JPS63139118A - Intraoral cleaning agent - Google Patents

Abstract

PURPOSE:To obtain a practicable intraoral cleaning agent, containing a solvent extract of a theaceous plant and azulene as active ingredients, having mild irritant feeling, taste, touch, etc., comfortable feeling of use, high safety and excellent deodorizing as well as odor neutralizing action and refreshing feeling. CONSTITUTION:An intraoral cleaning agent containing a solvent extract of a theaceous plant and azulene as active ingredients. For example, raw leaves or dried materials of Thea sinensis L., Camellia sasanqua Thunb., Camellia japonica L., Cleyera ochnacea DC., Eurya japonica Thunb., etc., are cited as the theaceous plant. Ethanol, propanol, isopropanol, water, etc., are preferred as the solvent for extraction. The extraction is carried out by a method for adding about 4-6pts.wt. solvent to 1pts. raw material and heating the mixture at the refluxing temperature of the solvent and the active ingredients are obtained as dark green greenish brown powdery solid substance by removing the solvent from the extract solution. Sodium 1,4-dimethyl-7-isopropylazulene-3- sulfonate, etc., are used as the azulene and the content thereof is preferably 0.001-0.2%. The content of the above-mentioned extract is preferably 0.01-5.0%.

Description

DETAILED DESCRIPTION OF THE INVENTION Field of the Invention The present invention relates to a mouth cleanser, and more particularly to a mouth cleanser containing a solvent extract of a plant of the Camellia family and azulene.

BACKGROUND OF THE INVENTION Conventionally, there have been rutting agents as pharmaceuticals for removing odors and disinfecting during the day, and mouth washes and mouth fresheners as quasi-drug products.

Rutting agents are mainly disinfectants and are used to sterilize, disinfect, deodorize, and clean the mouth and throat, while mouthwashes are used to prevent bad breath and cavities, and contain neutralizers and astringents. Antibiotics, bactericidal agents, anti-enzyme agents, etc. are mixed in, and some contain fluorine compounds to prevent cavities. Mouth fresheners are tablets, spray liquids, etc. whose main ingredients are acene tea, licorice, etc., and are small and convenient to carry, and are considered etiquette products. One of the purposes of this mouth freshener is to prevent bad breath, but it is also intended to relieve motion sickness, hangovers, discomfort, etc., and mainly contains fragrance.
It gives a refreshing and refreshing feeling. Similarly to this mouth freshener, there are also pharmaceutical tablets that contain chlorophyll for the purpose of eliminating bad breath and treating hangovers, and there are also products that can be taken to eliminate bad breath.

In addition, azulene has anti-inflammatory, antibacterial, and antifungal effects in the oral cavity, and is used in mouth cleansers.

Problems to be Solved by the Invention These conventional mouth cleansers, such as mouth rinses, mouth fresheners, and rinsing agents, mainly contain bactericidal agents, anti-enzyme agents, fragrances, neutralizing agents, etc. To prevent bad breath, there are many masking methods using fragrances, but there are few that contain ingredients that can directly remove bad breath. Some mouth fresheners are difficult to use due to their taste, feel, odor, etc. For example, when azulene is used, the mouth freshener becomes powdery.

Means for Solving the Problems As a result of various studies to solve the above problems, the inventors of the present invention found that mouth cleansers containing a solvent extract of Camelliaaceae plants and azulene were found to be irritating to the mouth cleansers themselves. The present invention was developed based on the discovery that it alleviates unpleasant sensations, bad taste, and powderiness, eliminates bad breath, and enhances the bactericidal effect.

That is, the present invention relates to a mouth cleanser characterized by containing a solvent extract of a plant of the Camellia family and azulene.

The Camellia family plants used as extraction raw materials in the present invention are:
For example, tea plants, sasanqua flowers, camellias, sakaki, hisakaki, etc.
Examples include fresh leaves or dried leaves thereof.

In particular, it is preferable to obtain fresh leaves of tea plants or dried products thereof because they are easy to obtain and are highly safe. In addition, in the case of tea plants, even if it is a decaffeinated extract, there is no problem in extracting the present deodorizing/deodorizing agent.

