JPS61205219A - 生物学的に活性なヒト第８因子断片からなる抗血友病剤およびその製造方法 - Google Patents
生物学的に活性なヒト第８因子断片からなる抗血友病剤およびその製造方法Info
- Publication number
- JPS61205219A JPS61205219A JP61045506A JP4550686A JPS61205219A JP S61205219 A JPS61205219 A JP S61205219A JP 61045506 A JP61045506 A JP 61045506A JP 4550686 A JP4550686 A JP 4550686A JP S61205219 A JPS61205219 A JP S61205219A
- Authority
- JP
- Japan
- Prior art keywords
- thr
- arg
- tyr
- factor
- daltons
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 229960002661 human antihemophilic factor Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 claims abstract description 15
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- 239000000203 mixture Substances 0.000 claims description 18
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 14
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims description 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 11
- 238000010828 elution Methods 0.000 claims description 9
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- FJQZXCPWAGYPSD-UHFFFAOYSA-N 1,3,4,6-tetrachloro-3a,6a-diphenylimidazo[4,5-d]imidazole-2,5-dione Chemical compound ClN1C(=O)N(Cl)C2(C=3C=CC=CC=3)N(Cl)C(=O)N(Cl)C12C1=CC=CC=C1 FJQZXCPWAGYPSD-UHFFFAOYSA-N 0.000 description 1
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- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 102100022641 Coagulation factor IX Human genes 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- AFSDNFLWKVMVRB-UHFFFAOYSA-N Ellagic acid Chemical compound OC1=C(O)C(OC2=O)=C3C4=C2C=C(O)C(O)=C4OC(=O)C3=C1 AFSDNFLWKVMVRB-UHFFFAOYSA-N 0.000 description 1
- ATJXMQHAMYVHRX-CPCISQLKSA-N Ellagic acid Natural products OC1=C(O)[C@H]2OC(=O)c3cc(O)c(O)c4OC(=O)C(=C1)[C@H]2c34 ATJXMQHAMYVHRX-CPCISQLKSA-N 0.000 description 1
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- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- 208000026552 Severe hemophilia A Diseases 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
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- FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 description 1
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- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- XZTJQQLJJCXOLP-UHFFFAOYSA-M sodium;decyl sulfate Chemical compound [Na+].CCCCCCCCCCOS([O-])(=O)=O XZTJQQLJJCXOLP-UHFFFAOYSA-M 0.000 description 1
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- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- E—FIXED CONSTRUCTIONS
- E02—HYDRAULIC ENGINEERING; FOUNDATIONS; SOIL SHIFTING
- E02D—FOUNDATIONS; EXCAVATIONS; EMBANKMENTS; UNDERGROUND OR UNDERWATER STRUCTURES
- E02D31/00—Protective arrangements for foundations or foundation structures; Ground foundation measures for protecting the soil or the subsoil water, e.g. preventing or counteracting oil pollution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/10—Factor VIII, AHF; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Life Sciences & Earth Sciences (AREA)
- Structural Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Civil Engineering (AREA)
- Paleontology (AREA)
- Mining & Mineral Resources (AREA)
- Hydrology & Water Resources (AREA)
- Environmental & Geological Engineering (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8501050-2 | 1985-03-05 | ||
| SE8501050A SE8501050D0 (sv) | 1985-03-05 | 1985-03-05 | Biologically active fragments of human antihemophilic factor and method for preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61205219A true JPS61205219A (ja) | 1986-09-11 |
| JPH0547524B2 JPH0547524B2 (https=) | 1993-07-19 |
Family
ID=20359353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61045506A Granted JPS61205219A (ja) | 1985-03-05 | 1986-03-04 | 生物学的に活性なヒト第８因子断片からなる抗血友病剤およびその製造方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US4749780A (https=) |
| EP (1) | EP0197901B1 (https=) |
