JPS59204117A - Therapeutic material for external application - Google Patents

Abstract

PURPOSE:To obtain a therapeutic material for external use, exhibiting strong initial cooling effect without lowering the drug action of aloe, and especially effective as a remedy for scald, by compounding aloe or aloe extract to a hydrophilic hydrous gel substrate, and forming the mixture in the form of a sheet. CONSTITUTION:Aloe or an aloe extract is compounded to a hydrophilic hydrated gel substrate containing 3-30wt% of a hydrophilic polymer and 10-95wt% of water, and the mixture is spread on a carrier and formed in the form of a sheet to obtain the objective material for external use. The hydrophilic polymer is selected from polyacrylic acid, acrylic acid copolymer, maleic anhydride copolymer, water-soluble polyamide, polyvinyl alcohol, etc., and the substrate is preferably incorporated further with a polyhydric alcohol to tackify the substrate and to increase the solubility during the preparation. The amount of aloe added to the material is preferably >=2% as aloe powder of 1-15% as aloe extract.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a sheet-shaped external treatment member. More specifically, the present invention relates to a sheet-shaped external treatment member containing aloe or aloe extract.

Aloe has been used as a medicinal herb for several centuries, and was listed as INt in the Japanese Pharmacopoeia in 1889, and has been used as a folk medicine since ancient times.

The effects of aloe are as follows.For internal use, it has a laxative effect on gastrointestinal diseases, a laxative for gastrointestinal disorders, a laxative for constipation, prevention of complications for high blood pressure, and a blood thinner for low blood pressure. External use includes improving circulation, inactivating viruses for colds, improving constitution for colds, activating metabolism for diabetes, detoxifying effects for liver disease, calming effects for motion sickness, and soothing effects for hangovers. Sterilizing effect and tissue recovery effect on burns, abrasions, and cuts, astringent effect and toxin neutralizing effect on insect bites, bactericidal effect on athlete's foot, keratin softening effect on corns, anti-inflammatory effect on cavities and alveolar pyorrhea, and sterilization effect on stomatitis. It has an anti-inflammatory effect on bruises and stiff shoulders, and an anti-inflammatory analgesic and hemostatic effect on hemorrhoids.

As described above, aloe has various medicinal effects, and depending on the purpose, raw aloe, juice, liquid, ointment, tablet, etc. are taken or applied.

By the way, if aloe vera is to be used externally as the most effective and highly effective treatment for burns, cuts, and abrasions, the earlier the initial treatment, the better. Particularly in the case of treatment for burns, it is preferable to keep a commercially available ointment on hand and use it once in an emergency.

In addition to treating burns as quickly as possible, it is important to cool the affected area, and the degree of initial cooling determines the speed of recovery. In that light, the cartilage agent is lacking in its ability to provide a cooling effect of 1 t/l. In addition, a treatment in which aloe grown at home is sterilized by soaking it in boiling water, removing the outer skin, and applying the jelly-like part of the leaf to the affected area in a wide array is a treatment that removes the large amount of aloe contained in aloe. It has the advantage of having a cooling effect due to the amount of water, and at the same time applying the medicinal ingredients of aloe directly to the affected area.Although it is a well-known method of use, it has the disadvantage that it is cumbersome to operate and takes time to open. There was.

The purpose of the present invention is to obtain an aloe preparation with a large initial cooling effect without impairing the medicinal efficacy of aloe, and its gist is to blend aloe or aloe extract into a hydrophilic hydrous gel base,
This is an external treatment member formed into a sheet shape.

Regarding the present invention, as a hydrophilic hydrogel base.

Usually, one that has been commonly used in the past is used. It may be either synthetic or natural, and any of those conventionally used for hydrophilic gel bases can be used. Representative examples include saccharides and their compounds, such as sodium alginate, gum arahya, dextrin, pullulanlatin, curdline, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, and carboxymethylcellulose, polyacrylic acid and its salts (for example, Sodium salt, ammonium salt, alkanolamide/
salts, etc.), acrylic acid copolymers and their salts (e.g., acrylic acid/ethyl acrylate copolymers, potassium salts of acrylic acid/ethyl acrylate copolymers, etc.), acrylic acid alkyl ester polymers (e.g., ethyl acrylate, hydroxyethyl polyacrylate, ethoxyethyl polyacrylate), maleic anhydride copolymer (
For example, methyl vinyl ether/maleic anhydride copolymer, imbutylene/maleic anhydride copolymer, etc.) and their salts (e.g., sodium salt, ammonium salt, etc.), polyvinyl alcohol and its Me form (e.g., partially gunned (such as borihinyl alcohol, carphokimolated borihinyl alcohol), acrylamide monomers and their copolymers (e.g., acrylamide/acrylic acid copolymer, acrylamide/acrylonitrile,
Acrylic acid copolymers, acrylamide/acrylonitrile/acrylic acid ester copolymers, etc.), polyvinylpyrrolitonos, etc. Such polymeric substances may be crosslinked using a crosslinking agent (eg, polyisocyanate, polyepoxide, benzoyl peroxide, etc.).

The blending amount of the polymeric substance in the parent aqueous hydrogel base varies depending on the strength of the base and the setting of the cooling capacity, but is usually about 3 to 30%.

