JPS6038367B2 - Treatment adhesive tape or sheet - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a therapeutic adhesive tape or sheet suitable for the treatment of various skin diseases, as well as for other anti-inflammatory and analgesic purposes.

For transdermal absorption of drugs, if the water content of the stratum corneum of the skin is increased, not only the hair follicle-sebaceous gland system but also the absorption route that passes directly through the stratum corneum can be used directly, resulting in effective skin absorption. I can do things.

For this reason, occlusive bandage therapy (ODT therapy), which involves applying external medicine such as ointment to the skin and covering it with an impermeable film to ensure effective drug absorption, has recently become popular as a treatment for skin diseases. There is. However, this occlusive bandage therapy is not only cumbersome to attach to the affected area, but also bulky and easy to peel off. It had drawbacks such as being difficult to use.

In order to improve this drawback, for example,
As seen in Publication No. 05, the adhesive layer containing the drug is
Adhesive tapes provided on one side of an impermeable film have been proposed.

Such conventional adhesive tapes have been manufactured by applying a drug together with a suitable solvent to the surface of an adhesive layer, or by mixing the drug with an adhesive solution and applying the mixture.

Therefore, according to the former method, the drug is simply applied to the surface of the adhesive layer, which has the disadvantage that it is rapidly absorbed into the affected area, and according to the latter method, the drug is applied inside the adhesive layer. Since it is dispersed throughout the body, it has the disadvantage that it takes a very long time for it to be absorbed into the affected area, and in any case, it has been difficult to gradually absorb it into the affected area at a desired rate. SUMMARY OF THE INVENTION In view of the above-mentioned drawbacks of the conventional art, it is an object of the present invention to provide an adhesive tape or sheet for lining that is easy to use and is capable of gradually absorbing a drug into an affected area at a desired rate.

The gist of the present invention is that a porous urethane adhesive layer is provided on one side of a base film by simultaneously foaming a mixture of a polyol, an isocyanate compound, a tackifying resin, and a foaming agent on the surface. The present invention relates to a therapeutic adhesive tape or sheet, characterized in that a drug is adsorbed to the adhesive layer. The base film used in the present invention includes polyethylene ethylene film, ethylene-vinyl acetate copolymer, soft polyvinyl chloride film, cellophane film, etc., or flexible films obtained by surface-treating these with corona treatment etc. Films having the following properties are preferably used.

The thickness of the base film is preferably in the range of 50 to 100 microns. The porous urethane pressure-sensitive adhesive used in the present invention is obtained by applying a polyol, an isocyanate compound, a tackifying resin, and a foaming agent onto a base layer, and performing foaming simultaneously with the reaction.

Drugs used in the present invention include corticosteroids such as dexamethasone, prednisolone, hydrocortisone, hydrocortisone acetate, betamethasone, methyl salicylate, salicylic acid, other anti-inflammatory agents and antihistamines,
Bactericides are used as appropriate depending on the purpose.

In the present invention, a porous urethane adhesive layer is provided on one side of the Motomura film.

A typical method for forming a porous adhesive layer is as follows. That is, polyols include polyoxypropylene glycol, polyoxyethylene glycol,
Polyoxybutylene glycol and polyether polyols, which are copolymers thereof, and polyester polyols, which are copolymers of dicarboxylic acid and polyol, are used.

These may be used in combination or may contain other polyols such as butadiene, but the hydroxyl value is 100
It is preferable to do the following. When the hydroxyl value is 100 or more, the adhesive properties of the adhesive deteriorate. The isocyanate compounds used in the present invention are aromatic, aliphatic, and alicyclic isocyanates. For example, tolylene diisocyanate, P-phenylene diisocyanate, 4-4'biphenylene diisocyanate, polymethylene polyphenyl isocyanate, xylylene diisocyanate, etc.
These isocyanates are isocyanate prepolymers added to the polymer ends.

As the tackifying resin, rosin resins such as hydrogenated rosin and hydrogenated rosin ester, Q or B pinene resin,
Terbene resins such as modified terbene resins, styrene resins such as polymers or copolymers such as styrene and Q-methylstyrene, petroleum resins such as polymers or copolymers such as isoprene, cyclobentadiene, 1,3 pentadiene, etc. One or more of the following may be used as appropriate. As a foaming agent, water,
Freon and hydrocarbons can be used.

As the curing catalyst, various amine-based or tin-based catalysts can be used.

Further, a foam stabilizer such as dimethylsiloxane may be used as appropriate. Further, in order to further impart adhesiveness, a plasticizer such as adipic acid ester or polyethylene glycol ester may be added. Typical mixing ratios are as follows. Polyol 20-40 parts by weight Isocyanate compound 1-40'' Tackifying resin
20-40 Foaming agent 1-
15 Catalyst 0.02-0.5
〃Foaming agent 1. Usually, the above composition is divided into two parts, liquid A and liquid B, and liquid A and liquid B are mixed together just before application.

