JPS6040304B2 - body fluid filtration device - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION 1. Background Technical Field of the Invention The present invention relates to a body fluid furnace of a so-called multilayer flow path type in which a plurality of filter units are stacked one on top of the other to form a multilayer body fluid flow path between them. related to the device.

BACKGROUND OF THE INVENTION As a prior art body fluid filtration device employing a multilayer flow path system, the one shown in FIG. 1 is already known.

As shown in the figure, this device has a large number of filter units 2 stacked directly on top of each other and housed in a case 1 made of synthetic resin. And the case is blood inlet 5 and blood number outlet 7.
, a blood cell outflow port 8 is provided, and on the other hand, the unit 2 covers the entire mesh-like core village 3 with membrane filters 4, 4, and is provided with a blood inflow port 2a and a blood outflow port 2c corresponding to the case. A liquid flow path 2b is provided inside the units 2, 2.
A blood flow path 6 is formed between them. In this body fluid infiltration device, when blood enters from the blood inlet 2a of the case, it passes through the blood flow path 6 from the blood inlet 2a, passes through the membrane filter 4, and then the blood cells are released from the blood cell outlet. It flows out from 8. On the other hand, the heated blood bran is in the liquid flow path 2b.
The blood passes through the liquid flow path 2b in the filter unit 2 and is discharged from the blood flow outlet 7 of the case. This body fluid filtration device has the advantage that it can be made into a 4-type device because it can be made into a multilayer flow path type by simply overlapping the filter units 2, but it has the following problems. There is.

Problems with the Prior Art This filtration device has two blood flow channels 6 at the upper and lower ends in contact with the case 1.
The flow path conditions are different between the blood flow path 6 in the central portion and the blood flow path 6 in the central portion, and the blood flow path 6 in the central portion has an uneven thickness and a sufficient flow path is not secured, resulting in a decrease in furnace overefficiency. Problems such as channeling, hemolysis at blood stagnation sites, etc. are likely to occur.

That is, as shown in an enlarged view of the filter units 2 and 2 and the blood flow path 6 in FIG. 2, the blood flow path 6 in the center is formed between the filter units 2 and 2 to increase the furnace efficiency. However, since each filter unit 2 has an uneven surface, the flow path may be blocked depending on the degree of overlap. As a result, the furnace efficiency decreases and hemolysis is likely to occur at locations where blood accumulates.

Moreover, since one side of the blood flow path 6' at the upper and lower ends is constituted by a hard case, a flow path is reliably formed there, and as a result, blood flows selectively into this flow path, resulting in channeling. 0 Purpose of the Invention The present invention has been made in view of the above-mentioned circumstances, and its purpose is to uniformize the flow path conditions of each blood flow path and to secure the blood flow path reliably to improve the flow rate of the blood flow channels. The present invention aims to provide a body fluid filtration device that can prevent ring hemolysis and increase the filtration efficiency.

That is, the present invention provides a structure in which the entire mesh-like or uneven core material has a surface shape that responds to the shape of the core material, and a liquid flow path is formed in a non-contact part with the core material. a filter unit that is covered with a membrane filter, and is provided with a body fluid inlet formed by the non-existing part of the membrane filter and a filtrate outlet that communicates with the liquid flow path;
A flat flow path regulating plate substantially of the same type as the filter unit and provided with a through hole for body fluid circulation and a through hole for filtrate circulation, the filter unit and a plurality of flat flow path regulating plates The body fluid inlet and the body fluid circulation hole are arranged in a manner that the body fluid inlet and the body fluid circulation hole communicate with each other, and the liquid flow hole that serves as the liquid outlet is liquid-tight from the outside of the outlet and the hole. The filtration body is formed into a filtration body with a lotus passage in the state, and this filtration body is housed in a case provided with a body fluid inlet, a filtrate outlet, and a filtrate residual liquid outlet, and the body fluid flows in from the body fluid inlet of this case. The body fluid passed through the body fluid inlet of the filter unit and the body fluid circulation hole of the flow path regulating plate, passed through the flow channel formed between the filter unit and the flow channel regulating plate, and was filtered by the membrane filter. The body fluid flow path where the residual liquid reaches the filtration residual liquid outlet of the case, and the filtered filtrate that exits the membrane filter passes through the flow path in the filter unit, and the filter unit passes through the liquid outlet and the flow path regulating plate. This body fluid filtration device is configured to form a filtrate passage that extends through a liquid circulation hole to a liquid outlet in which a case is mounted.

