JPS60130519A - 脂肪輸液剤 - Google Patents
脂肪輸液剤Info
- Publication number
- JPS60130519A JPS60130519A JP23751783A JP23751783A JPS60130519A JP S60130519 A JPS60130519 A JP S60130519A JP 23751783 A JP23751783 A JP 23751783A JP 23751783 A JP23751783 A JP 23751783A JP S60130519 A JPS60130519 A JP S60130519A
- Authority
- JP
- Japan
- Prior art keywords
- fat
- acid
- transfusion solution
- vol
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims abstract description 4
- 238000001802 infusion Methods 0.000 claims description 30
- 239000002253 acid Substances 0.000 claims description 26
- 238000002360 preparation method Methods 0.000 claims description 15
- 150000002148 esters Chemical class 0.000 claims description 10
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 235000019197 fats Nutrition 0.000 abstract description 39
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract description 13
- 239000003549 soybean oil Substances 0.000 abstract description 13
- 235000012424 soybean oil Nutrition 0.000 abstract description 13
- JQWAHKMIYCERGA-UHFFFAOYSA-N (2-nonanoyloxy-3-octadeca-9,12-dienoyloxypropoxy)-[2-(trimethylazaniumyl)ethyl]phosphinate Chemical compound CCCCCCCCC(=O)OC(COP([O-])(=O)CC[N+](C)(C)C)COC(=O)CCCCCCCC=CCC=CCCCCC JQWAHKMIYCERGA-UHFFFAOYSA-N 0.000 abstract description 7
- 230000002785 anti-thrombosis Effects 0.000 abstract description 7
- 235000019485 Safflower oil Nutrition 0.000 abstract description 6
- 238000002347 injection Methods 0.000 abstract description 6
- 239000007924 injection Substances 0.000 abstract description 6
- 239000003813 safflower oil Substances 0.000 abstract description 6
- 235000005713 safflower oil Nutrition 0.000 abstract description 6
- 239000012153 distilled water Substances 0.000 abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 5
- 239000003146 anticoagulant agent Substances 0.000 abstract description 3
- -1 ester derivative of alpha-linolenic acid Chemical class 0.000 abstract description 3
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 abstract description 2
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract description 2
- 230000001804 emulsifying effect Effects 0.000 abstract description 2
- 235000020778 linoleic acid Nutrition 0.000 abstract description 2
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 abstract description 2
- 239000000944 linseed oil Substances 0.000 abstract description 2
- 235000021388 linseed oil Nutrition 0.000 abstract description 2
- 239000000203 mixture Substances 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- 239000000243 solution Substances 0.000 abstract 6
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 abstract 4
- 235000020661 alpha-linolenic acid Nutrition 0.000 abstract 2
- 229960004488 linolenic acid Drugs 0.000 abstract 2
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- JYYFMIOPGOFNPK-AGRJPVHOSA-N ethyl linolenate Chemical compound CCOC(=O)CCCCCCC\C=C/C\C=C/C\C=C/CC JYYFMIOPGOFNPK-AGRJPVHOSA-N 0.000 abstract 1
- 229940090028 ethyl linolenate Drugs 0.000 abstract 1
- JYYFMIOPGOFNPK-UHFFFAOYSA-N ethyl linolenate Natural products CCOC(=O)CCCCCCCC=CCC=CCC=CCC JYYFMIOPGOFNPK-UHFFFAOYSA-N 0.000 abstract 1
- 230000000246 remedial effect Effects 0.000 abstract 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 8
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 6
- 125000004494 ethyl ester group Chemical group 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 5
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 4
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 3
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 3
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 3
- 239000005642 Oleic acid Substances 0.000 description 3
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 3
- 229940114079 arachidonic acid Drugs 0.000 description 3
- 235000021342 arachidonic acid Nutrition 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 3
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 235000011121 sodium hydroxide Nutrition 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 241000283977 Oryctolagus Species 0.000 description 1
- 208000010378 Pulmonary Embolism Diseases 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 210000000702 aorta abdominal Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229940105631 nembutal Drugs 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 229940083466 soybean lecithin Drugs 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 238000009461 vacuum packaging Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23751783A JPS60130519A (ja) | 1983-12-16 | 1983-12-16 | 脂肪輸液剤 |
| DE8484112091T DE3475870D1 (en) | 1983-12-16 | 1984-10-09 | Transfusion emulsion |
| EP84112091A EP0145873B1 (en) | 1983-12-16 | 1984-10-09 | Transfusion emulsion |
| BE0/214110A BE901206A (fr) | 1983-12-16 | 1984-12-04 | Emulsion pour transfusion. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23751783A JPS60130519A (ja) | 1983-12-16 | 1983-12-16 | 脂肪輸液剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60130519A true JPS60130519A (ja) | 1985-07-12 |
| JPH0421645B2 JPH0421645B2 (enrdf_load_stackoverflow) | 1992-04-13 |
Family
ID=17016493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP23751783A Granted JPS60130519A (ja) | 1983-12-16 | 1983-12-16 | 脂肪輸液剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60130519A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009518332A (ja) * | 2005-12-06 | 2009-05-07 | エルテーエス ローマン テラピー−ジステーメ アーゲー | トロンビン阻害剤としての不飽和脂肪酸 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3169094A (en) * | 1960-08-26 | 1965-02-09 | Wretlind Arvid Johannes | Method of preparing intravenously injectable fat emulsions free from side reactions or complications |
| JPS55147228A (en) * | 1979-05-07 | 1980-11-17 | Green Cross Corp:The | Fat emulsion for intravenous injection |
| JPS5791915A (en) * | 1980-09-24 | 1982-06-08 | Roussel Uclaf | Novel lipid composition useful for dietetics, resuscitation and treatment |
| JPS57198062A (en) * | 1981-05-30 | 1982-12-04 | Hideyoshi Kurose | Nutrient bean curd and its preparation |
| JPS58208217A (ja) * | 1982-02-03 | 1983-12-03 | スコッティア ホウルディングズ ピーエルシー | 局所性製薬組成物 |
-
1983
- 1983-12-16 JP JP23751783A patent/JPS60130519A/ja active Granted
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3169094A (en) * | 1960-08-26 | 1965-02-09 | Wretlind Arvid Johannes | Method of preparing intravenously injectable fat emulsions free from side reactions or complications |
| JPS55147228A (en) * | 1979-05-07 | 1980-11-17 | Green Cross Corp:The | Fat emulsion for intravenous injection |
| JPS5791915A (en) * | 1980-09-24 | 1982-06-08 | Roussel Uclaf | Novel lipid composition useful for dietetics, resuscitation and treatment |
| JPS57198062A (en) * | 1981-05-30 | 1982-12-04 | Hideyoshi Kurose | Nutrient bean curd and its preparation |
| JPS58208217A (ja) * | 1982-02-03 | 1983-12-03 | スコッティア ホウルディングズ ピーエルシー | 局所性製薬組成物 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009518332A (ja) * | 2005-12-06 | 2009-05-07 | エルテーエス ローマン テラピー−ジステーメ アーゲー | トロンビン阻害剤としての不飽和脂肪酸 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0421645B2 (enrdf_load_stackoverflow) | 1992-04-13 |
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