| JP (1) | JPS61205219A (https=) |
| AT (1) | ATE65505T1 (https=) |
| CA (1) | CA1341497C (https=) |
| DE (1) | DE3680368D1 (https=) |
| DK (1) | DK164282B (https=) |
| HK (1) | HK15293A (https=) |
| SE (1) | SE8501050D0 (https=) |
| SG (1) | SG1893G (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5362854A (en) * | 1983-03-31 | 1994-11-08 | Scripps Clinic & Research Foundation | Factor VIII coagulant polypeptides: method of making |
| US7138505B1 (en) | 1984-01-12 | 2006-11-21 | Novartis Vaccines And Diagnostics, Inc. | Factor VIII:C nucleic acid molecules |
| SE8501050D0 (sv) * | 1985-03-05 | 1985-03-05 | Kabivitrum Ab | Biologically active fragments of human antihemophilic factor and method for preparation thereof |
| KR910006424B1 (ko) * | 1985-08-21 | 1991-08-24 | 인코텍스 비.브이 | 편성브리프(brief) 제조방법 |
| US5198349A (en) * | 1986-01-03 | 1993-03-30 | Genetics Institute, Inc. | Method for producing factor VIII:C and analogs |
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| US5422260A (en) * | 1986-05-29 | 1995-06-06 | Genetics Institute, Inc. -Legal Affairs | Human factor VIII:c muteins |
| EP0251843A1 (fr) * | 1986-06-06 | 1988-01-07 | Transgene S.A. | Procédé de préparation de facteur VIII à partir de cellules de mammifères |
| FR2613379B2 (fr) * | 1987-04-03 | 1990-04-06 | Transgene Sa | Procede de preparation de fragments du facteur viii a partir de cellules de mammiferes |
| DE3788944T2 (de) * | 1986-06-24 | 1994-05-26 | Novonordisk As | Verfahren zur herstellung eines koagulationsaktiven komplexes vom faktor viii-fragment. |
| US4980456A (en) * | 1987-04-06 | 1990-12-25 | Scripps Clinic And Research Foundation | Recombinant factor VIIIC derived fragments |
| IL86693A (en) | 1987-06-12 | 1994-06-24 | Stichting Centraal Lab | Proteins with factor VIII activity, process for their preparation using genetically engineered cells and pharmaceutical compositions containing them |
| US6346513B1 (en) | 1987-06-12 | 2002-02-12 | Baxter Trading Gmbh | Proteins with factor VIII activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them |
| JP3263759B2 (ja) * | 1992-04-06 | 2002-03-11 | プレスマスター、トゥール、アーベー | クリンプ工具 |
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| US5576291A (en) * | 1993-09-13 | 1996-11-19 | Baxter International Inc. | Activated factor VIII as a therapeutic agent and method of treating factor VIII deficiency |
| SE9303601D0 (sv) * | 1993-11-01 | 1993-11-01 | Kabi Pharmacia Ab | Improved cell cultivation method and medium |
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| IL113010A0 (en) * | 1994-03-31 | 1995-10-31 | Pharmacia Ab | Pharmaceutical formulation comprising factor VIII or factor ix with an activity of at least 200 IU/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration |
| SE503424C2 (sv) * | 1994-11-14 | 1996-06-10 | Pharmacia Ab | Process för rening av rekombinant koagulationsfaktor VIII |
| SE9403915D0 (sv) * | 1994-11-14 | 1994-11-14 | Annelie Almstedt | Process A |
| SE9501189D0 (sv) * | 1995-03-31 | 1995-03-31 | Pharmacia Ab | Protein formulation |
| SE9503380D0 (sv) * | 1995-09-29 | 1995-09-29 | Pharmacia Ab | Protein derivatives |
| PT1754718E (pt) | 1996-04-24 | 2011-07-13 | Univ Michigan | Factor viii resistente à inactivação |
| US8183344B2 (en) | 1996-04-24 | 2012-05-22 | University Of Michigan | Inactivation resistant factor VIII |
| US5851800A (en) * | 1996-05-14 | 1998-12-22 | Pharmacia & Upjohn Ab | Process for producing a protein |
| EP0910581B1 (de) * | 1996-06-24 | 2000-04-05 | Max-Planck-Institut für Physiologische und Klinische Forschung Kerckhoff-Klink GmbH | Verfahren zur affinitätschromatographischen aufreinigung von faktor viii |
| US6197526B1 (en) | 1999-01-04 | 2001-03-06 | Dyax Corp. | Polypeptides for binding human factor VIII and fragments of human factor VIII |
