensive research and found that a mixture of bisabolol in an oily base having a specific composition satisfies the above objectives.

The invention has been completed.

That is, the present invention consists of primary components ta) to (dl(&) bisapol.

(b) Oily substances.

(C) volatile oil, (d) Lower alcohol.

This product provides a therapeutic agent for common and common diseases characterized by containing.

Bisabolol, which is the ta+ component of the present invention, may be used as such, but it may also be blended as a bisabolol-containing plant extract. Bisabolol-containing compound II extract contains chamomile, poplar, Myrocarb
rpus frondosus), Fr, Allem, lavender (L, o
fficinalisChaix), Bird's-headed butterfly (Myoporum Crcsifolium F.
orst) by extraction with an organic solvent such as ethanol, ether, or acetone. (a
Ingredient 1 is bisabolol or a plant extract containing it, which is 0.025 to 10% by weight of the total composition (hereinafter simply indicated by ``shi'')
is preferred.

(The oily substances of the BL component include avocado oil, almond oil, olive oil, hydrogenated olive oil, acacia oil, cuca/bar oil, quince oil, soybean oil, soybean oil, camellia oil,
Vegetable oils such as sunflower oil, safflower oil, jojoba oil, sesame oil, palm oil, cottonseed oil, coconut oil; Animal oils such as lanolin, tardle oil, beeswax, millet oil, squaleno, squala/, pristane; glycerin-tri-2-ethyl Tridaliserides such as hexanoate, fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, instearic acid, oleic acid, linoleic acid, ricinoleic acid, behenic acid, lanolin fatty acid.

Lauryl alcohol, cetanol, 2-hexyldodecanol, stearyl alcohol, instearyl alcohol, oleyl alcohol, 2-octyldodecanol, behenyl alcohol, lanolin alcohol, cholesterol, phytosterol, etc. f) 18th alcohol, ethylene glycol.

Ethylene 7g')col monoalkyl ether, diethyl/glycol monoethyl ether, triethylene/glycol, polyethylene glycol, propylene glycol, polypropylene gellicol.

1.3-Butylenoglycol, glycerin, polycrycerin, batyl alcohol, polyhydric alcohols such as pentaerythritol, diisopropyl adibate, hexyldecyl instearate, cetyl isooctanoate, oleyl oleate, decyl oleate, lanoli acetate/ , hexyldecyl dimethyloctanoate, butyl stearate, diisopropyl sebacate, trioleyl phosphate, cetyl lactate, myristyl lactate, imbropyl palmitate, isobuavir myristate, diethyl phthalate, octyldodecyl myristate, myristyl myristate,
Synthetic oils such as esters such as hexyl laurate, fluid polyisobutylene, α-olefins/oligomers, squara/hydrocarbons such as ceresin, etc. are wrinkled. These oily substances prevent the removal of excess sebum by volatile oils and impart appropriate oiliness to the skin, and their blending amount is preferably 2 to 50%, particularly 5 to 30%.

As the volatile oil for component (c), there may be used, for example, chain or cyclic NRICOH/R, dynamic isoparaphyte 7, etc., which has a viscosity at 5 DEG C. or less. Volatile oil has the effect of removing sebum, and its blending amount is 10~
70%, especially 20-60% is preferred. If the length is less than this, the removal of sebum will be insufficient, and if the length is too long, too much sebum will be removed, which is undesirable.

(As the lower alcohol for the dl component, ethanol, isopropanol, etc. are used, for example. This lower alcohol is blended to improve the compatibility between the oily substance of the (b) component and the volatile oil of the (cl) component. The blending amount is preferably 10 to 80%, particularly 10 to 60%.

When antibacterial substances other than the above-mentioned essential components (al to (dl and further fa)) are blended, a more effective therapeutic effect can be obtained.

Examples of the antibacterial substance include talolxylenol,
Be/zethonium chloride, inpropylmethylphenol,
Thymol, resorcinol, lysothychloride A, Ri/I
/:! 7-acid/lorhexidine, orthophenylphenol, sorbic acid, dehydroacetic acid primary sodium hypochlorite, iodine, iodine tincture, povidone-iodine, boric acid,
Borax, Oxidor.

Potassium permanganate, formali/, phenol.

Examples include hexaclofen, creonate, methylrosalinino chloride, benzalkonium chloride, sodium lauryl sulfate, urea, alkyl polyaminoethylglycine chloride, ictamol, and the like. These antibacterial substances should be added at a standard blending amount of 1/1 O to 1 when used alone in such cases.
A sufficient effect can be obtained at /2000.

