JPS5939889A - Preparation of 2,4,6-tri-0-acetyl-3-deoxy-hexono-1,5-lactone - Google Patents

Preparation of 2,4,6-tri-0-acetyl-3-deoxy-hexono-1,5-lactone

Info

Publication number
JPS5939889A
JPS5939889A JP15041882A JP15041882A JPS5939889A JP S5939889 A JPS5939889 A JP S5939889A JP 15041882 A JP15041882 A JP 15041882A JP 15041882 A JP15041882 A JP 15041882A JP S5939889 A JPS5939889 A JP S5939889A
Authority
JP
Japan
Prior art keywords
lactone
acetyl
acetic anhydride
catalyst
glucono
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15041882A
Other languages
Japanese (ja)
Inventor
Yoshio Nakamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NOGUCHI KENKYUSHO
Original Assignee
NOGUCHI KENKYUSHO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NOGUCHI KENKYUSHO filed Critical NOGUCHI KENKYUSHO
Priority to JP15041882A priority Critical patent/JPS5939889A/en
Publication of JPS5939889A publication Critical patent/JPS5939889A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the titled compound useful as a starting substance for deoxysaccharide industrially advantageously, by reacting tetra-O-acetyl-D-glucono- lactone with a hydrogen gas in acetic anhydride containing both a basic catalyst and a hydrogenating catalyst.
CONSTITUTION: 2,3,4,6-Tetra-O-acetyl-D-glucono-1,5-lactone is reacted with a hydrogen gas preferably at 30W80°C at 1W100kg/cm2 in acetic anhydride or a mixed solvent of acetic anhydride and a solvent (e.g., ethyl acetate, etc.) stable under reaction conditions, in the presence of both a base catalyst (e.g., potassium acetate, etc.) and a hydrogenating catalyst (e.g., palladium supported on carrier, etc.), to give the desired compound.
EFFECT: Obtained in high yield, and separation operation is extremely easy.
COPYRIGHT: (C)1984,JPO&Japio
JP15041882A 1982-08-30 1982-08-30 Preparation of 2,4,6-tri-0-acetyl-3-deoxy-hexono-1,5-lactone Pending JPS5939889A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15041882A JPS5939889A (en) 1982-08-30 1982-08-30 Preparation of 2,4,6-tri-0-acetyl-3-deoxy-hexono-1,5-lactone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15041882A JPS5939889A (en) 1982-08-30 1982-08-30 Preparation of 2,4,6-tri-0-acetyl-3-deoxy-hexono-1,5-lactone

Publications (1)

Publication Number Publication Date
JPS5939889A true JPS5939889A (en) 1984-03-05

Family

ID=15496503

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15041882A Pending JPS5939889A (en) 1982-08-30 1982-08-30 Preparation of 2,4,6-tri-0-acetyl-3-deoxy-hexono-1,5-lactone

Country Status (1)

Country Link
JP (1) JPS5939889A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9024009B2 (en) 2007-09-10 2015-05-05 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
US9035044B2 (en) 2011-05-09 2015-05-19 Janssen Pharmaceutica Nv L-proline and citric acid co-crystals of (2S, 3R, 4R, 5S,6R)-2-(3-((5-(4-fluorophenyl)thiopen-2-yl)methyl)4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
US9056850B2 (en) 2008-10-17 2015-06-16 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
US9174971B2 (en) 2009-10-14 2015-11-03 Janssen Pharmaceutica Nv Process for the preparation of compounds useful as inhibitors of SGLT2
US10544135B2 (en) 2011-04-13 2020-01-28 Janssen Pharmaceutica Nv Process for the preparation of compounds useful as inhibitors of SGLT2
US10617668B2 (en) 2010-05-11 2020-04-14 Janssen Pharmaceutica Nv Pharmaceutical formulations
US11207337B2 (en) 2015-09-15 2021-12-28 Janssen Pharmaceutica Nv Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9024009B2 (en) 2007-09-10 2015-05-05 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
US9056850B2 (en) 2008-10-17 2015-06-16 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
US9174971B2 (en) 2009-10-14 2015-11-03 Janssen Pharmaceutica Nv Process for the preparation of compounds useful as inhibitors of SGLT2
US10617668B2 (en) 2010-05-11 2020-04-14 Janssen Pharmaceutica Nv Pharmaceutical formulations
US10544135B2 (en) 2011-04-13 2020-01-28 Janssen Pharmaceutica Nv Process for the preparation of compounds useful as inhibitors of SGLT2
US9035044B2 (en) 2011-05-09 2015-05-19 Janssen Pharmaceutica Nv L-proline and citric acid co-crystals of (2S, 3R, 4R, 5S,6R)-2-(3-((5-(4-fluorophenyl)thiopen-2-yl)methyl)4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
US11207337B2 (en) 2015-09-15 2021-12-28 Janssen Pharmaceutica Nv Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders

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