JPS59181217A - Anticancer agent composition containing dammarane based compound - Google Patents

Anticancer agent composition containing dammarane based compound

Info

Publication number
JPS59181217A
JPS59181217A JP5467883A JP5467883A JPS59181217A JP S59181217 A JPS59181217 A JP S59181217A JP 5467883 A JP5467883 A JP 5467883A JP 5467883 A JP5467883 A JP 5467883A JP S59181217 A JPS59181217 A JP S59181217A
Authority
JP
Japan
Prior art keywords
dammarane
agent composition
anticancer agent
compounds
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5467883A
Other versions
JPS6312448B2 (en
Inventor
Shigenobu Arihara
Shinichi Hayashi
Kiju Nishimoto
Toshio Odajima
Noriko Takagi
Tsunematsu Takemoto
Yoshie Watanabe
Original Assignee
Toshio Odajima
Rooto Seiyaku Kk
Tsunematsu Takemoto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toshio Odajima, Rooto Seiyaku Kk, Tsunematsu Takemoto filed Critical Toshio Odajima
Priority to JP5467883A priority Critical patent/JPS6312448B2/ja
Publication of JPS59181217A publication Critical patent/JPS59181217A/en
Publication of JPS6312448B2 publication Critical patent/JPS6312448B2/ja
Application status is Expired legal-status Critical

Links

Abstract

PURPOSE: A low toxic anticancer agent composition, containing one or more specific dammarane based compounds, including novel compounds, and capable of inhibiting tumorous cells in a very small amount without damaging cells in the inhibitory concentration thereof.
CONSTITUTION: An anticancer agent composition containing one or more of compound expressed by formula I (glu is β-D-glucopyranosyl), formula II, III or IV. The compounds expressed by formulas I WIV are found to have powerful antitumor activity in prosapogenin and sapogenin obtained by hydrolyzing dammarane based sepogenin contained in Hydrangeae serrata Seringe var. thunbergii Sugimoto. The compounds expressed by formulas I WIV are capable of inhibiting remarkably the multiplication of uterine neck cancer calls or melanoma cells, etc. in an amount of ≤10μg/ml concentration and scarcely damaging the cell in the concentration. The agent is applicable to cancers in the skin, liver and stomach, etc. The compound of formula III is a novel compound and designated as Mh-2.
COPYRIGHT: (C)1984,JPO&Japio
JP5467883A 1983-03-30 1983-03-30 Expired JPS6312448B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5467883A JPS6312448B2 (en) 1983-03-30 1983-03-30

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5467883A JPS6312448B2 (en) 1983-03-30 1983-03-30

Publications (2)

Publication Number Publication Date
JPS59181217A true JPS59181217A (en) 1984-10-15
JPS6312448B2 JPS6312448B2 (en) 1988-03-18

Family

ID=12977443

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5467883A Expired JPS6312448B2 (en) 1983-03-30 1983-03-30

Country Status (1)

Country Link
JP (1) JPS6312448B2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002003996A1 (en) * 2000-07-12 2002-01-17 RAJKUMAR, Sujatha Use of dammarane-type tritepenoid saporins
WO2005040189A1 (en) * 2003-10-27 2005-05-06 Panagin Pharmaceuticals Inc. Novel dammarane sapogenins and their use as anti-cancer agents
CN104327148A (en) * 2014-10-24 2015-02-04 中央民族大学 Compounds with antitumor activity, and preparation method and application thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002003996A1 (en) * 2000-07-12 2002-01-17 RAJKUMAR, Sujatha Use of dammarane-type tritepenoid saporins
WO2005040189A1 (en) * 2003-10-27 2005-05-06 Panagin Pharmaceuticals Inc. Novel dammarane sapogenins and their use as anti-cancer agents
CN104327148A (en) * 2014-10-24 2015-02-04 中央民族大学 Compounds with antitumor activity, and preparation method and application thereof

Also Published As

Publication number Publication date
JPS6312448B2 (en) 1988-03-18

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