JPS6025998A - ９−デオキソ−９ａ−アルキル−９ａ−アザ−９ａ−ホモエリスロマイシンＡ誘導体 - Google Patents

９−デオキソ−９ａ−アルキル−９ａ−アザ−９ａ−ホモエリスロマイシンＡ誘導体

Info

Publication number
JPS6025998A
JPS6025998A JP59133396A JP13339684A JPS6025998A JP S6025998 A JPS6025998 A JP S6025998A JP 59133396 A JP59133396 A JP 59133396A JP 13339684 A JP13339684 A JP 13339684A JP S6025998 A JPS6025998 A JP S6025998A
Authority
JP
Japan
Prior art keywords
compound
formula
reaction
solvent
homoerythromycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP59133396A
Other languages
English (en)
Japanese (ja)
Inventor
ジ−ン・マイケル・ブライト
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of JPS6025998A publication Critical patent/JPS6025998A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP59133396A 1983-06-30 1984-06-29 ９−デオキソ−９ａ−アルキル−９ａ−アザ−９ａ−ホモエリスロマイシンＡ誘導体 Pending JPS6025998A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/509,538 US4464527A (en) 1983-06-30 1983-06-30 Antibacterial 9-deoxo-9a-alkyl-9a-aza-9a-homoerythromycin A derivatives and intermediates therefore
US509538 1983-06-30

Publications (1)

Publication Number Publication Date
JPS6025998A true JPS6025998A (ja) 1985-02-08

Family

ID=24027046

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59133396A Pending JPS6025998A (ja) 1983-06-30 1984-06-29 ９−デオキソ−９ａ−アルキル−９ａ−アザ−９ａ−ホモエリスロマイシンＡ誘導体

Country Status (7)

Country Link
US (1) US4464527A (https=)
EP (1) EP0132944B1 (https=)
JP (1) JPS6025998A (https=)
DE (1) DE3461805D1 (https=)
DK (1) DK158357C (https=)
GR (1) GR79536B (https=)
IE (1) IE57564B1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01153632A (ja) * 1987-11-10 1989-06-15 Pfizer Inc 抗細菌性９−デオキソ―９ａ―アリルおよびプロパルギル―９ａ―アザ―９ａ―ホモエリスロマイシンＡ誘導体

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
US5215980A (en) * 1992-01-17 1993-06-01 Merck & Co., Inc. 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
AU6082594A (en) * 1993-01-11 1994-08-15 Merck & Co., Inc. 8a-aza and 9a-aza macrolide antibiotics, and a process for producing same and methods of use
EP0699207B1 (en) * 1993-05-19 1997-06-25 Pfizer Inc. Intermediate for azithromycin
HRP931480B1 (en) * 1993-12-08 1997-08-31 Sour Pliva 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
WO2002015842A2 (en) 2000-08-23 2002-02-28 Wockhardt Limited Process for preparation of anhydrous azithromycin
ITMI20022292A1 (it) * 2002-10-29 2004-04-30 Zambon Spa 9a-azalidi ad attivita' antiinfiammatoria.
HRP20020885B1 (en) 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
HRP20020991A2 (en) 2002-12-12 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. N"-Substituted 9a-N-(N'-carbamoyl-Gamma-aminopropyl), 9a-N-(N'? -thiocarbamoyl-Gamma-aminopropyl), 9a-N-(N'-((Beta-cyanoethyl)-N'-carbamoyl-Gamma? -aminopropyl) and 9a-N-(N'-(Beta-cyanoethyl)-N'-thiocarbamoyl-Gamma? -aminopropyl) derivatives of 9-de

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57158798A (en) * 1981-03-06 1982-09-30 Sooru Puriba Fuarumaseutosuka Novel erythromycin a derivative, manufacture and use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI7910768A8 (en) * 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57158798A (en) * 1981-03-06 1982-09-30 Sooru Puriba Fuarumaseutosuka Novel erythromycin a derivative, manufacture and use

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01153632A (ja) * 1987-11-10 1989-06-15 Pfizer Inc 抗細菌性９−デオキソ―９ａ―アリルおよびプロパルギル―９ａ―アザ―９ａ―ホモエリスロマイシンＡ誘導体

Also Published As

Publication number Publication date
IE841665L (en) 1984-12-30
IE57564B1 (en) 1992-12-16
GR79536B (https=) 1984-10-30
DE3461805D1 (en) 1987-02-05
EP0132944A1 (en) 1985-02-13
DK319884A (da) 1984-12-31
US4464527A (en) 1984-08-07
DK319884D0 (da) 1984-06-29
DK158357C (da) 1990-10-08
DK158357B (da) 1990-05-07
EP0132944B1 (en) 1986-12-30

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