If the weight is less than 8%, the hydrogel strength will be insufficient even if it is used in a crosslinked state, 3071'! If the amount exceeds 1, the viscosity during production is too high, resulting in poor workability, and the amount of water that can be blended decreases in view of the solubility of the polymeric substance, which tends to result in poor cooling performance.

In addition, it is preferable to use a polyhydric alcohol such as ethylene glycol, diethyl glycol, polyethylene glycol, fluoropylene glycol, polypropylene glycol, or glycerin in the base material for the purpose of tackification and improving solubility during manufacturing. , the amount used is usually 5~
It is 80% by weight.

If it is less than 5% by weight, no significant effect can be obtained by adding it, and if it is more than 80% by weight, the strength of the hydrogel and the cooling ability will be poor.

If the water content in the hydrophilic hydrogel base is 104% by weight or more, a cooling effect can be expected, but if it is less than 20% by weight, the cooling effect disappears quickly, and if it is more than 95Mkk'l1, the hydrogel strength is insufficient. Therefore, it can be used depending on its shape and size. Therefore, the preferred water content is 25 to 70 M, more preferably 30 to 60% by weight, although it varies slightly depending on the polymer material used.

Aloe or aloe extract is blended as a medicinal ingredient, but depending on the purpose, known bactericides, anti-inflammatory agents, anti-deception M
IJ, filler, primary alcohol, etc. may all be added.

As aloe, it is preferable to use those listed in the pharmacopeia (Cuzo aloe, Socotra aloe, Curacao aloe), but of course, it is also possible to use pond aloe such as Natal aloe, Denver aloe, Shirtarapad aloe, etc. Good too. Aloe may be added in the form of its powder, aloe juice, or aloe extract. Examples of aloe extracts include water, alcohol such as ethanol, and water-alcohol.
It has been used for some time since it was extracted and mounted using a vmAK medium or the like.

If the blend md of Aloe Mataha aloe extract is 2% or more as 70g or aloe wood, and 0.84 or more as the above extract, it will be effective! The acid content of the extract is preferably 1 to 15%.

Kineri J's therapeutic components are manufactured by uniformly dispersing or dissolving aloe in a hydrophilic Koki base and spreading the whole carrier over the entire length.

As the carrier, conventionally known carriers such as cloth and plastic may be used.

Hereinafter, the misfire 1313 will be explained in more detail by showing an example and a medical inspection, but this is not something that can be ignored.

In addition, in the following description, "Miyako" refers to [ ]j 61
The moon tastes like salmon.

Example 1 Polyacrylic ridge having an average degree of polymerization of 20,000 6 parts of soda and 15 parts of glycerin are dissolved in 80 parts of water.

- triglycidyl isocyanurate -) 0.3 liters of water
It dissolves completely. Next, while stirring the sodium polyacrylate and glycerin water gi, triglycidyl isocyanate water was added, heated at about 70°C for 1 hour, and then cooled.
Add all 750 parts of liquid made from fresh aloe leaves and mix.

This mixture is applied to a rayon nonwoven fabric to a thickness of 1.0 mm to obtain a Pi medical member.

Example 2 90 parts of acrylic acid, 10 parts of butyl acrylate, 50 parts of polyoxypropylated sorbitol, and 2 parts of ammonium persulfate were dissolved in 350 parts of water, and 60 parts of the solution was dissolved in an inert gas atmosphere.
Polymerization was carried out at °C for 8 hours. To 100 parts of the obtained viscous liquid, add 60 g of polyoxypropylated sorbitol and 20 g of 20% potassium hydroxide water.

Miyako, 10% triglycidyl isocyanurate water soluble 10
Add the water and mix evenly, then add the water-based extract of aloe
The 0 part solution was added and mixed, and spread on a rayon nonwoven fabric with a thickness of 100 μm to a thickness of about 1 m to obtain a sheet-like treatment member.

Example 8 Maleinoic anhydride/methyl vinyl ether copolymer (maleic anhydride content 50% by weight) 20 strips aqueous solution 10081
SK, diethylene glycol 15 ffl East Triechnol) Add V amine 1 and mix, and after uniformly mixing, add 10% glycerin siglycyl ether in water;'le
20 parts of I and 50 parts of pharmacopoeial aloe powder were added to the rayon nonwoven fabric to a thickness of 1. Apply it so that it turns on, and then heat it up at the sewing temperature.
The treatment member of the present invention is obtained by bridging.

Examples The preparations obtained in Examples 1 to 3 were applied to the burns shown in Table 1,
The effectiveness was evaluated and the results were presented as a first example.

As is clear from the above results, Fukacho Treatment Department @ had a better therapeutic effect than the aloe insole.

leftover color

Claims (4)

[Claims] (1) An external treatment material prepared by blending aloe or aloe extract with a hydrophilic hydrogel base and forming it into a sheet. (2) The external treatment member according to claim 0, wherein the water content in the hydrophilic hydrogel base is 10 to 95% by weight. (3) The hydrophilic hydrogel base is polyacrylic acid and its salts, acrylic acid copolymers and their salts, maleic anhydride copolymers and their salts, water-soluble polyamides, borihinyl alcohol and its derivatives, and The external therapeutic device according to item (1), which is made of at least one hydrophilic polymeric substance selected from saccharides and derivatives thereof. (4) Claim No. 1, wherein the hydrophilic hydrogel base contains 8 to 30 layers of hydrophilic polymeric material.
Or the external treatment member described in (2).