In the present invention, the solvent used for extracting the active ingredient from the above-mentioned raw materials includes alcohol-based organic solvents such as ethanol, propatool, isopropatool, water, and mixed solvents thereof. From the viewpoint of efficiency, deodorizing effect, etc., ethanol, propatool, isopropateol, water, or a mixture thereof is preferable.

The method for extracting the Camellia family plant extract in the present invention can be carried out by the method described in JP-A-53-66434.

That is, about 4 to 6 parts of a solvent is added to 1 part of the above raw material; heating is carried out at the reflux temperature of the solvent. Although the extraction time varies slightly depending on the type of extraction device and raw materials, for example, when using a Soxhlet extraction device, it is preferably about 10 to 20 hours. Since the active ingredients in the raw material are transferred into the solvent and extracted, an extract containing the active ingredients can be obtained by removing the raw material residue by filtration or centrifugation.

By removing the solvent from this extract, the active ingredient can be obtained as a dark green to greenish brown powder or solid.

Other solvent extraction methods can also be used.

The solvent extract of the present invention has deodorizing and deodorizing effects as described in JP-A No. 53-66434, and although its mechanism of action is not clear, it is extracted from fresh leaves or dried products of plants of the Camellia family. The active ingredients include many flavone compounds, unsaturated aldehyde compounds, organic acids (tannic acid, etc.). It is presumed that addition to aldehydes, ammonia, and amine compounds are based on reactions to aldehydes, etc., and neutralization with the organic acids mentioned above.
It is thought that it acts effectively on removal. As is well known, bad breath includes physiological bad breath, such as garlic odor, cigarette odor,
There are bad breaths caused by food such as alcohol odor, luxury foods, bad breath when you wake up on an empty stomach, and pathological bad breath, such as bad breath caused by diseases of the respiratory system, digestive system, etc. These bad breaths are caused by, for example, protein components. This is said to be caused by the mixture of alcohol in the alcohol, such as decomposed amines, ammonia, hydrogen sulfide, methyl mercaptan, aldols, acetaldehyde, and trace amounts of amines, acetone, acetic acid, etc. It is being said.

The mouth cleansing agent containing a solvent extract of a plant of the Camellia family of the present invention exhibits excellent effects in removing these bad breaths.

In addition, it is known that tea confectionery contains ingredients that are effective in preservative action for food and drink (Japanese Patent No. 106680,
(Japanese Patent Publication No. 36-9129), the solvent extract of the tea leaves of the present invention also has bactericidal or antibacterial activity,
The mouth cleanser of the present invention not only removes bad breath, but also
A bactericidal sieve also has an antibacterial effect. In particular, extracts from tea confectionery are excellent in terms of safety, reduce the irritation of the mouth cleansing agent itself, and are extremely easy to handle and use.

Furthermore, since the solvent extract of the present invention has an excellent deodorizing effect, it is possible to soften or eliminate the irritating sensation of ingredients that are effective as mouth freshener ingredients due to its deodorizing and deodorizing effects. In the present invention, ingredients that are effective for mouth cleansing but are difficult to use due to irritation can be effectively used as mouth cleansing ingredients.

On the other hand, azulene is a compound in which a 5-membered ring and a 7-membered ring are fused.
It is obtained from plant essential oils and variously synthesized industrially, and is a blue plate-like crystal. In particular, guaiazulene has an anti-inflammatory effect and has been used for various inflammations since ancient times. For mouthwashes that use water, water-soluble azulene is used. This water-soluble azulene is usually a sulfonated azulene, such as radium 1,4-dimethyl-fluoriprobyl azulene-3-sulfonate.

The mouth cleansing agent of the present invention is an ingredient used in a mouth rinse, a mouth freshener, a rutting agent, a moisturizing agent, or a sweet preservative (e.g., glycerin, sorbitol, Celdex (registered trademark), etc.)
, solubilizers (polyoxyethylene hydrogenated castor oil, polyoxyethylene polypropylene glycol, etc.), preservatives (paraoxybenzoic acid ester, benzoic acid, etc.), pH adjusters (sodium hydrogen phosphate, (sodium hydroxide, etc.), solvents (ethanol, etc.), fragrances (eucalyptus, thymol, peppermint, menthol, etc.).