Furthermore, the present invention provides that the membrane filter is 0.1 to 1.
It has two pongee holes, and the flow path regulating plate is made of polycarbonate.
It is made of a hard or semi-hard resin such as polypropylene, polyester, methyl methacrylate, or styrene, and has a thickness of 400 to 5000 Å. m
DETAILED DESCRIPTION OF THE INVENTION The present invention will be explained below based on a body fluid filtering device for separating blood from blood.

As shown in FIGS. 3 to 5, the body fluid filtration device according to the present invention houses a filtration body 30 in which a filter unit 12 and a flow path regulating plate 13 are stacked alternately in a case 11. There is.

The case 11 is made of hard or semi-hard synthetic resin such as polycarbonate or polypropylene into a cylindrical shape by injection molding, etc. The case 11 has an inlet 11a for blood, which is body fluid, in the center of the upper surface shown in the figure, and a furnace outside. An outlet 11b for blood, which is a liquid, is provided, and an outlet 11c for blood cells, which is a furnace filtration liquid, is provided at the end.

The filter unit 12 is formed into a disk shape, and has an inlet 12a for blood, which is body fluid, in the center, and an outlet 12b for blood, which is furnace fluid, on the outside thereof.

This filter unit 12 has membrane filters 15 and 1 on both sides of a disc-shaped core village 14 having a liquid flow path inside.
These membrane filters coated with 5-15,15
and the outer periphery excluding the dish ring outflow port 12b and the blood inflow port i2
They are joined together at each peripheral edge of a. The membrane filters 15, 15 have a shape corresponding to the surface shape (mesh shape or uneven shape) of the disc-shaped core material 14, as shown in FIG.

A flow path is formed at a non-contact portion between the membrane filter 15, T5 and the core material 14. The core village 14 is made of synthetic resin such as polypropylene, polyester, nylon, polyethylene, etc., and is formed into a mesh shape or an uneven shape.

As for this core village 14, the pitch between the convex parts is usually 0.2 to 2.
．． The height of the protrusion is 0. Use a female with about 0.5 ribs. The membrane filter 15 is formed by forming a thin film of synthetic resin such as cellulose ester, polycarbonate, or nylon by a known method such as a phase separation method, an extraction method, a stretching method, or a charged particle irradiation method.

This membrane filter 15 is a microporous membrane, and when separating blood cells and protein-containing blood bran, the pores of the membrane are 0.
．． It is preferable to use one of about 1 to 1.2 Buddhas. Further, in order to separate blood cells from blood bran that does not contain specific proteins, it is preferable to use a material with a pore diameter of about 0.005 to 0.1 French. Note that the pore diameter shown here is a value obtained by determining the pore pot distribution using a mercury porosimeter and determining the average pore diameter from this.

However, if the pore is a so-called through hole, the value measured by the exposure method is shown. The flow path regulating plate turtle 3 is formed of a hard or semi-hard synthetic resin such as polycarbonate, polypropylene, polyester, methyl methacrylate, or styrene into a smooth disc shape that is substantially the same as the filter unit 12, and includes a blood inlet 12a, Through holes 13a and 13b having the same diameter are provided corresponding to the blood outflow row 2b, respectively.

The flow path regulating plate 13 is usually made to have a wall thickness of 400 mm to 50 mm, preferably about 500 mm, in consideration of hardness and miniaturization of the device. The filtration body 30 has a plurality of filter units 12 and flow path regulating plates 13 stacked on top of each other alternately, and a ring-shaped sealing material 17 is provided around the blood flow outlet I2b of the membrane filter 15 to seal the filter unit 12. 12
The blood circulation outflow port and the through hole 13b of the flow path regulating plate 13 are joined to the outside in a liquid dissolving state, and by housing this in the case 11, blood flows in from the blood inflow port 11a. After the blood passes through the flow path 16 formed between the filter unit 12 and the flow path regulating plate 13, the blood passes through the furnace body 3.
A body fluid passage is formed through a gap 31 formed between the outermost side of the case 11 and the blood cell outlet blade lc of the case 11. forms a furnace liquid passage leading to the furnace liquid outflow roll lb of the case furnace 1 via the furnace liquid outlet 12b. W. Specific Effects of the Invention In this body fluid filtration device, as shown in FIG. 16 or the flow path 16 between the filter unit 12 and the case 11
' as shown in FIG. 5, the remaining liquid flows out from the furnace residual liquid outlet 11c and is returned to the human body M together with the replacement liquid 18.

On the other hand, the filter filtered through the filter unit 12 passes through the liquid flow path in the filter unit 12, and passes through the furnace liquid outlet 12b.
The reactor liquid is discharged from the furnace liquid outlet 11b of the case 11.
In addition, in the system shown in Fig. 6, a part of the blood cells is transferred to the retransmission tube 1.
At 9, the blood is sent to the furnace, and the blood flow rate is increased to increase the appropriate amount of blood in the furnace. In Fig. 6, two blood pumps are shown, 21 is a pressure gauge, and 22 is an infusion pack for anticoagulants such as heparin and ACD. V. Specific Effects of the Invention According to the present invention, the flow path regulating plate 13 is provided between the filter units 12, and while the filter unit 12 has a mesh shape, the flow channel regulating plate 13 is smooth. Blood flow path 16 is reliably formed.

