JPS6075496A - ７α−置換３−オキソ−１７α−プレグン−４−エン−２１，１７−カルボラクトン、その製法及び該化合物を含有する抗アルドステロン作用を有する製薬的製剤 - Google Patents

７α−置換３−オキソ−１７α−プレグン−４−エン−２１，１７−カルボラクトン、その製法及び該化合物を含有する抗アルドステロン作用を有する製薬的製剤

Info

Publication number
JPS6075496A
JPS6075496A JP59170539A JP17053984A JPS6075496A JP S6075496 A JPS6075496 A JP S6075496A JP 59170539 A JP59170539 A JP 59170539A JP 17053984 A JP17053984 A JP 17053984A JP S6075496 A JPS6075496 A JP S6075496A
Authority
JP
Japan
Prior art keywords
oxo
ene
group
methylene
carbolactone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP59170539A
Other languages
English (en)
Japanese (ja)
Inventor
クラウス・ニキシユ
ヘンリイ・ラウレント
ペーター・エスペルリング
デイーター・ビトラー
ルドルフ・ヴイーヒエルト
ヴオルフガング・ローゼルト
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of JPS6075496A publication Critical patent/JPS6075496A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/005—3 membered carbocyclic rings in position 12

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
JP59170539A 1983-08-17 1984-08-17 ７α−置換３−オキソ−１７α−プレグン−４−エン−２１，１７−カルボラクトン、その製法及び該化合物を含有する抗アルドステロン作用を有する製薬的製剤 Pending JPS6075496A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3330084.4 1983-08-17
DE3330084A DE3330084A1 (de) 1983-08-17 1983-08-17 7(alpha)-alkoxycarbonyl-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone und deren 21-carbonsaeuresalze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3330085.2 1983-08-17
DE3330086.0 1983-08-17

Publications (1)

Publication Number Publication Date
JPS6075496A true JPS6075496A (ja) 1985-04-27

Family

ID=6207015

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59170539A Pending JPS6075496A (ja) 1983-08-17 1984-08-17 ７α−置換３−オキソ−１７α−プレグン−４−エン−２１，１７−カルボラクトン、その製法及び該化合物を含有する抗アルドステロン作用を有する製薬的製剤

Country Status (3)

Country Link
JP (1) JPS6075496A (de)
DE (1) DE3330084A1 (de)
ZA (1) ZA846432B (de)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52256A (en) * 1975-06-13 1977-01-05 Ciba Geigy Ag Production of steroidd carboxylic acid lactone
JPS5346952A (en) * 1976-10-05 1978-04-27 Ciba Geigy Ag Production of novel steroid having oxygen containing functional group at 19 position
JPS5382767A (en) * 1976-12-27 1978-07-21 Searle & Co Pregnenecarboxylic lactone corresponding carboxylic acid salts thereof and process for preparing same
JPS57177000A (en) * 1981-03-23 1982-10-30 Schering Ag 7 alpha-alkoxycarbonyl-15 beta, 16 beta- methylene-4-androstene compound, manufacture and medicine having cortex hormone inhibition

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52256A (en) * 1975-06-13 1977-01-05 Ciba Geigy Ag Production of steroidd carboxylic acid lactone
JPS5346952A (en) * 1976-10-05 1978-04-27 Ciba Geigy Ag Production of novel steroid having oxygen containing functional group at 19 position
JPS5382767A (en) * 1976-12-27 1978-07-21 Searle & Co Pregnenecarboxylic lactone corresponding carboxylic acid salts thereof and process for preparing same
JPS57177000A (en) * 1981-03-23 1982-10-30 Schering Ag 7 alpha-alkoxycarbonyl-15 beta, 16 beta- methylene-4-androstene compound, manufacture and medicine having cortex hormone inhibition

Also Published As

Publication number Publication date
DE3330084A1 (de) 1985-03-07
ZA846432B (en) 1985-03-27

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