JPS63145283A - Porphyrin derivative - Google Patents
Porphyrin derivativeInfo
- Publication number
- JPS63145283A JPS63145283A JP29190486A JP29190486A JPS63145283A JP S63145283 A JPS63145283 A JP S63145283A JP 29190486 A JP29190486 A JP 29190486A JP 29190486 A JP29190486 A JP 29190486A JP S63145283 A JPS63145283 A JP S63145283A
- Authority
- JP
- Japan
- Prior art keywords
- represents
- bis
- example
- 23h
- 21h
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000004033 porphyrin derivatives Chemical class 0 abstract title 2
- -1 (substituted)pyridinium halide Chemical class 0 abstract 3
- 125000000217 alkyl group Chemical group 0 abstract 2
- 201000011510 cancer Diseases 0 abstract 2
- 206010070834 Sensitisation Diseases 0 abstract 1
- 150000001875 compounds Chemical class 0 abstract 1
- 230000000875 corresponding Effects 0 abstract 1
- 125000005843 halogen atoms Chemical group 0 abstract 1
- 239000000463 materials Substances 0 abstract 1
- 125000002496 methyl group Chemical group data:image/svg+xml;base64,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 data:image/svg+xml;base64,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 [H]C([H])([H])* 0 abstract 1
- 230000003287 optical Effects 0 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Chemical compound 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C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0 abstract 1
- 239000008091 pyridine Substances 0 abstract 1
- 230000008313 sensitization Effects 0 abstract 1
- 230000001235 sensitizing Effects 0 abstract 1
- 238000003786 synthesis Methods 0 abstract 1
- 150000003512 tertiary amines Chemical class 0 abstract 1
Abstract
NEW MATERIAL:A compound expressed by formula I [R1 represents H or 1W4C alkyl; Y represents N+(R2)3.X- (R2 represents 1W4C alkyl; X represents halogen atom), (substituted)pyridinium halide or (substituted)quinolinium halide].
EXAMPLE: 7,12-Bis(2-pyridinioethyl)-3,8,13,17-tetramethyl-2,18-bis(2-methoxycarbo nylethyl)-21H,23H-porphine dibromide.
USE: A diagnosticum or remedy for cancer, which has both optical sensitization action and affinity for cancer cells.
PREPARATION: A porphyrin derivative expressed by formula II [example; methyl 7,12-bis(2-bromoethyl)-3,8,13,17-tetramethyl-21H,23H-porphi-ne-2,18-dipropionate, etc.] is reacted with the corresponding tertiary amine (example; pyridine, etc.).
COPYRIGHT: (C)1988,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29190486A JPS63145283A (en) | 1986-12-08 | 1986-12-08 | Porphyrin derivative |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29190486A JPS63145283A (en) | 1986-12-08 | 1986-12-08 | Porphyrin derivative |
| US07/004,333 US4772681A (en) | 1986-01-17 | 1987-01-15 | Porphyrin derivatives |
| CA000527443A CA1315780C (en) | 1986-01-17 | 1987-01-15 | Porphyrin derivatives |
| DE19873772064 DE3772064D1 (en) | 1986-01-17 | 1987-01-16 | Porphyrinderivate. |
| EP87300374A EP0233701B1 (en) | 1986-01-17 | 1987-01-16 | Porphyrin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS63145283A true JPS63145283A (en) | 1988-06-17 |
Family
ID=17774965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP29190486A Pending JPS63145283A (en) | 1986-12-08 | 1986-12-08 | Porphyrin derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS63145283A (en) |
-
1986
- 1986-12-08 JP JP29190486A patent/JPS63145283A/en active Pending
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