Moreover, the blood flow path 16' is in contact with the upper and lower ends of the case 11.
The flow path conditions are the same. Therefore, channeling in which blood flows only in a specific blood flow path does not occur, and blood stagnation does not occur, and the blood flows uniformly in each blood flow path. As a result, it is possible to increase the efficiency of blood passing through the furnace and prevent hemolysis. It was confirmed by the following experimental examples that the body fluid filtration device according to the present invention has the above-mentioned effects.

{i} Body fluid filtration equipment case used in the experiment: Material: polymethyl methacrylate, inner lining, height: 4 sails Membrane filter: Material: Cellulose triacetate membrane produced by phase separation method, average pore diameter of 0.45 Core material: Polyester material, mesh-like material with a thickness of 1.2 skin (height of the convex part: 0.3 fence) Flow path regulating plate: Material polycarbonate, thickness 0.4 Filter unit: Number of membrane layers: 8
(Number of channels: 16) "Membrane area: 434, inner diameter: 2.5 arcs, outer diameter: 8.5* arcs, channel thickness: 100 mm {ii} Experimental conditions: Heparinized cow with hematocrit value adjusted to 40 as blood. Using blood, the amount of furnace fluid and hemoglobin amount (presence or absence of hemolysis) was investigated by varying the pressure drop and blood flow rate.

The results are shown in Table 1.

In addition, even when the rare road regulating plate is not used, the amount of furnace liquid and the amount of hemoglobin are measured, and the results are also listed in Table 1.

From the upper table of Table 1, it is recognized that according to the present invention, a large amount of furnace excess can be obtained and port blood can be prevented.

Note that the present invention is not limited to the above-mentioned separation of blood cells and dish bran;
It can also be applied to the separation of blood cells and proteins.

[Brief explanation of drawings]

FIG. 1 is a sectional view of a conventional body fluid filtration device, FIG. 2 is an explanatory diagram thereof, FIG. 3 is a sectional view of a body fluid filtration device showing an embodiment of the present invention, and FIGS. 4 and 5 are FIG. 6 is an explanatory diagram showing the blood flow path and the flow of blood, and is a system diagram of this body fluid filtration device. 11...Case, 12...Filter unit, 13.
...Flow path regulation plate, 14... Core village, 15...
・Membrane filter, 16...Blood flow path. Figure 2 Figure 4 Figure 1 Figure 3 Figure 5 Figure 6

Claims (1)

[Claims] 1. The entire mesh-like or uneven core material has a surface shape that responds to the shape of the core material, and a liquid flow path is formed in a non-contact part with the core material. a filter unit which is covered with a membrane filter so as to have a body fluid inlet formed by a non-existing portion of the membrane filter and a filtrate outlet which communicates with the liquid flow path; and a flat flow path regulating plate of the same type as the filter unit and having a through hole for body fluid circulation and a through hole for filtrate circulation, and a plurality of the filter unit and the flat flow path regulating plate are stacked alternately. , a filtration body in which the body fluid inlet and the body fluid circulation hole are in communication with each other, and the filtrate outlet and the filtrate flow hole are in liquid-tight communication with the outside of the outlet and the hole; This filtration body is housed in a case provided with a body fluid inlet, a filtrate outlet, and a filtration residual liquid outlet, respectively.
The body fluid flowing in from the body fluid inlet of this case passes through the body fluid inlet of the filter unit and the body fluid circulation hole of the flow path regulating plate, and then passes through the flow path formed between the filter unit and the flow path regulating plate. There is a body fluid flow path where the filtrate is filtered through a membrane filter and the filtrate remains to the filtrate outflow port of the case, and a body fluid flow path where the filtrate that has been filtered through the membrane filter passes through the flow path inside the filter to the filtrate outflow port of the filter unit and the flow path. A body fluid filtration device in which a filtrate passage is formed through a filtrate distribution hole in a road regulating plate to a filtrate outlet in a case. 2. The body fluid filtration device according to claim 1, wherein the membrane filter has pores of 0.1 to 1.2 μ. 3 The flow path regulating plate is made of polycarbonate, polypropylene,
Made of hard or semi-hard resin such as polyester, methyl methacrylate, or styrene, with a thickness of 400~
The body fluid filtration device according to claim 1, which has a diameter of 5000μ.