| US7112438B2 (en) | 1999-01-04 | 2006-09-26 | Dyax Corp. | Binding molecules for human factor VIII and factor VIII-like proteins |
| EP1038959A1 (en) | 1999-03-17 | 2000-09-27 | Aventis Behring Gesellschaft mit beschränkter Haftung | Factor VIII without B-domain, comprising one or more insertions of a truncated intron I of factor IX |
| SE9901379D0 (sv) | 1999-04-19 | 1999-04-19 | Pharmacia & Upjohn Ab | Receptor structures |
| EP1233064A1 (en) | 2001-02-09 | 2002-08-21 | Aventis Behring Gesellschaft mit beschränkter Haftung | Modified factor VIII cDNA and its use for the production of factor VIII |
| US7205278B2 (en) * | 2001-06-14 | 2007-04-17 | The Scripps Research Institute | Stabilized proteins with engineered disulfide bonds |
| EP1418810A4 (en) | 2001-08-03 | 2006-08-02 | Us Gov Health & Human Serv | TREATMENT OF HEMOPHILIA ORAL |
| PL2235197T3 (pl) | 2007-12-27 | 2018-01-31 | Baxalta GmbH | Sposoby hodowli komórek |
| EP2704688B1 (en) * | 2011-05-05 | 2019-07-10 | Matinas BioPharma Nanotechnologies, Inc. | Cochleate compositions and methods of making and using same |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59184130A (ja) * | 1983-03-31 | 1984-10-19 | スクリツプス・クリニツク・アンド・リサ−チ・フアンデ−シヨン | フアクタ−８凝固因子ポリペプチド類 |
| JPS60185723A (ja) * | 1984-01-12 | 1985-09-21 | カイロン コーポレイション | フアクタ−ｖ３ｃ組成物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4361509A (en) * | 1981-12-14 | 1982-11-30 | Scripps Clinic And Research Foundation | Ultrapurification of factor VIII using monoclonal antibodies |
| US4495175A (en) * | 1982-08-05 | 1985-01-22 | University Of Rochester | Preparation of highly purified human antihemophilic factor |
| DE3481109D1 (de) * | 1983-05-09 | 1990-03-01 | Novo Nordisk As | Antihaemophilie-faktor-viii-konzentrat und dessen herstellungsverfahren. |
| US4710381A (en) * | 1984-05-22 | 1987-12-01 | The Blood Center Of Southeastern Wisconsin | Method for maintaining intact, non-degraded factor VIII/von-Willebrand factor during blood processing |
| US4543210A (en) * | 1984-10-04 | 1985-09-24 | Miles Laboratories, Inc. | Process for producing a high purity antihemophilic factor concentrate |
| SE8501050D0 (sv) * | 1985-03-05 | 1985-03-05 | Kabivitrum Ab | Biologically active fragments of human antihemophilic factor and method for preparation thereof |
-
1985
- 1985-03-05 SE SE8501050A patent/SE8501050D0/xx unknown
-
1986
- 1986-02-24 EP EP86850067A patent/EP0197901B1/en not_active Expired - Lifetime
- 1986-02-24 AT AT86850067T patent/ATE65505T1/de not_active IP Right Cessation
- 1986-02-24 DE DE8686850067T patent/DE3680368D1/de not_active Expired - Lifetime
- 1986-02-25 DK DK085786A patent/DK164282B/da unknown
- 1986-03-04 CA CA000503239A patent/CA1341497C/en not_active Expired - Lifetime
- 1986-03-04 JP JP61045506A patent/JPS61205219A/ja active Granted
- 1986-03-04 US US06/835,914 patent/US4749780A/en not_active Expired - Lifetime
-
1988
- 1988-04-25 US US07/185,629 patent/US4877614A/en not_active Expired - Lifetime
-
1993
- 1993-01-05 SG SG18/93A patent/SG1893G/en unknown
- 1993-02-25 HK HK152/93A patent/HK15293A/en not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59184130A (ja) * | 1983-03-31 | 1984-10-19 | スクリツプス・クリニツク・アンド・リサ−チ・フアンデ−シヨン | フアクタ−８凝固因子ポリペプチド類 |
| JPS60185723A (ja) * | 1984-01-12 | 1985-09-21 | カイロン コーポレイション | フアクタ−ｖ３ｃ組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE65505T1 (de) | 1991-08-15 |
| EP0197901A1 (en) | 1986-10-15 |
| EP0197901B1 (en) | 1991-07-24 |
| HK15293A (en) | 1993-03-05 |
| JPH0547524B2 (https=) | 1993-07-19 |
| DK85786A (da) | 1986-09-06 |
| DK85786D0 (da) | 1986-02-25 |
| DK164282B (da) | 1992-06-01 |
| US4877614A (en) | 1989-10-31 |
| CA1341497C (en) | 2006-02-14 |
| DE3680368D1 (de) | 1991-08-29 |
| SG1893G (en) | 1993-06-11 |
| SE8501050D0 (sv) | 1985-03-05 |
| US4749780A (en) | 1988-06-07 |
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