JPS60143762A - Hydroxy apatite for chromatography - Google Patents

Hydroxy apatite for chromatography

Info

Publication number
JPS60143762A
JPS60143762A JP58183161A JP18316183A JPS60143762A JP S60143762 A JPS60143762 A JP S60143762A JP 58183161 A JP58183161 A JP 58183161A JP 18316183 A JP18316183 A JP 18316183A JP S60143762 A JPS60143762 A JP S60143762A
Authority
JP
Japan
Prior art keywords
calcium
hydroxy apatite
chromatography
organic solvent
apatite
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP58183161A
Other versions
JPH0337706B2 (en
Inventor
Shinji Iino
Kensaku Maruyama
Shinji Miyata
Akihiko Nakamura
Original Assignee
Mitsui Toatsu Chem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chem Inc filed Critical Mitsui Toatsu Chem Inc
Priority to JP58183161A priority Critical patent/JPH0337706B2/ja
Publication of JPS60143762A publication Critical patent/JPS60143762A/en
Publication of JPH0337706B2 publication Critical patent/JPH0337706B2/ja
Anticipated expiration legal-status Critical
Application status is Expired - Lifetime legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/04—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of alkali metals, alkaline earth metals or magnesium
    • B01J20/048—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of alkali metals, alkaline earth metals or magnesium containing phosphorus, e.g. phosphates, apatites, hydroxyapatites

Abstract

PURPOSE:To obtain an excellent filling agent for chromatography by making phosphoric acid or a calcium salt thereof react with a calcium compound in an organic solvent to form a specified hydroxy apatite easily with a better reproducibility. CONSTITUTION:Phosphoric acid or a calcium salt thereof such as calcium hydrogenphosphate 2 water (CaHPO4.2H2O) is made to react with a calcium compound such as calcium hydroxide [Ca(OH)2] in an organic solvent, for example, n-hexane and water at about 60 deg.C. Here, Ca/P in the number of atoms is set at about 1.3-1.9. After about 2hr of reaction, an reactant is filtered and dewatered to obtain hydroxy apatite [Ca10(PO4)6(OH)2]. The apatite thus obtained is less than 50m<2>/g and forms a hexagonal prism-shaped assembly. Thus, the reaction in the organic solvent enables the manufacture of a filling agent for chromatography of hydroxy apatite excellent in the separation performance in a constant character with a better reproducibility.
JP58183161A 1983-10-03 1983-10-03 Expired - Lifetime JPH0337706B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP58183161A JPH0337706B2 (en) 1983-10-03 1983-10-03

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58183161A JPH0337706B2 (en) 1983-10-03 1983-10-03

Publications (2)

Publication Number Publication Date
JPS60143762A true JPS60143762A (en) 1985-07-30
JPH0337706B2 JPH0337706B2 (en) 1991-06-06

Family

ID=16130860

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58183161A Expired - Lifetime JPH0337706B2 (en) 1983-10-03 1983-10-03

Country Status (1)

Country Link
JP (1) JPH0337706B2 (en)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62231163A (en) * 1986-03-31 1987-10-09 Toa Nenryo Kogyo Kk Column for liquid chromatography and its production
JPS6316044A (en) * 1986-07-05 1988-01-23 Asahi Optical Co Ltd Packing agent for column
JPH01287462A (en) * 1988-05-16 1989-11-20 Mitsui Toatsu Chem Inc Packing material and column for liquid chromatography
US5039408A (en) * 1986-07-05 1991-08-13 Asahi Kogaku Kogyo K.K. Packing material for liquid chromatography
US5047031A (en) * 1988-04-20 1991-09-10 Norian Corporation In situ calcium phosphate minerals method
US5129905A (en) * 1988-04-20 1992-07-14 Norian Corporation Methods for in situ prepared calcium phosphate minerals
US5158756A (en) * 1989-06-24 1992-10-27 Asahi Kogaku Kogyo Kabushiki Kaisha Porous particles of calcium phosphate compound and production process thereof
WO1994003801A1 (en) * 1992-08-07 1994-02-17 Kanto Kagaku Kabushiki Kaisha Material of chromatographic stationary phase
US5441635A (en) * 1986-07-05 1995-08-15 Asahi Kogaku Kogyo Kabushiki Kaisha Packing material for liquid chromatography
USRE35340E (en) * 1986-07-05 1996-10-01 Asahi Kogaku Kogyo K.K. Packing material for liquid chromatography
US5728463A (en) * 1992-08-07 1998-03-17 Kanto Kagaku Kabushiki Kaisha Stationary phase material for chromatography
US6306297B1 (en) 1968-07-08 2001-10-23 Asahi Kogaku Kogyo Kabushiki Kaisha Packing material for liquid chromatography and process for producing the same
JP2008540495A (en) * 2005-05-13 2008-11-20 ダニエル チョッカ、 Drugs, especially cancer therapeutics for treatment using immunotherapy, especially for autologous treatment

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306297B1 (en) 1968-07-08 2001-10-23 Asahi Kogaku Kogyo Kabushiki Kaisha Packing material for liquid chromatography and process for producing the same
JPS62231163A (en) * 1986-03-31 1987-10-09 Toa Nenryo Kogyo Kk Column for liquid chromatography and its production
US5441635A (en) * 1986-07-05 1995-08-15 Asahi Kogaku Kogyo Kabushiki Kaisha Packing material for liquid chromatography
US5039408A (en) * 1986-07-05 1991-08-13 Asahi Kogaku Kogyo K.K. Packing material for liquid chromatography
US5651882A (en) * 1986-07-05 1997-07-29 Asahi Kogaku Kogyo Kabushiki Kaisha Packing material for liquid chromatography and process for producing the same
US5651884A (en) * 1986-07-05 1997-07-29 Asahi Kogaku Kogyo Kabushiki Kaisha Packing material for liquid chromatography
JPS6316044A (en) * 1986-07-05 1988-01-23 Asahi Optical Co Ltd Packing agent for column
USRE35340E (en) * 1986-07-05 1996-10-01 Asahi Kogaku Kogyo K.K. Packing material for liquid chromatography
US5047031A (en) * 1988-04-20 1991-09-10 Norian Corporation In situ calcium phosphate minerals method
US5129905A (en) * 1988-04-20 1992-07-14 Norian Corporation Methods for in situ prepared calcium phosphate minerals
JPH01287462A (en) * 1988-05-16 1989-11-20 Mitsui Toatsu Chem Inc Packing material and column for liquid chromatography
US5158756A (en) * 1989-06-24 1992-10-27 Asahi Kogaku Kogyo Kabushiki Kaisha Porous particles of calcium phosphate compound and production process thereof
WO1994003801A1 (en) * 1992-08-07 1994-02-17 Kanto Kagaku Kabushiki Kaisha Material of chromatographic stationary phase
US5728463A (en) * 1992-08-07 1998-03-17 Kanto Kagaku Kabushiki Kaisha Stationary phase material for chromatography
JP2008540495A (en) * 2005-05-13 2008-11-20 ダニエル チョッカ、 Drugs, especially cancer therapeutics for treatment using immunotherapy, especially for autologous treatment

Also Published As

Publication number Publication date
JPH0337706B2 (en) 1991-06-06

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