Part A: Polyol, tackifying resin, catalyst, foaming agent, foam stabilizer Part B: Isocyanate compound When a mixture of these is applied onto a substrate and heated to 60 to 100°C, foaming and reaction of the resin layer occur. occur at the same time.

Alternatively, the mixture may be applied onto a release paper, heated, foamed, and reacted, and then transferred onto a base material. When heated, the adhesive layer becomes porous due to foaming, and at the same time, the active hydrogen in the polyol reacts with the isocyanate compound to form a silk-like structure, which immobilizes the walls of the vertical pores and causes the adhesive to flow and close the pores. prevents it from being blocked. In the present invention, a drug is adsorbed onto the porous urethane adhesive layer.

Adsorption of the drug is carried out in a conventional manner, such as by dissolving the drug in a suitable solvent and impregnating an adhesive tape or sheet in which a porous adhesive layer is provided.
A method of applying or spraying a drug solution dissolved in a solvent onto the porous adhesive layer is appropriately employed. Then, the drug enters into the pores of the porous adhesive layer and is adsorbed. The amount of drug adsorbed to the porous adhesive layer is as follows:
Although it varies depending on the type of drug, 1 to 2,000 French grams per portion is preferable. Therefore, when the therapeutic adhesive tape or sheet of the present invention is applied to the affected area of the skin, it will adhere well to the skin due to the adhesive layer, increase the moisture content of the stratum corneum of the skin, and the urethane adhesive has hygroscopic properties. Because of its excellent properties, the drug adsorbed on the porous adhesive layer is gradually released over a period of, for example, 5 to 2 feeding hours, and is effectively absorbed through the skin.

The drug release rate can be adjusted depending on the application, type of drug, etc. by adjusting the pore size and number of the porous adhesive layer.
Can be controlled as desired.

As mentioned above, the therapeutic adhesive tape or sheet of the present invention has a porous urethane adhesive layer provided on one side of a base film, and a drug is adsorbed to the adhesive layer.
It can be used in a tube and allows the drug to be absorbed into the affected area at a desired rate.

The porous urethane adhesive layer in the present invention is
In particular, since the raw material mixture is applied to the base film and foamed at the same time as the reaction, the resulting pores have their walls fixed by crosslinking, etc.
Since the pongee pores are prevented from becoming rough due to the flow, they become uniform and fine, and the adsorption of drugs is uniform, and the adhesive tape or sheet for treatment can be made with good adhesion to the skin. Serve.

The present invention will be explained below with reference to Examples.

Example 1 Liquid A Polyoxypropylene glycol (hydroxyl value 56
) 6 female hydrogenated rosin ester 4 female trichlorofluoromethane 4 g butyltin dilaurate 0.1 g silicone foam stabilizer
0. Male B liquid Tolylene diisocyanate
5.5g (NCO index 105) liquid A and B
The solutions were mixed and applied to a thickness of 50 mounds on a corona discharge treated 70 mm thick ethylene-vinyl acetate copolymer film (vinyl acetate content: 1 wt %).

Thereafter, it was heated at 6,000°C for 1 hour to form a porous adhesive layer on the base material. An ethanol solution containing prednisolone was sprayed onto the surface of the porous adhesive layer of this adhesive tape to obtain a therapeutic adhesive tape containing 40 grams of prednisolone per portion.

The therapeutic adhesive tape was applied to the affected area, and the amount of prednisolone remaining on the therapeutic adhesive tape was analyzed after 3 and 6 hours.

As a result, 22 g of prednisolone remained after 3 hours and 16 g after 6 hours, and the prednisolone adsorbed to the porous adhesive layer was gradually released and absorbed into the affected area. This was confirmed. For analysis of prednisolone in the therapeutic adhesive tape, the tape was extracted with methanol, the extract was separated using liquid chromatography, and then quantified using an ultraviolet spectrometer. Example 2A liquid Polyoxypropylene glycol (hydroxyl value 80) 6 female hydrogenated rosin ester 4 thigh water 0.1 g water trichlorofluoromethane 1 female dibutyltin dilaurate
0.1g silicone foam stabilizer 0
．． Batter B liquid tolylene diisocyanate 9.0g
(NCO index 105) The above liquids A and B were mixed and the same procedure as in Example 1 was carried out to obtain a porous adhesive tape.

An ethanol solution containing brednisolone was applied to the surface of the porous adhesive layer of this adhesive tape, and
A therapeutic adhesive tape containing prednisolone was obtained.

Claims (1)

[Scope of Claims] 1. A porous urethane adhesive layer formed on one side of a base film by simultaneously reacting and foaming a mixture of a polyol, an isocyanate compound, a tackifying resin, and a foaming agent. 1. A therapeutic adhesive tape or sheet, characterized in that the adhesive layer is provided with a drug and a drug is adsorbed to the adhesive layer. 2. The therapeutic adhesive tape or sheet according to claim 2, wherein the polyol has a hydroxyl value of 100 or less.