Contains the solvent extract of the Camellia family plant of the present invention and azulene along with components such as sweeteners (saccharin sodium, etc.), colorants (Yellow No. 4, Blue No. 1, caramel, etc.), anti-inflammatory agents, bactericides, anti-enzyme agents, etc. Manufactured by

The content of the solvent extract of the Camellia family plant of the present invention is 0.01 to 5.0% based on the total amount of the mouth cleanser, and the amount of azulene used is 0.001 to 0.02%.

Water-soluble azulene is used as a mouthwash and has an anti-inflammatory effect, resulting in an effective mouthwash.Although it has a powdery and gritty feel, by containing it together with the solvent extract of the present invention, it can be used as a mouthwash. There is no bitterness, and it becomes mild and easy to use.

By incorporating a solvent extract of a plant belonging to the Camellia family and azulene in a mouth cleansing agent, the powderiness of azulene can be made mild, and the irritation that the mouth cleansing agent itself may have can be alleviated. Combined with the deodorizing/deodorizing and bactericidal effects of azulene and the anti-inflammatory, antibacterial and antifungal effects of azulene, it can be made into an excellent mouth cleanser.

EXAMPLES The present invention will be explained below with reference to Examples, but it goes without saying that the present invention is not limited to these Examples.

'Preparation' The solvent extract in the present invention was obtained by the following method.

(1) 250g of dried tea plant leaf powder and 6 isopropanol
00mQ was placed in a Soxhlet extractor and heated under reflux for 20 hours. The raw material residue was removed from the extract, and the 0 liquid was concentrated to dryness under reduced pressure to obtain a dark green solid of 78.0
get g.

(2) Put 18 g of fresh tea leaves and 100 IIIQ ethanol into a Soxhlet extractor, and heat and reflux for 12 hours.

Thereafter, the same treatment as in Example 1 was carried out to obtain 2.6 g of a dark green solid.

(3) Fresh leaves of Kantsubaki and Sasanqua with ethanol 100I + IQ
When the mixture was immersed in water and extracted under reflux, the results shown in Table 1 below were obtained.

Table 1 (4) 25g of dried tea plant leaf powder and solvent 6 shown in the second column below
When 0mQ was charged into a Soxhlet extractor and refluxed for 20 hours, the results shown in Table 2 were obtained.

Table 2 ``Smell experience of medium'' A deodorization test for the above solvent extract was conducted using the following method.

0.1 g of malodorous components (benzyl mercaptan and 30% trimethylamine aqueous solution) and 1 g of 10% ethanol extract solution are thoroughly mixed in a closed container. After that, the head space inside the sealed container was taken out with a gastight syringe, and a chromatogram was drawn using a gas chromatograph.
Find the peak area.

Separately, a blank test (when no deodorizing agent was added) was carried out, and the peak area of the chromatogram was set as 100, and the removal rates were determined, and the results shown in Table 3 were obtained.

In Table 3, the measurement conditions of the gas chromatograph are as follows.

<Benzyl mercaptan> 5ilicon DC-7100, 6m5ens
1091/4 15mu temperature 150°C <30% trimethylamine aqueous solution> 5jlicon DC-7102m 5ens 1091/ 128 10mΩ temperature
70'C Song Yu 4- To confirm the safety, we requested the Osaka Prefectural Institute of Public Health to test the extract LD5. measurements were taken.

Dose (g/kg body weight) Number of animals Mortality rate 1.
0 10 0 Animals used: 1. C,R,-JCL male (body weight approximately 25 g) Administration method: The sample was suspended in water and administered orally by force using a metal stomach probe.

Example 1 Mouth cleansers shown in Table 4 were produced using a 2% aqueous ethanol solution (55% ethanol, 43% water) of an ethanol extract from green tea leaves.

For comparison, a mouth cleanser was manufactured using chlorophyll (2% copper chlorophyllin sodium aqueous solution), which has been known to be effective in removing bad breath.

Table 4 These mouthwashes have a irritating flavor, whereas A has a irritating flavor.
In A-1 and A-2, the stimulation sensation becomes mellow.