91. The drug for treating Zuigai vulgaris of the present invention may optionally include:
Other anti-inflammatory agents, vitamins, antioxidants, humectants, astringents, antihistamines, antibiotics, sulfa drugs, fragrances, colorants, etc. can also be blended.

It is more preferable for the therapeutic agent of the present invention to be prepared to have a viscosity of 30 cs or less (at 5° C.), since this makes it easier to remove sebum and reduces stickiness.

This therapeutic agent is preferably filled into a spray or squeeze bottle to make it convenient to carry. [Actions and Effects] The therapeutic agent for common vulgaris of the present invention has the following actions and effects.

■ The low-viscosity oil base works by dissolving excess sebum secreted on the skin, so sebum can be easily removed by wiping the skin surface with cotton.

■ The low-viscosity oily base reduces mechanical friction between the cotton and the skin surface, so it does not damage the skin.

(2) Since the volatile main base [component (C)] and lower alcohol evaporate and do not remain after application, the drug concentration increases on the skin surface and the effect increases.

■ The remaining ingredients are covered with a thin oily film.

The effect lasts.

■ Bisabolol's antibacterial, anti-inflammatory and anti-ulcer properties effectively treat acne.

〔Example〕

Next, an example will be explained.

Example 1 (1) Preparation of product 1 of the present invention ■Oil-soluble chamomile extract 5g (bisabolol approx. 5 da/,!9) ■Chlorxylenol 0.00551 ■Toray Silicone 5H34450,9 (3JR silicone oil) ■Idemitsu IP Solvent toy (liquid imparaffin) ■Avocado oil 59■Ethanol remainder (total 100.9) At room temperature, ■, ■, and ■
2 and 3 were added to the mixture while stirring, and after stirring for 2 hours, 2 was added to obtain an acne treatment with a viscosity of 3 cs (5°C).

(11) Use test of the invention product I Has this invention been applied to 9 patients with vulgaris? Let me use it.

Its effect (therapeutic effect on acne)? Research friend.

Results: Very effective (3 people) Effective, 4 people (Effective), 2 people (Effective) Effect) wo investigation mind.

Comparison product L: Sulfur/camphorulose sulfur
609 Camphor 5g Gum arabic powder 30g Calcium hydroxide 1g Air freshener Appropriate amount Water Remaining (100g) Results 2 Invention product 1 is very good 2 people Invention product 1 is good 5 people are the same 2 people comparison 11HJ 1 (1 ) Preparation of comparative product 2■Raxylenol o,otg■Toray silicone 5H34450fi■Idemitsu IP solvent
15.9■Avocado oil 5I■
Ethanol residue (10(1) at room temperature,■,■
and (2) were mixed, and (2) was added thereto under stirring. After stirring for 2 hours, (2) was added to obtain an acne treatment.

(11) Irritation test of comparative product 2 In the same manner as (11) of Example 1, the irritation (
Itching, tingling] Complete investigation.

Results: 5 people felt it, 4 people didn't feel it (Ill) Am of Example 1 of comparative test with the invention product 1
Tested in the same manner.

Result 2: Invention product 1 is very good 81 people ・Invention product 1 is good 1 person Comparative example 2 (1) Preparation of comparative product 3 Bisabolol 0.3, 9. It was prepared by stirring 50 g of avocado oil and 49.79 g of ethanol at room temperature for 2 hours.

(11) Feeling of use test for comparison product 3 Test of feeling of use (stickiness) in the same manner as in (11) of Example 1.
I've researched everything.

Results: 8 people felt it. 1 person didn't feel it.
Tested in the same manner as 1D.

Result 2 Invented product 1 is very good Procedural amendment written by 9 or more people (voluntary) August 21, 1988 Patent application No. 171354 of 1988 2 Title of invention vulgaris treatment drug 3 Make amendment Relationship to the case filed by the applicant Applicant name (091) Kao Corporation, 61.8. 22 6. Column 7 of "Detailed Description of the Invention" of the specification subject to amendment, Contents of amendment (1) In the specification, page 5, lines 1 to 3 [Myroearpum frondosum]
.

Fr Alemu (Fr, Person Item) J and Aruo [Myrocarpus fromdo]
sus 'Fr Allam) J.

Claims (1)

[Claims] 1. It is characterized by containing the following components (a) to (d): (a) bisabolol, (b) oily substance, (c) volatile oil, and (d) lower alcohol. Treatment for acne vulgaris. 2, (a) component 0.3 to 10% by weight, (b) component 2 to 5
The acne vulgaris therapeutic drug according to claim 1, which contains 0% by weight, 10 to 70% by weight of component (c), and 10 to 80% by weight of component (d). The acne vulgaris therapeutic agent according to claim 1, which has a viscosity of 30 cs or less at 3.5°C.