Next, a breath odor removal test was conducted using the mouth cleanser, and the results are shown in Table 5.

Table 5 Average value of 8 panelists The halitosis adjustment method and evaluation criteria in this halitosis test are as follows.

How to adjust bad breath A: Tobacco odor To get rid of cigarette odor, remove 3 highlights in 5 minutes before filtering 2a
After smoking up to n, the exhalation smelled like cigarettes for 3Q. (Standard) B. Garlic odor The garlic odor was created by eating 2 servings (14 pieces) of gyoza, then taking 3Q of the exhaled air and making it smell like garlic (Standard) Test method After collecting the above bad breath, the mouth of Prescription A was Cleaning agent 30m
After gargling with Q for 30 seconds, 3Q of exhaled air was collected immediately after. Prescriptions A-1 and A-2 were also carried out in the same manner.

The effectiveness of removing bad breath was evaluated using eight expert panelists. First, they smelled the standard odor, then smelled the beauty product immediately after the sample was taken, and evaluated the strength of the odor based on the evaluation score. It was expressed in 6 stages.

Evaluation criteria for deodorizing effect: Smell strength 5 Strong odor 4 Strong odor 3 Easily detectable odor 2 Odor that you can tell what kind of odor it is 1 Odor that is almost undetectable 0 From odorless table 3 As is clear, the mouthwash using the solvent extract of the present invention has a significantly superior effect compared to conventionally used ones containing chlorophyll, and is an excellent mouthwash.

Example 2 Next, various mouth cleansers were manufactured using the solvent extract of the present invention.

<Formulation example 1> 1-A 1-B Ethanol 15.0 15.0
(% by weight) (weight) Phantom sorbitol 12.0 12.0 Polyoxyethylene hydrogenated castor oil 0.3 0.3 Fragrance 1.0 1.0 Green tea extract 3.0 - Water-soluble azulene
0.01 0.01 Paraoxybenzoic acid ester 0.1 0.1 Purified water
J! LJ5L100.0 100.0 <Formulation Example 2> 2-A 2-B Sorbitol 15.0 15. OQ
-Menthol 0.2o.2Green tea extract 2.0-Fragrance
1.0 1.0 Water-soluble azulene
0.01 0.01 Celldex
4.0 4.0 Purified water
J! LJL100.0 100.0 The results of the breath odor deodorization test for these mouth cleansers are shown in Table 6.

Table 6 Test method and evaluation method are the same as in Example 1 These mouth fresheners (1-A, 2-A) both have a good aroma,
It does not have an unpleasant odor when used, and has a milder odor and taste than those that do not use the solvent extract of the present invention (1-B, 2-B), making it easier to use. Combined, it had excellent effects and was excellent as a mouthwash since it could remove bad breath.

The mouth cleanser of the present invention is easy to use because the mouth cleanser itself has a mild irritation, feel, and taste.In particular, the tea confection extract is highly safe; Physiological bad breath can be effectively removed by using mouth fresheners or mouth fresheners constantly or in the morning and evening.

Since the mouth freshener of the present invention contains a solvent extract of a plant of the Camellia family, the irritation, taste, and feel of the mouth freshener itself are mild, making it comfortable to use. can be taken as a thing. In addition, this solvent extract has no safety problems, and due to its excellent deodorizing and deodorizing effects and refreshing feeling combined with the use of azulene, it is excellent as a mouth cleanser, and is suitable for everyday use. It is suitable as a mouthwash and a mouth freshener, and can be said to be highly practical.

Claims (5)

[Claims] (1) A mouth cleanser characterized by containing a solvent extract of a plant of the Camellia family and azulene. (2) The mouth cleanser according to claim 1, wherein the plant of the Camellia family is tea. (3) Claim 1 in which the plant of the Camellia family is sasanqua.
Mouth cleansers listed in section. (4) Claims 1, 2, or 3, wherein the solvent extract is alcohol, water, or a mixed solvent extract thereof.
Mouth cleansers listed in section. (5) The mouth cleanser according to claim 4, wherein the alcohol is selected from ethyl alcohol, propyl alcohol, and isopropyl alcohol.